Sager Gosai
@sagergosai.bsky.social
Computational biologist and postdoc at Stanford. Hobby dog trainer. COYG.
Pinned
Sager Gosai
@sagergosai.bsky.social
· Dec 3
Machine-guided design of cell-type-targeting cis-regulatory elements - Nature
A generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.
www.nature.com
Kicking off this account by sharing our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” published just over a month ago www.nature.com/articles/s41... #genomics #syntheticbiology #AI
Reposted by Sager Gosai
Exited to see this preprint led by Tammy Lan in the Sabeti Lab using spatial transcriptomics to study the impacts of aging on the cycling ovaries. www.biorxiv.org/content/10.1...
Aging disrupts spatiotemporal coordination in the cycling ovary
Throughout the female reproductive lifespan, the ovary completes hundreds of cycles of follicle development, ovulation, and tissue regeneration[1][1]–[3][2]. These processes rely on the precise coordi...
www.biorxiv.org
December 22, 2024 at 4:03 AM
Exited to see this preprint led by Tammy Lan in the Sabeti Lab using spatial transcriptomics to study the impacts of aging on the cycling ovaries. www.biorxiv.org/content/10.1...
Reposted by Sager Gosai
🧬 Genomic DNNs can be trained to learn a lot of different aspects of gene regulation, but they're not perfect and we don't know which predictions are reliable and which ones aren't.
We introduce DEGU: Uncertainty-aware Genomic Deep Learning with Knowledge Distillation. 1/n
We introduce DEGU: Uncertainty-aware Genomic Deep Learning with Knowledge Distillation. 1/n
November 16, 2024 at 4:14 PM
🧬 Genomic DNNs can be trained to learn a lot of different aspects of gene regulation, but they're not perfect and we don't know which predictions are reliable and which ones aren't.
We introduce DEGU: Uncertainty-aware Genomic Deep Learning with Knowledge Distillation. 1/n
We introduce DEGU: Uncertainty-aware Genomic Deep Learning with Knowledge Distillation. 1/n
Reposted by Sager Gosai
Pleased to share our latest work on genomic- and methylation-based #ctDNA analysis of baseline samples from patients with #DDR and #HRD tumors. New insights into tumor fraction estimation, HRD signatures, and reversion alterations including novel reversions in #ATM
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Comprehensive baseline ctDNA characterization in two biomarker-selected Phase 1/2 studies using genomic and methylation profiling
The development of DNA damage response (DDR)-directed therapies is a major area of clinical investigation, yet to date Poly (ADP-ribose) polymerase (PARP) inhibitors remain the only approved therapy i...
www.medrxiv.org
November 19, 2024 at 2:56 PM
Pleased to share our latest work on genomic- and methylation-based #ctDNA analysis of baseline samples from patients with #DDR and #HRD tumors. New insights into tumor fraction estimation, HRD signatures, and reversion alterations including novel reversions in #ATM
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Sager Gosai
Biology of Genomes 2025 is coming up:
- meeting dates: May 6 - 10, 2025
- abstract deadline: Feb 14, 2025
We hope to see you there for another great meeting with a fantastic speaker lineup!
meetings.cshl.edu/meetings.asp...
- meeting dates: May 6 - 10, 2025
- abstract deadline: Feb 14, 2025
We hope to see you there for another great meeting with a fantastic speaker lineup!
meetings.cshl.edu/meetings.asp...
Biology of Genomes
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
December 3, 2024 at 7:21 PM
Biology of Genomes 2025 is coming up:
- meeting dates: May 6 - 10, 2025
- abstract deadline: Feb 14, 2025
We hope to see you there for another great meeting with a fantastic speaker lineup!
meetings.cshl.edu/meetings.asp...
- meeting dates: May 6 - 10, 2025
- abstract deadline: Feb 14, 2025
We hope to see you there for another great meeting with a fantastic speaker lineup!
meetings.cshl.edu/meetings.asp...
Kicking off this account by sharing our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” published just over a month ago www.nature.com/articles/s41... #genomics #syntheticbiology #AI
Machine-guided design of cell-type-targeting cis-regulatory elements - Nature
A generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.
www.nature.com
December 3, 2024 at 9:13 PM
Kicking off this account by sharing our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” published just over a month ago www.nature.com/articles/s41... #genomics #syntheticbiology #AI