📢The Zheng Lab @hms-bcmp.bsky.social is recruiting a Postdoctoral Fellow in organic chemistry & chemical biology to develop covalent chemistry and cancer therapeutics.

🔬Website: sites.harvard.edu/zheng/
📧Contact: qinheng_zheng@hms.harvard.edu
Apply via👉 academicpositions.harvard.edu/postings/15510

🧵[1/10] A busy week for K-Ras! We reported three stories on covalent, mutant-selective targeting of oncogenic K-Ras mutations @pubs.acs.org. Covalent chemistry has been key in drugging this once “undruggable” GTPase. Sotorasib and adagrasib are the only approved therapeutics for K-Ras(G12C).

Now online in Cancer Discovery: Restoration of the Tumor Suppressor Function of Y220C-Mutant #p53 by Rezatapopt, a Small Molecule Reactivator - by @PuzioKuter, Lizhong Xu, Masha Poyurovsky, and colleagues doi.org/10.1158/2159...