@sagnera.bsky.social
Reposted
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
Reposted
How do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
October 27, 2025 at 5:25 PM
How do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
Reposted
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
October 27, 2025 at 8:50 AM
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
Reposted
Are you enthusiastic about stem cell biology and developmental biology and looking to start a PhD in 2026? Funded opportunites now available. Contact for more infomation. Links below! @lovegrovelab.bsky.social @veronicabiga.bsky.social @manchester.ac.uk @ukri.org
October 9, 2025 at 4:21 PM
Are you enthusiastic about stem cell biology and developmental biology and looking to start a PhD in 2026? Funded opportunites now available. Contact for more infomation. Links below! @lovegrovelab.bsky.social @veronicabiga.bsky.social @manchester.ac.uk @ukri.org
Reposted
Just published: The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born
authors.elsevier.com/sd/article/S...
A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born
authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
July 17, 2025 at 10:07 AM
Just published: The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born
authors.elsevier.com/sd/article/S...
A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born
authors.elsevier.com/sd/article/S...
Reposted
Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data"
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data
Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding dise...
www.biorxiv.org
May 29, 2025 at 12:08 PM
Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data"
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
First preprint from the lab!
Expression of 3 TFs - Onecut2, Pou2f2 and Pou3f1 - in sequentially generated neurons correlates with and is functionally required for the correct specification of neuronal subtypes mediating spinal sensory and motor output!
www.biorxiv.org/content/10.1...
Expression of 3 TFs - Onecut2, Pou2f2 and Pou3f1 - in sequentially generated neurons correlates with and is functionally required for the correct specification of neuronal subtypes mediating spinal sensory and motor output!
www.biorxiv.org/content/10.1...
www.biorxiv.org
May 29, 2025 at 11:56 AM
First preprint from the lab!
Expression of 3 TFs - Onecut2, Pou2f2 and Pou3f1 - in sequentially generated neurons correlates with and is functionally required for the correct specification of neuronal subtypes mediating spinal sensory and motor output!
www.biorxiv.org/content/10.1...
Expression of 3 TFs - Onecut2, Pou2f2 and Pou3f1 - in sequentially generated neurons correlates with and is functionally required for the correct specification of neuronal subtypes mediating spinal sensory and motor output!
www.biorxiv.org/content/10.1...
Reposted
Beautiful work from @sagnera.bsky.social & co on how spinal neurons diversify
A temporal TF clock in spinal neurons, sequentially specifying different motor and sensory neuron subtypes during development
A shared molecular timer driving cellular diversity
www.biorxiv.org/cgi/content/...
A temporal TF clock in spinal neurons, sequentially specifying different motor and sensory neuron subtypes during development
A shared molecular timer driving cellular diversity
www.biorxiv.org/cgi/content/...
www.biorxiv.org
May 29, 2025 at 6:29 AM
Beautiful work from @sagnera.bsky.social & co on how spinal neurons diversify
A temporal TF clock in spinal neurons, sequentially specifying different motor and sensory neuron subtypes during development
A shared molecular timer driving cellular diversity
www.biorxiv.org/cgi/content/...
A temporal TF clock in spinal neurons, sequentially specifying different motor and sensory neuron subtypes during development
A shared molecular timer driving cellular diversity
www.biorxiv.org/cgi/content/...