The Cousin Lab
@thecousinlab.bsky.social
We study presynaptic function and dysfunction, specifically how neurotransmission is sustained during neuronal activity.
• We are delighted to contribute to this work just out in @jneurochem.bsky.social, where we collaborate with the BlueSkyless Smillie lab to reveal that Huntington’s Disease model neurons display excess activity-dependent bulk endocytosis (ADBE).
onlinelibrary.wiley.com
June 27, 2025 at 7:38 AM
• We are delighted to contribute to this work just out in @jneurochem.bsky.social, where we collaborate with the BlueSkyless Smillie lab to reveal that Huntington’s Disease model neurons display excess activity-dependent bulk endocytosis (ADBE).
Reposted by The Cousin Lab
ISN is seeking volunteers for its committees!
This is a great opportunity to contribute, connect, and help lead our global community.
🗓️ Apply by June 29
📨 Email: secretariat@neurochemistry.org with a short bio and brief statement on why you’re applying.
#WeAreNeurochemistry #neurosky
This is a great opportunity to contribute, connect, and help lead our global community.
🗓️ Apply by June 29
📨 Email: secretariat@neurochemistry.org with a short bio and brief statement on why you’re applying.
#WeAreNeurochemistry #neurosky
June 26, 2025 at 7:57 AM
ISN is seeking volunteers for its committees!
This is a great opportunity to contribute, connect, and help lead our global community.
🗓️ Apply by June 29
📨 Email: secretariat@neurochemistry.org with a short bio and brief statement on why you’re applying.
#WeAreNeurochemistry #neurosky
This is a great opportunity to contribute, connect, and help lead our global community.
🗓️ Apply by June 29
📨 Email: secretariat@neurochemistry.org with a short bio and brief statement on why you’re applying.
#WeAreNeurochemistry #neurosky
Fantastic effort from the Presynaptic Pacers, covering the slow leg from an old PI in their team at the Hairy Haggis relay!! All done to support @epilepsyinst.bsky.social!
May 25, 2025 at 3:13 PM
Fantastic effort from the Presynaptic Pacers, covering the slow leg from an old PI in their team at the Hairy Haggis relay!! All done to support @epilepsyinst.bsky.social!
Huge thanks to James, Jess, Zita and Angus for manning the @mmecepilepsy.bsky.social table today at the CDBS friends and family day! Great to spread the word about the amazing work the Centre is doing!
May 16, 2025 at 3:36 PM
Huge thanks to James, Jess, Zita and Angus for manning the @mmecepilepsy.bsky.social table today at the CDBS friends and family day! Great to spread the word about the amazing work the Centre is doing!
Reposted by The Cousin Lab
What, what! We just published our work studying GABAB receptors in human and rat brain.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phylogenetic divergence of GABAB receptor signaling in neocortical networks over adult life - Nature Communications
GABAB receptors contribute to complex inhibition that regulates cortical neurons in a translationally relevant manner over adult life. Here, authors show stronger presynaptic inhibition in humans than...
www.nature.com
May 7, 2025 at 7:27 AM
What, what! We just published our work studying GABAB receptors in human and rat brain.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
All funds raised go to @epilepsyinst.bsky.social !!
At the end of the month, The Presynaptic Pacers - a team of epilepsy researchers from the Cousin Lab - are running the Edinburgh Hairy Haggis Relay (May 25th) to raise funds for the Epilepsy Research Institute. Support our run and help drive life-changing research: shorturl.at/hUPhh
2025 Hairy Haggis Marathon for Epilepsy Research Institute UK
Help Han Tan raise money to support Epilepsy Research Institute UK
shorturl.at
May 5, 2025 at 4:03 PM
All funds raised go to @epilepsyinst.bsky.social !!
Reposted by The Cousin Lab
At the end of the month, The Presynaptic Pacers - a team of epilepsy researchers from the Cousin Lab - are running the Edinburgh Hairy Haggis Relay (May 25th) to raise funds for the Epilepsy Research Institute. Support our run and help drive life-changing research: shorturl.at/hUPhh
2025 Hairy Haggis Marathon for Epilepsy Research Institute UK
Help Han Tan raise money to support Epilepsy Research Institute UK
shorturl.at
May 5, 2025 at 4:01 PM
At the end of the month, The Presynaptic Pacers - a team of epilepsy researchers from the Cousin Lab - are running the Edinburgh Hairy Haggis Relay (May 25th) to raise funds for the Epilepsy Research Institute. Support our run and help drive life-changing research: shorturl.at/hUPhh
At the end of the month, The Presynaptic Pacers - a team of epilepsy researchers from the Cousin Lab - are running the Edinburgh Hairy Haggis Relay (May 25th) to raise funds for the Epilepsy Research Institute. Support our run and help drive life-changing research: shorturl.at/hUPhh
2025 Hairy Haggis Marathon for Epilepsy Research Institute UK
Help Han Tan raise money to support Epilepsy Research Institute UK
shorturl.at
May 5, 2025 at 4:01 PM
At the end of the month, The Presynaptic Pacers - a team of epilepsy researchers from the Cousin Lab - are running the Edinburgh Hairy Haggis Relay (May 25th) to raise funds for the Epilepsy Research Institute. Support our run and help drive life-changing research: shorturl.at/hUPhh
Reposted by The Cousin Lab
Excited for our latest work! We developed nanobinders for the luminal domain of Synaptotagmin 1 (calcium sensor for synaptic vesicles). Thanks among others to @verstrekenlab.bsky.social @opazo.bsky.social @meunierlab.bsky.social @volkerhaucke-lab.bsky.social www.biorxiv.org/content/10.1...
Nanobinders for Synaptotagmin 1 enable the analysis of synaptic vesicle dynamics in rodent and human models.
Synaptic neurotransmission is a critical hallmark of brain activity and one of the first processes to be affected in neural diseases. Monitoring this process, and in particular synaptic vesicle recycl...
www.biorxiv.org
April 22, 2025 at 9:27 AM
Excited for our latest work! We developed nanobinders for the luminal domain of Synaptotagmin 1 (calcium sensor for synaptic vesicles). Thanks among others to @verstrekenlab.bsky.social @opazo.bsky.social @meunierlab.bsky.social @volkerhaucke-lab.bsky.social www.biorxiv.org/content/10.1...
This would not have been possible without the heroic effort of Dr. Katherine Bonnycastle who invested years in this long-term project! Thanks also to Sarfaraz for the blots!
These models have mutations in genes exclusive to either the pre- or postsynapse, suggesting ADBE is a presynaptic homeostatic mechanism that corrects for intrinsic dysfunction in ASD neurons.
April 17, 2025 at 3:44 PM
This would not have been possible without the heroic effort of Dr. Katherine Bonnycastle who invested years in this long-term project! Thanks also to Sarfaraz for the blots!
These models have mutations in genes exclusive to either the pre- or postsynapse, suggesting ADBE is a presynaptic homeostatic mechanism that corrects for intrinsic dysfunction in ASD neurons.
April 17, 2025 at 3:44 PM
These models have mutations in genes exclusive to either the pre- or postsynapse, suggesting ADBE is a presynaptic homeostatic mechanism that corrects for intrinsic dysfunction in ASD neurons.
Our latest paper is out in Molecular Autism! We reveal that in neurons from five independent rat models of monogenic Autism Spectrum Disorder (ASD), activity-dependent endocytosis (ADBE) is selectively depressed, with no other synaptic vesicle recycling phenotype. Link to paper - rdcu.be/eh4Qa
Convergent depression of activity-dependent bulk endocytosis in rodent models of autism spectrum disorder
rdcu.be
April 17, 2025 at 3:43 PM
Our latest paper is out in Molecular Autism! We reveal that in neurons from five independent rat models of monogenic Autism Spectrum Disorder (ASD), activity-dependent endocytosis (ADBE) is selectively depressed, with no other synaptic vesicle recycling phenotype. Link to paper - rdcu.be/eh4Qa
Reposted by The Cousin Lab
🎉 Congrats to Sabrin Haddad - winner of the 2024 JNC Young Scientist Paper of the Year Award (in honor of Mark A. Smith)!
Her paper reveals how a CACNA2D2 mutation disrupts calcium channel & synaptic function in encephalopathy.
🔗Read here: bit.ly/3EjpeXq
#WeAreNeurochemistry #YoungScientistAward
Her paper reveals how a CACNA2D2 mutation disrupts calcium channel & synaptic function in encephalopathy.
🔗Read here: bit.ly/3EjpeXq
#WeAreNeurochemistry #YoungScientistAward
April 15, 2025 at 10:55 AM
🎉 Congrats to Sabrin Haddad - winner of the 2024 JNC Young Scientist Paper of the Year Award (in honor of Mark A. Smith)!
Her paper reveals how a CACNA2D2 mutation disrupts calcium channel & synaptic function in encephalopathy.
🔗Read here: bit.ly/3EjpeXq
#WeAreNeurochemistry #YoungScientistAward
Her paper reveals how a CACNA2D2 mutation disrupts calcium channel & synaptic function in encephalopathy.
🔗Read here: bit.ly/3EjpeXq
#WeAreNeurochemistry #YoungScientistAward
Reposted by The Cousin Lab
No sign of the aurora but at least I got to see the castle lit in purple for #epilepsy #PurpleDay ❤️
March 26, 2025 at 8:27 PM
No sign of the aurora but at least I got to see the castle lit in purple for #epilepsy #PurpleDay ❤️
Reposted by The Cousin Lab
It's #PurpleDay: a day to increase awareness of #epilepsy. Hannah, a 1st year PhD @edinuni-irr.bsky.social, has written about the need to investigate the neurodevelopmental consequences of early-onset epilepsy and risk factors contributing to them: edin.ac/4j6PMKh
March 26, 2025 at 12:14 PM
It's #PurpleDay: a day to increase awareness of #epilepsy. Hannah, a 1st year PhD @edinuni-irr.bsky.social, has written about the need to investigate the neurodevelopmental consequences of early-onset epilepsy and risk factors contributing to them: edin.ac/4j6PMKh
Happy Purple Day from us to the whole epilepsy community 💜! #PurpleDay2025
March 26, 2025 at 10:12 AM
Happy Purple Day from us to the whole epilepsy community 💜! #PurpleDay2025
Reposted by The Cousin Lab
Job Opportunity at JNC!✍️
The Journal of Neurochemistry is looking for a Freelance Editorial Assistant! If you have a background in science and publishing, this is your chance to join a global research community.
✅ Remote & flexible
✅ Support publishing
✅ Global network
🔗Apply here: bit.ly/3FAs1M6
The Journal of Neurochemistry is looking for a Freelance Editorial Assistant! If you have a background in science and publishing, this is your chance to join a global research community.
✅ Remote & flexible
✅ Support publishing
✅ Global network
🔗Apply here: bit.ly/3FAs1M6
March 18, 2025 at 3:47 PM
Job Opportunity at JNC!✍️
The Journal of Neurochemistry is looking for a Freelance Editorial Assistant! If you have a background in science and publishing, this is your chance to join a global research community.
✅ Remote & flexible
✅ Support publishing
✅ Global network
🔗Apply here: bit.ly/3FAs1M6
The Journal of Neurochemistry is looking for a Freelance Editorial Assistant! If you have a background in science and publishing, this is your chance to join a global research community.
✅ Remote & flexible
✅ Support publishing
✅ Global network
🔗Apply here: bit.ly/3FAs1M6
Reposted by The Cousin Lab
We are looking for motivated post docs. Projects on Alzheimer’s and Synucleinopathy. New mouse models, combined lightsheet/15.2T MRI and high throughput cognitive testing using touchscreens. Perfect for a recent graduate in Neurosciences or related field. Come work with us in 🇨🇦 👊😀🧪 please share.
February 5, 2025 at 1:53 AM
We are looking for motivated post docs. Projects on Alzheimer’s and Synucleinopathy. New mouse models, combined lightsheet/15.2T MRI and high throughput cognitive testing using touchscreens. Perfect for a recent graduate in Neurosciences or related field. Come work with us in 🇨🇦 👊😀🧪 please share.
Reposted by The Cousin Lab
Come and join our @epilepsyinst.bsky.social Doctoral Training Centre. Are you bright and passionate about epilepsy research? Want to join a nurturing and exciting programme? We have space for one more exceptional student. For details see www.muirmaxwellcentre.com/doctoral-tra...
Research Projects
www.muirmaxwellcentre.com
February 7, 2025 at 2:43 PM
Come and join our @epilepsyinst.bsky.social Doctoral Training Centre. Are you bright and passionate about epilepsy research? Want to join a nurturing and exciting programme? We have space for one more exceptional student. For details see www.muirmaxwellcentre.com/doctoral-tra...
Reposted by The Cousin Lab
We're happy to announce the launch of the new website of the Club Exo-endo. From the site, you can register for the annual meeting, register as a new member, advertise a position, apply for the thesis prize or post your latest publication. Please visit us at exoendo.org and make it interactive !
Club Exo Endo - Exocytose Endocytose
Le Club Exocytose-Endocytose est une association à but non lucratif, sans financement ni cotisation. Il rassemble près de 340 chercheurs, enseignants ou étudiants travaillant dans des domaines variés ...
exoendo.org
February 6, 2025 at 8:26 PM
We're happy to announce the launch of the new website of the Club Exo-endo. From the site, you can register for the annual meeting, register as a new member, advertise a position, apply for the thesis prize or post your latest publication. Please visit us at exoendo.org and make it interactive !
Reposted by The Cousin Lab
The Donlin-Asp Lab ( @pdaphd.bsky.social ) is hiring a postdoc to conduct primary research into how neurons transport mRNA to distal sites and use these mRNAs as substrates for local protein synthesis during synaptic plasticity.
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
@edinunineuro.bsky.social
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
@edinunineuro.bsky.social
February 6, 2025 at 10:51 AM
The Donlin-Asp Lab ( @pdaphd.bsky.social ) is hiring a postdoc to conduct primary research into how neurons transport mRNA to distal sites and use these mRNAs as substrates for local protein synthesis during synaptic plasticity.
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
@edinunineuro.bsky.social
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
@edinunineuro.bsky.social
New review out from our lab on SV2A! Thanks to James for all his hard work on this!
New in #JNC: A review article from @thecousinlab.bsky.social 📄
"SV2A is an enigmatic presynaptic protein. We discuss its key role in trafficking Synaptotagmin-1, how this controls neurotransmitter release, and how its dysfunction may result in epilepsy."
👉 bit.ly/3PUKcOE
"SV2A is an enigmatic presynaptic protein. We discuss its key role in trafficking Synaptotagmin-1, how this controls neurotransmitter release, and how its dysfunction may result in epilepsy."
👉 bit.ly/3PUKcOE
January 28, 2025 at 5:12 PM
New review out from our lab on SV2A! Thanks to James for all his hard work on this!
Reposted by The Cousin Lab
🌟 ISN Membership 2025 is Open!
Join or renew today to unlock:
✅ Discounted ISN meeting registration fees
✅ Access to grants & awards
✅ Free online access to JNC
✅ Discounted JNC open access fees
Be part of the global neurochemistry community 👉 ow.ly/jf1250UjGWA
#WeAreNeurochemistry #neuroskyence
Join or renew today to unlock:
✅ Discounted ISN meeting registration fees
✅ Access to grants & awards
✅ Free online access to JNC
✅ Discounted JNC open access fees
Be part of the global neurochemistry community 👉 ow.ly/jf1250UjGWA
#WeAreNeurochemistry #neuroskyence
December 3, 2024 at 8:56 AM
🌟 ISN Membership 2025 is Open!
Join or renew today to unlock:
✅ Discounted ISN meeting registration fees
✅ Access to grants & awards
✅ Free online access to JNC
✅ Discounted JNC open access fees
Be part of the global neurochemistry community 👉 ow.ly/jf1250UjGWA
#WeAreNeurochemistry #neuroskyence
Join or renew today to unlock:
✅ Discounted ISN meeting registration fees
✅ Access to grants & awards
✅ Free online access to JNC
✅ Discounted JNC open access fees
Be part of the global neurochemistry community 👉 ow.ly/jf1250UjGWA
#WeAreNeurochemistry #neuroskyence
@thecousinlab.bsky.social have just joined BlueSky, please feel free to follow to keep up with all things presynaptic!
November 29, 2024 at 12:25 PM
@thecousinlab.bsky.social have just joined BlueSky, please feel free to follow to keep up with all things presynaptic!