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simulabetateam.bsky.social
SimulaBetaTeam
@simulabetateam.bsky.social
110 followers 200 following 3 posts
Current news on #insulin-#glucose #homeostasis and the physiological simulation software #SimulaBeta

Bochum, Ulm, London, Singapore

https://simulabeta.sourceforge.io
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drjwdietrich.bsky.social
Are you researching #endocrine #feedback control systems?

Our Research Topic "Mechanistic, Machine Learning and Hybrid Models of the 'Other' Endocrine Regulatory Systems in Health and Disease: Volume II" is still open for submission.

www.frontiersin.org/research-top...

#endocrinology #cybernetics
Screenshot of the web site of the Research Topic "Mechanistic, Machine Learning and Hybrid Models of the 'Other' Endocrine Regulatory Systems in Health and Disease: Volume II" in Frontiers in Systems Endocrinology
September 7, 2025 at 6:57 PM
Reposted by SimulaBetaTeam
spinateam.bsky.social
SPINA Carb 5.1.0 Cyclone has been released in its final version.

#SPINA-GBeta #SPINA-GR #SPINA-DI #SPINA_Carb #insulin #glucose #homeostasis #prediabetes #diabetes

sourceforge.net/projects/spi...

doi.org/10.5281/zeno...

doi.org/10.5281/zeno...
Screenshot of SPINA Carb 5.1.0 Cycline on macOS 15.5 Sequoia, showing two Windows (entry and results).
July 13, 2025 at 8:08 PM
Reposted by SimulaBetaTeam
spinateam.bsky.social
Release candidate 3 for the software SPINA Carb Cyclone is available for macOS, Windows and Linux.

sourceforge.net/projects/spi...

doi.org/10.5281/zeno...

doi.org/10.5281/zeno...

#SPINA_Carb #SPINA-GBeta #SPINA-GR #SPINA-DI #HOMA
Screenshot of release candidate 3 of SPINA Carb 5.1 Cyclone on mac OS 15.5 Sequoia
June 21, 2025 at 2:26 PM
Reposted by SimulaBetaTeam
spinateam.bsky.social
Release candidate 2 of #SPINA_Carb is available for testing.

sourceforge.net/projects/spi...

doi.org/10.5281/zeno...

doi.org/10.5281/zeno...
Screenshot of SPINA Carb 5.1.0 (Cyclone) RC2 on macOS Ventura 13.7.5.
May 18, 2025 at 9:19 AM
Reposted by SimulaBetaTeam
spinateam.bsky.social
After intensive internal testing, the release candidate 1 of the #SPINA_Carb app is available. This is the "sister" app for #SPINA_Thyr, and it is provided for purposes of testing.

sourceforge.net/projects/spi...

doi.org/10.5281/zeno...

doi.org/10.5281/zeno...
Screenshot of SPINA Carb Release Candidate 1 for macOS
April 21, 2025 at 11:09 AM
Reposted by SimulaBetaTeam
spinateam.bsky.social
#Hidradenitis suppurativa (acne inversa) is linked to #diabetes mellitus. In the affected, #SPINA-GR is reduced and not compensated by #SPINA-GBeta, resulting in low #SPINA-DI. This phenomenon may be mediated by #inflammation, as shown by ties to #haptoglobin.

pubmed.ncbi.nlm.nih.gov/40217596/
Table showing endotypes of insulin-glucose homeostasis in patients with hidradenitis suppurative (HS or acne inversa) and different expressions of haptoglobin concentration. In persons with HS and a high haptoglobin concentration, insulin sensitivity (SPINA-GR) and beta-cell function (SPINA-GBeta) are similar but combine to provide a reduced disposition index (SPINA-DI). Plot of SPINA-GBeta versus SPINA-GR in patients with HS and controls: The majority of patients with HS and diabetes are faced with rather low insulin sensitivity and a lack of dynamic compensation via pancreatic beta-cell function, resulting in a reduced disposition index.
April 13, 2025 at 3:26 PM
Reposted by SimulaBetaTeam
drjwdietrich.bsky.social
I am honoured to see our paper "A novel simple disposition index (SPINA-DI) from fasting insulin and glucose concentration as a robust measure of carbohydrate homeostasis" among the "most impactful papers" of the #Journal_of_Diabetes.

onlinelibrary.wiley.com/doi/toc/10.1...

doi.org/10.1111/1753...
Graphical Abstract: This novel fasting-based disposition index (SPINA-DI) is defined as the product of insulin receptor gain (SPINA-GR) multiplied by beta-cell function (SPINA-GBeta). SPINA-DI may be reduced due to insulin resistance with insufficient dynamical compensation of beta-cell mass (red horizontal arrow) or due to primary beta-cell failure (red vertical arrow). SPINA-DI was validated in three cohorts. It had advantages in validity, reliability and diagnostic power compared to established criteria. Sample title page of the Journal of Diabetes
January 21, 2025 at 6:16 PM
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drjwdietrich.bsky.social
Teilnehmer:innen gesucht! Klinische Studie zur Verbesserung der #Insulintherapie bei #Diabetes mellitus Typ 1.

www.klinikum-bochum.de/fachbereiche...
Teilnehmer:innen gesucht! Klinische Studie zur Verbesserung der Insulintherapie bei Typ 1-Diabetes Sind Sie eine Person mit Typ 1 Diabetes und interessiert daran, die Auswirkungen von verschiedenen Insulinpräparaten auf Ihren Blutzucker nach den Mahlzeiten zu erforschen? Haben Sie eventuell sogar Probleme mit Blutzuckerschwankungen nach der Mahlzeit? Wenn ja, könnten Sie der Schlüssel zu einer Personalisierung der Insulintherapie bei Menschen mit Typ 1 Diabetes sein. Sprechen Sie uns an! Kontaktieren Sie uns unter: insulinstudie@klinikum-bochum.de oder 0234-509-57813
January 8, 2025 at 11:07 PM
Reposted by SimulaBetaTeam
spinateam.bsky.social
The method of structure parameter inference approach, i.e. #SPINA-Thyr and #SPINA_Carb, has predictive power in the setting of #P4_medicine. In a large population sample, four SPINA parameters, #SPINA-GT, #SPINA-GD, #SPINA-GBeta and #SPINA-DI, predicted all-cause mortality.

doi.org/10.53201/LEI...
In an unselected population sample (NHANES 2009/2010), persons with low thyroid's secretory capacity (SPINA-GT) and total step-up deiodinase activity (SPINA-GD) face significantly worse survival over 10 years. In an unselected population sample (NHANES 2009/2010), persons with low beta-cell function (SPINA-GBeta) and static disposition index (SPINA-DI) are faced with significantly shorter survival over 10 years.
December 28, 2024 at 6:54 PM
Reposted by SimulaBetaTeam
drjwdietrich.bsky.social
The disposition index of #insulin-glucose #homeostasis is an estimate for its loop gain. Its determination used to be complex, requiring clamp, IVGTT or OGTT experiments. We have developed a fasting-based method that is simpler and better 🧪🩺

pubmed.ncbi.nlm.nih.gov/38169110/
doi.org/10.1111/1753...
Graphical abstract: The novel fasting-based disposition index (SPINA-DI) is defined as the product of insulin receptor gain (SPINA-GR) multiplied by beta-cell function (SPINA-GBeta). SPINA-DI may be reduced due to insulin resistance with insufficient dynamical compensation of beta-cell mass (red horizontal arrow) or primary beta-cell failure (red vertical arrow). SPINA-DI was validated in three cohorts. It had advantages in validity, reliability and diagnostic power compared to established criteria.
December 8, 2024 at 10:45 PM
Reposted by SimulaBetaTeam
drjwdietrich.bsky.social
Which programming language is fit for high-performance computer simulations in biomedical #cybernetics? We found that #Free_Pascal generates faster code than S/R and #Python. Interestingly, Object #Pascal even outperforms #Swift and C++. 🧪🩺

doi.org/10.14201/adc...

revistas.usal.es/cinco/index....
Simulation speed with implementations in different programming languages. Shown is the time needed to simulate a first-order linear feedback loop (A) and a zeroth-order MiMe-NoCoDI loop (B) dependent on the number of iterations (proportional to simulated time, abscissa) based on implementations of the simulation program and the CyberUnits Bricks library in S, Python, Swift, C++ and Object Pascal. The ordinate is logarithmically scaled and represents the mean of 10 replications of each number of iteration steps.
August 31, 2024 at 9:31 AM
Reposted by SimulaBetaTeam
drjwdietrich.bsky.social
Die Deutsche Gesellschaft für #Kybernetik, Informations- und #Systemtheorie hat Peter K. Fleissner und mir den Heinz von Foerster-Preis verliehen.
Ich danke meinen Lehrer:innen und Kooperationspartner:innen, die meine Arbeit im Laufe der letzten 30 Jahre möglich gemacht haben.
Urkunde über den Heinz von Foerster-Preis der Deutschen Gesellschaft für Kybernetik, Informations- und Systemtheorie e. V. an Johannes W. Dietrich
April 11, 2024 at 5:54 PM
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medruff.bsky.social
Gratulation an @drjwdietrich.bsky.social für den Heinz-von-Foerster Preis für Organisationskybernetik!
April 11, 2024 at 11:35 AM
Reposted by SimulaBetaTeam
scipastips.bsky.social
A novel method for early detection and #endotyping of #Diabetes mellitus relies on software written in #ObjectPascal.

Today, this innovative approach is covered by all major press agencies and news channels all over the globe.

news.rub.de/english/pres...
Simple and Reliable Early Prediction of Diabetes
A simple blood test could perform better than a complex test thanks to mathematical modeling.
news.rub.de
January 19, 2024 at 12:37 PM
simulabetateam.bsky.social
Recently, computer simulations with #SimulaBeta played a key role in the development of the fasting-based disposition index SPINA-DI, a substantially improved method to assess the function of the insulin-glucose feedback loop and for early diagnosis of diabetes mellitus. 🩺 doi.org/10.1111/1753...
4 Plots showing the hyperbolic relation between SPINA-GBeta (a measure for beta cell function) and SPINA-GR (reconstructed insulin receptor gain as a measure for insulin sensitivity). (A) SPINA-DI remains constant as long as changes in insulin sensitivity (as measured by SPINA-GR) are balanced by adequate variations in beta cell function (SPINA-GBeta, circles 1, 2, and 3). (B) If dynamic compensation fails, either due to insufficient adaptation to insulin resistance (circle 4) or primary beta cell failure (circle 5), the disposition index breaks down and is markedly reduced. (C) Computer simulations with systematic variations of insulin receptor gain (GR) and secretory capacity of beta cells (GBeta) and resulting blood glucose concentration. (D) SPINA-GBeta plotted against SPINA-GR in the definition dataset. Results of persons with normal glucose homeostasis are near the hyperbola of normal SPINA-DI. The ability of dynamical beta cell compensation is partly lost in prediabetes.
January 3, 2024 at 10:26 PM
simulabetateam.bsky.social
#SimulaBeta 3.1.2 is available. This service release fixes several bugs and is the first version to be based on #CyberUnits Bricks 2.0.

simulabeta.sourceforge.io
doi.org/10.5281/zeno...
doi.org/10.5281/zeno...
Screenshot of SimulaBeta 3.1.2 on macOS Ventura 13.4.1
January 3, 2024 at 7:10 PM