Debabrata Laha
@thelahalab.bsky.social
Assistant Professor, Department of Biochemistry, Indian Institute of Science, Bangalore. Molecular Plant Physiology, Inositol Phosphate Biology, Cell Signalling. Former @ZMBP Tuebingen, @LMCB UCL
Pinned
Debabrata Laha
@thelahalab.bsky.social
· Jul 31
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant - Nature Chemical Biology
A noncanonical pathway of DELLA regulation by a conserved inositol pyrophosphate synthase was identified in the liverwort, Marchantia polymorpha, that lacks the canonical gibberellin-induced DELLA deg...
www.nature.com
Delighted to share our work "GA-independent DELLA regulation by pyrophosphate in a nonvascular land plant" published now in Nature Chemical Biology! @natchembio.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Debabrata Laha
Our November issue is live!
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
October 31, 2025 at 2:00 PM
Our November issue is live!
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
Really delighted and humbled to see that we made it into cover! This is first time for us. Please see more details about work in PMID: 40745478.
Our November issue is live!
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
www.nature.com/nchembio/vol...
The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
October 31, 2025 at 4:27 PM
Really delighted and humbled to see that we made it into cover! This is first time for us. Please see more details about work in PMID: 40745478.
Happy to share our work on identification of non-archetypal activity of IPK2 in producing inositol pyrophosphate 4/6-IP7 and regulating heat stress acclimation-conserved in studied land plants. Grateful to @jessenlab.bsky.social for wonderful collaborative efforts!
journals.plos.org/plosgenetics...
journals.plos.org/plosgenetics...
Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP7 in land plants
Author summary Inositol pyrophosphates (PP-InsPs) are eukaryote-specific cellular messengers that control a plethora of critical physiological processes, ranging from cellular metabolism to cellular e...
journals.plos.org
September 11, 2025 at 6:25 PM
Happy to share our work on identification of non-archetypal activity of IPK2 in producing inositol pyrophosphate 4/6-IP7 and regulating heat stress acclimation-conserved in studied land plants. Grateful to @jessenlab.bsky.social for wonderful collaborative efforts!
journals.plos.org/plosgenetics...
journals.plos.org/plosgenetics...
Delighted to share our work "GA-independent DELLA regulation by pyrophosphate in a nonvascular land plant" published now in Nature Chemical Biology! @natchembio.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant - Nature Chemical Biology
A noncanonical pathway of DELLA regulation by a conserved inositol pyrophosphate synthase was identified in the liverwort, Marchantia polymorpha, that lacks the canonical gibberellin-induced DELLA deg...
www.nature.com
July 31, 2025 at 10:25 AM
Delighted to share our work "GA-independent DELLA regulation by pyrophosphate in a nonvascular land plant" published now in Nature Chemical Biology! @natchembio.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Debabrata Laha
congrats to Kevin! His paper on new inositol pyrophosphates is out in @angewandtechemie.bsky.social
doi.org/10.1002/anie...
doi.org/10.1002/anie...
Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP‐InsP4 Isomers in Plant Signaling
Inositol pyrophosphates (PP-InsPs) are highly phosphorylated signaling molecules that regulate diverse cellular processes, including phosphate homeostasis and energy metabolism across species. Despit...
doi.org
July 1, 2025 at 4:02 PM
congrats to Kevin! His paper on new inositol pyrophosphates is out in @angewandtechemie.bsky.social
doi.org/10.1002/anie...
doi.org/10.1002/anie...
Reposted by Debabrata Laha
An alternative strategy to access inositol derivatives by stereoselective dephosphorylation. Happy to share the work by Markus Haener together with @gabrielschaaf.bsky.social and many others.
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Stereoselective chemoenzymatic phytate transformations provide access to diverse inositol phosphate derivatives
Phosphorylated myo-inositols (InsPs) are essential cytoplasmic signaling molecules, while their lipidated analogs (PtdInsPs) play a crucial role in membrane signaling. Stereoselective synthesis of the...
chemrxiv.org
April 18, 2025 at 11:05 AM
An alternative strategy to access inositol derivatives by stereoselective dephosphorylation. Happy to share the work by Markus Haener together with @gabrielschaaf.bsky.social and many others.
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Reposted by Debabrata Laha
The final version of our study on SERK-BIR module in Marchantia is out.
Congratulations Cate and many thanks to collaborators!
www.sciencedirect.com/science/arti...
Congratulations Cate and many thanks to collaborators!
www.sciencedirect.com/science/arti...
April 17, 2025 at 3:23 PM
The final version of our study on SERK-BIR module in Marchantia is out.
Congratulations Cate and many thanks to collaborators!
www.sciencedirect.com/science/arti...
Congratulations Cate and many thanks to collaborators!
www.sciencedirect.com/science/arti...
Reposted by Debabrata Laha
Happy to share Kevin´s great work on PP-InsP4 synthesis and analysis now available on Chemrxiv!
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Expanding the PP-INSP₄ Toolbox: Synthesis, Stereochemical Assignment, and Application in Plant Phosphate Signaling
Inositol pyrophosphates (PP-InsPs) are highly phosphorylated signaling molecules that regulate diverse cellular processes, including phosphate homeostasis and energy metabolism across species. Despite...
chemrxiv.org
March 28, 2025 at 1:38 PM
Happy to share Kevin´s great work on PP-InsP4 synthesis and analysis now available on Chemrxiv!
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...