James Walshe
@scijameswalshe.bsky.social
Structural Biology | Protein-RNA interactions | current Postdoc
CramerLab MPI-NAT | Stewart Lab VCCRI alumni | PhD USyd | Views my own.
CramerLab MPI-NAT | Stewart Lab VCCRI alumni | PhD USyd | Views my own.
Reposted by James Walshe
How do flexible regions of histone chaperones team up to handle histones? Together with Fred Winston’s lab
@harvardmed.bsky.social, we reveal new insights in our study just out in Mol Cell. Hats off to James Warner and Vanda Lux @iocbprague.bsky.social for their key contributions! dlvr.it/TNB145
@harvardmed.bsky.social, we reveal new insights in our study just out in Mol Cell. Hats off to James Warner and Vanda Lux @iocbprague.bsky.social for their key contributions! dlvr.it/TNB145
September 21, 2025 at 7:31 PM
How do flexible regions of histone chaperones team up to handle histones? Together with Fred Winston’s lab
@harvardmed.bsky.social, we reveal new insights in our study just out in Mol Cell. Hats off to James Warner and Vanda Lux @iocbprague.bsky.social for their key contributions! dlvr.it/TNB145
@harvardmed.bsky.social, we reveal new insights in our study just out in Mol Cell. Hats off to James Warner and Vanda Lux @iocbprague.bsky.social for their key contributions! dlvr.it/TNB145
Reposted by James Walshe
Also check out related work: www.nature.com/articles/s41...
IWS1 positions downstream DNA to globally stimulate Pol II elongation - Nature Communications
Although IWS1 has been implicated in transcription-coupled processes, its direct role in RNA polymerase II function remained undefined. Here, the authors demonstrate that IWS1 enhances Pol II elongati...
www.nature.com
August 29, 2025 at 10:14 AM
Also check out related work: www.nature.com/articles/s41...
Reposted by James Walshe
🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...
August 29, 2025 at 10:14 AM
🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...
Happy to share some work led by Aiturgan Zheenbekova and myself in the lab of @patrick-cramer.maxplanck.de at @mpi-nat.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
IWS1 positions downstream DNA to globally stimulate Pol II elongation - Nature Communications
Although IWS1 has been implicated in transcription-coupled processes, its direct role in RNA polymerase II function remained undefined. Here, the authors demonstrate that IWS1 enhances Pol II elongati...
www.nature.com
August 20, 2025 at 12:48 PM
Happy to share some work led by Aiturgan Zheenbekova and myself in the lab of @patrick-cramer.maxplanck.de at @mpi-nat.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Preprint Alert! Check out our take on the molecular basis for co-transcriptional H3K36me3 deposition by SETD2. www.biorxiv.org/content/10.1...
Molecular mechanism of co-transcriptional H3K36 methylation by SETD2
Tri-methylation of histone H3 at residue lysine-36 (H3K36me3) is a hallmark of actively and recently transcribed genes and contributes to cellular memory and identity. The deposition of H3K36me3 occur...
www.biorxiv.org
December 14, 2024 at 1:50 PM
Preprint Alert! Check out our take on the molecular basis for co-transcriptional H3K36me3 deposition by SETD2. www.biorxiv.org/content/10.1...