Todd Lencz
@toddlencz.bsky.social
Genetics, Psychiatry, Polygenic Risk Scores, Embryo Screening... https://feinstein.northwell.edu/institutes-researchers/our-researchers/todd-lencz-phd
Pinned
Todd Lencz
@toddlencz.bsky.social
· Nov 25
https://acnp.org/wp-content/uploads/2021/09/Postdoc_listing-_Lencz_polygenic.pdf…
NOW HIRING
#postdocjobs
NIH funding for a #postdoc with interest in complex genetics / computation / analysis
#GWAS #rarevariants #polygenicriskscores
in multiple research contexts:
psychiatric genomics; cognitive genomics; embryo screening...
acnp.org/wp-content/u...
#postdocjobs
NIH funding for a #postdoc with interest in complex genetics / computation / analysis
#GWAS #rarevariants #polygenicriskscores
in multiple research contexts:
psychiatric genomics; cognitive genomics; embryo screening...
acnp.org/wp-content/u...
Greetings #WCPG2025 from Cancun!
If you’re at the meeting and looking for a postdoctoral or research scientist position, come find me at poster M66 tonight!
If you’re at the meeting and looking for a postdoctoral or research scientist position, come find me at poster M66 tonight!
October 20, 2025 at 4:40 PM
Greetings #WCPG2025 from Cancun!
If you’re at the meeting and looking for a postdoctoral or research scientist position, come find me at poster M66 tonight!
If you’re at the meeting and looking for a postdoctoral or research scientist position, come find me at poster M66 tonight!
Please see our new work, led by @shaicarmi.bsky.social - in addition to a free online risk calculator, we demonstrate (for the first time), the degree to which real-world live birth rates attenuate the potential risk reduction in polygenic embryo screening (PES)
Excited to present our new tool "PEStimate", an online app for predicting risk reductions after Polygenic Embryo Screening (PES).
Find the app here:
polygenicembryo.shinyapps.io/pestimate/
Preprint:
www.medrxiv.org/content/10.1...
Find the app here:
polygenicembryo.shinyapps.io/pestimate/
Preprint:
www.medrxiv.org/content/10.1...
PEStimate: Predicting offspring disease risk after Polygenic Embryo Screening
Motivation: Polygenic embryo screening (PES) is a new technology in reproductive medicine, whereby human in-vitro fertilization embryos are screened for their genetic risk of complex, polygenic diseas...
www.medrxiv.org
September 10, 2025 at 4:13 PM
Please see our new work, led by @shaicarmi.bsky.social - in addition to a free online risk calculator, we demonstrate (for the first time), the degree to which real-world live birth rates attenuate the potential risk reduction in polygenic embryo screening (PES)
Reposted by Todd Lencz
We lay out three consensuses from the field of psychiatric genetics that should be considered before approving genetic tests for psychiatric disorders. The letter was signed by 140 experts in psychiatric genetics and published in Lancet Psychiatry. Now on Pubmed: pmc.ncbi.nlm.nih.gov/articles/PMC...
Concerns About Genetic Risk Testing for Opioid Use Disorder
pmc.ncbi.nlm.nih.gov
August 6, 2025 at 5:04 PM
We lay out three consensuses from the field of psychiatric genetics that should be considered before approving genetic tests for psychiatric disorders. The letter was signed by 140 experts in psychiatric genetics and published in Lancet Psychiatry. Now on Pubmed: pmc.ncbi.nlm.nih.gov/articles/PMC...
New publication!
We expand on our prior work demonstrating that pleiotropic effects of cognitive GWAS can provide biological insights into schizophrenia GWAS results. We differentiated "concordant" from "discordant" subsets of schizophrenia risk SNPs (1/3)
We expand on our prior work demonstrating that pleiotropic effects of cognitive GWAS can provide biological insights into schizophrenia GWAS results. We differentiated "concordant" from "discordant" subsets of schizophrenia risk SNPs (1/3)
May 14, 2025 at 2:13 PM
New publication!
We expand on our prior work demonstrating that pleiotropic effects of cognitive GWAS can provide biological insights into schizophrenia GWAS results. We differentiated "concordant" from "discordant" subsets of schizophrenia risk SNPs (1/3)
We expand on our prior work demonstrating that pleiotropic effects of cognitive GWAS can provide biological insights into schizophrenia GWAS results. We differentiated "concordant" from "discordant" subsets of schizophrenia risk SNPs (1/3)
A very thoughtful and comprehensive piece on polygenic embryo screening in today's NY Times:
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Opinion | I.V.F., Gene Selection and Embryo Screening: Is This the Future of Making Babies? (Gift Article)
Advances in genetic testing and artificial intelligence are changing what’s possible for those undergoing I.V.F. Are we ready for the future of fertility?
www.nytimes.com
April 1, 2025 at 5:28 PM
A very thoughtful and comprehensive piece on polygenic embryo screening in today's NY Times:
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Re-upping for the early crowd - link in reply
New Paper!
Online now in JAMA Psychiatry, we have performed a large-scale Mendelian Randomization study of circulating proteins in schizophrenia, bipolar disorder, major depression, and cognitive task performance.
Online now in JAMA Psychiatry, we have performed a large-scale Mendelian Randomization study of circulating proteins in schizophrenia, bipolar disorder, major depression, and cognitive task performance.
March 13, 2025 at 1:03 PM
Re-upping for the early crowd - link in reply
New Paper!
Online now in JAMA Psychiatry, we have performed a large-scale Mendelian Randomization study of circulating proteins in schizophrenia, bipolar disorder, major depression, and cognitive task performance.
Online now in JAMA Psychiatry, we have performed a large-scale Mendelian Randomization study of circulating proteins in schizophrenia, bipolar disorder, major depression, and cognitive task performance.
March 12, 2025 at 6:54 PM
New Paper!
Online now in JAMA Psychiatry, we have performed a large-scale Mendelian Randomization study of circulating proteins in schizophrenia, bipolar disorder, major depression, and cognitive task performance.
Online now in JAMA Psychiatry, we have performed a large-scale Mendelian Randomization study of circulating proteins in schizophrenia, bipolar disorder, major depression, and cognitive task performance.
Reposted by Todd Lencz
Unsure how recent changes in U.S. policy regarding the NIH will impact the psychiatric genetics world? You're not alone. Join ISPG for a Member’s Meetup for community discussion and support:
📅 Wednesday, January 29
🕗 3 PM EST
📍 Pre-Register: us06web.zoom.us/meeting/regi...
📅 Wednesday, January 29
🕗 3 PM EST
📍 Pre-Register: us06web.zoom.us/meeting/regi...
January 24, 2025 at 5:55 PM
Unsure how recent changes in U.S. policy regarding the NIH will impact the psychiatric genetics world? You're not alone. Join ISPG for a Member’s Meetup for community discussion and support:
📅 Wednesday, January 29
🕗 3 PM EST
📍 Pre-Register: us06web.zoom.us/meeting/regi...
📅 Wednesday, January 29
🕗 3 PM EST
📍 Pre-Register: us06web.zoom.us/meeting/regi...
On my way to #ACNP2024 🌵
Now recruiting for a #postdoc position in psychiatric genetics: t.co/Stst3V9agM
If you are interested in the genetics of psychotic disorders and their endophenotypes, check out my poster M160 on Monday!
Now recruiting for a #postdoc position in psychiatric genetics: t.co/Stst3V9agM
If you are interested in the genetics of psychotic disorders and their endophenotypes, check out my poster M160 on Monday!
December 7, 2024 at 8:29 PM
On my way to #ACNP2024 🌵
Now recruiting for a #postdoc position in psychiatric genetics: t.co/Stst3V9agM
If you are interested in the genetics of psychotic disorders and their endophenotypes, check out my poster M160 on Monday!
Now recruiting for a #postdoc position in psychiatric genetics: t.co/Stst3V9agM
If you are interested in the genetics of psychotic disorders and their endophenotypes, check out my poster M160 on Monday!
Reposted by Todd Lencz
Guess who's joining the party over here?? 🎉🦋
@npp-journal.bsky.social
@dpn-journal.bsky.social &
@acnporg.bsky.social
Be sure to follow☝️ahead of #ACNP2024
@npp-journal.bsky.social
@dpn-journal.bsky.social &
@acnporg.bsky.social
Be sure to follow☝️ahead of #ACNP2024
a man in a sweater is standing in front of a door with christmas wreaths on it .
ALT: a man in a sweater is standing in front of a door with christmas wreaths on it .
media.tenor.com
December 2, 2024 at 10:02 PM
Guess who's joining the party over here?? 🎉🦋
@npp-journal.bsky.social
@dpn-journal.bsky.social &
@acnporg.bsky.social
Be sure to follow☝️ahead of #ACNP2024
@npp-journal.bsky.social
@dpn-journal.bsky.social &
@acnporg.bsky.social
Be sure to follow☝️ahead of #ACNP2024
I think this JAMA article from last week received insufficient attention - different computations of PRS for the same disease, despite nearly identical population performance, resulted in very different classifications at the individual level #polygenicriskscores
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores
This study aims to characterize the individual-level agreement of polygenic risk scores for coronary heart disease that perform similarly at the population level.
jamanetwork.com
November 25, 2024 at 7:58 PM
I think this JAMA article from last week received insufficient attention - different computations of PRS for the same disease, despite nearly identical population performance, resulted in very different classifications at the individual level #polygenicriskscores
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
NOW HIRING
#postdocjobs
NIH funding for a #postdoc with interest in complex genetics / computation / analysis
#GWAS #rarevariants #polygenicriskscores
in multiple research contexts:
psychiatric genomics; cognitive genomics; embryo screening...
acnp.org/wp-content/u...
#postdocjobs
NIH funding for a #postdoc with interest in complex genetics / computation / analysis
#GWAS #rarevariants #polygenicriskscores
in multiple research contexts:
psychiatric genomics; cognitive genomics; embryo screening...
acnp.org/wp-content/u...
https://acnp.org/wp-content/uploads/2021/09/Postdoc_listing-_Lencz_polygenic.pdf…
November 25, 2024 at 5:31 PM
NOW HIRING
#postdocjobs
NIH funding for a #postdoc with interest in complex genetics / computation / analysis
#GWAS #rarevariants #polygenicriskscores
in multiple research contexts:
psychiatric genomics; cognitive genomics; embryo screening...
acnp.org/wp-content/u...
#postdocjobs
NIH funding for a #postdoc with interest in complex genetics / computation / analysis
#GWAS #rarevariants #polygenicriskscores
in multiple research contexts:
psychiatric genomics; cognitive genomics; embryo screening...
acnp.org/wp-content/u...
Reposted by Todd Lencz
Just added the 106th amazing statistical/psychiatric geneticist! Even if you have seen this starter pack before have a look, find the new people filtering in!
November 16, 2024 at 4:44 PM
Just added the 106th amazing statistical/psychiatric geneticist! Even if you have seen this starter pack before have a look, find the new people filtering in!
Reposted by Todd Lencz
Ok friends! I made a starter pack of psychiatric genetics people! Please let me know if you want to be added and share widely on other platforms to get our community here go.bsky.app/SkkmtMG
October 19, 2024 at 4:17 AM
Ok friends! I made a starter pack of psychiatric genetics people! Please let me know if you want to be added and share widely on other platforms to get our community here go.bsky.app/SkkmtMG
A statement on the need for scientific rigor in the development of genetic tests, endorsed by @ISPGnet and signed by 140 experts in the field:
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Concerns about genetic risk testing for opioid use disorder
In 2023, the US Food and Drug Administration approved the first genetic test for predicting
risk of developing a susbstance use disorder.1 The test, which is based on a set of
15 genetic variants, was...
www.thelancet.com
October 16, 2024 at 11:01 PM
A statement on the need for scientific rigor in the development of genetic tests, endorsed by @ISPGnet and signed by 140 experts in the field:
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...