@abarbachanog.bsky.social
Reposted
A story of transposons, innate immunity, and how human (and primates) possess an endogenous system to tune interferon response through the relative expression level of a signaling receptor and its alternatively spliced decoy.
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Regulation of human interferon signaling by transposon exonization
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.
www.cell.com
December 12, 2024 at 7:29 PM
A story of transposons, innate immunity, and how human (and primates) possess an endogenous system to tune interferon response through the relative expression level of a signaling receptor and its alternatively spliced decoy.