#SPINA-GR
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svangmcom.bsky.social
When I was little, my mom filled an entire binder with notes, pictures, birthday cards, dried flowers and more. She gave it to me when she thought I was old enough to understand. Sometimes I still read it. ❤️🥹
On Monday evening, 31 January 1977, you arrived our prince number 2. Unfortunately, neither mother nor father was allowed to be with you when you came into the world. You were born with spina bifida, so we were only allowed to look at you through a glass door before you went to the neurosurgeon in Lund. You were so cute lying on your stomach naked with a yellow pacifier in the incubator. A nanny patted you all the time because you were already hungry. After a while, the ambulance drivers came and picked you up, much to our sorrow. You weighed 3750 gr when you were born and had a good general condition, said Dr. Wessner, who explained to us what a spina bifida means. On the night of the 1 February, you had your first operation. Prior to that, you were baptized Ulf Andreas by the hospital's pastor. The staff was gathered and had made nice with candles and flowers. This was followed by a troubled period of daily phone calls to Lund. One consolation was that you ate well and were alert.
December 14, 2023 at 7:07 PM
spinateam.bsky.social
Release candidate 3 for the software SPINA Carb Cyclone is available for macOS, Windows and Linux.

sourceforge.net/projects/spi...

doi.org/10.5281/zeno...

doi.org/10.5281/zeno...

#SPINA_Carb #SPINA-GBeta #SPINA-GR #SPINA-DI #HOMA
Screenshot of release candidate 3 of SPINA Carb 5.1 Cyclone on mac OS 15.5 Sequoia
June 21, 2025 at 2:26 PM
drjwdietrich.bsky.social
#Diabetes mellitus is common in hidradenitis suppurativa (acne inversa). Affected persons are faced with low insulin sensitivity ( #SPINA-GR ) and a lack of dynamic compensation via beta-cell function ( #SPINA-GBeta ), resulting in a reduced disposition index ( #SPINA-DI ).

doi.org/10.3390/jcm1...
Measured and calculated biomarkers for insulin–glucose homeostasis in patients with hidradenitis suppurativa (acne inversa, HS) and controls. Reconstructed insulin receptor gain (SPINA-GR) is reduced in HS, and the secretory capacity of pancreatic beta cells (SPINA-GBeta) is compensatorily increased. Parameters of insulin–glucose homeostasis in patients with HS and with and without diabetes mellitus. In persons affected by both HS and diabetes mellitus, reduced SPINA-GR is insufficiently compensated by SPINA-GBeta, resulting in reduced static disposition index (SPINA-DI) and diabetes. Parameters of insulin–glucose homeostasis in patients with HS and with and without diabetes mellitus. In persons affected by both HS and diabetes mellitus, reduced SPINA-GR is insufficiently compensated by SPINA-GBeta, resulting in reduced static disposition index (SPINA-DI) and diabetes. In persons with HS and a high haptoglobin concentration, insulin sensitivity (SPINA-GR) and beta-cell function (SPINA-GBeta) are similar but combine to provide a reduced disposition index (SPINA-DI).
March 21, 2025 at 5:41 PM
spinateam.bsky.social
#SPINA_Carb has high discriminatory power for the distinction between #diabetes and normal glucose homeostasis. SPINA-GBeta is better than HOMA-Beta, SPINA-GR is better than HOMA-IR and QUICKI, but SPINA-DI is best, being even more powerful than ivGTT. 🩺🧪 pubmed.ncbi.nlm.nih.gov/38169110/
Receiver operating characteristic (ROC) curves for insulin sensitivity index (ISI), insulinogenic index (IGI), the disposition index according to Matsuda and DeFronzo, HOMA-IR (homeostatic model assessment of insulin resistance), HOMA-Beta (homeostatic model assessment of β-cell function), QUICKI (quantitative insulin sensitivity check index), SPINA-GR (reconstructed insulin receptor gain), SPINA-GBeta (secretory capacity of pancreatic beta cells) and SPINA-DI (structure parameter inference approach-disposition index). SPINA-DI has high discriminatory power for the distinction between diabetes and normal glucose homeostasis. ROC curves and corresponding areas under the curve (AUC) are shown for several markers for the function of the insulin-glucose feedback control in the validation dataset. The area under the curve is highest for SPINA-DI (0.90). Table: Measured and calculated parameters of the feedback loop in subjects with diabetes mellitus, prediabetes and normal glucose homeostasis in two different studies. It showes that SPINA Carb has the best discriminatory power. Bar plots with reconstructed insulin receptor gain (SPINA-GR), secretory capacity of pancreatic beta cells (SPINA-GBeta) and fasting-based disposition index (SPINA-DI) in two different studies. It shows that SPINA-GBeta, SPINA-GR and SPINA-DI differ significantly between subjects with normal glucose homeostasis, prediabetes and diabetes mellitus.
January 6, 2024 at 10:59 AM
drjwdietrich.bsky.social
🧪In combination with SPINA-GR and whole-exome sequencing, calculating SPINA-GBeta made the discovery of a new form of monogenetic diabetes (MODY) possible. This new DM is characterised by primary insulin resistance and results from a missense variant of the type 2 ryanodine receptor (RyR2) gene. 🩺
spinateam.bsky.social SPINA Team @spinateam.bsky.social · Feb 20
Breaking news: In combination with whole-exome sequencing, #SPINA_Carb helped to discover a new form of #MODY #diabetes, caused by an atypical missense variant in the #RyR2 gene (coding the the type 2 #ryanodine receptor). doi.org/10.3389/fend... 🧪🩺
Family tree with affected and sequenced individuals. The p.N2291D is located in the RIH (RyR and IP3R Homology) domain of the protein and also overlaps hotspot II Both SPINA-GBeta and fasting proinsulin are significantly higher in RyR2 MODY diabetes. Increased SPINA-GBeta represents dynamical compensation of insulin resistance.
February 20, 2024 at 10:46 PM
drjwdietrich.bsky.social
Therefore, the non-increased and, in many cases, even reduced beta cell function in metabolic syndrome may not mirror an "either-or" question but be part of continuous evolution. It may be both the source of prediabetes and diabetes, but also prevent insulinoma. 🧪🩺

pubmed.ncbi.nlm.nih.gov/38169110/
(A) SPINA-DI remains constant as long as changes in insulin sensitivity (as measured by SPINA-GR) are balanced by adequate variations in beta cell function (SPINA-GBeta, circles 1, 2, and 3). (B) If dynamic compensation fails, either due to insufficient adaptation to insulin resistance (circle 4) or primary beta cell failure (circle 5), the disposition index breaks down and is markedly reduced. (C) Computer simulations with systematic variations of insulin receptor gain (GR) and secretory capacity of beta cells (GBeta) and resulting blood glucose concentration. (D) SPINA-GBeta plotted against SPINA-GR in the definition dataset. Results of persons with normal glucose homeostasis are near the hyperbola of normal SPINA-DI (green dots). The ability of dynamical beta cell compensation is partly lost in persons with prediabetes (orange dots) or diabetes (red dots), resulting in lower SPINA-DI.
March 17, 2024 at 5:44 PM
simulabetateam.bsky.social
Recently, computer simulations with #SimulaBeta played a key role in the development of the fasting-based disposition index SPINA-DI, a substantially improved method to assess the function of the insulin-glucose feedback loop and for early diagnosis of diabetes mellitus. 🩺 doi.org/10.1111/1753...
4 Plots showing the hyperbolic relation between SPINA-GBeta (a measure for beta cell function) and SPINA-GR (reconstructed insulin receptor gain as a measure for insulin sensitivity). (A) SPINA-DI remains constant as long as changes in insulin sensitivity (as measured by SPINA-GR) are balanced by adequate variations in beta cell function (SPINA-GBeta, circles 1, 2, and 3). (B) If dynamic compensation fails, either due to insufficient adaptation to insulin resistance (circle 4) or primary beta cell failure (circle 5), the disposition index breaks down and is markedly reduced. (C) Computer simulations with systematic variations of insulin receptor gain (GR) and secretory capacity of beta cells (GBeta) and resulting blood glucose concentration. (D) SPINA-GBeta plotted against SPINA-GR in the definition dataset. Results of persons with normal glucose homeostasis are near the hyperbola of normal SPINA-DI. The ability of dynamical beta cell compensation is partly lost in prediabetes.
January 3, 2024 at 10:26 PM
spinateam.bsky.social
SPINA Carb 5.1.0 Cyclone has been released in its final version.

#SPINA-GBeta #SPINA-GR #SPINA-DI #SPINA_Carb #insulin #glucose #homeostasis #prediabetes #diabetes

sourceforge.net/projects/spi...

doi.org/10.5281/zeno...

doi.org/10.5281/zeno...
Screenshot of SPINA Carb 5.1.0 Cycline on macOS 15.5 Sequoia, showing two Windows (entry and results).
July 13, 2025 at 8:08 PM
spinateam.bsky.social
Mathematical modelling of #insulin-#glucose #homeostasis delivers new and improved methods for metabolic endotyping. #prediabetes #diabetes #metabolic_syndrome #betacell pubmed.ncbi.nlm.nih.gov/36271244/ doi.org/10.1038/s415...
Information processing structure of the feedback model. [G](t): glucose concentration; S(t): insulin secretion rate; [I](t): insulin concentration; M(t): proximal insulin signalling; N(t) distal insulin signalling; P(t): constitutive glucose production rate; Q(t): regulated glucose production rate; W(t): intestinal glucose absorption rate; R(t): glucose arrival rate. G1 and G3 represent gains of ASIA elements. Units of measurement are displayed in the small, rounded boxes with red margins. Circular Maps of the correlation networks of novel biomarkers for insulin-glucose homeostasis with anthropometric and experimental data in the NHANES cohort (A) and the clamp study (B). Shown are significant correlations (p < 0.05) only, and line thickness indicates the strength of negative (blue) or positive (red) correlation. A green segment in the inner ring indicates a reduction of the corresponding biomarker in subjects with diabetes. Plot of SPINA-GBeta against SPINA-GR, suggesting a compensatory rise of beta cell function in the case of declining insulin sensitivity in subjects with normal glucose homeostasis (green dots). This ability of beta cell compensation is partly lost in subjects with prediabetes (orange dots) or diabetes (red dots).
September 26, 2025 at 9:24 PM
drjwdietrich.bsky.social
The disposition index of #insulin-glucose #homeostasis is an estimate for its loop gain. Its determination used to be complex, requiring clamp, IVGTT or OGTT experiments. We have developed a fasting-based method that is simpler and better 🧪🩺

pubmed.ncbi.nlm.nih.gov/38169110/
doi.org/10.1111/1753...
Graphical abstract: The novel fasting-based disposition index (SPINA-DI) is defined as the product of insulin receptor gain (SPINA-GR) multiplied by beta-cell function (SPINA-GBeta). SPINA-DI may be reduced due to insulin resistance with insufficient dynamical compensation of beta-cell mass (red horizontal arrow) or primary beta-cell failure (red vertical arrow). SPINA-DI was validated in three cohorts. It had advantages in validity, reliability and diagnostic power compared to established criteria.
December 8, 2024 at 10:45 PM
drjwdietrich.bsky.social
Early diagnosis of #diabetes and prediabetes continues to be a challenge. Recently, we developed a disposition index of insulin-glucose #homeostasis from fasting blood samples. The new parameter is not only less expensive but perhaps even better than established measures. 🩺 🧪 doi.org/10.1111/1753...
This novel fasting-based disposition index (SPINA-DI) is defined as the product of insulin receptor gain (SPINA-GR) multiplied by beta-cell function (SPINA-GBeta). SPINA-DI may be reduced due to insulin resistance with insufficient dynamical compensation of beta-cell mass (red horizontal arrow) or due to primary beta-cell failure (red vertical arrow). SPINA-DI was validated in three cohorts. It had advantages in validity, reliability and diagnostic power compared to established criteria.
January 3, 2024 at 10:23 AM
drjwdietrich.bsky.social
I am honoured to see our paper "A novel simple disposition index (SPINA-DI) from fasting insulin and glucose concentration as a robust measure of carbohydrate homeostasis" among the "most impactful papers" of the #Journal_of_Diabetes.

onlinelibrary.wiley.com/doi/toc/10.1...

doi.org/10.1111/1753...
Graphical Abstract: This novel fasting-based disposition index (SPINA-DI) is defined as the product of insulin receptor gain (SPINA-GR) multiplied by beta-cell function (SPINA-GBeta). SPINA-DI may be reduced due to insulin resistance with insufficient dynamical compensation of beta-cell mass (red horizontal arrow) or due to primary beta-cell failure (red vertical arrow). SPINA-DI was validated in three cohorts. It had advantages in validity, reliability and diagnostic power compared to established criteria. Sample title page of the Journal of Diabetes
January 21, 2025 at 6:16 PM
spinateam.bsky.social
#Hidradenitis suppurativa (acne inversa) is linked to #diabetes mellitus. In the affected, #SPINA-GR is reduced and not compensated by #SPINA-GBeta, resulting in low #SPINA-DI. This phenomenon may be mediated by #inflammation, as shown by ties to #haptoglobin.

pubmed.ncbi.nlm.nih.gov/40217596/
Table showing endotypes of insulin-glucose homeostasis in patients with hidradenitis suppurative (HS or acne inversa) and different expressions of haptoglobin concentration. In persons with HS and a high haptoglobin concentration, insulin sensitivity (SPINA-GR) and beta-cell function (SPINA-GBeta) are similar but combine to provide a reduced disposition index (SPINA-DI). Plot of SPINA-GBeta versus SPINA-GR in patients with HS and controls: The majority of patients with HS and diabetes are faced with rather low insulin sensitivity and a lack of dynamic compensation via pancreatic beta-cell function, resulting in a reduced disposition index.
April 13, 2025 at 3:26 PM