Gordon H. Guyatt
@guyattgh.bsky.social
Promoting use of the best evidence and patient values and preferences to inform optimal clinical and health policy decisions.
Gordon Henry Guyatt is a Canadian physician who is a professor at McMaster University in Hamilton, Ontario. He is known for his leadership in evidence-based medicine, a term that first appeared in a single-author paper he published in 1991. Subsequently, a 1992 JAMA article led by Guyatt proved instrumental in bringing the concept of evidence-based medicine to the world's attention. Guyatt's concerns with the role of the medical system, social justice, and medical reform remain central issues that he promoted in tandem with his medical work. He was named to the Canadian Medical Hall of Fame in 2015. .. more
Economics
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Mathematics
24%
Reposted by Víctor M. Montori
EBHC Conference | EBHC International Conference 2026 | Home
We are delighted to invite you to the 11th International Conference of Evidence-Based Health Care.
www.ebhcconference.org
I’ll be speaking at world’s best #EBM conference, 22nd to 24th October 2026, focus on EBM and AI . In #Taormina, renowned, picturesque hilltop town on #Sicily 's east coast, famous for its breathtaking views of the #IonianSea and active #MountEtna
www.ebhcconference.org/home.en-GB.h...
www.ebhcconference.org/home.en-GB.h...
Methodologic discussions for using and interpreting composite endpoints are limited, but still identify major concerns - PubMed
Methodologists have given limited attention to CEPs and their views are sometimes contradictory. Further work is needed to establish the role of CEPs in research and in guiding clinical practice.
pubmed.ncbi.nlm.nih.gov
#CompositeEndpoints frequently mislead by overestimating benefits: #death, #MyocardialInfarction (dominated), and #revascularization. Worse, add #stroke to these three and goes in opposite direction to revascularization and composite favors the wrong intervention!
pubmed.ncbi.nlm.nih.gov/17573977/
pubmed.ncbi.nlm.nih.gov/17573977/
All you need to know about EBM: A founder's guide to evidence, guidelines & getting back to the core
YouTube video by EBM One Platform
www.youtube.com
My favorite interview-based brief introduction to #EBM, the interviewer being my dear friend Jaeschke. Comment on the interview from the individual who organized ”It is well paced, illustrative and easy to follow – just the kind of conversation we were hoping for”
www.youtube.com/watch?v=I7ou...
www.youtube.com/watch?v=I7ou...
Guideline panels should seldom make good practice statements: guidance from the GRADE Working Group - PubMed
Guideline panels should seldom make good practice statements: guidance from the GRADE Working Group
pubmed.ncbi.nlm.nih.gov
#GRADE users frequently get confused about the appropriate – and inappropriate – use of good practice statements. This paper provides the needed #guidance.
pubmed.ncbi.nlm.nih.gov/27452192/
pubmed.ncbi.nlm.nih.gov/27452192/
Reposted by Thomas Agoritsas
https://www.clarityresearch.ca/frequently-asked-questions
t.co
Latest asked question about Core #GRADE, essence of the GRADE approach to #evidence certainty and moving to #recommendations in #BMJ in 2025. Addresses when and how much to rate down for #imprecision. Joins GRADE for single study and a priori hypotheses explaining #heterogeneity
t.co/hh6owWxn5O
t.co/hh6owWxn5O
Covert stroke after non-cardiac surgery: a prospective cohort study - PubMed
NCT01369537.
pubmed.ncbi.nlm.nih.gov
Study of patients undergoing #NonCardiacSurgery (NCS) reports that 1 in 10 patients will have a covert (not clinically evident) #stroke. But consequences for subsequent function still uncertain – under investigation. Over 65, considering elective NCS, think twice.
pubmed.ncbi.nlm.nih.gov/27440630/
pubmed.ncbi.nlm.nih.gov/27440630/
Influence of focusing on dominant first order loop when assessing the certainty of evidence of network meta-analysis: a case study - PubMed
NMA allows researchers to compare the relative effectiveness of multiple treatments. The GRADE working group provides guidance to establish the confidence in treatment effects (how likely they are to be true) by evaluating the COE to direct, indirect and NMA estimates, which can be high, moderate, l …
pubmed.ncbi.nlm.nih.gov
Just published key insight into #GRADE approach to #NMA. For assessing certainty of indirect #evidence GRADE relies on first order loop, ignores others. Maybe big problem, but review of 103 comparisons suggests almost no misleading conclusions. Hurrah for GRADE NMA!
pubmed.ncbi.nlm.nih.gov/41224137/
pubmed.ncbi.nlm.nih.gov/41224137/
[English] Hormone Therapy for Menopause & Evidence-Based Medicine #EBM
YouTube video by RenovaMeta
www.youtube.com
5 minute conversation with brilliant and charming colleague @leticiakawano.bsky.social, recorded in lovely setting, #EBM perspective on decisions when #evidence is low certainty focusing on individual #patient values and how #physician input can be problematic.
www.youtube.com/watch?v=2SN6...
www.youtube.com/watch?v=2SN6...
A framework for clinical evaluation of diagnostic technologies - PubMed
Most new diagnostic technologies have not been adequately assessed to determine whether their application improves health. Comprehensive evaluation of diagnostic technologies includes establishing technologic capability and determining the range of possible uses, diagnostic accuracy, impact on the h …
pubmed.ncbi.nlm.nih.gov
Old paper, remarkably relevant insights for assessing #DiagnosticTechnology: framework beginning range of possible uses, technologic capability, #DiagnosticAccuracy, impact on health care provider, #TherapeuticImpact, impact on #PRO and how to do each step.
pubmed.ncbi.nlm.nih.gov/3512062/
pubmed.ncbi.nlm.nih.gov/3512062/
Is Core GRADE really GRADE?
This is "Is Core GRADE really GRADE?" by Clarity- McMaster on Vimeo, the home for high quality videos and the people who love them.
vimeo.com
Core #GRADE, 7 papers #BMJ 2025, all you need for GRADE addressing paired treatment comparisons. Question: Is Core really GRADE? Answer: Core undertook comprehensive review all prior GRADE writing, summarizes essentials. Core GRADE as GRADE gets! Details in 1 minute video.
vimeo.com/1151358052?f...
vimeo.com/1151358052?f...
Core GRADE @ GIN 2025
This is "Core GRADE @ GIN 2025" by Clarity- McMaster on Vimeo, the home for high quality videos and the people who love them.
vimeo.com
56 second summary of rationale for and essence of Core #GRADE I delivered at the 2025 Guidelines International (GIN) meeting.
vimeo.com/1151372251?f...
vimeo.com/1151372251?f...
Patient values and preferences in decision making for antithrombotic therapy: a systematic review: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines - PubMed
Patient values and preferences regarding thromboprophylaxis treatment appear to be highly variable. Participant responses may depend on their prior experience with the treatments or health outcomes considered as well as on the methods used for preference elicitation. It should be standard for clinic …
pubmed.ncbi.nlm.nih.gov
Model for conducting a search for #evidence regarding #patient #ValuesAndPreferences crucial for #guideline panels in moving from evidence to #recommendations. This one addressed #antithrombotic therapy and found 48 relevant studies.
pubmed.ncbi.nlm.nih.gov/22315262/
pubmed.ncbi.nlm.nih.gov/22315262/
Level of Evidence and Strength of Recommendations in US Medical Society Clinical Practice Guidelines, 2019-2023: A Cross-Sectional Analysis - PubMed
Among recently issued CPG recommendations, overall SOR-LOE rating concordance was moderate, although recommendations with strong SOR ratings had minimal rating concordance. CPG authors could provide clearer rationales for strong recommendations when the corresponding evidence does not reflect commen …
pubmed.ncbi.nlm.nih.gov
Just published exploration of US Medical Society #ClinicalPracticeGuideline over 5 years documented epidemic of discordant #recommendation meaning strong recommendations despite low certainty #evidence. Big problem needs addressing.
pubmed.ncbi.nlm.nih.gov/41428154/
pubmed.ncbi.nlm.nih.gov/41428154/
Reposted by Víctor M. Montori
Reclaiming human care from surveillance capitalism
We must end the commodification of health data by big tech companies, centre healthcare on care, and put people back in control, argue Victor, J P, and Victor M Montori
Big tech companies are drivin...
www.bmj.com
Published in #BMJ, brilliant, startling exposition from Montori et al of our dystopic future as surveillance capitalism invades health care. Depicts how patients & clinicians are unable to know who is listening to their consultations, who is using their data & to what end
www.bmj.com/content/391/...
www.bmj.com/content/391/...