Yu-Ying Chen
@taniokinn.bsky.social
Postdoctoral Fellow in Reproductive & Developmental Biology at the Yao Lab, NIEHS, NIH. PhD at the Woodruff Lab @nu-crs.bsky.social, @nufeinbergmed.bsky.social FIRbees 23’
Reposted by Yu-Ying Chen
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
How Stowers Scientists Found the DNA Site Where Robertsonian Chromosomes Fuse
YouTube video by Stowers Institute for Medical Research
youtu.be
September 24, 2025 at 6:48 PM
🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...
Reposted by Yu-Ying Chen
Here are the curated lists of pubs in the #PlacentalCellBio
@biomednews.bsky.social report from the last two weeks!
biomed.news/bims-placeb/...
biomed.news/bims-placeb/...
My personal choice: this resource from the Zernicka-Goetz's lab! pubmed.ncbi.nlm.nih.gov/40882624/
Enjoy!
@biomednews.bsky.social report from the last two weeks!
biomed.news/bims-placeb/...
biomed.news/bims-placeb/...
My personal choice: this resource from the Zernicka-Goetz's lab! pubmed.ncbi.nlm.nih.gov/40882624/
Enjoy!
Efficient stem cell-derived mouse embryo models for environmental studies - PubMed
Blastoids are stem cell-derived structures that mimic natural blastocysts by incorporating all three lineages: trophectoderm, epiblast, and primitive endoderm. However, current methods often yield inc...
pubmed.ncbi.nlm.nih.gov
September 14, 2025 at 3:23 PM
Here are the curated lists of pubs in the #PlacentalCellBio
@biomednews.bsky.social report from the last two weeks!
biomed.news/bims-placeb/...
biomed.news/bims-placeb/...
My personal choice: this resource from the Zernicka-Goetz's lab! pubmed.ncbi.nlm.nih.gov/40882624/
Enjoy!
@biomednews.bsky.social report from the last two weeks!
biomed.news/bims-placeb/...
biomed.news/bims-placeb/...
My personal choice: this resource from the Zernicka-Goetz's lab! pubmed.ncbi.nlm.nih.gov/40882624/
Enjoy!
Reposted by Yu-Ying Chen
Excited to share the first review from our lab!
Together with Sara Pietroforte, we explore the idea that, beyond hormonal and biochemical cues, folliculogenesis may also be shaped by mechanical inputs from the ovary.
1/3
Together with Sara Pietroforte, we explore the idea that, beyond hormonal and biochemical cues, folliculogenesis may also be shaped by mechanical inputs from the ovary.
1/3
September 3, 2025 at 6:18 PM
Excited to share the first review from our lab!
Together with Sara Pietroforte, we explore the idea that, beyond hormonal and biochemical cues, folliculogenesis may also be shaped by mechanical inputs from the ovary.
1/3
Together with Sara Pietroforte, we explore the idea that, beyond hormonal and biochemical cues, folliculogenesis may also be shaped by mechanical inputs from the ovary.
1/3
Reposted by Yu-Ying Chen
Excited to share the first paper from the lab! 🥳 The ATG9 and lipid droplets saga continues! Open source!
Liver-specific loss of Atg9a perturbs lipid metabolism and hepatocyte integrity
The autophagy-related protein ATG9A is integral to cellular autophagy and lipid mobilization, yet its importance in mammalian physiology remains underexplored. Using a liver-specific conditional At...
doi.org
September 3, 2025 at 4:56 PM
Excited to share the first paper from the lab! 🥳 The ATG9 and lipid droplets saga continues! Open source!
Reposted by Yu-Ying Chen
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 1, 2025 at 2:59 PM
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
Such a beautiful ovary from @shmimberly.bsky.social 😍😍
✨If Monet studied mouse ovaries 🎨 Stromal cells 💜 Follicular cells 🔵 and Fatty Cells 🟡. Together, they reveal the cellular architecture and functional zones of the ovary 🔬 Image provided by @shmimberly.bsky.social 🧪 #FluorescenceFriday #ReproductiveBiology
August 22, 2025 at 7:09 PM
Such a beautiful ovary from @shmimberly.bsky.social 😍😍
Reposted by Yu-Ying Chen
Dr. Francesca Duncan will speak on this virtual webinar on "Women’s health: insights in research and inclusion"
Learn more and register for the event on August 28!
www.chemistryworld.com/webinars/wom...
Learn more and register for the event on August 28!
www.chemistryworld.com/webinars/wom...
Women’s health: insights in research and inclusion
Learn about the history and importance of the gender gap currently impacting women's health sciences - Join us on 28 August
www.chemistryworld.com
August 22, 2025 at 1:08 PM
Dr. Francesca Duncan will speak on this virtual webinar on "Women’s health: insights in research and inclusion"
Learn more and register for the event on August 28!
www.chemistryworld.com/webinars/wom...
Learn more and register for the event on August 28!
www.chemistryworld.com/webinars/wom...
Reposted by Yu-Ying Chen
Pleased to share my new review:
Ovulation: A cellular symphony in three movements 💥🥚
Ovulation is more than egg release—it's a tightly regulated, tissue-scale process. Here, I present a temporal framework structured as a symphony performed by the cells of the follicle.
🔗 doi.org/10.1016/j.se...
Ovulation: A cellular symphony in three movements 💥🥚
Ovulation is more than egg release—it's a tightly regulated, tissue-scale process. Here, I present a temporal framework structured as a symphony performed by the cells of the follicle.
🔗 doi.org/10.1016/j.se...
July 18, 2025 at 2:29 PM
Pleased to share my new review:
Ovulation: A cellular symphony in three movements 💥🥚
Ovulation is more than egg release—it's a tightly regulated, tissue-scale process. Here, I present a temporal framework structured as a symphony performed by the cells of the follicle.
🔗 doi.org/10.1016/j.se...
Ovulation: A cellular symphony in three movements 💥🥚
Ovulation is more than egg release—it's a tightly regulated, tissue-scale process. Here, I present a temporal framework structured as a symphony performed by the cells of the follicle.
🔗 doi.org/10.1016/j.se...
❤️❤️❤️
“We came from all over the world to be immersed in reproductive biology. It was magical.” For Gerton Lab predoc Anna Galligos her time at @mblscience.bsky.social was more than just a course. #MyMBLStory
Learn more about our satellite lab in #WoodsHole:
bit.ly/3PWPtWx
Learn more about our satellite lab in #WoodsHole:
bit.ly/3PWPtWx
July 18, 2025 at 10:31 PM
❤️❤️❤️
Reposted by Yu-Ying Chen
🧵1/
🚨 New tool for reproductive biology!
We generated a Nr2f2-iCreERT2 mouse—an inducible Cre model that specifically targets interstitial cells in both male and female gonads.
Read more in our new @biolreprod paper:
🔗 doi.org/10.1093/biol...
🚨 New tool for reproductive biology!
We generated a Nr2f2-iCreERT2 mouse—an inducible Cre model that specifically targets interstitial cells in both male and female gonads.
Read more in our new @biolreprod paper:
🔗 doi.org/10.1093/biol...
July 16, 2025 at 4:02 AM
🧵1/
🚨 New tool for reproductive biology!
We generated a Nr2f2-iCreERT2 mouse—an inducible Cre model that specifically targets interstitial cells in both male and female gonads.
Read more in our new @biolreprod paper:
🔗 doi.org/10.1093/biol...
🚨 New tool for reproductive biology!
We generated a Nr2f2-iCreERT2 mouse—an inducible Cre model that specifically targets interstitial cells in both male and female gonads.
Read more in our new @biolreprod paper:
🔗 doi.org/10.1093/biol...
Reposted by Yu-Ying Chen
📣 Paper alert!! Excited to share the 2nd research paper from my time in the @bokelab.bsky.social at @crg.eu, out today in the @embojournal.org!
We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?"
1/
We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?"
1/
July 16, 2025 at 11:36 AM
📣 Paper alert!! Excited to share the 2nd research paper from my time in the @bokelab.bsky.social at @crg.eu, out today in the @embojournal.org!
We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?"
1/
We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?"
1/
Reposted by Yu-Ying Chen
New Publication!
Congrats to Dr. Aubrey Converse on her manuscript which uses innovative approaches to define the transcriptomic signature of ovarian multinucleated giant cells and provide novel insight into the role of this cell population in ovarian aging!
journals.plos.org/plosbiology/...
Congrats to Dr. Aubrey Converse on her manuscript which uses innovative approaches to define the transcriptomic signature of ovarian multinucleated giant cells and provide novel insight into the role of this cell population in ovarian aging!
journals.plos.org/plosbiology/...
Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures
Ovarian multinucleated giant cells are a unique macrophage population that arise within the aging mammalian ovary. This study characterizes their transcriptome in mice, uncovering a potential role in ...
journals.plos.org
July 10, 2025 at 2:23 PM
New Publication!
Congrats to Dr. Aubrey Converse on her manuscript which uses innovative approaches to define the transcriptomic signature of ovarian multinucleated giant cells and provide novel insight into the role of this cell population in ovarian aging!
journals.plos.org/plosbiology/...
Congrats to Dr. Aubrey Converse on her manuscript which uses innovative approaches to define the transcriptomic signature of ovarian multinucleated giant cells and provide novel insight into the role of this cell population in ovarian aging!
journals.plos.org/plosbiology/...
Reposted by Yu-Ying Chen
Dr. Francesca Duncan and Dr. Kara Goldman were featured in this USA Today on ovarian aging and reproductive longevity!
www.usatoday.com/story/graphi...
www.usatoday.com/story/graphi...
Beyond fertility and menopause: See why the ovary is central to women’s health and longevity
See why the ovary − often reduced to its reproductive role − menopause, age and estrogen affect a woman’s health throughout her body and lifetime.
www.usatoday.com
June 30, 2025 at 3:03 PM
Dr. Francesca Duncan and Dr. Kara Goldman were featured in this USA Today on ovarian aging and reproductive longevity!
www.usatoday.com/story/graphi...
www.usatoday.com/story/graphi...
Reposted by Yu-Ying Chen
Super congrats to Chris and Pelin on this awesome work! First paper from the @joerodriguez11.bsky.social lab🎉!
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Altered cofactor recruitment and nucleosome dynamics underlie bisphenol A’s impact on ERα-mediated transcriptional bursting
Biochemistry; Molecular biology; Molecular interaction
www.cell.com
June 28, 2025 at 9:41 PM
Super congrats to Chris and Pelin on this awesome work! First paper from the @joerodriguez11.bsky.social lab🎉!
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Reposted by Yu-Ying Chen
New Duncan Lab publication!
Congratulations to Emma Gargus and Rhea Sharma and their co-authors on elucidating how caloric restriction impacts markers of ovarian function and aging in the rhesus macaque!
www.aging-us.com/article/2062...
Congratulations to Emma Gargus and Rhea Sharma and their co-authors on elucidating how caloric restriction impacts markers of ovarian function and aging in the rhesus macaque!
www.aging-us.com/article/2062...
Short-term moderate caloric restriction in the rhesus macaque attenuates markers of ovarian aging in select populations | Aging
Aging | doi:10.18632/aging.206253. Emma S. Gargus, Rhea Sharma, Rebecca Gu, Camille Mulcahy, Brian W. Johnson, Jing Song, Jungwha Lee, Mary Zelinski, Francesca E. Duncan
www.aging-us.com
June 16, 2025 at 9:00 PM
New Duncan Lab publication!
Congratulations to Emma Gargus and Rhea Sharma and their co-authors on elucidating how caloric restriction impacts markers of ovarian function and aging in the rhesus macaque!
www.aging-us.com/article/2062...
Congratulations to Emma Gargus and Rhea Sharma and their co-authors on elucidating how caloric restriction impacts markers of ovarian function and aging in the rhesus macaque!
www.aging-us.com/article/2062...
Reposted by Yu-Ying Chen
Join SPARK's first panel, Human Biospecimen Repositories Fueling Translational Reproductive Science and Medicine Research.
CRS faculty participants include panelist Dr. Mary Ellen Pavone and moderator Dr. Francesca Duncan
www.upsquad.com/event/regist...
CRS faculty participants include panelist Dr. Mary Ellen Pavone and moderator Dr. Francesca Duncan
www.upsquad.com/event/regist...
June 16, 2025 at 6:30 PM
Join SPARK's first panel, Human Biospecimen Repositories Fueling Translational Reproductive Science and Medicine Research.
CRS faculty participants include panelist Dr. Mary Ellen Pavone and moderator Dr. Francesca Duncan
www.upsquad.com/event/regist...
CRS faculty participants include panelist Dr. Mary Ellen Pavone and moderator Dr. Francesca Duncan
www.upsquad.com/event/regist...
Reposted by Yu-Ying Chen
Congrats on the new paper to Krystal who "doesn't do social media" but does do a ton of ATAC and Cut&Run to show how GATA3 pioneers enhancers with BRG1 and sometimes AP-1! #NIEHS #NAR doi.org/10.1093/nar/...
Pioneering new enhancers by GATA3: role of facilitating transcription factors and chromatin remodeling
Abstract. Pioneer transcription factors (PTFs) bind to inaccessible chromatin and recruit collaborating transcription factors to promote chromatin accessib
doi.org
June 10, 2025 at 3:57 PM
Congrats on the new paper to Krystal who "doesn't do social media" but does do a ton of ATAC and Cut&Run to show how GATA3 pioneers enhancers with BRG1 and sometimes AP-1! #NIEHS #NAR doi.org/10.1093/nar/...
Reposted by Yu-Ying Chen
Together with @virginiasavy.bsky.social, we curated a preList of preprints presented at the Keystone Symposia: Metabolic and Nutritional Control of Development and Cell Fate!
Explore the latest in the field, fresh from the conference! 📑🆕: prelights.biologists.com/prelists/ksm...
#DevBio #Metabolism
Explore the latest in the field, fresh from the conference! 📑🆕: prelights.biologists.com/prelists/ksm...
#DevBio #Metabolism
Keystone Symposium - Metabolic and Nutritional Control of Development and Cell Fate - preLights
The field of developmental metabolism seeks to understand how nutrient availability and the regulation of metabolic pathways support and influence critical biological processes such as tissue patterni...
prelights.biologists.com
May 15, 2025 at 1:18 AM
Together with @virginiasavy.bsky.social, we curated a preList of preprints presented at the Keystone Symposia: Metabolic and Nutritional Control of Development and Cell Fate!
Explore the latest in the field, fresh from the conference! 📑🆕: prelights.biologists.com/prelists/ksm...
#DevBio #Metabolism
Explore the latest in the field, fresh from the conference! 📑🆕: prelights.biologists.com/prelists/ksm...
#DevBio #Metabolism
Reposted by Yu-Ying Chen
🚨Excited to share my first postdoc paper, now published in Nature Communications! We uncover a key regulator of testis development and its link to differences of sex development (DSD). 🧵
🔗 nature.com/articles/s4146…
1/7
🔗 nature.com/articles/s4146…
1/7
April 29, 2025 at 5:24 AM
🚨Excited to share my first postdoc paper, now published in Nature Communications! We uncover a key regulator of testis development and its link to differences of sex development (DSD). 🧵
🔗 nature.com/articles/s4146…
1/7
🔗 nature.com/articles/s4146…
1/7
Reposted by Yu-Ying Chen
Ready for it???
To all the **sex determination lovers**
📢 Save the date to the 10th International Symposium on the Biology of Vertebrate Sex Determination (VSD) held in the beautiful Hawaii!!
Great community, amazing science, excellent speakers and superb location 🏝
📢 March 23-26, 2026 📢
To all the **sex determination lovers**
📢 Save the date to the 10th International Symposium on the Biology of Vertebrate Sex Determination (VSD) held in the beautiful Hawaii!!
Great community, amazing science, excellent speakers and superb location 🏝
📢 March 23-26, 2026 📢
March 25, 2025 at 5:45 AM
Ready for it???
To all the **sex determination lovers**
📢 Save the date to the 10th International Symposium on the Biology of Vertebrate Sex Determination (VSD) held in the beautiful Hawaii!!
Great community, amazing science, excellent speakers and superb location 🏝
📢 March 23-26, 2026 📢
To all the **sex determination lovers**
📢 Save the date to the 10th International Symposium on the Biology of Vertebrate Sex Determination (VSD) held in the beautiful Hawaii!!
Great community, amazing science, excellent speakers and superb location 🏝
📢 March 23-26, 2026 📢
Friends in RTP area exploring biomedical career options don’t miss out on this great (and free) opportunity 🤩🤩 Learn more at bit.ly/4bzNK2s
27th Annual NIEHS Biomedical Career Symposium
The annual NIEHS Biomedical Career Symposium, now in its 27th year, is one of the largest assemblies of biomedical organizations and young scientists in Research Triangle Park, North Carolina.
bit.ly
March 12, 2025 at 4:08 AM
Friends in RTP area exploring biomedical career options don’t miss out on this great (and free) opportunity 🤩🤩 Learn more at bit.ly/4bzNK2s
Reposted by Yu-Ying Chen
📢 #Reproseminars are back!
We are thrilled to kick off the semester on Monday 03/10 with an exciting talk by Dr. @jeanjuchung.bsky.social (@ Yale University) 🧪
💬Title: "Sperm Ca2+ channel research for reproductive medicine"
🕒 3 PM 🇦🇷 | 2 PM 🇺🇸 EST
Join us!
We are thrilled to kick off the semester on Monday 03/10 with an exciting talk by Dr. @jeanjuchung.bsky.social (@ Yale University) 🧪
💬Title: "Sperm Ca2+ channel research for reproductive medicine"
🕒 3 PM 🇦🇷 | 2 PM 🇺🇸 EST
Join us!
March 4, 2025 at 6:31 PM
📢 #Reproseminars are back!
We are thrilled to kick off the semester on Monday 03/10 with an exciting talk by Dr. @jeanjuchung.bsky.social (@ Yale University) 🧪
💬Title: "Sperm Ca2+ channel research for reproductive medicine"
🕒 3 PM 🇦🇷 | 2 PM 🇺🇸 EST
Join us!
We are thrilled to kick off the semester on Monday 03/10 with an exciting talk by Dr. @jeanjuchung.bsky.social (@ Yale University) 🧪
💬Title: "Sperm Ca2+ channel research for reproductive medicine"
🕒 3 PM 🇦🇷 | 2 PM 🇺🇸 EST
Join us!
Reposted by Yu-Ying Chen
New Akera's lab paper! Congrats @takashiakeralab.bsky.social and Eddie!
Meiosis-specific distal cohesion site decoupled from the kinetochore - Nature Communications
In general, the kinetochore position and the sister-chromatid cohesion site are spatially linked. Here, the authors find a meiosis-specific distal cohesion site decoupled from the kinetochore in Perom...
www.nature.com
March 3, 2025 at 2:33 PM
New Akera's lab paper! Congrats @takashiakeralab.bsky.social and Eddie!
How lucky am I to have such an awesome neighbor 🥹🥹🥰🥰🤭
Check out this cool preprint looking at the TF networks regulating sex-specific cell differentiation in the gonad from my awesome neighbor @taniokinn.bsky.social: www.biorxiv.org/content/10.1...
Single-nucleus multiomics of murine gonadal cells reveals transcriptional regulatory network underlying supporting lineage differentiation
Sex determination of mammalian gonads hinges upon sex-specific differentiation of gonadal supporting cells: Sertoli cells in the testis and granulosa cells in the ovary. To gain insights into how supp...
www.biorxiv.org
February 28, 2025 at 4:12 PM
How lucky am I to have such an awesome neighbor 🥹🥹🥰🥰🤭
Reposted by Yu-Ying Chen
Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem. www.biorxiv.org/content/10.1...
A versatile cohesion manipulation system reveals CENP-A dysfunction accelerates female reproductive age-related egg aneuploidy.
Female reproductive aging is accompanied by a dramatic rise in the incidence of egg aneuploidy. Premature loss of chromosome cohesion proteins and untimely separation of chromosomes is thought to unde...
www.biorxiv.org
February 28, 2025 at 12:39 PM
Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem. www.biorxiv.org/content/10.1...