Sahil Batra
@sahilbatra.bsky.social
Structural Biologist studying DNA replication
Nature enthusiast
Nature enthusiast
Reposted by Sahil Batra
Shout out to Sloan Kettering @mskcancercenter.bsky.social for supporting basic science / foundational biology...
www.mskcc.org/news/cryo-el...
www.mskcc.org/news/cryo-el...
Cryo-Electron Microscopy Reveals Hidden Mechanics of DNA Replication, Sheds New Light on Cancer Target
MSK researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer.
www.mskcc.org
March 7, 2025 at 4:33 PM
Shout out to Sloan Kettering @mskcancercenter.bsky.social for supporting basic science / foundational biology...
www.mskcc.org/news/cryo-el...
www.mskcc.org/news/cryo-el...
Thrilled to share first part of my post-doc work, published today in @science.org www.science.org/doi/10.1126/...
We use reconstituted replication system and cryo-EM to unravel an unexpected mechanism of DNA translocation employed by eukaryotic replicative helicase.
We use reconstituted replication system and cryo-EM to unravel an unexpected mechanism of DNA translocation employed by eukaryotic replicative helicase.
G-quadruplex–stalled eukaryotic replisome structure reveals helical inchworm DNA translocation
DNA G-quadruplexes (G4s) are non–B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork ...
www.science.org
March 6, 2025 at 11:54 PM
Thrilled to share first part of my post-doc work, published today in @science.org www.science.org/doi/10.1126/...
We use reconstituted replication system and cryo-EM to unravel an unexpected mechanism of DNA translocation employed by eukaryotic replicative helicase.
We use reconstituted replication system and cryo-EM to unravel an unexpected mechanism of DNA translocation employed by eukaryotic replicative helicase.