Most nematodes don't have piRNAs?!!
January 24, 2026 at 2:47 PM
Most nematodes don't have piRNAs?!!
This is really interesting. Tony Blair condemned Saddam Hussein's execution publicly. Was this genuine or was he perhaps happy with it behind the scenes? If he was genuinely opposed, what would he have preferred? UN trial might not have gone the way he would have wanted.
NEW EPISODE OUT NOW!
For the final episode in this series David talks to historian & political scientist Glen Rangwala about the trial and execution of Saddam Hussein in 2006. What plans did the Americans have for Saddam before the Iraq war began? Was justice served?
Find us at...🎧 ppfideas.com
For the final episode in this series David talks to historian & political scientist Glen Rangwala about the trial and execution of Saddam Hussein in 2006. What plans did the Americans have for Saddam before the Iraq war began? Was justice served?
Find us at...🎧 ppfideas.com
January 24, 2026 at 2:33 PM
This is really interesting. Tony Blair condemned Saddam Hussein's execution publicly. Was this genuine or was he perhaps happy with it behind the scenes? If he was genuinely opposed, what would he have preferred? UN trial might not have gone the way he would have wanted.
the current Greenland thing shows that fawning to Trump like Starmer has been doing is totally pointless as well as degrading.
It's time to stop subservience to Donald Trump.
And that starts with questions about how to stop US bases on UK soil and maintain our national security.
www.lbc.co.uk/article/subs...
And that starts with questions about how to stop US bases on UK soil and maintain our national security.
www.lbc.co.uk/article/subs...
'We need to stop our subservience to Trump': Zack Polanski questions US military bases on UK soil amid tariff threat | LBC
Donald Trump repeatedly said the US
www.lbc.co.uk
January 18, 2026 at 7:14 PM
the current Greenland thing shows that fawning to Trump like Starmer has been doing is totally pointless as well as degrading.
Reposted by Peter Sarkies
Check out our latest study on the PfRIPR protein,
essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.
essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.
January 18, 2026 at 6:21 PM
Check out our latest study on the PfRIPR protein,
essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.
essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.
Reposted by Peter Sarkies
Epimutations: raw material for evolution?
Nabeel Ganem & @psarkies.bsky.social explore how epimutations mediating transgenerational epigenetic inheritance compare to DNA sequence mutations w.r.t. influence on drift and natural selection
link.springer.com/article/10.1...
Nabeel Ganem & @psarkies.bsky.social explore how epimutations mediating transgenerational epigenetic inheritance compare to DNA sequence mutations w.r.t. influence on drift and natural selection
link.springer.com/article/10.1...
Epimutations: raw material for evolution? - The EMBO Journal
Epigenetics is fundamental to cell differentiation as it enables cells with identical genomes to adopt distinct fates. Some epigenetic information can also be transmitted between generations, in a pro...
link.springer.com
January 16, 2026 at 10:33 AM
Epimutations: raw material for evolution?
Nabeel Ganem & @psarkies.bsky.social explore how epimutations mediating transgenerational epigenetic inheritance compare to DNA sequence mutations w.r.t. influence on drift and natural selection
link.springer.com/article/10.1...
Nabeel Ganem & @psarkies.bsky.social explore how epimutations mediating transgenerational epigenetic inheritance compare to DNA sequence mutations w.r.t. influence on drift and natural selection
link.springer.com/article/10.1...
Incredibly cool- a must read!
Interested in the unexpected? How about a link between piRNAs and maternal histone mRNAs … Great collab with @sebastianfalk.bsky.social, @koenig-lab.bsky.social and Florian Steiner.
#piRNA #histone #mRNA #maternal #RNAbiology #RNASky
www.biorxiv.org/content/10.6...
#piRNA #histone #mRNA #maternal #RNAbiology #RNASky
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 8, 2026 at 4:48 PM
Incredibly cool- a must read!
don't miss this! will be very interesting
Oded Rechavi is presenting a Night Science Seminar next week about transgenerational epigenetic inheritance and his process of discovery! He will also talk about his influence on science communication & academia in general.
Free registration: cassyni.com/events/TjxgV...
@odedrechavi.bsky.social
Free registration: cassyni.com/events/TjxgV...
@odedrechavi.bsky.social
January 8, 2026 at 4:44 PM
don't miss this! will be very interesting
Need a bit of escapism? Not exactly Lord of the Rings, but in similar vein:
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Epimutations: raw material for evolution? - The EMBO Journal
Epigenetics is fundamental to cell differentiation as it enables cells with identical genomes to adopt distinct fates. Some epigenetic information can also be transmitted between generations, in a pro...
link.springer.com
January 6, 2026 at 6:33 PM
Need a bit of escapism? Not exactly Lord of the Rings, but in similar vein:
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Worth a read.
In my opinion possibly the only thing worse than humans recklessly driving a species to extinction is for us to attempt to bring it back- likely to be a vanity project with huge potential for cruelty and harm.
www.cell.com/trends/genet...
In my opinion possibly the only thing worse than humans recklessly driving a species to extinction is for us to attempt to bring it back- likely to be a vanity project with huge potential for cruelty and harm.
www.cell.com/trends/genet...
If we could turn back time
De-extinction critiques focus on animal welfare, ecosystem disruption, threats to
traditional conservation, and anxiety about human hubris. Respondents argue that humanity
is obligated to reverse dama...
www.cell.com
January 5, 2026 at 6:23 PM
Worth a read.
In my opinion possibly the only thing worse than humans recklessly driving a species to extinction is for us to attempt to bring it back- likely to be a vanity project with huge potential for cruelty and harm.
www.cell.com/trends/genet...
In my opinion possibly the only thing worse than humans recklessly driving a species to extinction is for us to attempt to bring it back- likely to be a vanity project with huge potential for cruelty and harm.
www.cell.com/trends/genet...
Reposted by Peter Sarkies
On BBC News today: striking that it’s the two old establishment parties - Labour and the Conservatives - refusing to condemn the US breaking international law and doing what it wants.
Feels like politics stuck in the past, while the public has clearly moved on.
Feels like politics stuck in the past, while the public has clearly moved on.
January 5, 2026 at 12:43 PM
On BBC News today: striking that it’s the two old establishment parties - Labour and the Conservatives - refusing to condemn the US breaking international law and doing what it wants.
Feels like politics stuck in the past, while the public has clearly moved on.
Feels like politics stuck in the past, while the public has clearly moved on.
Reposted by Peter Sarkies
Starmer and Farage both drape themselves in flags but once again it's really clear where their loyalty really is.
It's Trump first. They will always be on the side of the super rich and powerful - no matter how heinous the crime.
This is not patriotism. It's subservience.
It's Trump first. They will always be on the side of the super rich and powerful - no matter how heinous the crime.
This is not patriotism. It's subservience.
January 3, 2026 at 9:35 PM
Starmer and Farage both drape themselves in flags but once again it's really clear where their loyalty really is.
It's Trump first. They will always be on the side of the super rich and powerful - no matter how heinous the crime.
This is not patriotism. It's subservience.
It's Trump first. They will always be on the side of the super rich and powerful - no matter how heinous the crime.
This is not patriotism. It's subservience.
Reposted by Peter Sarkies
Whatever you might think of Maduro, the seizure and kidnapping of a head of state takes us to a very dark place. Vast, arbitrary, extra-legal power, which could be exercised almost anywhere, regardless of the character of the target government.
January 3, 2026 at 10:14 AM
Whatever you might think of Maduro, the seizure and kidnapping of a head of state takes us to a very dark place. Vast, arbitrary, extra-legal power, which could be exercised almost anywhere, regardless of the character of the target government.
Great to contribute in a small way to this study on the evolution of piRNA biogenesis in nematodes from @reneketting.bsky.social lab. GTSF-1 is preserved in many nematodes despite absence of piRNAs- it has evolved an alternative function in RNAi through RdRP interaction.
What a way to start the new year with one more submission to BioRxiv. This one is on how GTSF-1 enable RdRP activity in nematodes (for Piwi aficionados: correct, it does not affect Piwi😊)
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
An Evolutionarily Conserved N-terminal Domain of RRF-3 Governs GTSF-1 Binding in Nematodes
GTSF1 is an essential activating cofactor for PIWI proteins in many metazoans. In the nematode Caenorhabditis elegans, however, GTSF-1 does not bind PIWI, but associates with the RNA-dependent RNA pol...
www.biorxiv.org
January 4, 2026 at 3:13 PM
Great to contribute in a small way to this study on the evolution of piRNA biogenesis in nematodes from @reneketting.bsky.social lab. GTSF-1 is preserved in many nematodes despite absence of piRNAs- it has evolved an alternative function in RNAi through RdRP interaction.
RIP international law.
Spray paint a plane and they'll detain you without trial and call you a terrorist.
Kidnap a foreign head of state - and Keir Starmer will make it clear we've played no part in it but will wait for the scheduled press conference in a few hours before potentially condemning it
Kidnap a foreign head of state - and Keir Starmer will make it clear we've played no part in it but will wait for the scheduled press conference in a few hours before potentially condemning it
January 3, 2026 at 10:23 PM
RIP international law.
No cheating, reskeet with the most recent photo of your pet.
January 2, 2026 at 8:02 AM
Nibbler or Trimmer?
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Wigan pie-eating champion polishes off pie in 64 seconds
Tom O'Neil is crowned pie-eating champion after the annual contest in Wigan, Greater Manchester.
www.bbc.co.uk
December 20, 2025 at 8:20 AM
Nibbler or Trimmer?
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Very exciting to see this published- opens lots of real interesting possibilities about how memory works!
And here's the report @qedscience.bsky.social generated for our new paper, summarizing what's new and what was already known before. I'm planning to submit q.e.d's reports as cover letters together with my pre-prints from now on (and so should you!)
December 19, 2025 at 8:37 AM
Very exciting to see this published- opens lots of real interesting possibilities about how memory works!
Truly a great meeting with so many highlights- thanks to @embo.org and all organisers for inspiring science program!
Four days of great science, fun interactions, and breathtaking views at #EMBOevoChromo25 in San Feliu 🇪🇸
BIG THX to organizers @arnausebe.bsky.social @tobiaswarnecke.bsky.social & co @levine-lab.bsky.social @sandraduharcourt.bsky.social Nick Irwin 🙏👌
BIG THX to organizers @arnausebe.bsky.social @tobiaswarnecke.bsky.social & co @levine-lab.bsky.social @sandraduharcourt.bsky.social Nick Irwin 🙏👌
December 12, 2025 at 9:36 PM
Truly a great meeting with so many highlights- thanks to @embo.org and all organisers for inspiring science program!
Reposted by Peter Sarkies
Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR
UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6
Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...
rdcu.be
December 9, 2025 at 1:21 PM
Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR
I had heard of the trial of Lady Chatterley's Lover but had no idea of the details. The whole case is so strange it's amazing it took place during my parents' lifetime- today DH Lawrence would not be considered even edgy let alone obscene. Fascinating episode.
NEW EPISODE OUT NOW!
Today we return to our series about epoch-making trials with the case of the book they tried & failed to ban. In 1960 Penguin Books was prosecuted over its plans to produce a cheap, unexpurgated edition of DH Lawrence’s 'Lady Chatterley’s Lover.'
Find us at...🎧 ppfideas.com
Today we return to our series about epoch-making trials with the case of the book they tried & failed to ban. In 1960 Penguin Books was prosecuted over its plans to produce a cheap, unexpurgated edition of DH Lawrence’s 'Lady Chatterley’s Lover.'
Find us at...🎧 ppfideas.com
December 7, 2025 at 2:46 PM
I had heard of the trial of Lady Chatterley's Lover but had no idea of the details. The whole case is so strange it's amazing it took place during my parents' lifetime- today DH Lawrence would not be considered even edgy let alone obscene. Fascinating episode.
RIP Tom Stoppard. Forever with Rosencrantz and Guildenstern now.
November 29, 2025 at 6:54 PM
RIP Tom Stoppard. Forever with Rosencrantz and Guildenstern now.
Great seminar in @oxfordbiochemistry.bsky.social today from Laura Landweber on the awesome world of ciliate DNA elimination- so many different gene regulation/repair pathways come together to achieve this remarkable feat
November 28, 2025 at 9:36 PM
Great seminar in @oxfordbiochemistry.bsky.social today from Laura Landweber on the awesome world of ciliate DNA elimination- so many different gene regulation/repair pathways come together to achieve this remarkable feat
baffled that Black Friday deals seem to have spread to companies selling PCR reagents.
November 27, 2025 at 6:54 PM
baffled that Black Friday deals seem to have spread to companies selling PCR reagents.
I’m fairly sure we don’t have to go back to Farage’s schooldays to find evidence of racism.
November 25, 2025 at 10:38 PM
I’m fairly sure we don’t have to go back to Farage’s schooldays to find evidence of racism.
Reposted by Peter Sarkies
Climate change affects EVERYTHING. It’s mad that the issue has become left-coded when it should be just reality-coded
Climate change is a kitchen table issue. For most people a home is their largest investment, when climate change depresses their property values or makes their home uninsurable, it's a huge economic hit.
Rising Home Insurance Premiums Are Eating Into Home Values in Disaster-Prone Areas
Changes in the insurance market have started to affect home prices in the most disaster-prone areas, new research finds, pushing some homeowners’ finances to the breaking point.
www.nytimes.com
November 19, 2025 at 5:37 PM
Climate change affects EVERYTHING. It’s mad that the issue has become left-coded when it should be just reality-coded