Xavier Rios
xrios.bsky.social
Xavier Rios
@xrios.bsky.social
Pediatric Oncologist at TCH/BCM, from Puerto Rico (UPRM), then Boston (Harvard/MIT HST MSTP). Tweets my own.
Reposted by Xavier Rios
Presented at #ASH24:

The addition of blinatumomab after induction chemotherapy in children with standard-risk disease of average or high risk of relapse significantly improved disease-free survival.

Full AALL1731 trial results: nej.md/49CVkc1

#medsky
December 7, 2024 at 3:34 PM
Reposted by Xavier Rios
We are thrilled to share ProDomino a model for the prediction of domain insertion sites in proteins. Our approach enables the simple and rapid engineering of highly potent switchable proteins, as we exemplify by creating novel inducible variants of Cas9 and Cas12a.

www.biorxiv.org/content/10.1...
Rational engineering of allosteric protein switches by in silico prediction of domain insertion sites
Domain insertion engineering is a powerful approach to juxtapose otherwise separate biological functions, resulting in proteins with new-to-nature activities. A prominent example are switchable protei...
www.biorxiv.org
December 5, 2024 at 9:59 AM
Inspiring results for CAR-T cells for solid tumors from the Heczey Lab
IL-15-armoured GPC3 CAR T cells for patients with solid cancers
www.nature.com/articles/s41...
November 28, 2024 at 4:44 PM
Reposted by Xavier Rios
Post 2 pictures with your better half

12 years together
November 22, 2024 at 12:59 AM