Victoria Hart
@vichart33.bsky.social
Postdoc @ScienceShef | University of Sheffield | kRas Inhibition in Pancreatic Cancer
Another fantastic set of talks at the 7th Sheffield Pancreatic Cancer Research Interest Network. A big thank you to Stephen Bradley and Ifeoluwa Oyelade for sharing their inspiring research.
#PancreaticCancer #CancerResearch
#PancreaticCancer #CancerResearch
October 22, 2025 at 1:26 PM
Another fantastic set of talks at the 7th Sheffield Pancreatic Cancer Research Interest Network. A big thank you to Stephen Bradley and Ifeoluwa Oyelade for sharing their inspiring research.
#PancreaticCancer #CancerResearch
#PancreaticCancer #CancerResearch
A beautiful and inspiring location for the #TargetingRAS2025 conference. The pace of discovery in the field is truly astounding. It was such a pleasure to share ideas and meet some great people.
#Salamanca #RAS #Biology #CancerBiology
#Salamanca #RAS #Biology #CancerBiology
October 13, 2025 at 2:40 PM
A beautiful and inspiring location for the #TargetingRAS2025 conference. The pace of discovery in the field is truly astounding. It was such a pleasure to share ideas and meet some great people.
#Salamanca #RAS #Biology #CancerBiology
#Salamanca #RAS #Biology #CancerBiology
Reposted by Victoria Hart
What happens to packed cells in a monolayer during mitosis? @rlawson954.bsky.social presented varying experiments investigating shape and force changes, cell-cell junctions, and mechanics in mitotic cells, suggesting important roles for keratin and desmosomes #MBIMPG2025 @helenkmatthews.bsky.social
September 9, 2025 at 10:07 AM
What happens to packed cells in a monolayer during mitosis? @rlawson954.bsky.social presented varying experiments investigating shape and force changes, cell-cell junctions, and mechanics in mitotic cells, suggesting important roles for keratin and desmosomes #MBIMPG2025 @helenkmatthews.bsky.social
Interested in Pancreatic Cancer Research? We are gearing up to host our 7th Sheffield Pancreatic Cancer Research Network meeting!
Check out the details at: sites.google.com/sheffield.ac...
@mcb-sheffield.bsky.social @fohsheffield.bsky.social
Check out the details at: sites.google.com/sheffield.ac...
@mcb-sheffield.bsky.social @fohsheffield.bsky.social
Sheffield Pancreatic Cancer Research Network - Events
Upcoming Events
sites.google.com
September 1, 2025 at 10:45 AM
Interested in Pancreatic Cancer Research? We are gearing up to host our 7th Sheffield Pancreatic Cancer Research Network meeting!
Check out the details at: sites.google.com/sheffield.ac...
@mcb-sheffield.bsky.social @fohsheffield.bsky.social
Check out the details at: sites.google.com/sheffield.ac...
@mcb-sheffield.bsky.social @fohsheffield.bsky.social
Two fantastic talks at the 6th Pancreatic Cancer Research Network meeting by Megan Poxon and @isabelladavis00.bsky.social . Fancy speaking at the next one? Just get in touch!
p.s. Don't forget to check out our new website 🔬https://sites.google.com/sheffield.ac.uk/pancreatic-cancer-network/home
p.s. Don't forget to check out our new website 🔬https://sites.google.com/sheffield.ac.uk/pancreatic-cancer-network/home
July 7, 2025 at 11:45 AM
Two fantastic talks at the 6th Pancreatic Cancer Research Network meeting by Megan Poxon and @isabelladavis00.bsky.social . Fancy speaking at the next one? Just get in touch!
p.s. Don't forget to check out our new website 🔬https://sites.google.com/sheffield.ac.uk/pancreatic-cancer-network/home
p.s. Don't forget to check out our new website 🔬https://sites.google.com/sheffield.ac.uk/pancreatic-cancer-network/home
Reposted by Victoria Hart
Great talks by PhD students @isabelladavis00.bsky.social and Meg at the Sheffield Pancreatic Cancer Research Network meeting 👏
July 2, 2025 at 1:55 PM
Great talks by PhD students @isabelladavis00.bsky.social and Meg at the Sheffield Pancreatic Cancer Research Network meeting 👏
A beautiful day in the sunshine for our lovely lab summer social ☀️ @isabelladavis00.bsky.social @helenkmatthews.bsky.social @rlawson954.bsky.social
July 1, 2025 at 9:00 AM
A beautiful day in the sunshine for our lovely lab summer social ☀️ @isabelladavis00.bsky.social @helenkmatthews.bsky.social @rlawson954.bsky.social
Reposted by Victoria Hart
Last day of the #SmallGproteins meeting, great evening last night meeting researchers in the field hearing about people’s journeys, and gave advice on expressing a phosphorylated GTPase.
Looking forward to Session 6 kicked off by @vickysanzmoreno.bsky.social!
@biochemsoc.bsky.social #BiochemEvent
Looking forward to Session 6 kicked off by @vickysanzmoreno.bsky.social!
@biochemsoc.bsky.social #BiochemEvent
June 27, 2025 at 7:44 AM
Last day of the #SmallGproteins meeting, great evening last night meeting researchers in the field hearing about people’s journeys, and gave advice on expressing a phosphorylated GTPase.
Looking forward to Session 6 kicked off by @vickysanzmoreno.bsky.social!
@biochemsoc.bsky.social #BiochemEvent
Looking forward to Session 6 kicked off by @vickysanzmoreno.bsky.social!
@biochemsoc.bsky.social #BiochemEvent
Now some adhesion and migration at #SGP25
🔬 hunting for Ras allies
🧫 polarised trafficking regulation adaptability during change
🧬 RhoA and Cdc42 pathway crosstalk
Now onto the party!
@biochemsoc.bsky.social #BiochemEvent
🔬 hunting for Ras allies
🧫 polarised trafficking regulation adaptability during change
🧬 RhoA and Cdc42 pathway crosstalk
Now onto the party!
@biochemsoc.bsky.social #BiochemEvent
June 26, 2025 at 3:29 PM
Now some adhesion and migration at #SGP25
🔬 hunting for Ras allies
🧫 polarised trafficking regulation adaptability during change
🧬 RhoA and Cdc42 pathway crosstalk
Now onto the party!
@biochemsoc.bsky.social #BiochemEvent
🔬 hunting for Ras allies
🧫 polarised trafficking regulation adaptability during change
🧬 RhoA and Cdc42 pathway crosstalk
Now onto the party!
@biochemsoc.bsky.social #BiochemEvent
Now some adhesion and migration at #SGP25
🔬mechanosensing in cancer development
🧫 Rac1 driven plasticity in small cell lung cancer
🧬 actin in organelle transport
🧪 tool development to study spatial organisation of receptors
@biochemsoc.bsky.social #BiochemEvent
🔬mechanosensing in cancer development
🧫 Rac1 driven plasticity in small cell lung cancer
🧬 actin in organelle transport
🧪 tool development to study spatial organisation of receptors
@biochemsoc.bsky.social #BiochemEvent
June 26, 2025 at 1:52 PM
Now some adhesion and migration at #SGP25
🔬mechanosensing in cancer development
🧫 Rac1 driven plasticity in small cell lung cancer
🧬 actin in organelle transport
🧪 tool development to study spatial organisation of receptors
@biochemsoc.bsky.social #BiochemEvent
🔬mechanosensing in cancer development
🧫 Rac1 driven plasticity in small cell lung cancer
🧬 actin in organelle transport
🧪 tool development to study spatial organisation of receptors
@biochemsoc.bsky.social #BiochemEvent
Moving to a translational space
🔬 how we can revitalise therapies in response to resistance to Ras inhibitors
🧫 Arf6 alters matrix for metastatic niche in ovarian cancer
🧬 Novel phosphorylation regulates Arfs
🧪 Rac1 involvement in breast cancer metastases
@biochemsoc.bsky.social #BiochemEvent
🔬 how we can revitalise therapies in response to resistance to Ras inhibitors
🧫 Arf6 alters matrix for metastatic niche in ovarian cancer
🧬 Novel phosphorylation regulates Arfs
🧪 Rac1 involvement in breast cancer metastases
@biochemsoc.bsky.social #BiochemEvent
June 26, 2025 at 11:08 AM
Moving to a translational space
🔬 how we can revitalise therapies in response to resistance to Ras inhibitors
🧫 Arf6 alters matrix for metastatic niche in ovarian cancer
🧬 Novel phosphorylation regulates Arfs
🧪 Rac1 involvement in breast cancer metastases
@biochemsoc.bsky.social #BiochemEvent
🔬 how we can revitalise therapies in response to resistance to Ras inhibitors
🧫 Arf6 alters matrix for metastatic niche in ovarian cancer
🧬 Novel phosphorylation regulates Arfs
🧪 Rac1 involvement in breast cancer metastases
@biochemsoc.bsky.social #BiochemEvent
As day 3 of #SGP25 opens we heard brilliants talks covering…
🔬Ras lipid sensing to control localisation
🧫 Rnd3/RhoE importance in hepatocellular carcinoma
🔥 the role of Cdc42 in inflammation in response to wildfire smoke
🧪 the RhoA mutational landscape
@biochemsoc.bsky.social #BiochemEvent
🔬Ras lipid sensing to control localisation
🧫 Rnd3/RhoE importance in hepatocellular carcinoma
🔥 the role of Cdc42 in inflammation in response to wildfire smoke
🧪 the RhoA mutational landscape
@biochemsoc.bsky.social #BiochemEvent
June 26, 2025 at 9:27 AM
As day 3 of #SGP25 opens we heard brilliants talks covering…
🔬Ras lipid sensing to control localisation
🧫 Rnd3/RhoE importance in hepatocellular carcinoma
🔥 the role of Cdc42 in inflammation in response to wildfire smoke
🧪 the RhoA mutational landscape
@biochemsoc.bsky.social #BiochemEvent
🔬Ras lipid sensing to control localisation
🧫 Rnd3/RhoE importance in hepatocellular carcinoma
🔥 the role of Cdc42 in inflammation in response to wildfire smoke
🧪 the RhoA mutational landscape
@biochemsoc.bsky.social #BiochemEvent
Next, we look at how to target our small G proteins
🔬innovations in the targeting of Ras from Revolution Medicines
🧫 translating non-canonical functions of kRas to find targeting combinations
🧬 developing and testing a GAP glue
🧪 mutant and WT Ras crosstalk
@biochemsoc.bsky.social #BiochemEvent
🔬innovations in the targeting of Ras from Revolution Medicines
🧫 translating non-canonical functions of kRas to find targeting combinations
🧬 developing and testing a GAP glue
🧪 mutant and WT Ras crosstalk
@biochemsoc.bsky.social #BiochemEvent
June 25, 2025 at 1:59 PM
Next, we look at how to target our small G proteins
🔬innovations in the targeting of Ras from Revolution Medicines
🧫 translating non-canonical functions of kRas to find targeting combinations
🧬 developing and testing a GAP glue
🧪 mutant and WT Ras crosstalk
@biochemsoc.bsky.social #BiochemEvent
🔬innovations in the targeting of Ras from Revolution Medicines
🧫 translating non-canonical functions of kRas to find targeting combinations
🧬 developing and testing a GAP glue
🧪 mutant and WT Ras crosstalk
@biochemsoc.bsky.social #BiochemEvent
As a side what a beautiful site for a conference, flowers everywhere in the sunshine ☀️
@biochemsoc.bsky.social #BiochemEvent
@biochemsoc.bsky.social #BiochemEvent
June 25, 2025 at 12:20 PM
As a side what a beautiful site for a conference, flowers everywhere in the sunshine ☀️
@biochemsoc.bsky.social #BiochemEvent
@biochemsoc.bsky.social #BiochemEvent
And we continue #SGP25 with
🔬RAP1GDS1 isoform specific importance in lung cancer
🧫 how kRas oncogenic enhanced proliferation can occur without hyperactive ERK or Akt
🧬 RhoGAP family interactions in endometrial cancer
@biochemsoc.bsky.social #BiochemEvent
🔬RAP1GDS1 isoform specific importance in lung cancer
🧫 how kRas oncogenic enhanced proliferation can occur without hyperactive ERK or Akt
🧬 RhoGAP family interactions in endometrial cancer
@biochemsoc.bsky.social #BiochemEvent
June 25, 2025 at 10:51 AM
And we continue #SGP25 with
🔬RAP1GDS1 isoform specific importance in lung cancer
🧫 how kRas oncogenic enhanced proliferation can occur without hyperactive ERK or Akt
🧬 RhoGAP family interactions in endometrial cancer
@biochemsoc.bsky.social #BiochemEvent
🔬RAP1GDS1 isoform specific importance in lung cancer
🧫 how kRas oncogenic enhanced proliferation can occur without hyperactive ERK or Akt
🧬 RhoGAP family interactions in endometrial cancer
@biochemsoc.bsky.social #BiochemEvent
Reposted by Victoria Hart
SGP25 Session 2 (Part 1):
⚙️ “Branchgetic” Ras mutations indicate effector selection
🔬 RAF biosensors to monitor acivity in live cells
💥 C2 domain boosts RasGAP activity
💊 RhoB-Ral complex a target for EGFR TK inhibition?
@biochemsoc.bsky.social #BiochemEvent
⚙️ “Branchgetic” Ras mutations indicate effector selection
🔬 RAF biosensors to monitor acivity in live cells
💥 C2 domain boosts RasGAP activity
💊 RhoB-Ral complex a target for EGFR TK inhibition?
@biochemsoc.bsky.social #BiochemEvent
June 25, 2025 at 10:00 AM
SGP25 Session 2 (Part 1):
⚙️ “Branchgetic” Ras mutations indicate effector selection
🔬 RAF biosensors to monitor acivity in live cells
💥 C2 domain boosts RasGAP activity
💊 RhoB-Ral complex a target for EGFR TK inhibition?
@biochemsoc.bsky.social #BiochemEvent
⚙️ “Branchgetic” Ras mutations indicate effector selection
🔬 RAF biosensors to monitor acivity in live cells
💥 C2 domain boosts RasGAP activity
💊 RhoB-Ral complex a target for EGFR TK inhibition?
@biochemsoc.bsky.social #BiochemEvent
Day 2 of #SGP25 of to a great start with
✨ unpicking Ras effector binding in different tissues
✨ developing RAF based biosensors
✨ C2 domains and GAP functionality
✨ how RhoB and Ral affect EGFT therapy in lung cancer
@Biochemsoc #BiochemEvent
✨ unpicking Ras effector binding in different tissues
✨ developing RAF based biosensors
✨ C2 domains and GAP functionality
✨ how RhoB and Ral affect EGFT therapy in lung cancer
@Biochemsoc #BiochemEvent
June 25, 2025 at 9:12 AM
Day 2 of #SGP25 of to a great start with
✨ unpicking Ras effector binding in different tissues
✨ developing RAF based biosensors
✨ C2 domains and GAP functionality
✨ how RhoB and Ral affect EGFT therapy in lung cancer
@Biochemsoc #BiochemEvent
✨ unpicking Ras effector binding in different tissues
✨ developing RAF based biosensors
✨ C2 domains and GAP functionality
✨ how RhoB and Ral affect EGFT therapy in lung cancer
@Biochemsoc #BiochemEvent
Reposted by Victoria Hart
SGP25 Session 1 (Part 1):
⛓️ Mapping KRAS interactomes in organoid models
🧬 Isoform-specific KRAS vulnerabilities: one mutation, big difference
🔬 Novel tool tracks Ras mutation dynamics in vivo
✨ And a reminder that clear science communication empowers patients!
@biochemsoc.bsky.social #BiochemEvent
⛓️ Mapping KRAS interactomes in organoid models
🧬 Isoform-specific KRAS vulnerabilities: one mutation, big difference
🔬 Novel tool tracks Ras mutation dynamics in vivo
✨ And a reminder that clear science communication empowers patients!
@biochemsoc.bsky.social #BiochemEvent
June 24, 2025 at 6:09 PM
SGP25 Session 1 (Part 1):
⛓️ Mapping KRAS interactomes in organoid models
🧬 Isoform-specific KRAS vulnerabilities: one mutation, big difference
🔬 Novel tool tracks Ras mutation dynamics in vivo
✨ And a reminder that clear science communication empowers patients!
@biochemsoc.bsky.social #BiochemEvent
⛓️ Mapping KRAS interactomes in organoid models
🧬 Isoform-specific KRAS vulnerabilities: one mutation, big difference
🔬 Novel tool tracks Ras mutation dynamics in vivo
✨ And a reminder that clear science communication empowers patients!
@biochemsoc.bsky.social #BiochemEvent
Excited to be selected as a Social Media Contributor for Small G proteins in cellular signalling and disease 2025! 🧬
Follow along for insights into how these tiny but mighty proteins shape health and disease!
#BiochemEvent @BiochemSoc #SmallGProteins #CellBiology #SciComm
Follow along for insights into how these tiny but mighty proteins shape health and disease!
#BiochemEvent @BiochemSoc #SmallGProteins #CellBiology #SciComm
June 24, 2025 at 1:04 PM
Excited to be selected as a Social Media Contributor for Small G proteins in cellular signalling and disease 2025! 🧬
Follow along for insights into how these tiny but mighty proteins shape health and disease!
#BiochemEvent @BiochemSoc #SmallGProteins #CellBiology #SciComm
Follow along for insights into how these tiny but mighty proteins shape health and disease!
#BiochemEvent @BiochemSoc #SmallGProteins #CellBiology #SciComm
I am excited to share our new Sheffield Pancreatic Cancer Research Network website! Please check it out at... sites.google.com/sheffield.ac... @fohsheffield.bsky.social @mcb-sheffield.bsky.social
Sheffield Pancreatic Cancer Research Network
Meet the Team
sites.google.com
June 23, 2025 at 1:45 PM
I am excited to share our new Sheffield Pancreatic Cancer Research Network website! Please check it out at... sites.google.com/sheffield.ac... @fohsheffield.bsky.social @mcb-sheffield.bsky.social
A brilliant talk that sparked great discussions!
We are delighted to host @vickysanzmoreno.bsky.social today from the @icr.ac.uk!
"Biomechanical hallmarks and vulnerabilities of metastatic cancer cells"
📍 Alfred Denny Conference Room
📅 4th June - 1pm
@insigneoinstitute.bsky.social
@sheffielduni.bsky.social
@sheffielduni.bsky.social
"Biomechanical hallmarks and vulnerabilities of metastatic cancer cells"
📍 Alfred Denny Conference Room
📅 4th June - 1pm
@insigneoinstitute.bsky.social
@sheffielduni.bsky.social
@sheffielduni.bsky.social
June 5, 2025 at 1:23 PM
A brilliant talk that sparked great discussions!
Reposted by Victoria Hart
Great to hear about the research going on in @mcb-sheffield.bsky.social at University of Sheffield. Short talks from @helenkmatthews.bsky.social and @erainerolab.bsky.social about the projects going on in their labs 😊
April 14, 2025 at 1:25 PM
Great to hear about the research going on in @mcb-sheffield.bsky.social at University of Sheffield. Short talks from @helenkmatthews.bsky.social and @erainerolab.bsky.social about the projects going on in their labs 😊
loved having to opportunity to discuss our work and have plenty of great suggestions! #biologists100
@vichart33.bsky.social and Meg representing the lab at @bscb-official.bsky.social @biologists.bsky.social #biologists100
@mcb-sheffield.bsky.social
@mcb-sheffield.bsky.social
March 27, 2025 at 1:01 PM
loved having to opportunity to discuss our work and have plenty of great suggestions! #biologists100
Excited to be in the lovely Liverpool for the 100 year anniversary of the @biologists.bsky.social.
March 26, 2025 at 8:35 AM
Excited to be in the lovely Liverpool for the 100 year anniversary of the @biologists.bsky.social.