practiCal fMRI
@practicalfmri.bsky.social
practicalfmri.blogspot.com
www.youtube.com/@practiCalfMRI
www.youtube.com/@practiCalfMRI
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Transcranial focused ultrasound (tFUS) for neuromodulation: What's the role of blood vessels?
The mechanisms behind transcranial focused ultrasound (tFUS) for neuromodulation remain elusive. There are several hypotheses, but conflicti...
practicalfmri.blogspot.com
Transcranial focused ultrasound (tFUS) for neuromodulation: What's the role of blood vessels?
practicalfmri.blogspot.com/2026/01/tran...
practicalfmri.blogspot.com/2026/01/tran...
Reposted by practiCal fMRI
Pre-movement respiration-action coupling is specific to self-initiated action: Evidence for action alignment with ongoing breathing https://www.biorxiv.org/content/10.64898/2026.02.05.704105v1
February 9, 2026 at 7:15 PM
Pre-movement respiration-action coupling is specific to self-initiated action: Evidence for action alignment with ongoing breathing https://www.biorxiv.org/content/10.64898/2026.02.05.704105v1
Reposted by practiCal fMRI
Neuronavigation-free and MRI-free Localization of Deep Brain Targets https://www.biorxiv.org/content/10.64898/2026.02.04.703768v1
February 7, 2026 at 4:15 AM
Neuronavigation-free and MRI-free Localization of Deep Brain Targets https://www.biorxiv.org/content/10.64898/2026.02.04.703768v1
Reposted by practiCal fMRI
Multi-echo BOLD fMRI improves cerebrovascular reactivity estimates in stroke https://www.biorxiv.org/content/10.64898/2026.02.03.703581v1
February 6, 2026 at 5:15 AM
Multi-echo BOLD fMRI improves cerebrovascular reactivity estimates in stroke https://www.biorxiv.org/content/10.64898/2026.02.03.703581v1
More fMRI work at 5 T. The natural replacement for 3 T research scanners in future…?
Accessible and reproducible mesoscale fMRI at 5.0 T: A Pulseq-based open framework for human laminar mapping https://www.biorxiv.org/content/10.64898/2026.02.03.703466v1
February 6, 2026 at 2:38 AM
More fMRI work at 5 T. The natural replacement for 3 T research scanners in future…?
"The hemo-neural hypothesis: on the role of blood flow in information processing."
A classic paper I've only recently discovered! The fMRI crowd should give it a read.
pubmed.ncbi.nlm.nih.gov/17913979/
A classic paper I've only recently discovered! The fMRI crowd should give it a read.
pubmed.ncbi.nlm.nih.gov/17913979/
The hemo-neural hypothesis: on the role of blood flow in information processing - PubMed
Brain vasculature is a complex and interconnected network under tight regulatory control that exists in intimate communication with neurons and glia. Typically, hemodynamics are considered to exclusively serve as a metabolic support system. In contrast to this canonical view, we propose that hemodyn …
pubmed.ncbi.nlm.nih.gov
February 6, 2026 at 12:58 AM
"The hemo-neural hypothesis: on the role of blood flow in information processing."
A classic paper I've only recently discovered! The fMRI crowd should give it a read.
pubmed.ncbi.nlm.nih.gov/17913979/
A classic paper I've only recently discovered! The fMRI crowd should give it a read.
pubmed.ncbi.nlm.nih.gov/17913979/
Found this late, but better late than never!
Blood pressure pulsations modulate central neuronal
activity via mechanosensitive ion channels
pubmed.ncbi.nlm.nih.gov/38301001/
Blood pressure pulsations modulate central neuronal
activity via mechanosensitive ion channels
pubmed.ncbi.nlm.nih.gov/38301001/
Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels - PubMed
The transmission of the heartbeat through the cerebral vascular system causes intracranial pressure pulsations. We discovered that arterial pressure pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, vascular pressure pulsations elicited correlated lo …
pubmed.ncbi.nlm.nih.gov
February 3, 2026 at 3:50 AM
Found this late, but better late than never!
Blood pressure pulsations modulate central neuronal
activity via mechanosensitive ion channels
pubmed.ncbi.nlm.nih.gov/38301001/
Blood pressure pulsations modulate central neuronal
activity via mechanosensitive ion channels
pubmed.ncbi.nlm.nih.gov/38301001/
Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity
pubmed.ncbi.nlm.nih.gov/40328963/
pubmed.ncbi.nlm.nih.gov/40328963/
Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity - PubMed
The variation of heart rate in phase with breathing, known as 'respiratory sinus arrhythmia' (RSA), is a physiological phenomenon present in all air-breathing vertebrates. RSA arises from the interaction of several physiological mechanisms but is primarily mediated by rhythmic changes in cardiac par …
pubmed.ncbi.nlm.nih.gov
February 3, 2026 at 3:03 AM
Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity
pubmed.ncbi.nlm.nih.gov/40328963/
pubmed.ncbi.nlm.nih.gov/40328963/
Reposted by practiCal fMRI
New article with some legendary marine mammal research vets - we make the case for opportunistic, developmental studies of naturally occurring maternal exposure to algal neurotoxins in sea lions.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
February 2, 2026 at 6:46 PM
New article with some legendary marine mammal research vets - we make the case for opportunistic, developmental studies of naturally occurring maternal exposure to algal neurotoxins in sea lions.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
“These findings suggest that the MNI152 template does not reflect the average morphology of contemporary population samples and that linear registration alone cannot resolve these discrepancies. Therefore, more robust and unbiased template-generation pipelines may be necessary….”
Morphological bias of the MNI152 brain https://www.biorxiv.org/content/10.64898/2026.01.24.701532v1
January 29, 2026 at 5:37 PM
“These findings suggest that the MNI152 template does not reflect the average morphology of contemporary population samples and that linear registration alone cannot resolve these discrepancies. Therefore, more robust and unbiased template-generation pipelines may be necessary….”
Reposted by practiCal fMRI
Morphological bias of the MNI152 brain https://www.biorxiv.org/content/10.64898/2026.01.24.701532v1
January 29, 2026 at 2:15 PM
Morphological bias of the MNI152 brain https://www.biorxiv.org/content/10.64898/2026.01.24.701532v1
Reposted by practiCal fMRI
I don't know if this was well known, but NMR/MRS icon and NAS fellow Bob Shulman (middle) passed away a couple of weeks ago at the age of 101. He was the mentor of my mentors (left and right), so I suppose my grand mentor. Scientists like him are unlikely to be found ever again in this day and age
January 28, 2026 at 10:17 PM
I don't know if this was well known, but NMR/MRS icon and NAS fellow Bob Shulman (middle) passed away a couple of weeks ago at the age of 101. He was the mentor of my mentors (left and right), so I suppose my grand mentor. Scientists like him are unlikely to be found ever again in this day and age
Reposted by practiCal fMRI
Electro-Calcium uncoupling precedes neurodegeneration in Alzheimers disease https://www.biorxiv.org/content/10.64898/2026.01.26.701803v1
January 27, 2026 at 10:15 PM
Electro-Calcium uncoupling precedes neurodegeneration in Alzheimers disease https://www.biorxiv.org/content/10.64898/2026.01.26.701803v1
Reposted by practiCal fMRI
The mood stabilizer lithium alters behaviour and physiology via the gut brain axis. https://www.biorxiv.org/content/10.64898/2026.01.26.701868v1
January 27, 2026 at 7:15 PM
The mood stabilizer lithium alters behaviour and physiology via the gut brain axis. https://www.biorxiv.org/content/10.64898/2026.01.26.701868v1
Reposted by practiCal fMRI
This one was a long time in the making! Written with my great colleagues Heidi Harley and Gordon Bauer, and a host of people game enough to engage with us on cognition and marine mammal conservation at a special 2022 Marine Mammal Society workshop.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Exploring Marine Mammal Cognition as a Conservation Tool
Cognition is an animal's real-time adaptation system for responding to change. Rapid environmental change, often anthropogenic, is expanding the range and severity of challenges confronting wild anim...
onlinelibrary.wiley.com
January 27, 2026 at 12:28 PM
This one was a long time in the making! Written with my great colleagues Heidi Harley and Gordon Bauer, and a host of people game enough to engage with us on cognition and marine mammal conservation at a special 2022 Marine Mammal Society workshop.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Rotational ultrasound and photoacoustic tomography of the human body
www.nature.com/articles/s41...
pubmed.ncbi.nlm.nih.gov/41545778/
scitechdaily.com/scientists-d...
www.nature.com/articles/s41...
pubmed.ncbi.nlm.nih.gov/41545778/
scitechdaily.com/scientists-d...
Rotational ultrasound and photoacoustic tomography of the human body - Nature Biomedical Engineering
Fast panoramic rotational ultrasound tomography and photoacoustic tomography are integrated for hybrid rotational ultrasound and photoacoustic tomography, for three-dimensional dual-contrast imaging o...
www.nature.com
January 27, 2026 at 4:10 PM
Rotational ultrasound and photoacoustic tomography of the human body
www.nature.com/articles/s41...
pubmed.ncbi.nlm.nih.gov/41545778/
scitechdaily.com/scientists-d...
www.nature.com/articles/s41...
pubmed.ncbi.nlm.nih.gov/41545778/
scitechdaily.com/scientists-d...
Vascular smooth muscle cell loss, but not neuroinflammation, drives cerebrovascular reactivity impairment in Alzheimer's disease
pubmed.ncbi.nlm.nih.gov/41573926/
pubmed.ncbi.nlm.nih.gov/41573926/
Vascular smooth muscle cell loss, but not neuroinflammation, drives cerebrovascular reactivity impairment in Alzheimer's disease - PubMed
Cerebrovascular reactivity (CVR) impairment occurred in 5xFAD mice only when vascular smooth muscle cell (VSMC) loss was present5xFAD mice exhibited prominent parenchymal but minimal vascular amyloid-β depositionVSMC developmental deficiency resulted in CVR impairment in a small-vessel disease (SVD) …
pubmed.ncbi.nlm.nih.gov
January 26, 2026 at 3:14 PM
Vascular smooth muscle cell loss, but not neuroinflammation, drives cerebrovascular reactivity impairment in Alzheimer's disease
pubmed.ncbi.nlm.nih.gov/41573926/
pubmed.ncbi.nlm.nih.gov/41573926/
Is the World Cup still on? Are any fans still planning to attend?
January 25, 2026 at 4:19 PM
Is the World Cup still on? Are any fans still planning to attend?
Reposted by practiCal fMRI
Postdoc position to work on neuroimaging methods with @fmri-today.bsky.social (and me) fim.nimh.nih.gov/positions-av...
Positions Available
This is the webpage for the Section on Functional Imaging Methods at the National Institute of Mental Health.
fim.nimh.nih.gov
January 21, 2026 at 10:09 PM
Postdoc position to work on neuroimaging methods with @fmri-today.bsky.social (and me) fim.nimh.nih.gov/positions-av...
So I wasn't expecting to experience mild relief after laughing my ***s off after today's "presser." Having the clown represent the circus does at least ensure European leaders finally wake up to reality. The clown's deranged but the rest of the circus are worse. They really mean it!
January 20, 2026 at 11:03 PM
So I wasn't expecting to experience mild relief after laughing my ***s off after today's "presser." Having the clown represent the circus does at least ensure European leaders finally wake up to reality. The clown's deranged but the rest of the circus are worse. They really mean it!
Remember when we all used to chuckle at Kim Jong Un as the world's biggest clown supreme leader? Ah, the nostalgia.
January 20, 2026 at 5:23 AM
Remember when we all used to chuckle at Kim Jong Un as the world's biggest clown supreme leader? Ah, the nostalgia.
Greenland is closer to Canada than the US. 11th Canadian province? And then what about Alaska? It's bolted to Canada FFS. Surely AK should become another part of Canada, too!
January 18, 2026 at 4:34 PM
Greenland is closer to Canada than the US. 11th Canadian province? And then what about Alaska? It's bolted to Canada FFS. Surely AK should become another part of Canada, too!
I wonder when the European countries (including the UK) will decide to stand up to the bully. Hit Americans where it hurts.... in the stock market. Mobsters only understand mob tactics.
This weekend would be a perfect time for the EU to announce a new investigation into Apple, Google and Meta’s data privacy compliance, on NATSEC grounds. Let’s see what their share prices do….
January 18, 2026 at 12:46 AM
I wonder when the European countries (including the UK) will decide to stand up to the bully. Hit Americans where it hurts.... in the stock market. Mobsters only understand mob tactics.
"fus Forward" podcast, on focused ultrasound for neuromodulation and related issues/methods.
I found it a couple of months late but it's totally worth the wait. It's very good.
open.spotify.com/show/74NQ4qV...
podcasts.apple.com/us/podcast/f...
I found it a couple of months late but it's totally worth the wait. It's very good.
open.spotify.com/show/74NQ4qV...
podcasts.apple.com/us/podcast/f...
Spotify – Web Player
open.spotify.com
January 18, 2026 at 12:36 AM
"fus Forward" podcast, on focused ultrasound for neuromodulation and related issues/methods.
I found it a couple of months late but it's totally worth the wait. It's very good.
open.spotify.com/show/74NQ4qV...
podcasts.apple.com/us/podcast/f...
I found it a couple of months late but it's totally worth the wait. It's very good.
open.spotify.com/show/74NQ4qV...
podcasts.apple.com/us/podcast/f...
I gave it a speed read. Local motion effects? Certainly I see the optic nerves wiggling like worms in EPI time series data. And in the brain I wonder if they're seeing changes in arterial compliance (vasodilation), the first step in the functional hyperemia chain, perhaps. I'll watch and wait.
Another new way to do direct neural activity imaging...? This paper just hit my inbox belatedly. Anyone read it? I'll try to give it a read over the next week or two.
pubmed.ncbi.nlm.nih.gov/39259483/
pubmed.ncbi.nlm.nih.gov/39259483/
Functional conductivity imaging: quantitative mapping of brain activity - PubMed
Theory and modelling suggest that detection of neuronal activity may be feasible using phase sensitive MRI methods. Successful detection of neuronal activity both in vitro and in vivo has been described while others have reported negative results. Magnetic resonance electrical properties tomography …
pubmed.ncbi.nlm.nih.gov
January 14, 2026 at 7:55 PM
I gave it a speed read. Local motion effects? Certainly I see the optic nerves wiggling like worms in EPI time series data. And in the brain I wonder if they're seeing changes in arterial compliance (vasodilation), the first step in the functional hyperemia chain, perhaps. I'll watch and wait.
Another new way to do direct neural activity imaging...? This paper just hit my inbox belatedly. Anyone read it? I'll try to give it a read over the next week or two.
pubmed.ncbi.nlm.nih.gov/39259483/
pubmed.ncbi.nlm.nih.gov/39259483/
Functional conductivity imaging: quantitative mapping of brain activity - PubMed
Theory and modelling suggest that detection of neuronal activity may be feasible using phase sensitive MRI methods. Successful detection of neuronal activity both in vitro and in vivo has been described while others have reported negative results. Magnetic resonance electrical properties tomography …
pubmed.ncbi.nlm.nih.gov
January 14, 2026 at 4:42 PM
Another new way to do direct neural activity imaging...? This paper just hit my inbox belatedly. Anyone read it? I'll try to give it a read over the next week or two.
pubmed.ncbi.nlm.nih.gov/39259483/
pubmed.ncbi.nlm.nih.gov/39259483/