Pablo Perez Lopez
@pabloplopez.bsky.social
🩺 UAM MD Y5 | 👥 Medical Student Leadership ACC | 🫀CNIC Student | 🗞️ SoMe Editor @escardio.bsky.social #CardioSky
#EHJCVI Number 1️⃣ 🏆👉 What’s the incremental value of CMR for risk stratification in non-dilated LV cardiomyopathy? 🫀🧲 Midwall LGE is a strong independent predictor of MAACE ⚠️ with an HR of 6.7 (1.33–33.67). More 👉 doi.org/10.1093/ehjc... #MedSky
December 31, 2025 at 5:00 PM
#EHJCVI Number 1️⃣ 🏆👉 What’s the incremental value of CMR for risk stratification in non-dilated LV cardiomyopathy? 🫀🧲 Midwall LGE is a strong independent predictor of MAACE ⚠️ with an HR of 6.7 (1.33–33.67). More 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI Number 2️⃣ 👉 What are the recommendations for multimodality imaging of the LA and LAA? 🫀📘 This new consensus highlights techniques 🔍, integration into prognostic evaluation 📊, and periprocedural imaging to optimize outcomes ⚙️ More 👉 doi.org/10.1093/ehjc... #MedSky
December 30, 2025 at 5:00 PM
#EHJCVI Number 2️⃣ 👉 What are the recommendations for multimodality imaging of the LA and LAA? 🫀📘 This new consensus highlights techniques 🔍, integration into prognostic evaluation 📊, and periprocedural imaging to optimize outcomes ⚙️ More 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI Number 3️⃣ 👉 What are the outcomes of non-ischaemic ring-like LGE on CMR? 🫀🧲 Although uncommon and non-specific across morpho-functional phenotypes, it is associated with genetic aetiologies 🧬 and a high burden of adverse outcomes ⚠️ 👉 doi.org/10.1093/ehjc... #MedSky
December 29, 2025 at 5:00 PM
#EHJCVI Number 3️⃣ 👉 What are the outcomes of non-ischaemic ring-like LGE on CMR? 🫀🧲 Although uncommon and non-specific across morpho-functional phenotypes, it is associated with genetic aetiologies 🧬 and a high burden of adverse outcomes ⚠️ 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI Number 4️⃣ 👉 What’s the prognostic value of the left AV coupling index in heart failure? 🫀📊 In patients with HF and LVEF <50%, LACI is independently associated with adverse events after adjustment for multiple factors (HR 1.77) ⚠️ More 👉 doi.org/10.1093/ehjc... #MedSky
December 28, 2025 at 5:00 PM
#EHJCVI Number 4️⃣ 👉 What’s the prognostic value of the left AV coupling index in heart failure? 🫀📊 In patients with HF and LVEF <50%, LACI is independently associated with adverse events after adjustment for multiple factors (HR 1.77) ⚠️ More 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI Number 5️⃣ 👉 What’s the effect of high-intensity statins on PCAT attenuation? 💊 They reduce PCAT attenuation in both statin-continued and statin-initiated patients 📉, in relation to LDL changes, after correction for CV risk factors 🫀 More 👉 doi.org/10.1093/ehjc... #MedSky
December 27, 2025 at 5:00 PM
#EHJCVI Number 5️⃣ 👉 What’s the effect of high-intensity statins on PCAT attenuation? 💊 They reduce PCAT attenuation in both statin-continued and statin-initiated patients 📉, in relation to LDL changes, after correction for CV risk factors 🫀 More 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI Number 6️⃣ 👉 Have inter-vendor differences in GLS improved over the last 10 years? 🤔 Semi-automated endocardial and mid-/full-wall strain showed only a 0.6% bias 🧪 with a minimal detectable change of 2.5% when comparing six manufactorers📏 👉 doi.org/10.1093/ehjc... #MedSky
December 26, 2025 at 5:00 PM
#EHJCVI Number 6️⃣ 👉 Have inter-vendor differences in GLS improved over the last 10 years? 🤔 Semi-automated endocardial and mid-/full-wall strain showed only a 0.6% bias 🧪 with a minimal detectable change of 2.5% when comparing six manufactorers📏 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI Number 7️⃣ 👉 What’s the incidence of structural valve deterioration after TAVI? 🫀 In this registry, 8-year incidence was 13.3% 📊, higher with balloon-expandable valves 🎈, and associated with increased HF hospitalizations and CV death ⚠️ 👉 doi.org/10.1093/ehjc... #MedSky
December 25, 2025 at 5:00 PM
#EHJCVI Number 7️⃣ 👉 What’s the incidence of structural valve deterioration after TAVI? 🫀 In this registry, 8-year incidence was 13.3% 📊, higher with balloon-expandable valves 🎈, and associated with increased HF hospitalizations and CV death ⚠️ 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI Number 8️⃣ 👉 Can cardiac imaging provide a quantitative assessment of LV diastolic pressures? 📊 Combining LV volumes, LVGLS, LA reservoir strain, and MV flow velocities 📈 allows accurate pressure estimation🫀 More 👉 doi.org/10.1093/ehjc... #MedSky
December 24, 2025 at 5:00 PM
#EHJCVI Number 8️⃣ 👉 Can cardiac imaging provide a quantitative assessment of LV diastolic pressures? 📊 Combining LV volumes, LVGLS, LA reservoir strain, and MV flow velocities 📈 allows accurate pressure estimation🫀 More 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI Number 9️⃣ 👉 How can we use multimodality cardiovascular imaging in Anderson–Fabry disease? 🧬 This expert consensus outlines its role from early diagnosis to therapy monitoring 🔍, including aspects such as sex differences 🫀 More 👉 doi.org/10.1093/ehjc... #MedSky
December 23, 2025 at 5:00 PM
#EHJCVI Number 9️⃣ 👉 How can we use multimodality cardiovascular imaging in Anderson–Fabry disease? 🧬 This expert consensus outlines its role from early diagnosis to therapy monitoring 🔍, including aspects such as sex differences 🫀 More 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI Number 🔟 👉 New exercise echocardiography–based HFpEF criteria 🏃♂️A powerful combo: rest LA reservoir <20% 📉 + exercise septal E/e′ >13 📈 + exercise lung congestion 🫁 helps diagnose dyspnoeic HFpEF patients (AUC 0.9 ⭐, HR 1.17). More 👉 doi.org/10.1093/ehjc... #MedSky
December 22, 2025 at 5:00 PM
#EHJCVI Number 🔟 👉 New exercise echocardiography–based HFpEF criteria 🏃♂️A powerful combo: rest LA reservoir <20% 📉 + exercise septal E/e′ >13 📈 + exercise lung congestion 🫁 helps diagnose dyspnoeic HFpEF patients (AUC 0.9 ⭐, HR 1.17). More 👉 doi.org/10.1093/ehjc... #MedSky
🫀 #EHJCVI 🔍 Case challenge: A 77-year-old woman, 6 years post-SAVR, undergoes routine follow-up 🩺 Echo reveals para-aortic masses of unclear aetiology with elevated transprosthetic gradients 📈 CT angiography and TOE then reveal the following findings… 👀 What’s your diagnosis? 🧩 #MedSky
December 20, 2025 at 5:35 PM
#EHJCVI 🫀📈 DB or DS for stress CMR perfusion? In 570 patients, both flagged higher risk, but DS outperformed DB, with DS-derived stress MBF and MPR independently predicting MACE and driving better survival separation. Preferred when available 🔍 👉 doi.org/10.1093/ehjc... #MedSky
December 18, 2025 at 6:28 PM
#EHJCVI 🫀📈 DB or DS for stress CMR perfusion? In 570 patients, both flagged higher risk, but DS outperformed DB, with DS-derived stress MBF and MPR independently predicting MACE and driving better survival separation. Preferred when available 🔍 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI🫀What’s the value of left and right AV coupling? This new review outlines their central role across HF, ICM, CMH, VHD, PH, and beyond. Should LACI and RACI enter routine imaging? Could AV coupling become a therapeutic target? 🔍 Read more 👉 doi.org/10.1093/ehjc... #MedSky
December 16, 2025 at 8:00 PM
#EHJCVI🫀What’s the value of left and right AV coupling? This new review outlines their central role across HF, ICM, CMH, VHD, PH, and beyond. Should LACI and RACI enter routine imaging? Could AV coupling become a therapeutic target? 🔍 Read more 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI🫀The GLIDE Score predicts procedural success in transcatheter tricuspid valve annuloplasty 🔍 Performance improves after incorporating anteroseptal and bicommisural annular diameters, achieving AUC = 0.84, supporting better patient selection 👉doi.org/10.1093/ehjc... #MedSky
December 15, 2025 at 7:52 PM
#EHJCVI🫀The GLIDE Score predicts procedural success in transcatheter tricuspid valve annuloplasty 🔍 Performance improves after incorporating anteroseptal and bicommisural annular diameters, achieving AUC = 0.84, supporting better patient selection 👉doi.org/10.1093/ehjc... #MedSky
#EHJCVI 🫀A novel approach to PISA correction improves quantitative TR assessment. By adjusting for flow, leaflet angle, and regurgitant orifice shape, this method reduces EROA underestimation and shows strong agreement with established techniques 👉 doi.org/10.1093/ehjc... #MedSky
December 14, 2025 at 6:17 PM
#EHJCVI 🫀A novel approach to PISA correction improves quantitative TR assessment. By adjusting for flow, leaflet angle, and regurgitant orifice shape, this method reduces EROA underestimation and shows strong agreement with established techniques 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI🫀Case challenge: A 90-year-old woman with atrial flutter and uncontrolled rhythm undergoes routine pre-cardioversion TEE. Findings include mild–moderate MR and a PFO with basal right-to-left flow 👉 What’s your diagnosis? @escardio.bsky.social @jgrapsa.bsky.social #MedSky
December 13, 2025 at 7:43 PM
#EHJCVI🫀Case challenge: A 90-year-old woman with atrial flutter and uncontrolled rhythm undergoes routine pre-cardioversion TEE. Findings include mild–moderate MR and a PFO with basal right-to-left flow 👉 What’s your diagnosis? @escardio.bsky.social @jgrapsa.bsky.social #MedSky
#EHJCVI 🔍 How is cardiovascular imaging reshaping VHD trials? This new review explores the expanding role of CV imaging across RCTs in different VHD, highlighting its impact on design, endpoints, and translation into clinical practice🫀📊 Read more 👉 doi.org/10.1093/ehjc... #MedSky
December 12, 2025 at 9:37 PM
#EHJCVI 🔍 How is cardiovascular imaging reshaping VHD trials? This new review explores the expanding role of CV imaging across RCTs in different VHD, highlighting its impact on design, endpoints, and translation into clinical practice🫀📊 Read more 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI🫀Can EAT predict MACE in HCM? In 457 patients, CMR EAT volume index independently predicted events. Outcomes worsened above 62.5 mL/m², with clear curve separation, even in low-risk groups. Adding EATVI improved clinical and imaging models 👉 doi.org/10.1093/ehjc... #MedSky
December 11, 2025 at 8:22 PM
#EHJCVI🫀Can EAT predict MACE in HCM? In 457 patients, CMR EAT volume index independently predicted events. Outcomes worsened above 62.5 mL/m², with clear curve separation, even in low-risk groups. Adding EATVI improved clinical and imaging models 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI 🩺 A new review shows how sex differences influence every stage of valvular heart disease, from aetiology to imaging features and timing of intervention 📊 Multimodality imaging is key to preventing underdiagnosis, especially in women 👉 doi.org/10.1093/ehjc... #MedSky @jgrapsa.bsky.social
December 10, 2025 at 7:51 PM
#EHJCVI 🩺 A new review shows how sex differences influence every stage of valvular heart disease, from aetiology to imaging features and timing of intervention 📊 Multimodality imaging is key to preventing underdiagnosis, especially in women 👉 doi.org/10.1093/ehjc... #MedSky @jgrapsa.bsky.social
#EHJCVI🫀 3D RegFr sharpens TR assessment, reflecting the true hemodynamic burden by “normalizing” for lower right-sided pressures, loading conditions, and RV size/function. Updated corrected PISA refine grading, with RegFr ≥27% marking increased risk 👉 doi.org/10.1093/ehjc... #MedSky #Echofirst
December 9, 2025 at 6:40 PM
#EHJCVI🫀 3D RegFr sharpens TR assessment, reflecting the true hemodynamic burden by “normalizing” for lower right-sided pressures, loading conditions, and RV size/function. Updated corrected PISA refine grading, with RegFr ≥27% marking increased risk 👉 doi.org/10.1093/ehjc... #MedSky #Echofirst
#EHJCVI 🫀Check out HeartAge, a CMR-based ML model that turns routine metrics into CV “biological age" 🗓️ A higher HeartAge-gap flagged more CV events in both sexes and higher all-cause mortality in women, driven largely by aortic distensibility 👉 doi.org/10.1093/ehjc... #MedSky
December 8, 2025 at 5:52 PM
#EHJCVI 🫀Check out HeartAge, a CMR-based ML model that turns routine metrics into CV “biological age" 🗓️ A higher HeartAge-gap flagged more CV events in both sexes and higher all-cause mortality in women, driven largely by aortic distensibility 👉 doi.org/10.1093/ehjc... #MedSky
#EHJCVI 🩻 How much radiation comes from cardiac procedures? They account for 30–50% of all medical exposure, with doses up to 194 mSv (≈ 9700 chest X-rays). Excess cancers appear 3–12 years post-exposure. Should it be included as an endpoint in RCT? 👉 doi.org/10.1093/ehjc... #MedSky
December 7, 2025 at 7:40 PM
#EHJCVI 🩻 How much radiation comes from cardiac procedures? They account for 30–50% of all medical exposure, with doses up to 194 mSv (≈ 9700 chest X-rays). Excess cancers appear 3–12 years post-exposure. Should it be included as an endpoint in RCT? 👉 doi.org/10.1093/ehjc... #MedSky
#EHJIMP ✨Are there gender disparities in VHD management and outcomes? 🌍 This first multicenter, international registry explores differences in treatment patterns, guideline adherence, and clinical outcomes in valvular heart disease 🫀📊 Read more 👉 doi.org/10.1093/ehji... #MedSky
December 5, 2025 at 8:25 PM
#EHJIMP ✨Are there gender disparities in VHD management and outcomes? 🌍 This first multicenter, international registry explores differences in treatment patterns, guideline adherence, and clinical outcomes in valvular heart disease 🫀📊 Read more 👉 doi.org/10.1093/ehji... #MedSky
#EHJCVI 🩺 4D Flow CMR is redefining fetal CHD assessment. In 3rd-trimester fetuses, it provides hemodynamic insights in 51% of cases of CHD, strengthening perinatal planning and risk stratification in complex CHD ✨ Read more 👉 doi.org/10.1093/ehjc... #MedSky
December 5, 2025 at 7:38 PM
#EHJCVI 🩺 4D Flow CMR is redefining fetal CHD assessment. In 3rd-trimester fetuses, it provides hemodynamic insights in 51% of cases of CHD, strengthening perinatal planning and risk stratification in complex CHD ✨ Read more 👉 doi.org/10.1093/ehjc... #MedSky