Tyler Pearson
@tylerpearson.bsky.social
Process Chemist
Formerly postdoc with @levinchem at UChicago
Formerly PhD with @dannafreedman
Formerly postdoc with @levinchem at UChicago
Formerly PhD with @dannafreedman
Even after just a few months working in a group dedicated to scale up and process transfer, this absolutely tracks. If your reaction is at all heterogeneous, it's likely there is a strong mixing component at play that will affect the chemistry across different batch sizes if not controlled.
Magnetic stirrers could be a significant source of variation between reactions, making procedures harder to reproduce. cen.acs.org/research-int... #chemsky 🧪
How magnetic stirrers could be reducing your yield
From the lab that found impurities on your stir bar—your flask’s placement on a stirrer plate can mess with your reaction too
cen.acs.org
June 20, 2025 at 7:44 PM
Even after just a few months working in a group dedicated to scale up and process transfer, this absolutely tracks. If your reaction is at all heterogeneous, it's likely there is a strong mixing component at play that will affect the chemistry across different batch sizes if not controlled.
Proposing this as a solution to poor pharmaceutical availability is like proposing burning down your house to get rid of bed bugs. This "solution" will literally kill people.
@chemjobber.bsky.social I absolutely get why people are so angry about medication costs, but it's kind of stunning to me that this piece doesn't make a single mention of the analytical side of synthesis and GMP.
www.404media.co/right-to-rep...
www.404media.co/right-to-rep...
‘Right to Repair for Your Body’: The Rise of DIY, Pirated Medicine
Four Thieves Vinegar Collective has made DIY medicine cheaper and more accessible to the masses.
www.404media.co
September 5, 2024 at 1:31 AM
Proposing this as a solution to poor pharmaceutical availability is like proposing burning down your house to get rid of bed bugs. This "solution" will literally kill people.
A productive afternoon yesterday at Montrose Point Bird Sanctuary! Lots of people out sharing sightings with each other which was so nice!
Some photo highlights for me were this *dramatic* downy woodpecker, a very cooperative common yellowthroat, and a lovely black and white warbler.
#birds
Some photo highlights for me were this *dramatic* downy woodpecker, a very cooperative common yellowthroat, and a lovely black and white warbler.
#birds
May 2, 2024 at 1:03 PM
A productive afternoon yesterday at Montrose Point Bird Sanctuary! Lots of people out sharing sightings with each other which was so nice!
Some photo highlights for me were this *dramatic* downy woodpecker, a very cooperative common yellowthroat, and a lovely black and white warbler.
#birds
Some photo highlights for me were this *dramatic* downy woodpecker, a very cooperative common yellowthroat, and a lovely black and white warbler.
#birds
took a swing past Jackson Park and had some fun sightings - a Caspian tern swooping over the lagoon, a grey-blue gnatcatcher, an orange-crowned warbler (I think!), and a northern flicker, among others
#birds
#birds
May 1, 2024 at 12:54 AM
took a swing past Jackson Park and had some fun sightings - a Caspian tern swooping over the lagoon, a grey-blue gnatcatcher, an orange-crowned warbler (I think!), and a northern flicker, among others
#birds
#birds
Visited Montrose Point Bird Sanctuary today and was not disappointed - got some beautiful shots of a yellow warbler, a black capped chickadee, a female downy woodpecker, and a common yellowthroat, and a less beautiful shot of a peregrine falcon (!!) in flight!
April 29, 2024 at 11:43 PM
Visited Montrose Point Bird Sanctuary today and was not disappointed - got some beautiful shots of a yellow warbler, a black capped chickadee, a female downy woodpecker, and a common yellowthroat, and a less beautiful shot of a peregrine falcon (!!) in flight!
Took my camera out for a spin at the beach. These were two of my favorite captures. I saw sparrows (song, house, and field sparrows), mourning doves, robins, red winged blackbirds, gulls, , ducks, cormorants, and, of course, pigeons on this particular outing.
April 28, 2024 at 1:05 PM
Took my camera out for a spin at the beach. These were two of my favorite captures. I saw sparrows (song, house, and field sparrows), mourning doves, robins, red winged blackbirds, gulls, , ducks, cormorants, and, of course, pigeons on this particular outing.
there's a slippery slope between wondering what bird that is you're seeing to impulse-buying hundreds of dollars of camera equipment
April 18, 2024 at 2:36 PM
there's a slippery slope between wondering what bird that is you're seeing to impulse-buying hundreds of dollars of camera equipment
Things are getting tense over on the chemistry faculty search status tracker. Stay kind to yourselves!
January 16, 2024 at 2:35 PM
Things are getting tense over on the chemistry faculty search status tracker. Stay kind to yourselves!
Reposted by Tyler Pearson
Tips for succeeding in a chem class TL;DR:
1. Schedule weekly support
2. Expose yourself to the content early & often
3. “Chemistry is learned w/ a pencil in your hand.”
4. Reflect to seek out support
5. Reminder that your ability is changeable!
#chemsky
1. Schedule weekly support
2. Expose yourself to the content early & often
3. “Chemistry is learned w/ a pencil in your hand.”
4. Reflect to seek out support
5. Reminder that your ability is changeable!
#chemsky
January 9, 2024 at 5:22 PM
Tips for succeeding in a chem class TL;DR:
1. Schedule weekly support
2. Expose yourself to the content early & often
3. “Chemistry is learned w/ a pencil in your hand.”
4. Reflect to seek out support
5. Reminder that your ability is changeable!
#chemsky
1. Schedule weekly support
2. Expose yourself to the content early & often
3. “Chemistry is learned w/ a pencil in your hand.”
4. Reflect to seek out support
5. Reminder that your ability is changeable!
#chemsky
What a huge honor to have our chemistry featured on In the Pipeline!
Poof! Instant pyridines, where there were none before:
Instant Pyridines
www.science.org
October 23, 2023 at 7:47 PM
What a huge honor to have our chemistry featured on In the Pipeline!
Reposted by Tyler Pearson
These skeletal editing papers are so much fun to write about. I spoke to @levinchem.bsky.social and @tylerpearson.bsky.social for @cenmag.bsky.social about their aromatic atom swap.
Atoms swap spots in aromatic rings
New reaction replaces carbon with nitrogen
cen.acs.org
October 5, 2023 at 9:14 PM
These skeletal editing papers are so much fun to write about. I spoke to @levinchem.bsky.social and @tylerpearson.bsky.social for @cenmag.bsky.social about their aromatic atom swap.
Reposted by Tyler Pearson
Lots of chemistry in Science this week! First up, @levinchem.bsky.social group turn aryl azides into pyridines with precise regioselectivity using a well-chosen oxidant www.science.org/doi/full/10....
Chemsky 🧪
Chemsky 🧪
Science | AAAS
www.science.org
September 28, 2023 at 7:10 PM
Lots of chemistry in Science this week! First up, @levinchem.bsky.social group turn aryl azides into pyridines with precise regioselectivity using a well-chosen oxidant www.science.org/doi/full/10....
Chemsky 🧪
Chemsky 🧪
Today it's my pleasure to present my magnum opus from my time in the Levin group: a site-selective benzene-to-pyridine "transmutation"
Now, you can replace carbon atoms in benzene rings with a nitrogen with intuitive and predictable site selectivity!
Read it here: www.science.org/doi/full/10....
Now, you can replace carbon atoms in benzene rings with a nitrogen with intuitive and predictable site selectivity!
Read it here: www.science.org/doi/full/10....
Aromatic nitrogen scanning by ipso-selective nitrene internalization
The proper oxidant enables conversion of aryl azides to pyridines with the nitrogen atom selectively replacing the azide-bound carbon.
www.science.org
September 28, 2023 at 6:22 PM
Today it's my pleasure to present my magnum opus from my time in the Levin group: a site-selective benzene-to-pyridine "transmutation"
Now, you can replace carbon atoms in benzene rings with a nitrogen with intuitive and predictable site selectivity!
Read it here: www.science.org/doi/full/10....
Now, you can replace carbon atoms in benzene rings with a nitrogen with intuitive and predictable site selectivity!
Read it here: www.science.org/doi/full/10....
Check out this sick paper from the Levin group - now finally out in ASAPs
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Core-Labeling (Radio) Synthesis of Phenols
We report a method that enables the fast incorporation of carbon isotopes into the ipso carbon of phenols. Our approach relies on the synthesis of a 1,5-dibromo-1,4-pentadiene precursor, which upon li...
pubs.acs.org
September 27, 2023 at 4:23 PM
Check out this sick paper from the Levin group - now finally out in ASAPs
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...