Alex Anderson
@a-anderson.bsky.social
Postdoctoral scientist in the @lancasterlab.bsky.social at MRC LMB, Cambridge
A mito fanatic studying metabolism, brain development and evolution in cerebral organoids 🧠
Melbourne made 🇦🇺
Opinions my own
A mito fanatic studying metabolism, brain development and evolution in cerebral organoids 🧠
Melbourne made 🇦🇺
Opinions my own
Feel like a proud dad! My first attempt at reprogramming - from a lymphoprep to a lovely forebrain organoid! A successful new Chimpanzee iPSC line for the lab 🙊
August 20, 2025 at 4:53 PM
Feel like a proud dad! My first attempt at reprogramming - from a lymphoprep to a lovely forebrain organoid! A successful new Chimpanzee iPSC line for the lab 🙊
Reposted by Alex Anderson
We noticed CII assembly factor SDHAF2 accumulates in some OXPHOS deficient cell lines but not others. New Dr Kugan cracked the case: CII assembly controls a balance btwn TCA cycle direction and protection from Q-pool stress to support ROS-meditated metabolic reprogramming in OXPHOS adapted cells.
Complex II assembly drives metabolic adaptation to OXPHOS dysfunction
Succinate dehydrogenase assembly dynamics maintains metabolic homeostasis during mitochondrial oxidative stress.
www.science.org
August 15, 2025 at 9:16 PM
We noticed CII assembly factor SDHAF2 accumulates in some OXPHOS deficient cell lines but not others. New Dr Kugan cracked the case: CII assembly controls a balance btwn TCA cycle direction and protection from Q-pool stress to support ROS-meditated metabolic reprogramming in OXPHOS adapted cells.
Reposted by Alex Anderson
#Legionella pumps 100s of effector proteins into host cells, including to #mitochondria. @drdstojanovski.bsky.social &co show that effector LpPIP is a tail-anchored protein of the MOM that recruits protein phosphatase 1 to modulate the host mitochondrial P-proteome @plosbiology.org 🧪 plos.io/4f2T5kE
July 25, 2025 at 1:57 PM
#Legionella pumps 100s of effector proteins into host cells, including to #mitochondria. @drdstojanovski.bsky.social &co show that effector LpPIP is a tail-anchored protein of the MOM that recruits protein phosphatase 1 to modulate the host mitochondrial P-proteome @plosbiology.org 🧪 plos.io/4f2T5kE
Reposted by Alex Anderson
Exciting news! Our most important work is out as preprint!
We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use.
Next step is the clinical trial starting early next year!
www.medrxiv.org/content/10.1...
We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use.
Next step is the clinical trial starting early next year!
www.medrxiv.org/content/10.1...
Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease
Mitochondrial disease encompasses inherited disorders affecting mitochondrial function. A severe and untreatable form of mitochondrial disease is Leigh syndrome (LS) causing psychomotor regression and...
www.medrxiv.org
May 19, 2025 at 12:19 PM
Exciting news! Our most important work is out as preprint!
We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use.
Next step is the clinical trial starting early next year!
www.medrxiv.org/content/10.1...
We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use.
Next step is the clinical trial starting early next year!
www.medrxiv.org/content/10.1...
Reposted by Alex Anderson
February 13, 2025 at 12:47 AM
Reposted by Alex Anderson
New year, new version of mitoXplorer 3.0 (mitoxplorer3.ibdm.univ-amu.fr) : mine your single-cell RNA-seq data from a mitochondrial perspective by creating cell-type specific pseudo-bulks or by looking at mitochondrial variability on single-cell level. Check it out at doi: doi.org/10.1101/2024...
mitoXplorer 3.0, a web tool for exploring mitochondrial dynamics in single-cell RNA-seq data
Mitochondria are important eukaryotic organelles, best known for their function in ATP production and in cellular metabolism and signalling. It is widely accepted that their structure, composition and...
doi.org
January 2, 2025 at 3:29 PM
New year, new version of mitoXplorer 3.0 (mitoxplorer3.ibdm.univ-amu.fr) : mine your single-cell RNA-seq data from a mitochondrial perspective by creating cell-type specific pseudo-bulks or by looking at mitochondrial variability on single-cell level. Check it out at doi: doi.org/10.1101/2024...
Reposted by Alex Anderson
It’s been an exciting holiday season for the Lancaster Lab, with not 1, not 2, but 3 new preprints to share!
Check ‘em out:
doi.org/10.1101/2024...
doi.org/10.1101/2024...
doi.org/10.1101/2024...
Happy holidays and best wishes for 2025 from our lab to yours! 🎄🎉
Check ‘em out:
doi.org/10.1101/2024...
doi.org/10.1101/2024...
doi.org/10.1101/2024...
Happy holidays and best wishes for 2025 from our lab to yours! 🎄🎉
Mouse brain organoids model in vivo neurodevelopment and function and capture differences to human
In the last decade since their emergence, brain organoids have offered an increasingly popular and powerful model for the study of early development and disease in humans. These 3D stem cell-derived m...
www.biorxiv.org
December 30, 2024 at 3:25 PM
It’s been an exciting holiday season for the Lancaster Lab, with not 1, not 2, but 3 new preprints to share!
Check ‘em out:
doi.org/10.1101/2024...
doi.org/10.1101/2024...
doi.org/10.1101/2024...
Happy holidays and best wishes for 2025 from our lab to yours! 🎄🎉
Check ‘em out:
doi.org/10.1101/2024...
doi.org/10.1101/2024...
doi.org/10.1101/2024...
Happy holidays and best wishes for 2025 from our lab to yours! 🎄🎉
Nice to end the year with a paper! Very excited to share my first authorship in the @lancasterlab.bsky.social lab - making mouse organoids 🧠
Check it out: doi.org/10.1101/2024...
Check it out: doi.org/10.1101/2024...
Mouse brain organoids model in vivo neurodevelopment and function and capture differences to human
In the last decade since their emergence, brain organoids have offered an increasingly popular and powerful model for the study of early development and disease in humans. These 3D stem cell-derived m...
doi.org
December 31, 2024 at 7:38 PM
Nice to end the year with a paper! Very excited to share my first authorship in the @lancasterlab.bsky.social lab - making mouse organoids 🧠
Check it out: doi.org/10.1101/2024...
Check it out: doi.org/10.1101/2024...