Sandra Castillo
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sandradcastillo.bsky.social
Sandra Castillo
@sandradcastillo.bsky.social
200 followers 520 following 4 posts
RyC Researcher at Institut de Recerca Sant Joan de Déu, Pediatric Cancer Center Barcelona.
Vascular Malformations & Tumours | Rare diseases | Genetics | Cell Signalling
👩🏻‍🔬🧬🧫🔬
https://www.irsjd.org/en/people/staff/1367/sandra-castillo-diez
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sandradcastillo.bsky.social
We’re happy 😄 to share our latest work in Cancer Discov @theaacr.bsky.social – we discover that PTEN UPD 🧬 in endothelial cells causes vascular malformations in PTEN Hamartoma Tumor Syndrome (PHTS), create a new mouse model 🐀 & test PI3K signaling inhibitors 💊.

aacrjournals.org/cancerdiscov...
Somatic uniparental disomy of PTEN in endothelial cells causes vascular malformations in patients with PTEN Hamartoma Tumor Syndrome
Abstract. PTEN Hamartoma Tumor Syndrome (PHTS) is a rare tumor risk disorder caused by germline loss-of-function mutations in PTEN. Half of these patients develop vascular malformations, a hamartoma c...
aacrjournals.org
March 29, 2025 at 12:12 PM
Reposted by Sandra Castillo
grauperalab.bsky.social
We are excited to share our work on Context-dependent response of endothelial cells to PIK3CA mutation. A tour the force of many; thank you all for your invaluable contribution. @aangulou.bsky.social @ruibenedito.bsky.social @debocklab.bsky.social @sandradcastillo.bsky.social
bit.ly/4blKSqa
Context-dependent response of endothelial cells to PIK3CA mutation
Cancer mutations in the PIK3CA gene cause congenital disorders. The endothelium is among the most frequently affected tissues in these disorders, displaying aberrant vascular overgrowth in the form of...
bit.ly
February 26, 2025 at 12:19 PM
sandradcastillo.bsky.social
🔬 ¡Buscamos Técnico/a de laboratorio!
📋 Mantenimiento de colonia, procesamiento de muestras y más.
📍 Barcelona
📩+info: hospitalsantjoandedeu.talentclue.com/es/node/1129...

Please RT!
December 18, 2024 at 12:58 PM
Reposted by Sandra Castillo
irbbarcelona.org
📰 #IRBBarcelona spin-off #Gate2Brain receives European Medicines Agency (EMA) Orphan Drug Designation for its #PediatricCancer treatment.

🗣️Meritxell Teixidó (CEO): "We are moving toward clinical trials that could transform the treatment of pediatric brain tumors".

➡️ bit.ly/4fLmnEb

#Innovation

🧪
Gate2Brain Receives EMA Orphan Drug Designation for Its Pediatric Cancer Treatment
The IRB Barcelona spin-off Gate2Brain, a cutting-edge technology platform focused on enhancing drug delivery to the brain, has reached a major milestone in the fight against pediatric brain tumors by ...
bit.ly
November 27, 2024 at 9:54 AM
Reposted by Sandra Castillo
klausokken.bsky.social
Our latest paper reveals an intriguing and essential role for the class III #PI3K VPS34 in Treg homeostasis and function. Selective deletion of VPS34 in Treg led to a scurfy-like phenotype, suggesting an essential role for VPS34 in Treg-suppression.
doi.org/10.3389/fimm...
#immunosky
November 27, 2024 at 10:38 AM
Reposted by Sandra Castillo
barrigalabvhio.bsky.social
Hi!

I just compiled some of the new Barcelona cancer labs! Many more missing, so let me know if anyone needs to be added!

go.bsky.app/AkCGugm
November 26, 2024 at 5:10 PM
Reposted by Sandra Castillo
grauperalab.bsky.social
The freshly cooked video summarizing the Art project developed in the frame of our PIPgen MSCA DN: “PIPgenerating ART: Where Art meet Science “. A collaborative activitys between our students and the Cambridge School of Visual Performing Arts.
www.youtube.com/watch?v=tQxA...
PIPgenerating ART: Where Art meet Science
YouTube video by PIPgen
www.youtube.com
November 23, 2024 at 6:46 PM