Siggy Nachtergaele
@siggyn5.bsky.social
Assistant Prof @ Yale MCDB; RNA enthusiast; washed up college athlete; kid wrangler x2 (not necessarily in that order)
Reposted by Siggy Nachtergaele
Excited to share our latest work on a new cilia disassembly pathway and a link between this pathway and the neurological disorder focal cortical dysplasia: www.science.org/doi/10.1126/...
Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...
Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...
A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia
A gain-of-function screen uncovers a cilia disassembly pathway linked to genes somatically mutated in neurodevelopmental disease.
www.science.org
October 30, 2025 at 3:14 PM
Excited to share our latest work on a new cilia disassembly pathway and a link between this pathway and the neurological disorder focal cortical dysplasia: www.science.org/doi/10.1126/...
Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...
Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...
Reposted by Siggy Nachtergaele
Don't forget to join us tomorrow for the RNA Club!
🎟️ Don’t miss your chance to add a new stamp to your RNA Club card and keep the collection growing
🎟️ Don’t miss your chance to add a new stamp to your RNA Club card and keep the collection growing
October RNA Club 🎃
Join us to explore some spooktacular discoveries in RNA. This month’s presentations feature:
🦇 Kumari Kavita Thakur (Breaker Lab)
🦇 Kyrillos Abdallah (Gilbert Lab)
Come, collect the next RNA Club collectible, and celebrate RNA science that’s anything but scary
Join us to explore some spooktacular discoveries in RNA. This month’s presentations feature:
🦇 Kumari Kavita Thakur (Breaker Lab)
🦇 Kyrillos Abdallah (Gilbert Lab)
Come, collect the next RNA Club collectible, and celebrate RNA science that’s anything but scary
October 13, 2025 at 1:49 PM
Don't forget to join us tomorrow for the RNA Club!
🎟️ Don’t miss your chance to add a new stamp to your RNA Club card and keep the collection growing
🎟️ Don’t miss your chance to add a new stamp to your RNA Club card and keep the collection growing
Reposted by Siggy Nachtergaele
Congrats to Chia-Ling Chou, Emmanuel Saliba, Anna Marie Pyle, Li-Tao Guo and co-authors on demonstrating how single-cell RNA-Seq with UltraMarathonRT® reveals unexpected transcriptomic diversity.
🔗👇
@emmanuel-saliba.bsky.social @litaoguo.bsky.social
#singlecell #scRNAseq #RNA #RNAresearch #RNASky
🔗👇
@emmanuel-saliba.bsky.social @litaoguo.bsky.social
#singlecell #scRNAseq #RNA #RNAresearch #RNASky
October 7, 2025 at 11:01 PM
Congrats to Chia-Ling Chou, Emmanuel Saliba, Anna Marie Pyle, Li-Tao Guo and co-authors on demonstrating how single-cell RNA-Seq with UltraMarathonRT® reveals unexpected transcriptomic diversity.
🔗👇
@emmanuel-saliba.bsky.social @litaoguo.bsky.social
#singlecell #scRNAseq #RNA #RNAresearch #RNASky
🔗👇
@emmanuel-saliba.bsky.social @litaoguo.bsky.social
#singlecell #scRNAseq #RNA #RNAresearch #RNASky
Reposted by Siggy Nachtergaele
Save the Date!
2025 Yale RNA Center for Science and Medicine Retreat on Nov 7 @Grace Hopper Memorial Auditorium, West Campus
Deadlines:
Registration: Oct 17
Talk Abstracts: Sept 26
Poster Abstracts: Oct 17
👉Registration yalesurvey.ca1.qualtrics.com/jfe/form/SV_...
or using the QR code in the image
2025 Yale RNA Center for Science and Medicine Retreat on Nov 7 @Grace Hopper Memorial Auditorium, West Campus
Deadlines:
Registration: Oct 17
Talk Abstracts: Sept 26
Poster Abstracts: Oct 17
👉Registration yalesurvey.ca1.qualtrics.com/jfe/form/SV_...
or using the QR code in the image
September 15, 2025 at 9:35 PM
Save the Date!
2025 Yale RNA Center for Science and Medicine Retreat on Nov 7 @Grace Hopper Memorial Auditorium, West Campus
Deadlines:
Registration: Oct 17
Talk Abstracts: Sept 26
Poster Abstracts: Oct 17
👉Registration yalesurvey.ca1.qualtrics.com/jfe/form/SV_...
or using the QR code in the image
2025 Yale RNA Center for Science and Medicine Retreat on Nov 7 @Grace Hopper Memorial Auditorium, West Campus
Deadlines:
Registration: Oct 17
Talk Abstracts: Sept 26
Poster Abstracts: Oct 17
👉Registration yalesurvey.ca1.qualtrics.com/jfe/form/SV_...
or using the QR code in the image
Thrilled to share a new preprint from the lab! We investigated how m6A regulates the transcriptome in chemoresistant glioblastoma through unexpected mechanisms, and the potential therapeutic applications of this discovery.
Check out the preprint here ⬇️
www.biorxiv.org/content/10.1...
Check out the preprint here ⬇️
www.biorxiv.org/content/10.1...
N6-methyladenosine promotes temozolomide resistance through non-canonical regulation of mRNA stability in glioblastoma cells
N6-methyladenosine (m6A) is a critical regulator of mRNA processing and function, impacting nearly every step of the mRNA lifecycle. Changes in m6A status have been implicated in many different types ...
www.biorxiv.org
September 15, 2025 at 8:41 PM
Thrilled to share a new preprint from the lab! We investigated how m6A regulates the transcriptome in chemoresistant glioblastoma through unexpected mechanisms, and the potential therapeutic applications of this discovery.
Check out the preprint here ⬇️
www.biorxiv.org/content/10.1...
Check out the preprint here ⬇️
www.biorxiv.org/content/10.1...
Reposted by Siggy Nachtergaele
Excited to share groundbreaking research from our members!
Researchers, including Dr. Stephanie Halene & Dr. Diane Krause, discovered a potential treatment pathway for aggressive leukemia, making it a possible target for the development of new therapies
Read more:
medicine.yale.edu/news-article...
Researchers, including Dr. Stephanie Halene & Dr. Diane Krause, discovered a potential treatment pathway for aggressive leukemia, making it a possible target for the development of new therapies
Read more:
medicine.yale.edu/news-article...
Yale Study: Potential Treatment Pathway Found for Rare and Aggressive Leukemia
A Yale study published Aug. 28 on the cover of the journal Blood explains basic scientific discoveries that could lead to innovative therapies for acute myeloid
medicine.yale.edu
September 4, 2025 at 5:01 PM
Excited to share groundbreaking research from our members!
Researchers, including Dr. Stephanie Halene & Dr. Diane Krause, discovered a potential treatment pathway for aggressive leukemia, making it a possible target for the development of new therapies
Read more:
medicine.yale.edu/news-article...
Researchers, including Dr. Stephanie Halene & Dr. Diane Krause, discovered a potential treatment pathway for aggressive leukemia, making it a possible target for the development of new therapies
Read more:
medicine.yale.edu/news-article...
Reposted by Siggy Nachtergaele
✨ RNA Club is back! ✨
We’ve missed you and the great science talks!
Kick off the semester with us on Tuesday, September 9 at 9:00 AM in Bass Center 305, Yale Science Building.
Enjoy bagels & coffee plus exciting talks from Clara Wang and Dr. Xiaolin Niu.
Don’t miss it! 🧬
We’ve missed you and the great science talks!
Kick off the semester with us on Tuesday, September 9 at 9:00 AM in Bass Center 305, Yale Science Building.
Enjoy bagels & coffee plus exciting talks from Clara Wang and Dr. Xiaolin Niu.
Don’t miss it! 🧬
September 3, 2025 at 9:10 AM
✨ RNA Club is back! ✨
We’ve missed you and the great science talks!
Kick off the semester with us on Tuesday, September 9 at 9:00 AM in Bass Center 305, Yale Science Building.
Enjoy bagels & coffee plus exciting talks from Clara Wang and Dr. Xiaolin Niu.
Don’t miss it! 🧬
We’ve missed you and the great science talks!
Kick off the semester with us on Tuesday, September 9 at 9:00 AM in Bass Center 305, Yale Science Building.
Enjoy bagels & coffee plus exciting talks from Clara Wang and Dr. Xiaolin Niu.
Don’t miss it! 🧬
Reposted by Siggy Nachtergaele
🔬 Join us LIVE on Zoom this Wednesday, June 11, at 4 PM ET!
We’re excited to co-host the RNA Collaborative Seminar Series featuring
🎙️ Dr. @siggyn5.bsky.social (Yale RNA Center)
🎙️ Dr. Alex Wesselhoeft (HMS Initiative for RNA Medicine)
Registration 👉 lnkd.in/e-9Huhzd
We’re excited to co-host the RNA Collaborative Seminar Series featuring
🎙️ Dr. @siggyn5.bsky.social (Yale RNA Center)
🎙️ Dr. Alex Wesselhoeft (HMS Initiative for RNA Medicine)
Registration 👉 lnkd.in/e-9Huhzd
June 2, 2025 at 7:50 PM
🔬 Join us LIVE on Zoom this Wednesday, June 11, at 4 PM ET!
We’re excited to co-host the RNA Collaborative Seminar Series featuring
🎙️ Dr. @siggyn5.bsky.social (Yale RNA Center)
🎙️ Dr. Alex Wesselhoeft (HMS Initiative for RNA Medicine)
Registration 👉 lnkd.in/e-9Huhzd
We’re excited to co-host the RNA Collaborative Seminar Series featuring
🎙️ Dr. @siggyn5.bsky.social (Yale RNA Center)
🎙️ Dr. Alex Wesselhoeft (HMS Initiative for RNA Medicine)
Registration 👉 lnkd.in/e-9Huhzd
Reposted by Siggy Nachtergaele
We're looking forward to another productive day at #RNA25! Join us Friday morning at 7:45am for Breakfast & Breakthroughs plus engaging poster sessions in the evening featuring the latest innovations with UltraMarathonRT.
#RNA2025 #RNAresearch #Transcriptomics #RNASky
#RNA2025 #RNAresearch #Transcriptomics #RNASky
May 30, 2025 at 12:47 PM
We're looking forward to another productive day at #RNA25! Join us Friday morning at 7:45am for Breakfast & Breakthroughs plus engaging poster sessions in the evening featuring the latest innovations with UltraMarathonRT.
#RNA2025 #RNAresearch #Transcriptomics #RNASky
#RNA2025 #RNAresearch #Transcriptomics #RNASky
Reposted by Siggy Nachtergaele
Join Drs. Jason Underwood & Anthony Mustoe at RNAConnect's ‘Breakfast & Breakthroughs’ during RNA 2025!
🗓 Fri, May 30 | 7:45–8:45 AM
📍Town and Country Ballroom
Seats are limited so register today! 🔗https://bit.ly/43qC0vU
#RNA2025 #RNA25 #RNASociety #RNAConnect #RNA #RNABiology #RNASky
🗓 Fri, May 30 | 7:45–8:45 AM
📍Town and Country Ballroom
Seats are limited so register today! 🔗https://bit.ly/43qC0vU
#RNA2025 #RNA25 #RNASociety #RNAConnect #RNA #RNABiology #RNASky
May 15, 2025 at 7:31 PM
Join Drs. Jason Underwood & Anthony Mustoe at RNAConnect's ‘Breakfast & Breakthroughs’ during RNA 2025!
🗓 Fri, May 30 | 7:45–8:45 AM
📍Town and Country Ballroom
Seats are limited so register today! 🔗https://bit.ly/43qC0vU
#RNA2025 #RNA25 #RNASociety #RNAConnect #RNA #RNABiology #RNASky
🗓 Fri, May 30 | 7:45–8:45 AM
📍Town and Country Ballroom
Seats are limited so register today! 🔗https://bit.ly/43qC0vU
#RNA2025 #RNA25 #RNASociety #RNAConnect #RNA #RNABiology #RNASky
Reposted by Siggy Nachtergaele
🌸 Spring RNA vibes at Yale 🌸
Join us for the Yale RNA Club on
📅 Tuesday, April 8
🕛 9:00 AM
📍Cohen Auditorium (Neison Irving Harris Building, YSM)
Breakfast+two great talks on stem cells and leukemia.
Details in the flyer 👇
Join us for the Yale RNA Club on
📅 Tuesday, April 8
🕛 9:00 AM
📍Cohen Auditorium (Neison Irving Harris Building, YSM)
Breakfast+two great talks on stem cells and leukemia.
Details in the flyer 👇
April 2, 2025 at 2:11 PM
🌸 Spring RNA vibes at Yale 🌸
Join us for the Yale RNA Club on
📅 Tuesday, April 8
🕛 9:00 AM
📍Cohen Auditorium (Neison Irving Harris Building, YSM)
Breakfast+two great talks on stem cells and leukemia.
Details in the flyer 👇
Join us for the Yale RNA Club on
📅 Tuesday, April 8
🕛 9:00 AM
📍Cohen Auditorium (Neison Irving Harris Building, YSM)
Breakfast+two great talks on stem cells and leukemia.
Details in the flyer 👇
Reposted by Siggy Nachtergaele
✨Hey Postdocs and ARS!
Our social event is happening this Monday🎉
To help us plan food and drinks, please use the sign-up link sent through the institutional mailing list by the end of today
Not on the list? Comment below to make sure you get the info
Let’s start the week with new and good company
Our social event is happening this Monday🎉
To help us plan food and drinks, please use the sign-up link sent through the institutional mailing list by the end of today
Not on the list? Comment below to make sure you get the info
Let’s start the week with new and good company
🌟 Postdocs & ARSs🌟
New at Yale or looking to strengthen your connections?
Join us for an informal Peer Support Program social on
📅Monday, March 24, 2025
🕠4:30–6:30 PM
📍Rose Garden🌹Sterling Hall of Medicine I-Wing, 1st floor 🌹
Looking forward to seeing you there!
More info on institutional email
New at Yale or looking to strengthen your connections?
Join us for an informal Peer Support Program social on
📅Monday, March 24, 2025
🕠4:30–6:30 PM
📍Rose Garden🌹Sterling Hall of Medicine I-Wing, 1st floor 🌹
Looking forward to seeing you there!
More info on institutional email
March 21, 2025 at 5:36 PM
✨Hey Postdocs and ARS!
Our social event is happening this Monday🎉
To help us plan food and drinks, please use the sign-up link sent through the institutional mailing list by the end of today
Not on the list? Comment below to make sure you get the info
Let’s start the week with new and good company
Our social event is happening this Monday🎉
To help us plan food and drinks, please use the sign-up link sent through the institutional mailing list by the end of today
Not on the list? Comment below to make sure you get the info
Let’s start the week with new and good company
Reposted by Siggy Nachtergaele
🌟 Postdocs & ARSs🌟
New at Yale or looking to strengthen your connections?
Join us for an informal Peer Support Program social on
📅Monday, March 24, 2025
🕠4:30–6:30 PM
📍Rose Garden🌹Sterling Hall of Medicine I-Wing, 1st floor 🌹
Looking forward to seeing you there!
More info on institutional email
New at Yale or looking to strengthen your connections?
Join us for an informal Peer Support Program social on
📅Monday, March 24, 2025
🕠4:30–6:30 PM
📍Rose Garden🌹Sterling Hall of Medicine I-Wing, 1st floor 🌹
Looking forward to seeing you there!
More info on institutional email
March 17, 2025 at 5:14 PM
🌟 Postdocs & ARSs🌟
New at Yale or looking to strengthen your connections?
Join us for an informal Peer Support Program social on
📅Monday, March 24, 2025
🕠4:30–6:30 PM
📍Rose Garden🌹Sterling Hall of Medicine I-Wing, 1st floor 🌹
Looking forward to seeing you there!
More info on institutional email
New at Yale or looking to strengthen your connections?
Join us for an informal Peer Support Program social on
📅Monday, March 24, 2025
🕠4:30–6:30 PM
📍Rose Garden🌹Sterling Hall of Medicine I-Wing, 1st floor 🌹
Looking forward to seeing you there!
More info on institutional email
Reposted by Siggy Nachtergaele
Reposted by Siggy Nachtergaele
So, for those of us who don’t know how medical research funding works (I myself did not), this nice researcher broke it down for me.
when we get a grant we get two pots of money: direct costs that directly fund the research (supplies and stipends for trainees) and indirects, that provide funds for the institution to support the research (electricity for equipment, staff to administer the grants, space for the research, etc.).
February 8, 2025 at 12:59 AM
So, for those of us who don’t know how medical research funding works (I myself did not), this nice researcher broke it down for me.
Reposted by Siggy Nachtergaele
💖RNA lovers, this one’s for you!💖
RNA Club: Valentine’s Day edition
Hear fantastic talks from Nachtergaele and Breaker labs, and kick off the morning with fresh, heart-shaped waffles 🧇❤️
📅Tuesday, Feb 11 | 🕢 8:45 AM| 📍 BASS 305
Spread the word, bring a friend, and share your RNA love💕
RNA Club: Valentine’s Day edition
Hear fantastic talks from Nachtergaele and Breaker labs, and kick off the morning with fresh, heart-shaped waffles 🧇❤️
📅Tuesday, Feb 11 | 🕢 8:45 AM| 📍 BASS 305
Spread the word, bring a friend, and share your RNA love💕
February 4, 2025 at 11:04 PM
💖RNA lovers, this one’s for you!💖
RNA Club: Valentine’s Day edition
Hear fantastic talks from Nachtergaele and Breaker labs, and kick off the morning with fresh, heart-shaped waffles 🧇❤️
📅Tuesday, Feb 11 | 🕢 8:45 AM| 📍 BASS 305
Spread the word, bring a friend, and share your RNA love💕
RNA Club: Valentine’s Day edition
Hear fantastic talks from Nachtergaele and Breaker labs, and kick off the morning with fresh, heart-shaped waffles 🧇❤️
📅Tuesday, Feb 11 | 🕢 8:45 AM| 📍 BASS 305
Spread the word, bring a friend, and share your RNA love💕