Giulia Pasquesi
@giuliapasquesi.bsky.social
Postdoctoral K99/R00 NIH fellow at CU Boulder in Ed Chuong lab. Transposable Elements, alternative splicing, vertebrate genome evolution.
https://scholar.google.com/citations?hl=en&user=S0mlwusAAAAJ
Job hunting
🇮🇹
https://scholar.google.com/citations?hl=en&user=S0mlwusAAAAJ
Job hunting
🇮🇹
Reposted by Giulia Pasquesi
New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!
April 16, 2025 at 7:14 AM
New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!
Reposted by Giulia Pasquesi
All the credit for this discovery goes to postdoc @giuliapasquesi.bsky.social , who first noticed the isoform in her 2020 Lockdown Sideproject (tm). Her perseverance, creativity, and talent made this study possible and it was an honor to be a part of it. Watch out for her--she's on the job market! 😉
December 12, 2024 at 6:57 PM
All the credit for this discovery goes to postdoc @giuliapasquesi.bsky.social , who first noticed the isoform in her 2020 Lockdown Sideproject (tm). Her perseverance, creativity, and talent made this study possible and it was an honor to be a part of it. Watch out for her--she's on the job market! 😉
A story of transposons, innate immunity, and how human (and primates) possess an endogenous system to tune interferon response through the relative expression level of a signaling receptor and its alternatively spliced decoy.
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Regulation of human interferon signaling by transposon exonization
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.
www.cell.com
December 12, 2024 at 7:29 PM
A story of transposons, innate immunity, and how human (and primates) possess an endogenous system to tune interferon response through the relative expression level of a signaling receptor and its alternatively spliced decoy.
It wouldn't be my profile otherwise 😍
December 12, 2024 at 7:13 AM
It wouldn't be my profile otherwise 😍
First work out of my Postdoc (and the pandemic) in 2022. We looked at the contribution of TEs to bat immune responses. Surprisingly, no strong evidence in support of genome-wide epigenetic activation of TEs in response to IFN (contrary to other mammals)!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells - Mobile DNA
Background Bats are a major reservoir of zoonotic viruses, and there has been growing interest in characterizing bat-specific features of innate immunity and inflammation. Recent studies have revealed...
link.springer.com
December 10, 2024 at 10:47 PM
First work out of my Postdoc (and the pandemic) in 2022. We looked at the contribution of TEs to bat immune responses. Surprisingly, no strong evidence in support of genome-wide epigenetic activation of TEs in response to IFN (contrary to other mammals)!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Following up on Nat. Commun. 2018, we analyzed the relationship between TE transcription and expression levels of genes involved in TE silencing in somatic and germline tissues across vertebrates.
doi.org/10.1093/gbe/...
doi.org/10.1093/gbe/...
Vertebrate Lineages Exhibit Diverse Patterns of Transposable Element Regulation and Expression across Tissues
Abstract. Transposable elements (TEs) comprise a major fraction of vertebrate genomes, yet little is known about their expression and regulation across tis
doi.org
December 7, 2024 at 2:28 AM
Following up on Nat. Commun. 2018, we analyzed the relationship between TE transcription and expression levels of genes involved in TE silencing in somatic and germline tissues across vertebrates.
doi.org/10.1093/gbe/...
doi.org/10.1093/gbe/...
One of my favorite works. And it had been an honor to be a part of it
genome.cshlp.org/content/29/4...
genome.cshlp.org/content/29/4...
December 7, 2024 at 2:13 AM
One of my favorite works. And it had been an honor to be a part of it
genome.cshlp.org/content/29/4...
genome.cshlp.org/content/29/4...
In the awe of next week big reveal, a little bit of my past.
My very first First-author paper (Nat Commun 2018), as a grad student in Todd Castoe lab. We showed unique characteristics of the conflict between genome size and TE activity in squamates compared to other amniotes.
doi.org/10.1038/s414...
My very first First-author paper (Nat Commun 2018), as a grad student in Todd Castoe lab. We showed unique characteristics of the conflict between genome size and TE activity in squamates compared to other amniotes.
doi.org/10.1038/s414...
Squamate reptiles challenge paradigms of genomic repeat element evolution set by birds and mammals - Nature Communications
Large-scale patterns of genomic repeat element evolution have been studied mainly in birds and mammals. Here, the authors analyze the genomes of over 60 squamate reptiles and show high variation in re...
doi.org
December 7, 2024 at 2:08 AM
In the awe of next week big reveal, a little bit of my past.
My very first First-author paper (Nat Commun 2018), as a grad student in Todd Castoe lab. We showed unique characteristics of the conflict between genome size and TE activity in squamates compared to other amniotes.
doi.org/10.1038/s414...
My very first First-author paper (Nat Commun 2018), as a grad student in Todd Castoe lab. We showed unique characteristics of the conflict between genome size and TE activity in squamates compared to other amniotes.
doi.org/10.1038/s414...