Rodrigo Castro
@rodrigoicastro.bsky.social
Computational Scientist at The Jackson Laboratory | ML and CRE design
Pinned
Kicking off this account by sharing our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” published just over a month ago www.nature.com/articles/s41... #genomics #syntheticbiology #AI
Machine-guided design of cell-type-targeting cis-regulatory elements - Nature
A generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.
www.nature.com
Also kicking off this account by sharing our sequence design paper published last year.
Reposted by Rodrigo Castro
Excited to share our MPAC preprint, a scalable ensemble of ML models for genome-wide non-coding variant effect prediction and our findings from 575M predictions across databases including @ukbiobank.bsky.social, GTEx, ClinVar, COSMIC, and @gnomad-project.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
https://www.biorxiv.org/content/10.1101/2025.04.16.648420v1\
April 23, 2025 at 5:28 PM
Excited to share our MPAC preprint, a scalable ensemble of ML models for genome-wide non-coding variant effect prediction and our findings from 575M predictions across databases including @ukbiobank.bsky.social, GTEx, ClinVar, COSMIC, and @gnomad-project.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Also kicking off this account by sharing our sequence design paper published last year.
Kicking off this account by sharing our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” published just over a month ago www.nature.com/articles/s41... #genomics #syntheticbiology #AI
Machine-guided design of cell-type-targeting cis-regulatory elements - Nature
A generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.
www.nature.com
April 22, 2025 at 2:26 PM
Also kicking off this account by sharing our sequence design paper published last year.