Raphael Onuku
@raphaelonuku.bsky.social
PhD Candidate (Medicinal Chemistry) @ University of Michigan | MOE Taiwan Government Scholar & Top Graduate @ Taipei Medical University
Publication:
Contribution of Prostaglandin E2‐Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood–Brain Barrier Crossing Celecoxib Derivative - Shen - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
#newpublication
Contribution of Prostaglandin E2‐Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood–Brain Barrier Crossing Celecoxib Derivative - Shen - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
#newpublication
Contribution of Prostaglandin E2‐Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood–Brain Barrier Crossing Celecoxib Derivative
Glioblastoma (GBM) is an aggressive brain cancer that often recurs and resists chemotherapy. This study found that a chemical called PGE2 causes surrounding brain cells (neurons) to become over-excit....
advanced.onlinelibrary.wiley.com
July 16, 2025 at 10:41 PM
Publication:
Contribution of Prostaglandin E2‐Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood–Brain Barrier Crossing Celecoxib Derivative - Shen - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
#newpublication
Contribution of Prostaglandin E2‐Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood–Brain Barrier Crossing Celecoxib Derivative - Shen - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
#newpublication
The medicinal chemist has demonstrated remarkable prowess in furnishing dual inhibitory antitumor chemical architectures. Scaffold hopping-based drug design strategies have yielded a plethora of pharmacodynamically superior dual modulatory antitumor agents.
#scaffoldhopping #drugdiscovery
1/5
#scaffoldhopping #drugdiscovery
1/5
November 14, 2024 at 3:37 PM
The medicinal chemist has demonstrated remarkable prowess in furnishing dual inhibitory antitumor chemical architectures. Scaffold hopping-based drug design strategies have yielded a plethora of pharmacodynamically superior dual modulatory antitumor agents.
#scaffoldhopping #drugdiscovery
1/5
#scaffoldhopping #drugdiscovery
1/5
What is the best way to learn AI and Machine Learning for Drug Discovery purposes?
#AI #machinelearning #drugdiscovery
#AI #machinelearning #drugdiscovery
November 14, 2024 at 12:22 PM
What is the best way to learn AI and Machine Learning for Drug Discovery purposes?
#AI #machinelearning #drugdiscovery
#AI #machinelearning #drugdiscovery
Reposted by Raphael Onuku
one of the reasons bluesky works differently is because early users waged a successful fight to get the devs to prioritize safety features to protect communities at risk
as a result bluesky now has a suite of controls that i think are unmatched on social media
here’s the list, lmk what i’ve missed
as a result bluesky now has a suite of controls that i think are unmatched on social media
here’s the list, lmk what i’ve missed
November 10, 2024 at 7:42 PM
one of the reasons bluesky works differently is because early users waged a successful fight to get the devs to prioritize safety features to protect communities at risk
as a result bluesky now has a suite of controls that i think are unmatched on social media
here’s the list, lmk what i’ve missed
as a result bluesky now has a suite of controls that i think are unmatched on social media
here’s the list, lmk what i’ve missed
Reposted by Raphael Onuku
I swear nothing has caused more problems for me in my life than my inability to say no or turn people down. Soft and empathic nature costs you a lot.
July 8, 2023 at 3:01 AM
I swear nothing has caused more problems for me in my life than my inability to say no or turn people down. Soft and empathic nature costs you a lot.
Reposted by Raphael Onuku
In the lab: A protein fragment has been synthesized by scientists in Brazil that acts as molecular shield preventing #SARSCoV2 from infecting cells. That fragment—a peptide—protected human lung cells from infection in the laboratory. The aim is drug development medicalxpress.com/news/2024-10...
Synthetic peptide acts as molecular shield to prevent SARS-CoV-2 from infecting cells
A peptide synthesized by researchers at the University of São Paulo (USP) in Brazil protected human lung cells against infection by SARS-CoV-2 in the laboratory and eliminated the inflammation caused ...
medicalxpress.com
October 2, 2024 at 10:17 PM
In the lab: A protein fragment has been synthesized by scientists in Brazil that acts as molecular shield preventing #SARSCoV2 from infecting cells. That fragment—a peptide—protected human lung cells from infection in the laboratory. The aim is drug development medicalxpress.com/news/2024-10...
Reposted by Raphael Onuku
Doing peer review for a paper and it's just a fascinating read. Love to see colleagues doing great work! 🤩 🧪🔭 #academicsky
July 16, 2024 at 7:05 PM
Doing peer review for a paper and it's just a fascinating read. Love to see colleagues doing great work! 🤩 🧪🔭 #academicsky
Reposted by Raphael Onuku
Our latest paper is out! “Analysis of AlphaFold and molecular dynamics structure predictions of mutations in serpins” doi.org/10.1371/jour...
Analysis of AlphaFold and molecular dynamics structure predictions of mutations in serpins
Serine protease inhibitors (serpins) include thousands of structurally conserved proteins playing key roles in many organisms. Mutations affecting serpins may disturb their conformation, leading to in...
doi.org
July 6, 2024 at 9:50 AM
Our latest paper is out! “Analysis of AlphaFold and molecular dynamics structure predictions of mutations in serpins” doi.org/10.1371/jour...
Success is achieved not by mere desire, but by the relentless pursuit of small, actionable steps towards the goal.
August 2, 2023 at 2:10 AM
Success is achieved not by mere desire, but by the relentless pursuit of small, actionable steps towards the goal.
Let's stop assuming because someone is older that they are mature. Maturity comes with self-awareness and growth... not age.
August 1, 2023 at 7:01 PM
Let's stop assuming because someone is older that they are mature. Maturity comes with self-awareness and growth... not age.
Sometimes, the best therapy is a long walk and a deep breath. Nature's serenity has a way of realigning our thoughts and soothing our souls. 🌳 #MentalHealth #NatureTherapy
July 14, 2023 at 6:40 PM
Sometimes, the best therapy is a long walk and a deep breath. Nature's serenity has a way of realigning our thoughts and soothing our souls. 🌳 #MentalHealth #NatureTherapy
Food for thought: how would our cities look if we redesigned them with sustainability at the heart? Dreaming of green roofs, community gardens, and renewable energy systems. 🌱 #Sustainability #UrbanPlanning
July 14, 2023 at 6:39 PM
Food for thought: how would our cities look if we redesigned them with sustainability at the heart? Dreaming of green roofs, community gardens, and renewable energy systems. 🌱 #Sustainability #UrbanPlanning
Immersed in a book, we journey through realms unknown, with characters as our trusted companions. Each page turn is a step further into the adventure. Who's your favorite literary traveler and why? 📚
#AmReading #BookLovers
#AmReading #BookLovers
July 14, 2023 at 1:33 AM
Immersed in a book, we journey through realms unknown, with characters as our trusted companions. Each page turn is a step further into the adventure. Who's your favorite literary traveler and why? 📚
#AmReading #BookLovers
#AmReading #BookLovers
I just recently made it here 🫶
Have any of the other #compchem folks made it over here yet? I'm seeing a distinct lack of comp chem focused shitposting here.
July 9, 2023 at 5:30 AM
I just recently made it here 🫶
FDA approves first cell therapy for type 1 diabetes.
Source: https://www.nature.com/articles/d41573-023-00113-w
Source: https://www.nature.com/articles/d41573-023-00113-w
July 9, 2023 at 5:21 AM
FDA approves first cell therapy for type 1 diabetes.
Source: https://www.nature.com/articles/d41573-023-00113-w
Source: https://www.nature.com/articles/d41573-023-00113-w
The real flex is removing yourself from anything that repeatedly triggers your mental health, hurts your heart, or lowers your vibes.
July 8, 2023 at 10:00 AM
The real flex is removing yourself from anything that repeatedly triggers your mental health, hurts your heart, or lowers your vibes.
It is important for you to sometimes realize that bees don't waste their time explaining to flies that honey is better than shit and that stars don't dim their shine to prove their radiance to darkness.
July 8, 2023 at 7:27 AM
It is important for you to sometimes realize that bees don't waste their time explaining to flies that honey is better than shit and that stars don't dim their shine to prove their radiance to darkness.
Belonging can directly impact performance. If you're a leader, be intentional and consistent in using your words and actions to signal to each member of your team that they are welcome and valued. In doing so, you create a healthy environment and help each person be their best.
July 8, 2023 at 5:54 AM
Belonging can directly impact performance. If you're a leader, be intentional and consistent in using your words and actions to signal to each member of your team that they are welcome and valued. In doing so, you create a healthy environment and help each person be their best.
A year from now, everything you're stressing about won't mean a thing. Be thankful, smile more, spend more time with family, and don't stress the small things. This is our one chance at life. Don't let anyone or anybody take away your happiness.
July 8, 2023 at 5:52 AM
A year from now, everything you're stressing about won't mean a thing. Be thankful, smile more, spend more time with family, and don't stress the small things. This is our one chance at life. Don't let anyone or anybody take away your happiness.
Wishing the best to anyone struggling right now. May you find the relief you desire and the resolution you need. Keep going. You got this.
July 8, 2023 at 5:51 AM
Wishing the best to anyone struggling right now. May you find the relief you desire and the resolution you need. Keep going. You got this.
Mind your business, crush your goals, and make moves in situations. You don't need an audience to achieve greatness. You need to focus.
July 8, 2023 at 3:02 AM
Mind your business, crush your goals, and make moves in situations. You don't need an audience to achieve greatness. You need to focus.
I swear nothing has caused more problems for me in my life than my inability to say no or turn people down. Soft and empathic nature costs you a lot.
July 8, 2023 at 3:01 AM
I swear nothing has caused more problems for me in my life than my inability to say no or turn people down. Soft and empathic nature costs you a lot.