StayCurious Metabolism
@staycuriousmetabolism.skystack.xyz
We will cultivate nuance and curiosity for all things metabolism. Make Metabolic Health Mainstream!
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This is an automated Substack Account of https://staycuriousmetabolism.substack.com
Discover more/Create at: @skystack.xyz
The Carb-Loading Myth Is Finally Dead • For decades, athletes have been preached the gospel of carb loading: load up on carbohydrates to unlock peak performance. That myth just died—in style.
The Carb-Loading Myth Is Finally Dead
For decades, athletes have been preached the gospel of carb loading: load up on carbohydrates to unlock peak performance. That myth just died—in style.
staycuriousmetabolism.substack.com
January 22, 2026 at 2:49 PM
The Carb-Loading Myth Is Finally Dead • For decades, athletes have been preached the gospel of carb loading: load up on carbohydrates to unlock peak performance. That myth just died—in style.
Lowering Cholesterol Killed: A Study Buried for 40 Years • A forgotten trial, buried for decades, revealed that a cholesterol-lowering didn’t save lives—it cost them. Here’s what the data actually showed, and what you haven't been told.
Lowering Cholesterol Killed: A Study Buried for 40 Years
A forgotten trial, buried for decades, revealed that a cholesterol-lowering didn’t save lives—it cost them. Here’s what the data actually showed, and what you haven't been told.
staycuriousmetabolism.substack.com
January 20, 2026 at 2:48 PM
Lowering Cholesterol Killed: A Study Buried for 40 Years • A forgotten trial, buried for decades, revealed that a cholesterol-lowering didn’t save lives—it cost them. Here’s what the data actually showed, and what you haven't been told.
A Way Out of Long COVID • In this letter, I’m going to offer a possible way of thinking about long COVID symptoms and how to treat them.
A Way Out of Long COVID
In this letter, I’m going to offer a possible way of thinking about long COVID symptoms and how to treat them.
staycuriousmetabolism.substack.com
January 18, 2026 at 2:48 PM
A Way Out of Long COVID • In this letter, I’m going to offer a possible way of thinking about long COVID symptoms and how to treat them.
What If the Statin Trial That Changed Medicine... Got It Half-Right? • The 4S trial is credited with launching the statin era—but a closer look reveals a surprising story about metabolic health, risk prediction, and when statins might not deliver the benefits we assume.
What If the Statin Trial That Changed Medicine... Got It Half-Right?
The 4S trial is credited with launching the statin era—but a closer look reveals a surprising story about metabolic health, risk prediction, and when statins might not deliver the benefits we assume.
staycuriousmetabolism.substack.com
January 17, 2026 at 2:53 PM
What If the Statin Trial That Changed Medicine... Got It Half-Right? • The 4S trial is credited with launching the statin era—but a closer look reveals a surprising story about metabolic health, risk prediction, and when statins might not deliver the benefits we assume.
Pitting Facts Against Sensationalism Regarding the Role of LDL Cholesterol in ASCVD • Peter Attia warns that simplicity is crushing nuance in science. I agree—so I took a closer look at his own argument on LDL, statins, and longevity. What I found: Peter Petered himself.
Pitting Facts Against Sensationalism Regarding the Role of LDL Cholesterol in ASCVD
Peter Attia warns that simplicity is crushing nuance in science. I agree—so I took a closer look at his own argument on LDL, statins, and longevity. What I found: Peter Petered himself.
staycuriousmetabolism.substack.com
January 15, 2026 at 2:53 PM
Pitting Facts Against Sensationalism Regarding the Role of LDL Cholesterol in ASCVD • Peter Attia warns that simplicity is crushing nuance in science. I agree—so I took a closer look at his own argument on LDL, statins, and longevity. What I found: Peter Petered himself.
Cholesterol and ApoB Don't Predict Death. This Does. • “You are going to die young.” The first time I heard those six words, they were jarring. And I chuckle when I hear them. Because...
Cholesterol and ApoB Don't Predict Death. This Does.
“You are going to die young.” The first time I heard those six words, they were jarring. And I chuckle when I hear them. Because...
staycuriousmetabolism.substack.com
January 13, 2026 at 2:53 PM
Cholesterol and ApoB Don't Predict Death. This Does. • “You are going to die young.” The first time I heard those six words, they were jarring. And I chuckle when I hear them. Because...
New Dietary Guidelines: What Everyone Missed • The nutrition world is in full-blown tailspin mode after the government dropped the new 2025–2030 Dietary Guidelines for Americans. I had a strong reaction. But perhaps not the one you’d expect.
New Dietary Guidelines: What Everyone Missed
The nutrition world is in full-blown tailspin mode after the government dropped the new 2025–2030 Dietary Guidelines for Americans. I had a strong reaction. But perhaps not the one you’d expect.
staycuriousmetabolism.substack.com
January 11, 2026 at 2:54 PM
New Dietary Guidelines: What Everyone Missed • The nutrition world is in full-blown tailspin mode after the government dropped the new 2025–2030 Dietary Guidelines for Americans. I had a strong reaction. But perhaps not the one you’d expect.
“Definitely Don’t Stop Statins”— Biohacker Bryan Johnson Oversteps • A detailed, evidence-based rebuttal to Bryan Johnson’s statin advice—exploring key risks, overlooked nuance, and alternative strategies for cardiovascular health.
“Definitely Don’t Stop Statins”— Biohacker Bryan Johnson Oversteps
A detailed, evidence-based rebuttal to Bryan Johnson’s statin advice—exploring key risks, overlooked nuance, and alternative strategies for cardiovascular health.
staycuriousmetabolism.substack.com
January 10, 2026 at 2:53 PM
“Definitely Don’t Stop Statins”— Biohacker Bryan Johnson Oversteps • A detailed, evidence-based rebuttal to Bryan Johnson’s statin advice—exploring key risks, overlooked nuance, and alternative strategies for cardiovascular health.
A Concise Masterclass on Cholesterol-Lowering Medications • A concise, high-yield guide to cholesterol-lowering therapies—statins, Zetia, PCSK9 inhibitors, bempedoic acid, berberine, and key dietary tweaks—plus insights on benefits, risks, and mechanisms.
A Concise Masterclass on Cholesterol-Lowering Medications
A concise, high-yield guide to cholesterol-lowering therapies—statins, Zetia, PCSK9 inhibitors, bempedoic acid, berberine, and key dietary tweaks—plus insights on benefits, risks, and mechanisms.
staycuriousmetabolism.substack.com
January 6, 2026 at 2:52 PM
A Concise Masterclass on Cholesterol-Lowering Medications • A concise, high-yield guide to cholesterol-lowering therapies—statins, Zetia, PCSK9 inhibitors, bempedoic acid, berberine, and key dietary tweaks—plus insights on benefits, risks, and mechanisms.
Never get Alzheimer’s Disease: The NAD+ Breakthrough • A brand-new paper has just been published that claims to challenge the century-old dogma that Alzheimer’s disease is irreversible. That’s a big claim—and big claims demand strong data...
Never get Alzheimer’s Disease: The NAD+ Breakthrough
A brand-new paper has just been published that claims to challenge the century-old dogma that Alzheimer’s disease is irreversible. That’s a big claim—and big claims demand strong data...
staycuriousmetabolism.substack.com
January 3, 2026 at 2:53 PM
Never get Alzheimer’s Disease: The NAD+ Breakthrough • A brand-new paper has just been published that claims to challenge the century-old dogma that Alzheimer’s disease is irreversible. That’s a big claim—and big claims demand strong data...
The 2025 Metabolic Highlight Reel: Breakthroughs, Surprises & Hidden Gems • This edition highlights a mix of crowd favorites (judged by your engagement) and a few underrated gems...
The 2025 Metabolic Highlight Reel: Breakthroughs, Surprises & Hidden Gems
This edition highlights a mix of crowd favorites (judged by your engagement) and a few underrated gems...
staycuriousmetabolism.substack.com
January 1, 2026 at 2:54 PM
The 2025 Metabolic Highlight Reel: Breakthroughs, Surprises & Hidden Gems • This edition highlights a mix of crowd favorites (judged by your engagement) and a few underrated gems...
Lp(a): The Match, the Fuse, and the Escape Route • A new study finds that elevated Lp(a) may increase the risk of death from cardiovascular disease by as much as 230%. But there's good news hidden in the "how" ...
Lp(a): The Match, the Fuse, and the Escape Route
A new study finds that elevated Lp(a) may increase the risk of death from cardiovascular disease by as much as 230%. But there's good news hidden in the "how" ...
staycuriousmetabolism.substack.com
December 30, 2025 at 2:44 PM
Lp(a): The Match, the Fuse, and the Escape Route • A new study finds that elevated Lp(a) may increase the risk of death from cardiovascular disease by as much as 230%. But there's good news hidden in the "how" ...
The Biomarker That Ate Cardiology • LDL cholesterol (LDL-C) has been elevated to a position of dominance in cardiovascular medicine that is not justified by its relative contribution to risk. That imbalance doesn’t just distort...
The Biomarker That Ate Cardiology
LDL cholesterol (LDL-C) has been elevated to a position of dominance in cardiovascular medicine that is not justified by its relative contribution to risk. That imbalance doesn’t just distort...
staycuriousmetabolism.substack.com
December 28, 2025 at 2:44 PM
The Biomarker That Ate Cardiology • LDL cholesterol (LDL-C) has been elevated to a position of dominance in cardiovascular medicine that is not justified by its relative contribution to risk. That imbalance doesn’t just distort...
Young Blood Can Extend Lifespan by 12%. Here's the Mechanism. • Tiny bubbles in your blood might help turn back the clock on aging. Scientists are learning how they boost energy, brain health, and more.
Young Blood Can Extend Lifespan by 12%. Here's the Mechanism.
Tiny bubbles in your blood might help turn back the clock on aging. Scientists are learning how they boost energy, brain health, and more.
staycuriousmetabolism.substack.com
December 27, 2025 at 2:53 PM
Young Blood Can Extend Lifespan by 12%. Here's the Mechanism. • Tiny bubbles in your blood might help turn back the clock on aging. Scientists are learning how they boost energy, brain health, and more.
Poop Calories & Burn Fat: A Guide for the Metabolically Curious • A practical guide to science-backed diet and lifestyle strategies designed to safely boost your metabolism.
Poop Calories & Burn Fat: A Guide for the Metabolically Curious
A practical guide to science-backed diet and lifestyle strategies designed to safely boost your metabolism.
staycuriousmetabolism.substack.com
December 23, 2025 at 2:53 PM
Poop Calories & Burn Fat: A Guide for the Metabolically Curious • A practical guide to science-backed diet and lifestyle strategies designed to safely boost your metabolism.
Nattokinase: The Heart Health Supplement on Everyone’s Tongue • When it comes to cardiovascular health, few supplements have sparked as much public interest — or confusion — as nattokinase. Let's unpack...
Nattokinase: The Heart Health Supplement on Everyone’s Tongue
When it comes to cardiovascular health, few supplements have sparked as much public interest — or confusion — as nattokinase. Let's unpack...
staycuriousmetabolism.substack.com
December 21, 2025 at 2:50 PM
Nattokinase: The Heart Health Supplement on Everyone’s Tongue • When it comes to cardiovascular health, few supplements have sparked as much public interest — or confusion — as nattokinase. Let's unpack...
High-Fat Cheese Lowers Dementia Risk—Too Gouda to Be True? • A brand-new paper in Neurology that followed people for 25 years and found that higher intake of high-fat cheese, but not low-fat cheese, was associated with a reduced risk of dementia. But...
High-Fat Cheese Lowers Dementia Risk—Too Gouda to Be True?
A brand-new paper in Neurology that followed people for 25 years and found that higher intake of high-fat cheese, but not low-fat cheese, was associated with a reduced risk of dementia. But...
staycuriousmetabolism.substack.com
December 20, 2025 at 2:47 PM
High-Fat Cheese Lowers Dementia Risk—Too Gouda to Be True? • A brand-new paper in Neurology that followed people for 25 years and found that higher intake of high-fat cheese, but not low-fat cheese, was associated with a reduced risk of dementia. But...
Inside My Supplement Stack: What I Take and Why • A transparent look at the supplements I use for muscle, brain, gut, and sleep health — and the personal reasoning behind each choice.
Inside My Supplement Stack: What I Take and Why
A transparent look at the supplements I use for muscle, brain, gut, and sleep health — and the personal reasoning behind each choice.
staycuriousmetabolism.substack.com
December 18, 2025 at 2:49 PM
Inside My Supplement Stack: What I Take and Why • A transparent look at the supplements I use for muscle, brain, gut, and sleep health — and the personal reasoning behind each choice.
This Drug Raises LDL Cholesterol—And Saves Lives • What if I told you there’s a medication that raises LDL “bad” cholesterol—yet actually saves lives, including from cardiovascular disease?
This Drug Raises LDL Cholesterol—And Saves Lives
What if I told you there’s a medication that raises LDL “bad” cholesterol—yet actually saves lives, including from cardiovascular disease?
staycuriousmetabolism.substack.com
December 16, 2025 at 2:50 PM
This Drug Raises LDL Cholesterol—And Saves Lives • What if I told you there’s a medication that raises LDL “bad” cholesterol—yet actually saves lives, including from cardiovascular disease?
A Doctor Texted Me: “I’m Stopping My Statin”—Here’s Why • New study finds statin use is associated with a decline in muscle function and mass over time. Let's discuss what the data reveal and what questions remain...
A Doctor Texted Me: “I’m Stopping My Statin”—Here’s Why
New study finds statin use is associated with a decline in muscle function and mass over time. Let's discuss what the data reveal and what questions remain...
staycuriousmetabolism.substack.com
December 13, 2025 at 2:54 PM
A Doctor Texted Me: “I’m Stopping My Statin”—Here’s Why • New study finds statin use is associated with a decline in muscle function and mass over time. Let's discuss what the data reveal and what questions remain...
How Sardines Accidentally Supercharged my Metabolism • I recently did a radical dietary experiment — and something totally unexpected happened...
How Sardines Accidentally Supercharged my Metabolism
I recently did a radical dietary experiment — and something totally unexpected happened...
staycuriousmetabolism.substack.com
December 11, 2025 at 2:51 PM
How Sardines Accidentally Supercharged my Metabolism • I recently did a radical dietary experiment — and something totally unexpected happened...
Omega-3 Supplements Don't Work - With One Exception • Paradox: Eating more dietary omega-3s is associated with superior cognitive longevity. But there is not a strong signal for the benefits of supplemental omega-3s. Why? And what should you do?
Omega-3 Supplements Don't Work - With One Exception
Paradox: Eating more dietary omega-3s is associated with superior cognitive longevity. But there is not a strong signal for the benefits of supplemental omega-3s. Why? And what should you do?
staycuriousmetabolism.substack.com
December 9, 2025 at 5:47 PM
Omega-3 Supplements Don't Work - With One Exception • Paradox: Eating more dietary omega-3s is associated with superior cognitive longevity. But there is not a strong signal for the benefits of supplemental omega-3s. Why? And what should you do?
How Metabolic Disease Feeds Emotional Eating • Metabolic disease shape mood through the gut. Let's unpack how a microbiome-made molecule, ImP, alters stress coping & fuels emotional eating.
How Metabolic Disease Feeds Emotional Eating
Metabolic disease shape mood through the gut. Let's unpack how a microbiome-made molecule, ImP, alters stress coping & fuels emotional eating.
staycuriousmetabolism.substack.com
December 7, 2025 at 2:52 PM
How Metabolic Disease Feeds Emotional Eating • Metabolic disease shape mood through the gut. Let's unpack how a microbiome-made molecule, ImP, alters stress coping & fuels emotional eating.
Cholesterol Is Dropping… But Is Your Cardiovascular Risk? • In this letter, we examine not one but three meta-analyses of randomized controlled trials to explore a provocative question: Is modern medicine confused about how statins work?
Cholesterol Is Dropping… But Is Your Cardiovascular Risk?
In this letter, we examine not one but three meta-analyses of randomized controlled trials to explore a provocative question: Is modern medicine confused about how statins work?
staycuriousmetabolism.substack.com
December 6, 2025 at 2:55 PM
Cholesterol Is Dropping… But Is Your Cardiovascular Risk? • In this letter, we examine not one but three meta-analyses of randomized controlled trials to explore a provocative question: Is modern medicine confused about how statins work?
A Keto Diet Cured my Inflammatory Bowel Disease. What Does the Science Say... • A look into groundbreaking data from Cell, combined with personal insights, showing how a well-formulated ketogenic diet may hold the key to healing intestinal inflammation at its root.
A Keto Diet Cured my Inflammatory Bowel Disease. What Does the Science Say...
A look into groundbreaking data from Cell, combined with personal insights, showing how a well-formulated ketogenic diet may hold the key to healing intestinal inflammation at its root.
staycuriousmetabolism.substack.com
December 4, 2025 at 2:54 PM
A Keto Diet Cured my Inflammatory Bowel Disease. What Does the Science Say... • A look into groundbreaking data from Cell, combined with personal insights, showing how a well-formulated ketogenic diet may hold the key to healing intestinal inflammation at its root.