Safer Medicines
@safermedicines.org
UK charity working to make medicines safer through far greater use of better predictive human-relevant science.
https://SaferMedicines.org
https://SaferMedicines.org
Reposted by Safer Medicines
🚨 The UK needs a clear plan to end animal testing. We want to see a roadmap that is detailed and action-focused.
✍️ Sign the petition today: https://you.38degrees.org.uk/petitions/a-real-roadmap-to-phase-out-animal-testing
✍️ Sign the petition today: https://you.38degrees.org.uk/petitions/a-real-roadmap-to-phase-out-animal-testing
October 28, 2025 at 11:45 AM
🚨 The UK needs a clear plan to end animal testing. We want to see a roadmap that is detailed and action-focused.
✍️ Sign the petition today: https://you.38degrees.org.uk/petitions/a-real-roadmap-to-phase-out-animal-testing
✍️ Sign the petition today: https://you.38degrees.org.uk/petitions/a-real-roadmap-to-phase-out-animal-testing
Film review: ‘How to make drugs and feel great about everything’ considers the science and ethics of drug development. Our verdict: Well worth watching and even funny!
safermedicines.org/blog_post/ho...
safermedicines.org/blog_post/ho...
How to make drugs and feel great about everything. First Spark Media. September 2025 - Safer Medicines
The film ‘How to make drugs and feel great about everything’, by director Journey Wade-Hak and co-producer / writer Keegan Kuhn covers what will be familiar ground to many – the translational failure ...
safermedicines.org
October 31, 2025 at 2:35 PM
Film review: ‘How to make drugs and feel great about everything’ considers the science and ethics of drug development. Our verdict: Well worth watching and even funny!
safermedicines.org/blog_post/ho...
safermedicines.org/blog_post/ho...
The time may come when we look back and realise that animal experiments have been a huge and costly distraction, a path we might have done better to completely avoid.
#betterscience
#humanrelevant safermedicines.org/blog_post/mi...
#betterscience
#humanrelevant safermedicines.org/blog_post/mi...
Misplacement, replacement, displacement - Safer Medicines
When considering the use of animals in research intended to have relevance for human health, the time may come when we look back and realise that animal experiments have been a huge and costly distrac...
safermedicines.org
October 28, 2025 at 8:58 AM
The time may come when we look back and realise that animal experiments have been a huge and costly distraction, a path we might have done better to completely avoid.
#betterscience
#humanrelevant safermedicines.org/blog_post/mi...
#betterscience
#humanrelevant safermedicines.org/blog_post/mi...
Reposted by Safer Medicines
👏 Don't miss this excellent commentary in @nature.com.
Nonanimal methods are revolutionizing research, yet many editors, reviewers, and funders still overlook their robustness and value—leaving researchers struggling for recognition despite #NAMs’ potential to deliver better results. 🧪
Nonanimal methods are revolutionizing research, yet many editors, reviewers, and funders still overlook their robustness and value—leaving researchers struggling for recognition despite #NAMs’ potential to deliver better results. 🧪
October 24, 2025 at 12:41 PM
👏 Don't miss this excellent commentary in @nature.com.
Nonanimal methods are revolutionizing research, yet many editors, reviewers, and funders still overlook their robustness and value—leaving researchers struggling for recognition despite #NAMs’ potential to deliver better results. 🧪
Nonanimal methods are revolutionizing research, yet many editors, reviewers, and funders still overlook their robustness and value—leaving researchers struggling for recognition despite #NAMs’ potential to deliver better results. 🧪
Reposted by Safer Medicines
Are you a researcher with an interest in human-focused #biomedical technologies? Join our upcoming Science+ meeting in London. You can also apply to present your poster at the meeting: royalsociety.org/science-even... @safermedicines.org
October 24, 2025 at 4:05 PM
Are you a researcher with an interest in human-focused #biomedical technologies? Join our upcoming Science+ meeting in London. You can also apply to present your poster at the meeting: royalsociety.org/science-even... @safermedicines.org
A brilliant paper by my brilliant colleague Pandora Pound, with a short blog to introduce it - an essential read! safermedicines.org/blog_post/ho...
How can a sociological perspective facilitate the transition from animal research to non-animal, new approach methodologies? - Safer Medicines
In our new paper, Safer Medicines Trust Research Director, Pandora Pound, explores whether a sociological perspective can help explain why animal research persists within academia despite the availabi...
safermedicines.org
October 9, 2025 at 3:34 PM
A brilliant paper by my brilliant colleague Pandora Pound, with a short blog to introduce it - an essential read! safermedicines.org/blog_post/ho...
Reposted by Safer Medicines
In a powerful new article, Pandora Pound of @safermedicines.org uses sociologist Pierre Bourdieu’s ideas on power and legitimacy to ask why animal experimentation still dominates academia—despite scientific advances and increasing external pressure for change.
🧵
#sociology #scipol #philsci 🧪
🧵
#sociology #scipol #philsci 🧪
October 9, 2025 at 1:24 PM
In a powerful new article, Pandora Pound of @safermedicines.org uses sociologist Pierre Bourdieu’s ideas on power and legitimacy to ask why animal experimentation still dominates academia—despite scientific advances and increasing external pressure for change.
🧵
#sociology #scipol #philsci 🧪
🧵
#sociology #scipol #philsci 🧪
Reposted by Safer Medicines
Most animals used in experimentation are still in academic settings.
Pound argues this isn’t due to scientific necessity, but because the enculturated paradigm is a powerful source of symbolic and economic capital, due to its history and systems of inertia.
2/
Pound argues this isn’t due to scientific necessity, but because the enculturated paradigm is a powerful source of symbolic and economic capital, due to its history and systems of inertia.
2/
October 9, 2025 at 1:24 PM
Most animals used in experimentation are still in academic settings.
Pound argues this isn’t due to scientific necessity, but because the enculturated paradigm is a powerful source of symbolic and economic capital, due to its history and systems of inertia.
2/
Pound argues this isn’t due to scientific necessity, but because the enculturated paradigm is a powerful source of symbolic and economic capital, due to its history and systems of inertia.
2/
Reposted by Safer Medicines
She explores how academics' "reluctance to relinquish their models" is a defensive tactic, given that "the animal research field is fully open to external forces and its autonomy and legitimacy are at risk as never before."
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October 9, 2025 at 1:24 PM
She explores how academics' "reluctance to relinquish their models" is a defensive tactic, given that "the animal research field is fully open to external forces and its autonomy and legitimacy are at risk as never before."
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Reposted by Safer Medicines
Pound also calls for a rethink in how we talk about change.
Rather than using “replacement” (which still treats animal experimentation as the default), she suggests “displacement” — a term that signals the intent to phase it out entirely.
4/
Rather than using “replacement” (which still treats animal experimentation as the default), she suggests “displacement” — a term that signals the intent to phase it out entirely.
4/
October 9, 2025 at 1:24 PM
Pound also calls for a rethink in how we talk about change.
Rather than using “replacement” (which still treats animal experimentation as the default), she suggests “displacement” — a term that signals the intent to phase it out entirely.
4/
Rather than using “replacement” (which still treats animal experimentation as the default), she suggests “displacement” — a term that signals the intent to phase it out entirely.
4/
Reposted by Safer Medicines
This shift in language matters.
“Replacement” implies there’s something that must be preserved.
“Displacement” reframes the goal: not to replicate animal models, but to move beyond them toward more innovative, human-relevant approaches.
5/
“Replacement” implies there’s something that must be preserved.
“Displacement” reframes the goal: not to replicate animal models, but to move beyond them toward more innovative, human-relevant approaches.
5/
October 9, 2025 at 1:24 PM
This shift in language matters.
“Replacement” implies there’s something that must be preserved.
“Displacement” reframes the goal: not to replicate animal models, but to move beyond them toward more innovative, human-relevant approaches.
5/
“Replacement” implies there’s something that must be preserved.
“Displacement” reframes the goal: not to replicate animal models, but to move beyond them toward more innovative, human-relevant approaches.
5/
Reposted by Safer Medicines
There's a lot to unpack here, some of which is summarized in the graphic above.
Sit down with a coffee or a cocktail this weekend and give it a full read.
🔚
www.sciencedirect.com/science/arti...
Sit down with a coffee or a cocktail this weekend and give it a full read.
🔚
www.sciencedirect.com/science/arti...
A sociological perspective on the challenges of displacing animal research within academia: the contribution of Bourdieu
The use of non-animal, new approach methodologies (NAMs) is increasing but there has been no associated decrease in animal use. Reasons may include th…
www.sciencedirect.com
October 9, 2025 at 1:24 PM
There's a lot to unpack here, some of which is summarized in the graphic above.
Sit down with a coffee or a cocktail this weekend and give it a full read.
🔚
www.sciencedirect.com/science/arti...
Sit down with a coffee or a cocktail this weekend and give it a full read.
🔚
www.sciencedirect.com/science/arti...
The UK government promised to phase out animal testing. A promise isn't enough. We need an ambitious roadmap with firm deadlines, not more delays. Sign the petition demanding a real plan to bring UK science into the 21st century. you.38degrees.org.uk/petitions/a-...
A real roadmap to phase out animal testing
It's time for the UK to catch up and focus on modern, human-relevant science. Add your name to the petition calling on the government to create an ambitious and detailed roadmap to phase out animal te...
you.38degrees.org.uk
October 7, 2025 at 1:48 PM
The UK government promised to phase out animal testing. A promise isn't enough. We need an ambitious roadmap with firm deadlines, not more delays. Sign the petition demanding a real plan to bring UK science into the 21st century. you.38degrees.org.uk/petitions/a-...
Sign and share this petition to make sure animal testing is REALLY phased out in the UK! #betterscience #humanrelevant you.38degrees.org.uk/petitions/a-...
A real roadmap to phase out animal testing
The government promised to work towards phasing out animal testing. Now they're creating a roadmap to make it happen, but it needs to be an ambitious and detailed plan, with clear milestones to drive ...
you.38degrees.org.uk
September 3, 2025 at 7:37 AM
Sign and share this petition to make sure animal testing is REALLY phased out in the UK! #betterscience #humanrelevant you.38degrees.org.uk/petitions/a-...
Will the UK government's forthcoming strategy to reduce the use of animals in science reflect the bold developments in the US?
safermedicines.org/blog_post/fd...
safermedicines.org/blog_post/fd...
FDA-NIH Workshop: Reducing Animal Testing - Safer Medicines
A cultural shift Much has been written about Nicole Kleinstreuer’s announcement in the joint workshop between the FDA and the National Institutes for Health (NIH), namely that all new NIH funding oppo...
safermedicines.org
July 18, 2025 at 8:48 AM
Will the UK government's forthcoming strategy to reduce the use of animals in science reflect the bold developments in the US?
safermedicines.org/blog_post/fd...
safermedicines.org/blog_post/fd...
Patients would benefit from human-relevant science in place of preclinical animal tests that risk incorrect predictions of safety and efficacy. #betterscience #humanrelevant safermedicines.org/blog_post/on...
On Clinical Trials Day - May 20 2025 - Safer Medicines
May 20th every year marks Clinical Trials Day, to recognise the day in 1747 when James Lind, a ship’s surgeon in the British Royal Navy initiated what is considered to be one of the first ever clinica...
safermedicines.org
May 20, 2025 at 7:51 AM
Patients would benefit from human-relevant science in place of preclinical animal tests that risk incorrect predictions of safety and efficacy. #betterscience #humanrelevant safermedicines.org/blog_post/on...
UK government needs to quickly up its game, or be left in the dirt by the forward-thinking US FDA, NIH and EPA, who now realise that #betterscience is #humanrelevant
safermedicines.org/blog_post/as...
safermedicines.org/blog_post/as...
Astonishing April! - Safer Medicines
It all began on 10th April, when the US Food and DrugAdministration (FDA) announced its intention to take ‘a groundbreaking step to advance public health’ by using ‘more effective, human-relevant meth...
safermedicines.org
May 2, 2025 at 9:10 AM
UK government needs to quickly up its game, or be left in the dirt by the forward-thinking US FDA, NIH and EPA, who now realise that #betterscience is #humanrelevant
safermedicines.org/blog_post/as...
safermedicines.org/blog_post/as...
Vivodyne human tissues are making human-first drug testing a reality... yielding rich human data without relying on animal vivariums 👏https://www.contractpharma.com/exclusives/advantages-and-impact-of-fdas-plan-to-phase-out-animal-testing-for-mabs-and-other-drugs/
Advantages and Impact of FDA’s Plan to Phase Out Animal Testing for mAbs and Other Drugs
Andrei Georgescu of Vivodyne discusses key advantages of its humanized drug testing platform and the impact of the FDA’s policy shift.
www.contractpharma.com
April 25, 2025 at 12:20 PM
Vivodyne human tissues are making human-first drug testing a reality... yielding rich human data without relying on animal vivariums 👏https://www.contractpharma.com/exclusives/advantages-and-impact-of-fdas-plan-to-phase-out-animal-testing-for-mabs-and-other-drugs/
Experimental methods that don’t use animals, like tissue chips and computational models, lead to the development of safer and more effective therapies and pharmaceuticals.
#betterscience #humanrelevant
utahnewsdispatch.com/2025/04/16/k...
#betterscience #humanrelevant
utahnewsdispatch.com/2025/04/16/k...
Kudos to the FDA and EPA for planning to phase out animal testing • Utah News Dispatch
Commentary: The Food and Drug Administration and the Environmental Protection Agency say they will start backing off of animal testing.
utahnewsdispatch.com
April 19, 2025 at 7:52 AM
Experimental methods that don’t use animals, like tissue chips and computational models, lead to the development of safer and more effective therapies and pharmaceuticals.
#betterscience #humanrelevant
utahnewsdispatch.com/2025/04/16/k...
#betterscience #humanrelevant
utahnewsdispatch.com/2025/04/16/k...
Reposted by Safer Medicines
“This is a lot easier than I thought!” We hear this often after our workshops. And it's true #organonchip doesn't need to be complicated as long as you start with the small questions & increase complexity with time. The video shows our Online Academy, an e-learning platform for learning #ooc tech.
February 18, 2025 at 12:16 PM
“This is a lot easier than I thought!” We hear this often after our workshops. And it's true #organonchip doesn't need to be complicated as long as you start with the small questions & increase complexity with time. The video shows our Online Academy, an e-learning platform for learning #ooc tech.
Reposted by Safer Medicines
[𝐍𝐞𝐰 𝐛𝐥𝐨𝐠] Only ~10% of drugs have been tested for safety in pregnant women, risking unexpected side effects. In collaboration with esqLABs, Bayer & Placenta Lab we developed an #organonchip platform to study if small molecules can cross the blood-placenta-barrier. Read it here: shorturl.at/5gfpY
3D Intestine-on-chip model to understand fungal infection
Summary of our recent publication on an intestine-on-chip model for gaining a deeper understanding of the pathogenicity mechanisms of Candida albicans.
shorturl.at
February 19, 2025 at 8:18 AM
[𝐍𝐞𝐰 𝐛𝐥𝐨𝐠] Only ~10% of drugs have been tested for safety in pregnant women, risking unexpected side effects. In collaboration with esqLABs, Bayer & Placenta Lab we developed an #organonchip platform to study if small molecules can cross the blood-placenta-barrier. Read it here: shorturl.at/5gfpY
Reposted by Safer Medicines
[𝐍𝐞𝐰 𝐛𝐥𝐨𝐠] The PDAC-on-Chip – A New Dimension in Pancreatic Cancer Research. Read a summary of the most important findings of our recent study with the team of Prof. Dr. Nicole Teusch at the University of Düsseldorf here: zurl.co/7pdot
#drugdevelopment #cancer #spheroids #preclinic
#drugdevelopment #cancer #spheroids #preclinic
The PDAC-on-Chip - A New Dimension in Pancreatic Cancer Research
A new biochip replicates key aspects of the PDAC microenvironment, providing a powerful tool for drug development and reduction of animal testing.
dynamic42.com
March 13, 2025 at 1:16 PM
[𝐍𝐞𝐰 𝐛𝐥𝐨𝐠] The PDAC-on-Chip – A New Dimension in Pancreatic Cancer Research. Read a summary of the most important findings of our recent study with the team of Prof. Dr. Nicole Teusch at the University of Düsseldorf here: zurl.co/7pdot
#drugdevelopment #cancer #spheroids #preclinic
#drugdevelopment #cancer #spheroids #preclinic
Reposted by Safer Medicines
👏 the good news we all needed! FDA announces to replace animal testing with more effective, human-relevant methods including #organonchip. Below, we've summarized the most important points. Curious about organ models? We help researchers bridge the gap between 2D cell culture and animal models.
April 14, 2025 at 8:19 AM
👏 the good news we all needed! FDA announces to replace animal testing with more effective, human-relevant methods including #organonchip. Below, we've summarized the most important points. Curious about organ models? We help researchers bridge the gap between 2D cell culture and animal models.
Reposted by Safer Medicines
Organ models trump traditional 2D models for studying barrier function. They recreate the complex microenvironments of specific organs and allow for a more consistent and reproducible way of measuring TEER.
April 15, 2025 at 9:05 AM
Organ models trump traditional 2D models for studying barrier function. They recreate the complex microenvironments of specific organs and allow for a more consistent and reproducible way of measuring TEER.