Marion Campbell

@marionkcampbell.bsky.social

970 followers 180 following 220 posts

Trialist; Methodologist; Statistician; Professor of Health Services Research; University of Aberdeen. Views my own. Hebridean.
https://www.abdn.ac.uk/people/m.k.campbell

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Marion Kay Campbell is a Scottish medical statistician, clinical trialist, and academic administrator who is the dean of research for life sciences and medicine and a professor of health services research at the University of Aberdeen. .. more

Economics 26%

Mathematics 24%

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Reposted by Marion Campbell

American Statistical Association History of Statistics @hos-asa.bsky.social · 22h

Beginning Nov 1924, studies on the effect of lighting on worker productivity were performed at the Western Electric Hawthorn Plant. These were the basis for the concept of the Hawthorne Effect 1/2

Reposted by Marion Campbell

Marion Campbell @marionkcampbell.bsky.social · 8d

The work provides accessible definitions of the core elements of an estimand which will help aid understanding and should ease the use of the estimand framework across the range of stakeholders 8/8

Marion Campbell @marionkcampbell.bsky.social · 8d

A new paper by @suziecro.bsky.social and colleagues will help in this regard. Working with public partners, they developed a practical tool to explain the attributes of an estimand in an accessible manner 7/8
trialsjournal.biomedcentral.com/articles/10....

Marion Campbell @marionkcampbell.bsky.social · 8d

However, the technical language around estimands makes it hard to discuss the concept with patients and public (and indeed with many researchers and clinicians). 6/8

Marion Campbell @marionkcampbell.bsky.social · 8d

Kahan et al provide a useful introduction to the estimand approach and to the different terms/approaches used: 5/8
www.bmj.com/content/384/...

Marion Campbell @marionkcampbell.bsky.social · 8d

We may want to know how effective the treatment was in all patients allocated to it (this is called a “treatment policy” estimand strategy); or only in those patients who received it as planned (called a “principal stratum” approach) or some other variation. 4/8

Marion Campbell @marionkcampbell.bsky.social · 8d

“Intercurrent events” are post-randomisation events (eg discontinuation of treatment or treatment switching) and the estimand describes precisely how these events will be handled in the analysis. 3/8

Marion Campbell @marionkcampbell.bsky.social · 8d

An #estimand is effectively a more precise specification of the research question(s) and how the treatment effect is to be estimated (hence estimand). It also specifically describes how so called “intercurrent events” will be handled in the analysis. 2/8

Marion Campbell @marionkcampbell.bsky.social · 8d

The term #estimand is now part of the technical language of trials - but it remains a concept that many find hard to understand. Recent work has aimed to make the term more accessible to researchers, patients & public 1/8
#MethodologyMonday #127

Reposted by Marion Campbell

NEJM.org @nejm.org · 9d

In the EVERDAC trial involving patients with shock, results for death at day 28 indicated that management without early arterial catheter insertion was noninferior to early catheter insertion. Full trial results and Research Summary: nej.md/3LmOO0D 

#MedSky #PulmSky

The New England Journal of Medicine
Deferring Arterial Catheterization in Critically Ill Patients with Shock
A Research Summary based on Muller G et al. | 10.1056/NEJMoa2502136 | Published on October 29, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

Reposted by Marion Campbell

Canadian Critical Care Trials Group (CCCTG) @ccctg.bsky.social · 10d

The world’s largest and longest clinical trial in critical care, SuDDICU found a significant reduction in hospital-acquired infection in critically ill patients on mechanical ventilation, when given antibiotics preventatively before a new infection can develop.

Reposted by Maria Snegovaya, Naftali Kaminski, Olivia S. Mitchell , and 3 more Maria Snegovaya, Naftali Kaminski, Olivia S. Mitchell, Marion Campbell, Maria Rosaria Gualano, Mariam Camarero

Reposted by Marion Campbell

Reposted by Jeremy Grimshaw

Reposted by Marion Campbell

NEJM.org @nejm.org · 12d

In the SuDDICU trial of patients undergoing mechanical ventilation in the intensive care unit, selective decontamination of the digestive tract did not result in a lower incidence of in-hospital death than standard care alone. Full trial results: nej.md/4nhyeN8

#LIVES2025 | @esicm.bsky.social

European Society of Intensive Care Medicine
Original Article | Oct 29, 2025 | NEJM.org
Selective Decontamination of the Digestive Tract during Ventilation in the ICU

Figure 2. Subgroup Analysis of In-Hospital Death at 90 Days.

Reposted by Jonathan Portes, Marion Campbell, Paul Nightingale , and 1 more Jonathan Portes, Marion Campbell, Paul Nightingale, Juanjo Medina

Hetan Shah @hetanshah.bsky.social · 17d

Recruitment has begun for a new National Statistician (£200k). Important role as the strategic head of the UK statistical system. There is less operational work as there is now a Perm Sec for ONS. So they are seeking an ‘internationally recognised leader in statistics’
www.saxbam.com/appointment/...

UK Statistics Authority

Official statistics play a vital role in supporting society and the economy - informing government policymaking and evaluation, guiding economic and

www.saxbam.com

Reposted by Marion Campbell

Richard Hooper @richardhooper.bsky.social · 17d

📢 As one of the next round of TRMP PhD students (below) you could join me, Clare Robinson, @averoniki.bsky.social and @marionkcampbell.bsky.social to work on developing a typology of research outputs in trials methodology, based at @wiphcem.bsky.social. Details here: www.findaphd.com/phds/project...

Reposted by Marion Campbell

Richard Hooper @richardhooper.bsky.social · 17d

📢 Interested in a PhD in clinical trials methodology? The Trials Methodology Research Partnership are advertising projects for PhDs starting Oct 2026, in statistics, health economics, epidemiology, social science, and more, hosted at one of 12 UK partner institutions.
mrctmrpdtp.com/current-oppo...

Current Opportunities

We have an iCASE studentship available to start for the 2025/2026 academic year, and applications to our fifth round of recruitment to our DTP to start in October 2026 are now also open. Please see…

mrctmrpdtp.com

Marion Campbell @marionkcampbell.bsky.social · 21d

It’s the UN #WorldStatisticsDay today! Perfect time to celebrate all the awesome statisticians who ensure robust data, design and analysis 😊

Marion Campbell @marionkcampbell.bsky.social · 22d

Bigirumurame et al also published a useful review of SMART trials and highlighted the need for accurate reporting 7/7
www.sciencedirect.com/science/arti...

Marion Campbell @marionkcampbell.bsky.social · 22d

Kidwell & Almirall wrote a short primer paper on the design 6/7
jamanetwork.com/journals/jam...

Marion Campbell @marionkcampbell.bsky.social · 22d

They have also be used in scenarios where one might begin with testing less costly or less intensive treatment strategies in the first phase and stepping up to testing more intensive strategies only if there is lack of response 5/7

Marion Campbell @marionkcampbell.bsky.social · 22d

The SMART design is typically more used in chronic conditions where response can be measured over time and different interventions/doses/sequences are available should individuals not respond to their first line allocated intervention 4/7

Marion Campbell @marionkcampbell.bsky.social · 22d

These designs are often seen as attractive to patients as the intervention they receive can be changed if they see no improvement 3/7

Marion Campbell @marionkcampbell.bsky.social · 22d

In a SMART trial each individual can undergo multiple randomisations. All get initially randomised in stage 1, but non-responders can then get randomised in stage 2 to further treatment options etc 2/7

Marion Campbell @marionkcampbell.bsky.social · 22d

One of the adaptive designs we are seeing more frequently is the Sequential Multiple Assignment Randomised Trial (or SMART trial) 1/7
#MethodologyMonday #126

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