Md. Shuaib Akther
@shuaib47.bsky.social
Medical student with a keen interest in neuroscience.
Aiming to become a physician-neuroscientist.
Aiming to become a physician-neuroscientist.
A superb work from @dulaclab.bsky.social lab led by @harriskaplan.bsky.social! Congratulations to all the members involved in this beautiful study!🧠
I’m excited to share our publication from @dulaclab.bsky.social in @nature.com, where we illuminate the development of hypothalamic cell types involved in a broad range of functions, from social behaviors to thirst, thermoregulation, and sleep. Highlights below! 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sensory input, sex and function shape hypothalamic cell type development - Nature
Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell types with ke...
www.nature.com
March 10, 2025 at 3:00 PM
A superb work from @dulaclab.bsky.social lab led by @harriskaplan.bsky.social! Congratulations to all the members involved in this beautiful study!🧠
What a great experimental demonstration from @sergiuppasca.bsky.social 's lab 🧪🧠! Using together human brain organoid, multiplexed scRNA-seq & transcriptomics, they create a novel platform which allows them to understand better about the generation of brain cell diversity in the neural assembloid 🧠
Today we report in 𝘾𝙚𝙡𝙡 𝙎𝙩𝙚𝙢 𝘾𝙚𝙡𝙡 a systematic approach to generate neural #organoids resembling various domains of the neural axis
Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS
Neal Amin & @kevinkelley.bsky.social developed a multiplexed morphogen screen to generate #organoids that mapped to almost 2/3 of the clusters in the 1st trimester CNS
December 6, 2024 at 5:56 AM
What a great experimental demonstration from @sergiuppasca.bsky.social 's lab 🧪🧠! Using together human brain organoid, multiplexed scRNA-seq & transcriptomics, they create a novel platform which allows them to understand better about the generation of brain cell diversity in the neural assembloid 🧠
Prolonged maturation of cortical neurons and synapses, also called synaptic neotany, is a key feature of human brain development. A beautiful work on synaptic neotany by @blibep.bsky.social from @vanderhaeghenp2.bsky.social 's lab 🧠.
Hi Bluesky 🧪🧠,
Let me introduce my second postdoctoral piece published a couple of weeks ago, under the direction of @vanderhaeghenp2.bsky.social, with @franckp.bsky.social and Cécile Charrier, in #Neuron @cellpress.bsky.social 🧵:
doi.org/10.1016/j.ne...
#neuron #neoteny #human #SYNGAP1
Let me introduce my second postdoctoral piece published a couple of weeks ago, under the direction of @vanderhaeghenp2.bsky.social, with @franckp.bsky.social and Cécile Charrier, in #Neuron @cellpress.bsky.social 🧵:
doi.org/10.1016/j.ne...
#neuron #neoteny #human #SYNGAP1
Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition
Libé-Philippot et al. investigate the mechanisms underlying the prolonged synaptic
development characteristic of human cortical neurons. They demonstrate that the human-specific
genes SRGAP2B/C are re...
www.cell.com
November 20, 2024 at 12:25 AM
Prolonged maturation of cortical neurons and synapses, also called synaptic neotany, is a key feature of human brain development. A beautiful work on synaptic neotany by @blibep.bsky.social from @vanderhaeghenp2.bsky.social 's lab 🧠.
Assembloid, an emerging and powerful tool for future neuroscience research 🧠!
Great review from @sergiuppasca.bsky.social 's lab on this topic.
Great review from @sergiuppasca.bsky.social 's lab on this topic.
Assembloids have emerged as a powerful tool for studying previously inaccessible processes of development and tissue homeostasis.
In our article in Cell Stem Cell, we summarize advances in the generation & application of neural and non-neural #assembloids to explore complex cell-cell interactions.
In our article in Cell Stem Cell, we summarize advances in the generation & application of neural and non-neural #assembloids to explore complex cell-cell interactions.
November 18, 2024 at 1:27 PM
Assembloid, an emerging and powerful tool for future neuroscience research 🧠!
Great review from @sergiuppasca.bsky.social 's lab on this topic.
Great review from @sergiuppasca.bsky.social 's lab on this topic.
Beautiful!!
E10.5 mouse spinal cord (neural tube), labeled with Sox2 (red, neural progenitors), nestin (green, radial fibers) and neurofilament (blue, axons). The ventral motor columns are the most developed structure at this early time point.
November 18, 2024 at 1:23 PM
Beautiful!!