Brandon Pickett
@pickettbd.bsky.social
Bioinformatics Postdoc at NHGRI/NIH. Posts are my own. He/him
Reposted by Brandon Pickett
This is the way
The "kitchen sink" of omics to solve the basis for an undiagnosed disease: long read genome , transcriptome, methytome, epigenome, all synchronized (a first)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synchronized long-read genome, methylome, epigenome and transcriptome profiling resolve a Mendelian condition - Nature Genetics
Simultaneous profiling of the genome, methylome, epigenome and transcriptome using single-molecule chromatin fiber sequencing and multiplexed arrays isoform sequencing identifies the genetic and molec...
www.nature.com
January 29, 2025 at 2:54 PM
This is the way
Reposted by Brandon Pickett
Congrats to Bryce Kille on absolutely smashing his PhD defense at Rice today with advisor @treangen.bsky.social ! Collaborating with Bryce over the past few years has been an absolute delight 👏🎉👏🎉
January 27, 2025 at 8:56 PM
Congrats to Bryce Kille on absolutely smashing his PhD defense at Rice today with advisor @treangen.bsky.social ! Collaborating with Bryce over the past few years has been an absolute delight 👏🎉👏🎉
Reposted by Brandon Pickett
We may have cut our last Canu release in 2024, but we are starting off 2025 with Verkko2! 🎉 Not only is it 4x faster than Verkko1, this version integrates Hi-C data for both phasing and scaffolding, enabling the automated assembly of acrocentric chromosomes! Preprint: www.biorxiv.org/content/10.1...
January 2, 2025 at 3:27 PM
We may have cut our last Canu release in 2024, but we are starting off 2025 with Verkko2! 🎉 Not only is it 4x faster than Verkko1, this version integrates Hi-C data for both phasing and scaffolding, enabling the automated assembly of acrocentric chromosomes! Preprint: www.biorxiv.org/content/10.1...
Reposted by Brandon Pickett
"The formation and propagation of human Robertsonian chromosomes" ROBs are the most common translocation in humans, approx. ~1 per 800 people. Last year we proposed a simple mechanism for ROB formation; This year we prove it by finishing some T2T! New preprint: www.biorxiv.org/content/10.1...
September 27, 2024 at 2:15 PM
"The formation and propagation of human Robertsonian chromosomes" ROBs are the most common translocation in humans, approx. ~1 per 800 people. Last year we proposed a simple mechanism for ROB formation; This year we prove it by finishing some T2T! New preprint: www.biorxiv.org/content/10.1...
Reposted by Brandon Pickett
Very happy to see the NIH director co-author this opinion piece. elifesciences.org/articles/102...
Point of View: Applied research won’t flourish without basic science
Three senior figures at the US National Institutes of Health explain why the agency remains committed to supporting basic science and research.
elifesciences.org
September 11, 2024 at 9:40 PM
Very happy to see the NIH director co-author this opinion piece. elifesciences.org/articles/102...
Genome assembly is difficult, but we reduce some of the mystery and barriers to entry (both w.r.t. knowledge and compute resources) by implementing our pipeline in Galaxy: www.nature.com/articles/s41...
Thanks to many, incl. @mikeschatz.bsky.social @aphillippy.bsky.social @arhie.bsky.social
Thanks to many, incl. @mikeschatz.bsky.social @aphillippy.bsky.social @arhie.bsky.social
Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy - Nature Bi...
Nature Biotechnology - Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy
www.nature.com
January 26, 2024 at 3:31 PM
Genome assembly is difficult, but we reduce some of the mystery and barriers to entry (both w.r.t. knowledge and compute resources) by implementing our pipeline in Galaxy: www.nature.com/articles/s41...
Thanks to many, incl. @mikeschatz.bsky.social @aphillippy.bsky.social @arhie.bsky.social
Thanks to many, incl. @mikeschatz.bsky.social @aphillippy.bsky.social @arhie.bsky.social
Reposted by Brandon Pickett
So we decided not to stop with human and have finished sex chromosomes for the great apes as well 🙊 They make for the prettiest dotplots, e.g. compare human Y vs. bonobo Y. So many palindromes! 📄 "The Complete Sequence and Comparative Analysis of Ape Sex Chromosomes" www.biorxiv.org/content/10.1...
December 2, 2023 at 6:23 PM
So we decided not to stop with human and have finished sex chromosomes for the great apes as well 🙊 They make for the prettiest dotplots, e.g. compare human Y vs. bonobo Y. So many palindromes! 📄 "The Complete Sequence and Comparative Analysis of Ape Sex Chromosomes" www.biorxiv.org/content/10.1...
Reposted by Brandon Pickett
"The p-Arms of Human Acrocentric Chromosomes Play by a Different Set of Rules" An excellent review by Brian McStay on these newly completed regions of the human genome and why you should care: www.annualreviews.org/doi/abs/10.1...
www.annualreviews.org
October 5, 2023 at 10:32 PM
"The p-Arms of Human Acrocentric Chromosomes Play by a Different Set of Rules" An excellent review by Brian McStay on these newly completed regions of the human genome and why you should care: www.annualreviews.org/doi/abs/10.1...
@danirabaiotti.bsky.social do I need to do anything special to become a contributor to the What’s Science feed? Still learning about how these work..
September 27, 2023 at 12:24 AM
@danirabaiotti.bsky.social do I need to do anything special to become a contributor to the What’s Science feed? Still learning about how these work..