Paul Bollyky
@pbollyky.bsky.social
Stanford University Infectious Disease Doc studying bacteriophages, bacterial infections, and innate immunity.
Biology
56%
Medicine
19%
Paul Bollyky
@pbollyky.bsky.social
· Jul 9
Check it out - phages seem to cross the placenta from mom to fetus! Check it out here: insight.jci.org/articles/vie...
Congrats to Jen Sequioia, Naomi Haddock and our terrific collaborators in the Winn Lab
Congrats to Jen Sequioia, Naomi Haddock and our terrific collaborators in the Winn Lab
Paul Bollyky
@pbollyky.bsky.social
· Jan 23
Very excited to see this preprint from @JasonAndrewsMD on a method using phages to detect environmental pathogens - this is a terrific idea
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Paul Bollyky
@pbollyky.bsky.social
· Jan 6
Randomized double-blind study on safety and tolerability of TP-102 phage cocktail in patients with infected and non-infected diabetic foot ulcers
The bacteriophage formulation TP-102 was tested in a phase I/IIa clinical trial and was well tolerated. No significant adverse events were observed, suggesting its therapeutic potential for bacterial infections in diabetic foot ulcers.
www.cell.com
Enjoyed reading these encouraging results from a new phage therapy trial in diabetic foot ulcers.
www.cell.com/med/abstract...
www.cell.com/med/abstract...
Paul Bollyky
@pbollyky.bsky.social
· Dec 11
We find JukA (formerly YaaW, WP_003137196.1) in 10 of our 80 CPA. With OMK01, The 10 Juk+ strains are resistant but so are 66 Juk- strains. The 4 susceptible strains are indeed Juk-. The association with Juk was non-significant.
Paul Bollyky
@pbollyky.bsky.social
· Dec 7
I'm thrilled to welcome our new class of Infectious Disease fellows to Stanford! We are so excited have such a talented group of physicians coming to join us next year.
Paul Bollyky
@pbollyky.bsky.social
· Dec 6
Thanks for these great questions Chase and for your interest in our work!
Paul Bollyky
@pbollyky.bsky.social
· Dec 6
Bacterial Receptors but Not Anti-Phage Defence Mechanisms Determine Host Range for a Pair of Pseudomonas aeruginosa Lytic Phages
Lytic bacteriophages (phage), viral predators of bacteria, offer a promising solution for treating bacterial infections. However, the narrow host range of phages limits the broad utility of individual...
www.biorxiv.org
In a recent pre-print, we used transposon mutagenic to identify the receptors for OMK01 and find that it indeed used flagella www.biorxiv.org/content/10.1...
Paul Bollyky
@pbollyky.bsky.social
· Dec 6
Bacterial Receptors but Not Anti-Phage Defence Mechanisms Determine Host Range for a Pair of Pseudomonas aeruginosa Lytic Phages
Lytic bacteriophages (phage), viral predators of bacteria, offer a promising solution for treating bacterial infections. However, the narrow host range of phages limits the broad utility of individual...
www.biorxiv.org
With closely related phages having distinct receptor usage patterns, we address this in figure 2 - we find that this is the case for several phages, suggesting that phages may switch receptors with some frequency.
Paul Bollyky
@pbollyky.bsky.social
· Dec 6
I would wonder what MOI was used in other studies with phikz and PA14. We used 100.
Paul Bollyky
@pbollyky.bsky.social
· Dec 4
Thank you!!
Paul Bollyky
@pbollyky.bsky.social
· Dec 2
Many thanks to our outstanding collaborators including Liz Burgener, Carlos Milla, and Niaz Banaei
Paul Bollyky
@pbollyky.bsky.social
· Dec 2
In this work, we describe a streamlined protocol for identifying cross-resistant phages and antibiotics, which we call complementarity grouping. Cocktails targeting 3 or more complementarity groups were effective vs >80% of P. aeruginosa isolates. Add a synergistic antibiotic and its >96%
Paul Bollyky
@pbollyky.bsky.social
· Dec 2
A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections - Nature Communications
The application of phage therapy for multidrug-resistant infections is mainly limited to personalized therapy due to the narrow host range of individual phages. Here, Kim et al. identify groups of pha...
www.nature.com
Excited to share our work on broadly effective phage-antibiotic cocktails. We report 4 cocktails that each work against 96% of 153 antibiotic resistant Pseudomonas isolates. Check it out here: www.nature.com/articles/s41... Congrats to Kevin Kim @KevinMinyo6651