Ricky Wolff
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rwolff.bsky.social
Ricky Wolff
@rwolff.bsky.social
Ecology and evolution of the human gut microbiome in Nandita Garud's lab at UCLA
Reposted by Ricky Wolff
Super excited that the bulk of my PhD work is now preprinted! Here we used whole-community competition, or coalescence, experiments to quantify selection acting on genetically diverged strains within larger communities. (1/n)
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 11, 2025 at 5:15 PM
Reposted by Ricky Wolff
Check out our new paper led by brilliant @jhuisman.bsky.social about how microbial communities cope with stress due to increasing salinity in their environment. We have all your favorites: isolate phenotyping, pairwise competitions, community propagations, and theory. #microsky #mevosky #ecosky
August 25, 2025 at 2:47 PM
Reposted by Ricky Wolff
You can get an accurate estimate of total bacterial biomass from stool metagenomes by simply normalizing by host read count, without needing any additional measurements.

Excellent work by UW Master's student Gechlang Tang in @asm.org #mSystems Journal.

journals.asm.org/doi/10.1128/...
🧵
Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization | mSystems
In this study, we asked whether normalization by host reads alone was sufficient to estimate absolute bacterial biomass directly from stool metagenomic data, without the need for synthetic spike-ins, ...
journals.asm.org
July 31, 2025 at 3:33 PM
Reposted by Ricky Wolff
Because of a lack of separation of the time scales for TF binding/unbinding and fluctuations in active TF levels, non-equilibrium gene regulation may be common in bacteria.
Check out this nice piece by ‪@philipcball.bsky.social‬ on our new publication in PRX Life.
physics.aps.org/articles/v18...
Different Bacterial Genes Have Different Turn-Ons
Not all genes respond in the same way to regulation by the same molecule—a property that might enable cells to produce complex genetic responses.
physics.aps.org
July 18, 2025 at 9:30 PM
Reposted by Ricky Wolff
The Wadsworth Center, New York State Department of Health, is currently recruiting for a Research Scientist 5 (Assistant/Associate Professor equivalent) to lead an independent research program focused on zoonotic and/or vector-borne pathogens (viral and bacterial).
June 3, 2025 at 9:21 PM
Reposted by Ricky Wolff
Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 3, 2025 at 6:23 PM
Reposted by Ricky Wolff
One of the coolest papers I've ever read: www.nature.com/articles/s41...

Within-colony bacterial dynamics.

And the figures are absolutely striking and clear.
Spatiotemporal development of expanding bacterial colonies driven by emergent mechanical constraints and nutrient gradients - Nature Communications
Bacterial colonies growing on solid surfaces can exhibit robust expansion kinetics, with constant radial growth and saturating vertical expansion. Here, the authors use modeling and experiments to sho...
www.nature.com
May 30, 2025 at 2:22 PM
Reposted by Ricky Wolff
We organized this one: academic.oup.com/femsle/artic... in 2024. It is coming back in 2026 with 2 hubs in the US (Michigan and SoCal). It was a great experience
MEEhubs2024: A hub-based conference on microbial ecology and evolution fostering sustainability
This paper presents a multi-hub conference on microbial ecology and evolution, analyzing participant and organizer feedback to provide a template and recom
academic.oup.com
May 26, 2025 at 4:55 PM
Reposted by Ricky Wolff
Bacteria have a simple yet potent mechanism that controls their sensitivity to environmental stimuli. A new study by researchers led by <a href="https://bsky.app/profile/did:plc:mpi2uwwkiofxvcgr5lzmjnra" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@erikvannimwegen.bsky.social @biozentrum.unibas.ch shows: the slower cells grow, the more sensitively they respond to their environment.
Slow-growing bacteria respond more sensitively to their environment
Bacteria have a simple yet potent mechanism that controls their sensitivity to environmental stimuli. A new study by researchers at the Univer...
www.unibas.ch
May 8, 2025 at 8:15 AM
Whimsical Friday afternoon read—1976 study of the microbiomes of astronauts undergoing isolation training, which concluded B. theta abundance responds specifically to "anger stress"
May 9, 2025 at 9:18 PM
Reposted by Ricky Wolff
Wow

www.biorxiv.org/content/10.1...

A cellular entity retaining only its replicative core: Hidden archaeal lineage with an ultra-reduced genome
May 6, 2025 at 2:09 PM
Reposted by Ricky Wolff
Kevin Hall, one of the only nutrition researchers in the world running controlled trials of ultraprocessed foods, just announced his early retirement from NIH, citing censorship of his research communications: www.cnn.com/2025/04/16/h...
Top NIH nutrition researcher studying ultraprocessed foods departs, citing censorship under Kennedy | CNN
When President Donald Trump named Robert F. Kennedy Jr. as his choice to lead the US Department of Health and Human Services, one group of health researchers was cautiously optimistic that their cause...
www.cnn.com
April 16, 2025 at 9:17 PM
... but how many genetic edits would one have to make to actually get a new species?
April 8, 2025 at 8:59 PM
Reposted by Ricky Wolff
Taxa is hiring! We're looking for a Computational Biologist to spearhead the analysis of massive genomic datasets for our flagship probiotics. Exciting science, great team, and transparent compensation. Apply here 👇
Taxa hiring Computational Biologist in San Francisco, CA | LinkedIn
Posted 4:13:15 PM. The OpportunityWe are looking for a talented Computational Biologist to spearhead the analysis of…See this and similar jobs on LinkedIn.
www.linkedin.com
April 4, 2025 at 8:16 PM
Reposted by Ricky Wolff
Know any soon to graduate or recently graduated undergrads interested in a full year, paid postbac research position in microbiome sciences? Have them join our zoom Q&A session on Friday, April 11, 11:30am-12:30pm PST. More info here: sites.google.com/berkeley.edu...
Bay Area RaMP - 2025-26 Cohort
2025-2026 Cohort
sites.google.com
April 8, 2025 at 5:32 PM
Greatly enjoyed this thought provoking, deeply researched, and extremely well written review from @saradirienzi.bsky.social and Robert Britton

www.sciencedirect.com/science/arti...
Adaptation of the Gut Microbiota to Modern Dietary Sugars and Sweeteners
The consumption of sugar has become central to the Western diet. Cost and health concerns associated with sucrose spurred the development and consumpt…
www.sciencedirect.com
March 28, 2025 at 7:05 PM
Reposted by Ricky Wolff
Super interesting study www.nature.com/articles/s41...
March 19, 2025 at 8:16 PM
Reposted by Ricky Wolff
My lab at NYU is hiring a postdoc in microbial ecology and evolution! We are looking for someone interested in both wet and dry lab techniques, including experimental evolution, genome editing, bioinformatics, and some modeling. Apply here: apply.interfolio.com/164683
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
March 18, 2025 at 8:08 PM
Reposted by Ricky Wolff
New online! Interactions and evolutionary relationships among bacterial mobile genetic elements
Interactions and evolutionary relationships among bacterial mobile genetic elements
Nature Reviews Microbiology, Published online: 11 March 2025; doi:10.1038/s41579-025-01157-yIn this Review, Lang and colleagues present an overview of the current knowledge landscape regarding mobile genetic elements in bacteria, with a focus on their…
www.nature.com
March 11, 2025 at 1:14 PM
Reposted by Ricky Wolff
Finally, our paper, "A Conserved Bacterial Genetic Basis for Commensal-Host Specificity," has been officially published in Science.

www.science.org/doi/10.1126/...
A conserved bacterial genetic basis for commensal-host specificity
Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are...
www.science.org
December 23, 2024 at 2:53 PM
Reposted by Ricky Wolff
Interesting new study in @science.org:

A conserved bacterial genetic basis for commensal-host specificity

www.science.org/doi/10.1126/...
A conserved bacterial genetic basis for commensal-host specificity
Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are...
www.science.org
December 6, 2024 at 12:48 PM
Reposted by Ricky Wolff
Please suggest a cool paper/preprint in your field in the last year or so!

For a course I teach, I am collecting papers on: cell/dev bio, microbio, neuro, maths/stats/CS/chem/phys applied to biology.

Students use one paper as the basis for a "research grant application" that they will write. 1/2
December 3, 2024 at 2:55 PM
Reposted by Ricky Wolff
The bacteria in your gut depend on where you are in the social network around you.

The microbes within us treat our social networks as the extended environment in which they thrive. They can spread from person to person.

New #HNL work out today in @natureportfolio.bsky.social . 1/
November 21, 2024 at 3:45 PM
Reposted by Ricky Wolff
I'm new here, so I'll share our recent work here too 😁🧫

Using Tn-seq + live imaging in engineered airway organoids, we explored the fitness tradeoffs P. aeruginosa faces while growing and surviving antibiotic treatment on the mucosal surface.

Check it out: www.nature.com/articles/s41...

#MicroSky
Pseudomonas aeruginosa faces a fitness trade-off between mucosal colonization and antibiotic tolerance during airway infection - Nature Microbiology
Tn-seq and live imaging of Pseudomonas aeruginosa during airway epithelial organoid infections reveal metabolic adaptations and trade-offs between growth and antibiotic tolerance in biofilm lifestyle,...
www.nature.com
November 11, 2024 at 3:57 PM