PLMcCarthyBuffalo
@plmbuffalo.bsky.social
Translational Hematology Oncology Investigator, Roswell Park Comprehensive Cancer Center, Buffalo, NY
Chimeric antigen receptor T cells against the IGHV4-34 B cell receptor specifically eliminate neoplastic and autoimmune B cells | Science Translational Medicine www.science.org/doi/10.1126/...
Chimeric antigen receptor T cells against the IGHV4-34 B cell receptor specifically eliminate neoplastic and autoimmune B cells
CAR T cells against the IGHV4-34 B cell receptor specifically target pathogenic B cells in both lymphoproliferative neoplasms and lupus.
www.science.org
February 5, 2026 at 1:08 PM
Chimeric antigen receptor T cells against the IGHV4-34 B cell receptor specifically eliminate neoplastic and autoimmune B cells | Science Translational Medicine www.science.org/doi/10.1126/...
Reposted by PLMcCarthyBuffalo
“I didn’t take the conventional approach. I decided to develop a new system for isolating antigens,” @roswellpark.bsky.social's Seon said in 2019. “It’s always been in my mind that hopefully someday I could find a new cancer drug, a better cancer drug.”
https://cancerletter.com/obituary/20260116_5/
https://cancerletter.com/obituary/20260116_5/
January 22, 2026 at 1:00 AM
“I didn’t take the conventional approach. I decided to develop a new system for isolating antigens,” @roswellpark.bsky.social's Seon said in 2019. “It’s always been in my mind that hopefully someday I could find a new cancer drug, a better cancer drug.”
https://cancerletter.com/obituary/20260116_5/
https://cancerletter.com/obituary/20260116_5/
Reposted by PLMcCarthyBuffalo
Congratulations to our very own Dr. Saeed Daneshmandi and Dr. Lisa Niswander for being selected by @ash.hematology.org to receive the ASH Scholar Award!
www.hematology.org/newsroom/pre...
#ASHAwards #Fight4Hematology
www.hematology.org/newsroom/pre...
#ASHAwards #Fight4Hematology
January 22, 2026 at 8:18 PM
Congratulations to our very own Dr. Saeed Daneshmandi and Dr. Lisa Niswander for being selected by @ash.hematology.org to receive the ASH Scholar Award!
www.hematology.org/newsroom/pre...
#ASHAwards #Fight4Hematology
www.hematology.org/newsroom/pre...
#ASHAwards #Fight4Hematology
Inhaled nitric oxide at 300 ppm treats multidrug-resistant Pseudomonas pneumonia in swine and is safe in humans | Science Translational Medicine www.science.org/doi/10.1126/...
Inhaled nitric oxide at 300 ppm treats multidrug-resistant Pseudomonas pneumonia in swine and is safe in humans
A swine and human study shows that treating multidrug-resistant Pseudomonas aeruginosa pneumonia with inhaled high-dose nitric oxide is safe.
www.science.org
January 23, 2026 at 1:17 PM
Inhaled nitric oxide at 300 ppm treats multidrug-resistant Pseudomonas pneumonia in swine and is safe in humans | Science Translational Medicine www.science.org/doi/10.1126/...
CXCR2 chemokine receptor – a master regulator in cancer and physiology: Trends in Molecular Medicine www.cell.com/trends/molec...
CXCR2 chemokine receptor – a master regulator in cancer and physiology
Recent findings have modified our understanding of the roles of chemokine receptor
CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific
knockout mice show that...
www.cell.com
January 18, 2026 at 1:46 AM
CXCR2 chemokine receptor – a master regulator in cancer and physiology: Trends in Molecular Medicine www.cell.com/trends/molec...
High-risk genomic consensus validation for patients with newly diagnosed multiple myeloma using next-generation sequencing url: ashpublications.org/blood/articl...
High-risk genomic consensus validation for patients with newly diagnosed multiple myeloma using next-generation sequencing
Key PointsAccording to the Consensus Genomic Staging, 22.4% of patients are classified as high risk (excluding β2-microglobulin criterion).
ashpublications.org
January 16, 2026 at 1:12 AM
High-risk genomic consensus validation for patients with newly diagnosed multiple myeloma using next-generation sequencing url: ashpublications.org/blood/articl...
Reposted by PLMcCarthyBuffalo
Prime ribs are just like regular ribs except they’re only divisible by themselves.
February 5, 2024 at 5:43 PM
Prime ribs are just like regular ribs except they’re only divisible by themselves.
Targeting STK17B kinase activates ferroptosis and suppresses drug resistance in multiple myeloma url: ashpublications.org/blood/articl...
Targeting STK17B kinase activates ferroptosis and suppresses drug resistance in multiple myeloma
Key PointsSTK17B phosphorylates key regulators of iron homeostasis, thereby controlling an equilibrium between pro- and antiferroptotic proteins.Pharmacolo
ashpublications.org
January 4, 2026 at 3:01 AM
Targeting STK17B kinase activates ferroptosis and suppresses drug resistance in multiple myeloma url: ashpublications.org/blood/articl...
Targeting STK17B: unlocking ferroptosis in myeloma url: ashpublications.org/blood/articl...
Targeting STK17B: unlocking ferroptosis in myeloma
In this issue of Blood, Yan et al1 identified that STK17B was highly expressed in multiple myeloma (MM) cells from relapsed and drug-resistant patients wit
ashpublications.org
January 4, 2026 at 3:00 AM
Targeting STK17B: unlocking ferroptosis in myeloma url: ashpublications.org/blood/articl...
Evolution of Multiple Myeloma from a Genomic Perspective url: ashpublications.org/blood/articl...
Evolution of Multiple Myeloma from a Genomic Perspective
In this review we explore the role of complex interactions between genomic evolution, environmental and genetic predispositions, and immune surveillance in
ashpublications.org
January 4, 2026 at 2:59 AM
Evolution of Multiple Myeloma from a Genomic Perspective url: ashpublications.org/blood/articl...
Orca-T versus allogeneic hematopoietic stem cell transplantation (PRECISION-T): a multicenter, randomized phase 3 trial url: ashpublications.org/blood/articl...
Orca-T versus allogeneic hematopoietic stem cell transplantation (PRECISION-T): a multicenter, randomized phase 3 trial
Key Points. In a randomized ph3 study, Orca-T significantly improved survival free cGVHD compared to conventional alloHSCT with Tac/MTX.In addition to lowe
ashpublications.org
January 4, 2026 at 2:58 AM
Orca-T versus allogeneic hematopoietic stem cell transplantation (PRECISION-T): a multicenter, randomized phase 3 trial url: ashpublications.org/blood/articl...
Selective depletion of B-cell subsets underlies increased risk of infection in MM patients treated with anti-BCMA vs -GPRC5D bsAbs url: ashpublications.org/blood/articl...
Selective depletion of B-cell subsets underlies increased risk of infection in MM patients treated with anti-BCMA vs -GPRC5D bsAbs
Key Points. While GPRC5D is highly expressed on tumor plasma cells and less on normal plasma cells, BCMA is detectable throughout the B-cell lineageIn cont
ashpublications.org
January 4, 2026 at 2:53 AM
Selective depletion of B-cell subsets underlies increased risk of infection in MM patients treated with anti-BCMA vs -GPRC5D bsAbs url: ashpublications.org/blood/articl...