What I heard and how I’m approaching this moment.

If you're a US scientist feeling demoralized, burned out, or anxious in this unprecedented political moment--you are not alone. (Free event)

Synthetic biologists make artificial cells, but one particular kind isn’t worth the risk.

A central question in biology is how macromolecular machines function cooperatively. In bacteria, transcription and translation occur in the same cellular compartment, and can be physically and functionally coupled1–4. Although high-resolution structures of the ribosome–RNA polymerase (RNAP) complex have provided initial mechanistic insights into the coupling process5–10, we lack knowledge of how these structural snapshots are placed along a dynamic reaction trajectory. Here we reconstitute a complete and active transcription–translation system and develop multi-colour single-molecule fluorescence microscopy experiments to directly and simultaneously track transcription elongation, translation elongation and the physical and functional coupling between the ribosome and the RNAP in real time. Our data show that physical coupling between ribosome and RNAP can occur over hundreds of nucleotides of intervening mRNA by mRNA looping, a process facilitated by NusG. We detect active transcript

Hidden Brain · Episode

Mark Hailwood The conditions under which the obscure mass of women live and fulfil their duties as human beings, have a vital influence upon the destinies of the human race… Alice Clark, 1919…

Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range...

Journalist Carl Zimmer chats about aerobiology and his new book Air-Borne: The Hidden History of the Life We Breathe.

The Thomson Reuters decision has big implications for the battle between generative AI companies and rights holders.