Rupesh Jayachandran
@rupeshjayachandran.bsky.social
PhD student at Umeå University, studying viruses using cryo-EM. He/Him.
Reposted by Rupesh Jayachandran
Open and closed forms of assembled henipavirus nucleoprotein suggest structural basis of genome access www.biorxiv.org/content/10.1101/2025.11.02.686081v1 #cryoem
November 3, 2025 at 3:50 PM
Open and closed forms of assembled henipavirus nucleoprotein suggest structural basis of genome access www.biorxiv.org/content/10.1101/2025.11.02.686081v1 #cryoem
Very happy to share our work on the Langya henipavirus nucleoprotein with everyone! 🥳
Check out the preprint to find more about how a serendipitous finding led us to this amazing story!
Check out the preprint to find more about how a serendipitous finding led us to this amazing story!
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
November 3, 2025 at 3:21 PM
Very happy to share our work on the Langya henipavirus nucleoprotein with everyone! 🥳
Check out the preprint to find more about how a serendipitous finding led us to this amazing story!
Check out the preprint to find more about how a serendipitous finding led us to this amazing story!
Reposted by Rupesh Jayachandran
Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
August 13, 2025 at 10:10 PM
Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
Open #PhDposition in structural virology in my group! Join us in Umeå, Sweden to uncover how arboviruses remodel infected cells. In situ #cryoET and #cryoEM combined with #virology, #cellbiology, and #biophysics.
Deadline 7 September. More info: www.carlsonlab.se/join/
Reposted by Rupesh Jayachandran
Very grateful for the support from Pandemifonden and it was a pleasure to share a bit of what our team has been up to 😊
(In Swedish)
www.linkedin.com/feed/update/...
(In Swedish)
www.linkedin.com/feed/update/...
Läs hela intervjun med Max Renner: Mottagare av Pandemifondens pris 2023 | Virus- och pandemifonden
Läs hela intervjun med Max Renner: Mottagare av Pandemifondens pris 2023
Sedan Max mottog Pandemifondens pris 2023 har mycket hunnit hända. Priset har inte bara möjliggjort viktiga framsteg i hans fo...
www.linkedin.com
June 30, 2025 at 5:00 PM
Very grateful for the support from Pandemifonden and it was a pleasure to share a bit of what our team has been up to 😊
(In Swedish)
www.linkedin.com/feed/update/...
(In Swedish)
www.linkedin.com/feed/update/...
Reposted by Rupesh Jayachandran
My PhD student @rupeshjayachandran.bsky.social wrote a comment piece on recent #nipah virus #polymerase structures, especially the one reported by @salafernanda.bsky.social from the lab of @haukehillen.bsky.social
Please check it out 😊
www.sciencedirect.com/science/arti...
Please check it out 😊
www.sciencedirect.com/science/arti...
From disorder to order: cryo-EM reveals RNA-dependent remodeling of Nipah virus polymerase
A flurry of recent structural studies have focused on the polymerase complex of the deadly zoonotic pathogen Nipah virus (NiV). These include a report…
www.sciencedirect.com
May 30, 2025 at 12:49 PM
My PhD student @rupeshjayachandran.bsky.social wrote a comment piece on recent #nipah virus #polymerase structures, especially the one reported by @salafernanda.bsky.social from the lab of @haukehillen.bsky.social
Please check it out 😊
www.sciencedirect.com/science/arti...
Please check it out 😊
www.sciencedirect.com/science/arti...
Reposted by Rupesh Jayachandran
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis
Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...
www.science.org
May 15, 2025 at 7:51 PM
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Rupesh Jayachandran
Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET combined with #virology, #cellbiology, and #biophysics.
Deadline 4 May. More info: www.carlsonlab.se/join/
Open #PhDposition in structural virology in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET combined with #virology, #cellbiology, and #biophysics.
Deadline 4 May. More info: www.carlsonlab.se/join/
April 4, 2025 at 8:06 AM
Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET combined with #virology, #cellbiology, and #biophysics.
Deadline 4 May. More info: www.carlsonlab.se/join/
Open #PhDposition in structural virology in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET combined with #virology, #cellbiology, and #biophysics.
Deadline 4 May. More info: www.carlsonlab.se/join/
Reposted by Rupesh Jayachandran
We have a PhD student position open in the context of the ENDAMR doctoral network. Deadline is 31/May. Apply here: umu.varbi.com/en/what:job/...
PhD position in Chemistry, with a specialization in biochemistry
The Department of Chemistry is opening a PhD position in Chemistry with a specialization in biochemistry. The thesis project will focus on drug resistance mechanisms in microbiome species, and is part
umu.varbi.com
March 19, 2025 at 7:36 AM
We have a PhD student position open in the context of the ENDAMR doctoral network. Deadline is 31/May. Apply here: umu.varbi.com/en/what:job/...
Reposted by Rupesh Jayachandran
We are looking for a postdoc!
Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria!
Please share!
www.nature.com/naturecareer...
Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria!
Please share!
www.nature.com/naturecareer...
Postdoctoral position to study Gram-positive Type 4 Secretion Systems - Umeå, Sweden job with Umeå University | 12837918
A two-year Postdoctoral position for studies of Gram-positive Type 4 Secretion Systems that facilitate the spread of antibiotic resistance
www.nature.com
March 14, 2025 at 3:00 PM
We are looking for a postdoc!
Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria!
Please share!
www.nature.com/naturecareer...
Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria!
Please share!
www.nature.com/naturecareer...
Reposted by Rupesh Jayachandran
Been thinking about creating a collection of good protein structure figures, as inspiration for my own work.
#1 www.nature.com/articles/s41...
#1 www.nature.com/articles/s41...
March 3, 2024 at 8:37 AM
Been thinking about creating a collection of good protein structure figures, as inspiration for my own work.
#1 www.nature.com/articles/s41...
#1 www.nature.com/articles/s41...
Reposted by Rupesh Jayachandran
1/ A new series of #CryoSPARC tutorial videos from this year’s S2C2 #cryoEM image processing workshop are now online! These videos will be interesting to all users and especially those newer to #cryoEM.
www.youtube.com/playlist?lis...
www.youtube.com/playlist?lis...
2024 S2C2 Single-Particle Cryo-EM Image Processing Workshop - YouTube
This playlist contains six recordings covering single particle cryo-EM data processing in CryoSPARC from the 2024 Single-Particle Cryo-EM Image Processing Wo...
www.youtube.com
December 13, 2024 at 6:56 PM
1/ A new series of #CryoSPARC tutorial videos from this year’s S2C2 #cryoEM image processing workshop are now online! These videos will be interesting to all users and especially those newer to #cryoEM.
www.youtube.com/playlist?lis...
www.youtube.com/playlist?lis...
Reposted by Rupesh Jayachandran
Given the growth of this forum in the last couple of weeks, I'm reposting our open PhD position. Come do a PhD on virus replication using our world-class, in-house cryo-EM facility. Dynamic and friendly infection biology community. Deadline in <2 weeks!
Repost appreciated:
Open #PhDposition in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET with great #virology and #biophysics collaborators. Customisable project.
Application deadline 15 December. More info:
www.carlsonlab.se/join/
Open #PhDposition in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET with great #virology and #biophysics collaborators. Customisable project.
Application deadline 15 December. More info:
www.carlsonlab.se/join/
December 2, 2024 at 3:24 PM
Given the growth of this forum in the last couple of weeks, I'm reposting our open PhD position. Come do a PhD on virus replication using our world-class, in-house cryo-EM facility. Dynamic and friendly infection biology community. Deadline in <2 weeks!