Rubayet Elahi
@rubayet.bsky.social
Dr.E | Research Associate | Graham Fellow | JohnsHopkinsMMI | JHMRIMalaria | JohnsHopkinsSPH | PhD from vtbiochem
Reposted by Rubayet Elahi
1/ You did a CRISPR screen.
Found top hits that kill cancer cells.
You think: this is it.
Your next paper. Your next drug.
But then…
Found top hits that kill cancer cells.
You think: this is it.
Your next paper. Your next drug.
But then…
October 22, 2025 at 1:15 PM
1/ You did a CRISPR screen.
Found top hits that kill cancer cells.
You think: this is it.
Your next paper. Your next drug.
But then…
Found top hits that kill cancer cells.
You think: this is it.
Your next paper. Your next drug.
But then…
Reposted by Rubayet Elahi
Professor Umberto D’Alessandro, #MRCG Unit Director shares insights on the first malaria medicine approved for babies.
“Babies have been systematically excluded from clinical trials assessing the safety and efficacy of antimalarial treatments….”
Read more: tinyurl.com/mwftby5h
#EndMalaria
“Babies have been systematically excluded from clinical trials assessing the safety and efficacy of antimalarial treatments….”
Read more: tinyurl.com/mwftby5h
#EndMalaria
Expert Comment: First malaria medicine for babies approved | LSHTM
The first malaria treatment specifically developed for newborn babies and young infants has been approved for use. The approval, by Switzerland’s medical agency Swissmedic, of Coartem Baby
tinyurl.com
July 9, 2025 at 9:24 AM
Professor Umberto D’Alessandro, #MRCG Unit Director shares insights on the first malaria medicine approved for babies.
“Babies have been systematically excluded from clinical trials assessing the safety and efficacy of antimalarial treatments….”
Read more: tinyurl.com/mwftby5h
#EndMalaria
“Babies have been systematically excluded from clinical trials assessing the safety and efficacy of antimalarial treatments….”
Read more: tinyurl.com/mwftby5h
#EndMalaria
First federal grant submission in the bag!
I need a beer and some junk food!
I need a beer and some junk food!
June 16, 2025 at 9:04 PM
First federal grant submission in the bag!
I need a beer and some junk food!
I need a beer and some junk food!
Plasmodium apicoplast genome contains the fewest known tRNA isotypes, making the apicoplast an ideal model to study minimal translation machinery. Such minimal systems depends heavily on posttranscriptional tRNA modifications for accurate protein translation.
@jhmrimalaria.bsky.social 1/2 🧪
@jhmrimalaria.bsky.social 1/2 🧪
Decoding the Minimal Translation System of the Plasmodium falciparum Apicoplast: Essential tRNA-modifying Enzymes and Their Roles in Organelle Maintenance
Post-transcriptional tRNA modifications are essential for accurate and efficient protein translation across all organisms. The apicoplast organelle ge…
www.sciencedirect.com
May 6, 2025 at 12:48 PM
Plasmodium apicoplast genome contains the fewest known tRNA isotypes, making the apicoplast an ideal model to study minimal translation machinery. Such minimal systems depends heavily on posttranscriptional tRNA modifications for accurate protein translation.
@jhmrimalaria.bsky.social 1/2 🧪
@jhmrimalaria.bsky.social 1/2 🧪
Is that Katy Perry? 🙄
Astronomers Detect a Signature of Life on a Distant Planet
Further studies are needed to determine whether K2-18b, which orbits a star 120 light-years away, is inhabited, or even habitable.
www.nytimes.com
April 17, 2025 at 1:49 AM
Is that Katy Perry? 🙄
Reposted by Rubayet Elahi
Just really grim news from all over. I just want a world that values empathy over hate. We could be addressing climate change or global poverty or any other number of issues, but the US, UK, and others are spending their energy making it legal to harass an already-vulnerable group of people.
The U.K. Supreme Court rules that Britain's equalities law defines a woman as someone born biologically female. The ruling means a transgender person with a certificate that recognizes them as female should not be considered a woman for equality purposes.
UK Supreme Court rules that equalities law defines a woman as someone born biologically female
The Supreme Court has ruled that the U.K. equalities law defines a woman as someone born biologically female.
bit.ly
April 16, 2025 at 10:33 AM
Just really grim news from all over. I just want a world that values empathy over hate. We could be addressing climate change or global poverty or any other number of issues, but the US, UK, and others are spending their energy making it legal to harass an already-vulnerable group of people.
A stage III and a IV gametocyte in a red blood cell? That's a first for a gametocytes culture newbie like me!
#Plasmodium 🧪
#Plasmodium 🧪
April 11, 2025 at 3:57 AM
A stage III and a IV gametocyte in a red blood cell? That's a first for a gametocytes culture newbie like me!
#Plasmodium 🧪
#Plasmodium 🧪
March 23, 2025 at 7:57 PM
Reposted by Rubayet Elahi
tRNA lysidinylation is essential for the minimal #translation system in the #Plasmodium falciparum apicoplast.
-> www.embopress.org/doi/full/10....
First characterization of a TilS enzyme that functions in an endosymbiotic organelle.
-> www.embopress.org/doi/full/10....
First characterization of a TilS enzyme that functions in an endosymbiotic organelle.
March 21, 2025 at 12:33 PM
tRNA lysidinylation is essential for the minimal #translation system in the #Plasmodium falciparum apicoplast.
-> www.embopress.org/doi/full/10....
First characterization of a TilS enzyme that functions in an endosymbiotic organelle.
-> www.embopress.org/doi/full/10....
First characterization of a TilS enzyme that functions in an endosymbiotic organelle.
Amid all these turmoil in our lives, a good news!
A paper just came online on @emboreports.org. in this paper we describe an essential apicoplast tRNA modifying enzyme. 🧪
A paper just came online on @emboreports.org. in this paper we describe an essential apicoplast tRNA modifying enzyme. 🧪
tRNA lysidinylation is essential for the minimal translation system in the Plasmodium falciparum apicoplast | EMBO reports
imageimageThe tRNA isoleucine lysidine synthetase (TilS) catalyzes lysidine modifications at
the wobble position of tRNACAU, enabling precise codon discrimination. This study provides the first charac...
www.embopress.org
March 20, 2025 at 12:45 PM
Amid all these turmoil in our lives, a good news!
A paper just came online on @emboreports.org. in this paper we describe an essential apicoplast tRNA modifying enzyme. 🧪
A paper just came online on @emboreports.org. in this paper we describe an essential apicoplast tRNA modifying enzyme. 🧪
but but... I don't want my money in the form of taxes to save lives.
Simple! 🙄
Simple! 🙄
Malaria No More Statement on the Administration’s Termination of USAID Malaria Programs
"Modeling shows that a year of disruptions would lead to nearly 15 million additional cases of malaria and 107,000 additional deaths."
www.malarianomore.org/news/malaria...
"Modeling shows that a year of disruptions would lead to nearly 15 million additional cases of malaria and 107,000 additional deaths."
www.malarianomore.org/news/malaria...
Malaria No More Statement on the Administration’s Termination of USAID Malaria Programs - Malaria No More
Malaria No More CEO Martin Edlund issued the following statement upon the U.S. Department of State’s termination of 90% of USAID contracts, including contracts for life-saving malaria programs:
www.malarianomore.org
February 28, 2025 at 1:21 PM
but but... I don't want my money in the form of taxes to save lives.
Simple! 🙄
Simple! 🙄
Reposted by Rubayet Elahi
Everyone who ever got funding through NIAID should be aware of this bill and start sending messages to their US legislators. The bill intends to dissolve NIAID. This is Project 2025
www.congress.gov/bill/119th-c...
www.congress.gov/bill/119th-c...
www.congress.gov
February 22, 2025 at 9:38 PM
Everyone who ever got funding through NIAID should be aware of this bill and start sending messages to their US legislators. The bill intends to dissolve NIAID. This is Project 2025
www.congress.gov/bill/119th-c...
www.congress.gov/bill/119th-c...
Reposted by Rubayet Elahi
NIH research grants still frozen despite lawsuits challenging Trump order
The administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo
🧪 #AcademicSky
@nature.com @natureportfolio.nature.com
www.nature.com/articles/d41...
The administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo
🧪 #AcademicSky
@nature.com @natureportfolio.nature.com
www.nature.com/articles/d41...
Revealed: NIH research grants still frozen despite lawsuits challenging Trump order
The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.
www.nature.com
February 21, 2025 at 7:00 AM
NIH research grants still frozen despite lawsuits challenging Trump order
The administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo
🧪 #AcademicSky
@nature.com @natureportfolio.nature.com
www.nature.com/articles/d41...
The administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo
🧪 #AcademicSky
@nature.com @natureportfolio.nature.com
www.nature.com/articles/d41...
Reposted by Rubayet Elahi
Thanks to all of the NIHers and their friends who reached out to me. I am still here (DM me or Signal jeremymberg.78)
I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine
1/n
I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine
1/n
February 16, 2025 at 6:32 AM
Thanks to all of the NIHers and their friends who reached out to me. I am still here (DM me or Signal jeremymberg.78)
I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine
1/n
I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine
1/n
Good news is Congress is at work! 🤷♂️
H.R.1161 - To authorize the President to enter into negotiations to acquire Greenland and to rename Greenland as "Red, White, and Blueland".
This CANNOT be real.
www.congress.gov/bill/119th-c...
This CANNOT be real.
www.congress.gov/bill/119th-c...
www.congress.gov
February 11, 2025 at 10:18 PM
Good news is Congress is at work! 🤷♂️
Reposted by Rubayet Elahi
The Howard Hughes Medical Institute, a huge funder of biomedical research, has cut a $60-million initiative to boost diversity in science education.
February 8, 2025 at 3:15 PM
The Howard Hughes Medical Institute, a huge funder of biomedical research, has cut a $60-million initiative to boost diversity in science education.
Reposted by Rubayet Elahi
Idaho State University has an indirect rate of 44% and also no multi-million $ endowment. We will be devastated by this.
The University of Idaho has an indirect rate of 50%.
They do not have a multi-billion dollar endowment. They will be devastated by this.
The NIH is deliberately deceiving us.
They do not have a multi-billion dollar endowment. They will be devastated by this.
The NIH is deliberately deceiving us.
February 8, 2025 at 9:36 PM
Idaho State University has an indirect rate of 44% and also no multi-million $ endowment. We will be devastated by this.
Reposted by Rubayet Elahi
Executive wants to frame the NIH indirects cut as $4B in savings.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
Direct Economic Contributions
NIH directly supports the economy through investments in research institutions and job formation.
www.nih.gov
February 8, 2025 at 3:08 AM
Executive wants to frame the NIH indirects cut as $4B in savings.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
Reposted by Rubayet Elahi
⚠️ Effective Monday 2/10/25, NIH indirect rate capped at 15%. Applies to existing & future grants.
—> Deep budget cuts & program closures coming to a university near you.
Is this the break the glass moment for university administrators who have been silent so far about the attack on science?
—> Deep budget cuts & program closures coming to a university near you.
Is this the break the glass moment for university administrators who have been silent so far about the attack on science?
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 7, 2025 at 11:33 PM
⚠️ Effective Monday 2/10/25, NIH indirect rate capped at 15%. Applies to existing & future grants.
—> Deep budget cuts & program closures coming to a university near you.
Is this the break the glass moment for university administrators who have been silent so far about the attack on science?
—> Deep budget cuts & program closures coming to a university near you.
Is this the break the glass moment for university administrators who have been silent so far about the attack on science?
Reposted by Rubayet Elahi
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:18 AM
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
Reposted by Rubayet Elahi
Do you work on parasites and reside in an LMIC? Consider applying for a 2025 MPM LMIC award. The deadline is March 3rd, 2025—details on the website.
www.parasitesrule.com/mpm-xxxvi/tr...
www.parasitesrule.com/mpm-xxxvi/tr...
Molecular Parasitology Community - Travelaward2025
Scroll down for the application form
www.parasitesrule.com
February 5, 2025 at 2:20 AM
Do you work on parasites and reside in an LMIC? Consider applying for a 2025 MPM LMIC award. The deadline is March 3rd, 2025—details on the website.
www.parasitesrule.com/mpm-xxxvi/tr...
www.parasitesrule.com/mpm-xxxvi/tr...
Reposted by Rubayet Elahi
Plastids & mitochondria arose from separate endosymbioses of prokaryotes.Their prokaryotic ancestry makes them susceptible to antibiotics. Antibiotics kill pathogenic protists by targeting their plastids or mitochondria. Here we review the lop sided inheritance.
journals.plos.org/plospathogen...
Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists
Pathogenic protists are responsible for many diseases that significantly impact human and animal health across the globe. Almost all protists possess mitochondria or mitochondrion-related organelles, ...
journals.plos.org
January 25, 2025 at 10:29 PM
Plastids & mitochondria arose from separate endosymbioses of prokaryotes.Their prokaryotic ancestry makes them susceptible to antibiotics. Antibiotics kill pathogenic protists by targeting their plastids or mitochondria. Here we review the lop sided inheritance.
journals.plos.org/plospathogen...
xm5s2U #tRNA modification is crucial for proper protein #translation, especially in a translation system with minimal components. We have described the players of xm5s2U34 biosythesis in #Plasmodium #apicoplast. Read the story to find out why parasites need this and how we did it. 1/6
tRNA modifying enzymes MnmE and MnmG are essential for Plasmodium falciparum apicoplast maintenance https://www.biorxiv.org/content/10.1101/2024.12.21.629855v1
December 23, 2024 at 3:58 PM
xm5s2U #tRNA modification is crucial for proper protein #translation, especially in a translation system with minimal components. We have described the players of xm5s2U34 biosythesis in #Plasmodium #apicoplast. Read the story to find out why parasites need this and how we did it. 1/6