✨New in Nat Chem Biol: Site-selective protein editing by backbone extension acyl rearrangements
bit.ly/4oKQ251

Congrats @roeleah.bsky.social, Izzi, Carly, Taylor, Bhavana, @nxhamlish.bsky.social, Arjun, Diondra, Zhongqi, @achemsynbio.bsky.social, Matt, Scott, Alanna, and collaborators!
#NSFfunded

A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-, γ-, or δ-peptide backbone

www.nature.com/articles/s41...

I created a protein backbone editing method and named it after my alma mater (x2)! Out now in Nature ChemBio, we show the first examples of a β2-, γ-, and δ-amino acid encoded into full length proteins expressed in cells. www.nature.com/articles/s41...

✨ New from C-GEM:
High yield, low magnesium flexizyme reactions in a water-ice eutectic phase 💧🧊

Congrats to Josh, Jose, Mace, Evan, Angelin, Isaac, Alanna, Aaron, and Kate! #NSFfunded #synbio
www.biorxiv.org/content/10.1...