Matt Parker
@1m1a2t.bsky.social
plant molecular biology 🧬 bioinfomatics 🧬postdoc
@mpipz.bsky.social 🇩🇪🇪🇺, formerly @dundee.ac.uk 🏴🇬🇧, @sheffielduni.bsky.social 🏴🇬🇧
@mpipz.bsky.social 🇩🇪🇪🇺, formerly @dundee.ac.uk 🏴🇬🇧, @sheffielduni.bsky.social 🏴🇬🇧
Reposted by Matt Parker
AlphaFold is great, but contrary to public opinion it has not completely solved the protein folding problem. Much work remains to be done.
clauswilke.substack.com/p/no-alphafo...
clauswilke.substack.com/p/no-alphafo...
No, AlphaFold has not completely solved protein folding
Biology is hard. Yes, even for AI.
clauswilke.substack.com
July 12, 2025 at 6:19 PM
AlphaFold is great, but contrary to public opinion it has not completely solved the protein folding problem. Much work remains to be done.
clauswilke.substack.com/p/no-alphafo...
clauswilke.substack.com/p/no-alphafo...
Reposted by Matt Parker
Carey is a post-doc in my lab working on RNA methylation - but we spend a lot of time talking about ash trees! Today, her PhD work on the population genomics of ash die-back is published in Science www.science.org/doi/10.1126/...
Rapid polygenic adaptation in a wild population of ash trees under a novel fungal epidemic
Rapid evolution through small shifts in allele frequencies at thousands of loci is a long-standing neo-Darwinian prediction but is hard to characterize in the wild. European ash tree (Fraxinus excelsi...
www.science.org
June 26, 2025 at 6:22 PM
Carey is a post-doc in my lab working on RNA methylation - but we spend a lot of time talking about ash trees! Today, her PhD work on the population genomics of ash die-back is published in Science www.science.org/doi/10.1126/...
Reposted by Matt Parker
1/
🚨 My first PhD preprint is out on bioRxiv!
We show how tiny mutations—point mutations and kb-level indels—can shape the massive structure of Arabidopsis centromeres.
📄 Read it here: doi.org/10.1101/2025...
🧵 A short thread 👇
🚨 My first PhD preprint is out on bioRxiv!
We show how tiny mutations—point mutations and kb-level indels—can shape the massive structure of Arabidopsis centromeres.
📄 Read it here: doi.org/10.1101/2025...
🧵 A short thread 👇
doi.org
June 5, 2025 at 8:47 AM
1/
🚨 My first PhD preprint is out on bioRxiv!
We show how tiny mutations—point mutations and kb-level indels—can shape the massive structure of Arabidopsis centromeres.
📄 Read it here: doi.org/10.1101/2025...
🧵 A short thread 👇
🚨 My first PhD preprint is out on bioRxiv!
We show how tiny mutations—point mutations and kb-level indels—can shape the massive structure of Arabidopsis centromeres.
📄 Read it here: doi.org/10.1101/2025...
🧵 A short thread 👇
Reposted by Matt Parker
HMMER is the bedrock of genomic annotation globally, and now its funding is terminated for no reason.
@cryptogenomicon.bsky.social is now on bsky:
@cryptogenomicon.bsky.social is now on bsky:
NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
May 28, 2025 at 4:25 PM
HMMER is the bedrock of genomic annotation globally, and now its funding is terminated for no reason.
@cryptogenomicon.bsky.social is now on bsky:
@cryptogenomicon.bsky.social is now on bsky:
Reposted by Matt Parker
a society where "bad immigrants" are demonised is a society where no immigrant can truly feel welcome, because aren't we all just one wrong turn or accident away from being unemployed? on disability benefits? unable to care for our children without state help? just no such thing as a safe immigrant
May 12, 2025 at 12:19 PM
a society where "bad immigrants" are demonised is a society where no immigrant can truly feel welcome, because aren't we all just one wrong turn or accident away from being unemployed? on disability benefits? unable to care for our children without state help? just no such thing as a safe immigrant
Reposted by Matt Parker
📢 We are hiring! 📢
We are looking for a postdoc to help us work out why mice cannot regenerate the spinal cord but spiny mice *can*.
More info and how to apply: tinyurl.com/4m6yzbef
Get in touch if interested!
We are looking for a postdoc to help us work out why mice cannot regenerate the spinal cord but spiny mice *can*.
More info and how to apply: tinyurl.com/4m6yzbef
Get in touch if interested!
Postdoctoral Research Associate
We are looking for a Postdoctoral Research Associate to join our group at the Centre for Regenerative Medicine (CRM) and the Institute for Regeneration and Repair (IRR), The University of Edinburgh.
tinyurl.com
March 5, 2025 at 6:36 PM
📢 We are hiring! 📢
We are looking for a postdoc to help us work out why mice cannot regenerate the spinal cord but spiny mice *can*.
More info and how to apply: tinyurl.com/4m6yzbef
Get in touch if interested!
We are looking for a postdoc to help us work out why mice cannot regenerate the spinal cord but spiny mice *can*.
More info and how to apply: tinyurl.com/4m6yzbef
Get in touch if interested!
Reposted by Matt Parker
Reposted by Matt Parker
Cool new study:
Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis
www.biorxiv.org/content/10.1...
Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis
www.biorxiv.org/content/10.1...
Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis
Distinguishing self from non-self is crucial to direct immune responses against pathogens. Unmodified RNAs stimulate human innate immunity, but RNA modifications suppress this response. mRNA m6A modif...
www.biorxiv.org
February 26, 2025 at 12:12 PM
Cool new study:
Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis
www.biorxiv.org/content/10.1...
Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis
www.biorxiv.org/content/10.1...
Reposted by Matt Parker
New preprint from us!
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...
Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis
Distinguishing self from non-self is crucial to direct immune responses against pathogens. Unmodified RNAs stimulate human innate immunity, but RNA modifications suppress this response. mRNA m6A modif...
www.biorxiv.org
February 24, 2025 at 12:05 PM
New preprint from us!
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...
Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis doi.org/10.1101/2025...
Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis
Distinguishing self from non-self is crucial to direct immune responses against pathogens. Unmodified RNAs stimulate human innate immunity, but RNA modifications suppress this response. mRNA m6A modif...
doi.org
February 23, 2025 at 7:53 PM
Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis doi.org/10.1101/2025...
Reposted by Matt Parker
🥳Happy International Day of Women and Girls in Science! 🥳🎉🔬🧪. A special nod to all the inspiring female scientists at @mpipz.bsky.social, shaping the future of #plant science with dedication and passion 🌿🪴Read more 👉: bit.ly/4bc1TmF #womeninscience #womeninSTEM #11Feb
February 11, 2025 at 1:44 PM
🥳Happy International Day of Women and Girls in Science! 🥳🎉🔬🧪. A special nod to all the inspiring female scientists at @mpipz.bsky.social, shaping the future of #plant science with dedication and passion 🌿🪴Read more 👉: bit.ly/4bc1TmF #womeninscience #womeninSTEM #11Feb
RNA splicing: a split consensus reveals two major 5′ splice site classes royalsocietypublishing.org/doi/full/10....
RNA splicing: a split consensus reveals two major 5′ splice site classes | Open Biology
The established consensus sequence for human 5′ splice sites masks the presence of
two major splice site classes defined by preferential base-pairing potentials with
either U5 snRNA loop 1 or the U6 s...
royalsocietypublishing.org
January 17, 2025 at 5:10 PM
RNA splicing: a split consensus reveals two major 5′ splice site classes royalsocietypublishing.org/doi/full/10....
Reposted by Matt Parker
When asked about knockout vs knockdown, Google AI wonderfully bet-hedges on whether you're interested in genetics or boxing
January 10, 2025 at 7:44 PM
When asked about knockout vs knockdown, Google AI wonderfully bet-hedges on whether you're interested in genetics or boxing