Ian Silverman
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iansilverman.bsky.social
Ian Silverman
@iansilverman.bsky.social
22 followers 240 following 1 posts
Precision Oncology, Translational Genomics, Molecular Diagnostics.
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sylvaingigan.bsky.social
Happy birthday Google Scholar - making my life easier since 2004.
November 18, 2024 at 6:55 PM
Reposted by Ian Silverman
vonmeyennlab.bsky.social
🧬 New in @Nature: Our team found that fat cells keep a “memory” of their previous obese state even after weight loss, helping explain why maintaining weight loss is so challenging. Excited to share this work!!

www.nature.com/articles/s41...
Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature
Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...
www.nature.com
November 19, 2024 at 5:12 AM
iansilverman.bsky.social
Pleased to share our latest work on genomic- and methylation-based #ctDNA analysis of baseline samples from patients with #DDR and #HRD tumors. New insights into tumor fraction estimation, HRD signatures, and reversion alterations including novel reversions in #ATM

www.medrxiv.org/content/10.1...
Comprehensive baseline ctDNA characterization in two biomarker-selected Phase 1/2 studies using genomic and methylation profiling
The development of DNA damage response (DDR)-directed therapies is a major area of clinical investigation, yet to date Poly (ADP-ribose) polymerase (PARP) inhibitors remain the only approved therapy i...
www.medrxiv.org
November 19, 2024 at 2:56 PM