Xin Gu Lab at DFCI/HMS
@xingulab.bsky.social
Enthusiastic about transcription factor turnover!
Reposted by Xin Gu Lab at DFCI/HMS
Congratulations Xin Gu, Ph.D., recipient of a Klingenstein Fellowship Award in Neuroscience for the project, "Elucidating the Role of the Midnolin-Proteasome Pathway in the Central Nervous System." @xingulab.bsky.social
xingulab.dana-farber.org
xingulab.dana-farber.org
July 1, 2025 at 1:36 PM
Congratulations Xin Gu, Ph.D., recipient of a Klingenstein Fellowship Award in Neuroscience for the project, "Elucidating the Role of the Midnolin-Proteasome Pathway in the Central Nervous System." @xingulab.bsky.social
xingulab.dana-farber.org
xingulab.dana-farber.org
Reposted by Xin Gu Lab at DFCI/HMS
New work from @xingulab.bsky.social @sshaolab.bsky.social & Elledge lab report structure of Midnolin-proteasome complex & its role in controlling myeloma via ubiquitin-independent degradation. www.cell.com/molecular-ce...
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
Nardone et al. elucidate the mechanism of the midnolin-proteasome pathway, showing
how midnolin achieves nuclear substrate selection and how established proteasomal
components are repurposed to enable...
www.cell.com
June 21, 2025 at 9:06 PM
New work from @xingulab.bsky.social @sshaolab.bsky.social & Elledge lab report structure of Midnolin-proteasome complex & its role in controlling myeloma via ubiquitin-independent degradation. www.cell.com/molecular-ce...
Reposted by Xin Gu Lab at DFCI/HMS
A new study in Molecular Cell led by @danafarber.bsky.social’s Xin Gu, PhD, highlights midnolin as a key regulatory component of proteostasis in plasma cells and suggests that restoring or enhancing this pathway could represent a novel therapeutic avenue in myeloma treatment. bit.ly/4l8Zuwu
June 17, 2025 at 6:00 PM
A new study in Molecular Cell led by @danafarber.bsky.social’s Xin Gu, PhD, highlights midnolin as a key regulatory component of proteostasis in plasma cells and suggests that restoring or enhancing this pathway could represent a novel therapeutic avenue in myeloma treatment. bit.ly/4l8Zuwu
So happy and proud to see our story online!! Thank you, the midnolin team!
Online Now: Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma Online now:
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
Nardone et al. elucidate the mechanism of the midnolin-proteasome pathway, showing how midnolin achieves nuclear substrate selection and how established proteasomal components are repurposed to enable a unique form of ubiquitination-independent proteolysis. This study also unveils midnolin downregulation as a key driver of multiple myeloma through the aberrant stabilization of IRF4.
dlvr.it
June 17, 2025 at 3:30 PM
So happy and proud to see our story online!! Thank you, the midnolin team!
Reposted by Xin Gu Lab at DFCI/HMS
~1 week left to register for the EMBO workshop on RNA meets protein decay! #EMBOrnaDecay
Come join us for a fun time and invigorating scientific discussions in Vienna!
meetings.embo.org/event/25-rna...
Come join us for a fun time and invigorating scientific discussions in Vienna!
meetings.embo.org/event/25-rna...
RNA meets protein decay
Establishing the composition of RNAs and proteins that defines the identities and functions of cells relies not only on the regulated biosynthesis of these molecules, but also equally importantly, on…
meetings.embo.org
March 24, 2025 at 2:15 PM
~1 week left to register for the EMBO workshop on RNA meets protein decay! #EMBOrnaDecay
Come join us for a fun time and invigorating scientific discussions in Vienna!
meetings.embo.org/event/25-rna...
Come join us for a fun time and invigorating scientific discussions in Vienna!
meetings.embo.org/event/25-rna...
Reposted by Xin Gu Lab at DFCI/HMS
👏 Another chapter in the midnolin proteasome story from @xingulab.bsky.social www.biorxiv.org/content/10.1...
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...
www.biorxiv.org
February 25, 2025 at 6:31 AM
👏 Another chapter in the midnolin proteasome story from @xingulab.bsky.social www.biorxiv.org/content/10.1...
Reposted by Xin Gu Lab at DFCI/HMS
Check out these insights into (and the importance of) delivering ubiquitin-independent proteasomal substrates for degradation in the nucleus!
Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with Chris Nardone from the Elledge lab, Jingjing Gao from the Shao lab @sshaolab.bsky.social and all the co-authors who put in the hard work! www.biorxiv.org/content/10.1...
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...
www.biorxiv.org
February 24, 2025 at 9:35 PM
Check out these insights into (and the importance of) delivering ubiquitin-independent proteasomal substrates for degradation in the nucleus!
Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with Chris Nardone from the Elledge lab, Jingjing Gao from the Shao lab @sshaolab.bsky.social and all the co-authors who put in the hard work! www.biorxiv.org/content/10.1...
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...
www.biorxiv.org
February 24, 2025 at 2:11 AM
Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with Chris Nardone from the Elledge lab, Jingjing Gao from the Shao lab @sshaolab.bsky.social and all the co-authors who put in the hard work! www.biorxiv.org/content/10.1...