Olli Kärkkäinen
@ollikarkkainen.bsky.social
Toxicometabolomics associate professor (tenure track) at the University of Eastern Finland and co-founder and CEO of Afekta Technologies Ltd. Metabolomics, alcohol, drugs, chemicals, treatment, disease progression. https://orcid.org/0000-0003-0825-4956
Pinned
Serum Metabolite Profile in Progressive Versus Nonprogressive Alcohol‐Related Liver Disease: A Cross‐Sectional Metabolomics Study
Background and Aims Alcohol-related liver disease (ALD) is a major cause of mortality and disability-adjusted life years. It is not fully understood why a small proportion of patients develop progre...
doi.org
First first author article for Eemeli Puhakka published!
We identified a profile of metabolites separating those with early stage progressive alcohol-related liver disease from non-progressive alcohol-related liver disease using metabolomics
doi.org/10.1111/liv....
#metabolomics #alcohol
We identified a profile of metabolites separating those with early stage progressive alcohol-related liver disease from non-progressive alcohol-related liver disease using metabolomics
doi.org/10.1111/liv....
#metabolomics #alcohol
Reposted by Olli Kärkkäinen
Villa Lanten ystävien loppuvuoteen kuuluu kiinnostavia webinaareja antiikin merkkihenkilöistä. Ensin vuorossa Kleopatra, johon meidät tutustuttaa dos. Jaakkojuhani Peltonen 18.11. Tervetuloa mukaan!
www.villalantenystavat.fi?page_id=249
www.villalantenystavat.fi?page_id=249
November 5, 2025 at 9:25 AM
Villa Lanten ystävien loppuvuoteen kuuluu kiinnostavia webinaareja antiikin merkkihenkilöistä. Ensin vuorossa Kleopatra, johon meidät tutustuttaa dos. Jaakkojuhani Peltonen 18.11. Tervetuloa mukaan!
www.villalantenystavat.fi?page_id=249
www.villalantenystavat.fi?page_id=249
Reposted by Olli Kärkkäinen
Starting today, we’re excited to introduce the EMN Committee members for 2024/2025. It’s going to be an amazing year, and we can’t wait to share what we’ve been working on! #EMN #MetSoc #Metabolomics #EarlyCareer #STEM #ECR
October 21, 2025 at 3:36 PM
Starting today, we’re excited to introduce the EMN Committee members for 2024/2025. It’s going to be an amazing year, and we can’t wait to share what we’ve been working on! #EMN #MetSoc #Metabolomics #EarlyCareer #STEM #ECR
Interesting new paper on using multi-omics data-analysis methods in integrative holo-omics data-analysis. We were happy to contribute to the metabolomics part.
Congrats @jennymerkesvik.bsky.social for the excellent work!
Congrats @jennymerkesvik.bsky.social for the excellent work!
Check out this preprint of the first article for my PhD thesis!
www.biorxiv.org/content/10.1...
We've leveraged methods developed for multi-omics to investigate a holo-omic system (🐷🦠), and predicted host-microbiome interactions between important features for observed cross-omic data patterns 🔍📊
www.biorxiv.org/content/10.1...
We've leveraged methods developed for multi-omics to investigate a holo-omic system (🐷🦠), and predicted host-microbiome interactions between important features for observed cross-omic data patterns 🔍📊
October 24, 2025 at 10:47 AM
Interesting new paper on using multi-omics data-analysis methods in integrative holo-omics data-analysis. We were happy to contribute to the metabolomics part.
Congrats @jennymerkesvik.bsky.social for the excellent work!
Congrats @jennymerkesvik.bsky.social for the excellent work!
Reposted by Olli Kärkkäinen
Interesting new analysis of ADHD meds in schizophrenia-spectrum disorders: reduced risk of psychosis with atomoxetine and reduced risk for somatic hospitalizations with lisdexamphetamine.
Higher somatic hospitalization with polytherapy, no other negative safety signals. #psychiatry #medsky
Higher somatic hospitalization with polytherapy, no other negative safety signals. #psychiatry #medsky
July 5, 2025 at 8:11 AM
Interesting new analysis of ADHD meds in schizophrenia-spectrum disorders: reduced risk of psychosis with atomoxetine and reduced risk for somatic hospitalizations with lisdexamphetamine.
Higher somatic hospitalization with polytherapy, no other negative safety signals. #psychiatry #medsky
Higher somatic hospitalization with polytherapy, no other negative safety signals. #psychiatry #medsky
Reposted by Olli Kärkkäinen
New publication!
Luykx et al. Long term safety of ADHD medication in patients with schizophrenia spectrum disorders. doi.org/10.1038/s413...
#ADHD #schizophrenia
Luykx et al. Long term safety of ADHD medication in patients with schizophrenia spectrum disorders. doi.org/10.1038/s413...
#ADHD #schizophrenia
Long term safety of ADHD medication in patients with schizophrenia spectrum disorders - Molecular Psychiatry
Molecular Psychiatry - Long term safety of ADHD medication in patients with schizophrenia spectrum disorders
doi.org
July 4, 2025 at 7:30 PM
New publication!
Luykx et al. Long term safety of ADHD medication in patients with schizophrenia spectrum disorders. doi.org/10.1038/s413...
#ADHD #schizophrenia
Luykx et al. Long term safety of ADHD medication in patients with schizophrenia spectrum disorders. doi.org/10.1038/s413...
#ADHD #schizophrenia
New publication!
Luykx et al. Long term safety of ADHD medication in patients with schizophrenia spectrum disorders. doi.org/10.1038/s413...
#ADHD #schizophrenia
Luykx et al. Long term safety of ADHD medication in patients with schizophrenia spectrum disorders. doi.org/10.1038/s413...
#ADHD #schizophrenia
Long term safety of ADHD medication in patients with schizophrenia spectrum disorders - Molecular Psychiatry
Molecular Psychiatry - Long term safety of ADHD medication in patients with schizophrenia spectrum disorders
doi.org
July 4, 2025 at 7:30 PM
New publication!
Luykx et al. Long term safety of ADHD medication in patients with schizophrenia spectrum disorders. doi.org/10.1038/s413...
#ADHD #schizophrenia
Luykx et al. Long term safety of ADHD medication in patients with schizophrenia spectrum disorders. doi.org/10.1038/s413...
#ADHD #schizophrenia
Today in the #MetSoc2025 conference, I was presenting a poster about the microsample global metabolomics method development we have been doing in the 3D'omics project at Afekta Technologies !
June 25, 2025 at 5:24 PM
Today in the #MetSoc2025 conference, I was presenting a poster about the microsample global metabolomics method development we have been doing in the 3D'omics project at Afekta Technologies !
Reposted by Olli Kärkkäinen
Heading to #Metabolomics2025? Here are some quick tips:
✅ Prague Congress Centre is easy to reach by public transport
✅ It can get warm – pack a water bottle
✅ Conference essentials: poster, laptop, and charger
✅ Check out the full agenda here: tinyurl.com/4vudznw8
#Prague2025 #EMN #ConferenceTips
✅ Prague Congress Centre is easy to reach by public transport
✅ It can get warm – pack a water bottle
✅ Conference essentials: poster, laptop, and charger
✅ Check out the full agenda here: tinyurl.com/4vudznw8
#Prague2025 #EMN #ConferenceTips
Agenda - Metabolomics 2025
www.metabolomics2025.org
June 21, 2025 at 7:06 PM
Heading to #Metabolomics2025? Here are some quick tips:
✅ Prague Congress Centre is easy to reach by public transport
✅ It can get warm – pack a water bottle
✅ Conference essentials: poster, laptop, and charger
✅ Check out the full agenda here: tinyurl.com/4vudznw8
#Prague2025 #EMN #ConferenceTips
✅ Prague Congress Centre is easy to reach by public transport
✅ It can get warm – pack a water bottle
✅ Conference essentials: poster, laptop, and charger
✅ Check out the full agenda here: tinyurl.com/4vudznw8
#Prague2025 #EMN #ConferenceTips
Reposted by Olli Kärkkäinen
To everyone heading to #Metabolomics2025 in Prague, I recommend installing the Prague public transport app. It's extremely helpful!
play.google.com/store/apps/d...
play.google.com/store/apps/d...
PID Litacka - Apps on Google Play
Official transport application of Prague integrated transport system (PID)
play.google.com
June 21, 2025 at 9:08 AM
To everyone heading to #Metabolomics2025 in Prague, I recommend installing the Prague public transport app. It's extremely helpful!
play.google.com/store/apps/d...
play.google.com/store/apps/d...
Reposted by Olli Kärkkäinen
Just in time for Midsummer festives and next weeks Metabolomics conference, two new articles were published!
Masvosva et al. Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine: doi.org/10.1111/adb....
...
Masvosva et al. Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine: doi.org/10.1111/adb....
...
Metabolic Alterations in Human Post‐Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine
A metabolic profile associated with high levels of the nicotine metabolite cotinine was measured from human postmortem frontal cortex and cerebrospinal fluid samples using non-targeted metabolomics. ....
doi.org
June 20, 2025 at 7:40 PM
Just in time for Midsummer festives and next weeks Metabolomics conference, two new articles were published!
Masvosva et al. Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine: doi.org/10.1111/adb....
...
Masvosva et al. Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine: doi.org/10.1111/adb....
...
Just in time for Midsummer festives and next weeks Metabolomics conference, two new articles were published!
Masvosva et al. Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine: doi.org/10.1111/adb....
...
Masvosva et al. Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine: doi.org/10.1111/adb....
...
Metabolic Alterations in Human Post‐Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine
A metabolic profile associated with high levels of the nicotine metabolite cotinine was measured from human postmortem frontal cortex and cerebrospinal fluid samples using non-targeted metabolomics. ....
doi.org
June 20, 2025 at 7:40 PM
Just in time for Midsummer festives and next weeks Metabolomics conference, two new articles were published!
Masvosva et al. Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine: doi.org/10.1111/adb....
...
Masvosva et al. Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine: doi.org/10.1111/adb....
...
New preprint alert! 🚨
We compared metabolite coverage of three blood microsampling devices as an alternative to conventional samples for human biomonitoring. All devices were suitable for #metabolomics analysis and the choice of device depends on the application
chemrxiv.org/engage/chemr...
We compared metabolite coverage of three blood microsampling devices as an alternative to conventional samples for human biomonitoring. All devices were suitable for #metabolomics analysis and the choice of device depends on the application
chemrxiv.org/engage/chemr...
An LC-MS untargeted metabolomic comparison between three blood microsampling devices, whole blood, and plasma.
Introduction: Blood microsampling (BµS) devices collect less than 100 µL of blood, offering a less invasive and more cost-effective alternative to venipuncture. However, its metabolomic comparability ...
chemrxiv.org
June 16, 2025 at 6:33 PM
New preprint alert! 🚨
We compared metabolite coverage of three blood microsampling devices as an alternative to conventional samples for human biomonitoring. All devices were suitable for #metabolomics analysis and the choice of device depends on the application
chemrxiv.org/engage/chemr...
We compared metabolite coverage of three blood microsampling devices as an alternative to conventional samples for human biomonitoring. All devices were suitable for #metabolomics analysis and the choice of device depends on the application
chemrxiv.org/engage/chemr...
Reposted by Olli Kärkkäinen
If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...
The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids
Mass spectrometry data mining tools enabled the creation of an MS/MS spectral library
containing hundreds of N-acyl lipids, including conjugates with short-chain fatty
acids. This resource enabled the...
www.cell.com
June 12, 2025 at 5:56 PM
If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...
Reposted by Olli Kärkkäinen
New preprint! 🚨
Itkonen et al. Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies
doi.org/10.1101/2025...
Itkonen et al. Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies
doi.org/10.1101/2025...
Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies
Introduction Antenatal depression, a common pregnancy complication, poses significant risks if untreated. Consequently, pregnant mothers are prescribed selective serotonin reuptake inhibitors (SSRIs)....
doi.org
May 19, 2025 at 6:50 PM
New preprint! 🚨
Itkonen et al. Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies
doi.org/10.1101/2025...
Itkonen et al. Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies
doi.org/10.1101/2025...
New preprint! 🚨
Itkonen et al. Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies
doi.org/10.1101/2025...
Itkonen et al. Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies
doi.org/10.1101/2025...
Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies
Introduction Antenatal depression, a common pregnancy complication, poses significant risks if untreated. Consequently, pregnant mothers are prescribed selective serotonin reuptake inhibitors (SSRIs)....
doi.org
May 19, 2025 at 6:50 PM
New preprint! 🚨
Itkonen et al. Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies
doi.org/10.1101/2025...
Itkonen et al. Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies
doi.org/10.1101/2025...
Reposted by Olli Kärkkäinen
HS:n eilisessä velka-artikkelissa sivuutettiin lähes kokonaan valtionvelan hoitokustanukset ja inflaatio. Vaikka valtionvelan määrä on kasvanut, se kuormittaa julkista taloutta 2000-luvun alkua vähemmän, koska Suomi saa lainaa paljon aiempaa halvemmalla ja inflaatio pienentää lainapääoman arvoa. 1/
May 19, 2025 at 2:49 PM
HS:n eilisessä velka-artikkelissa sivuutettiin lähes kokonaan valtionvelan hoitokustanukset ja inflaatio. Vaikka valtionvelan määrä on kasvanut, se kuormittaa julkista taloutta 2000-luvun alkua vähemmän, koska Suomi saa lainaa paljon aiempaa halvemmalla ja inflaatio pienentää lainapääoman arvoa. 1/
Reposted by Olli Kärkkäinen
Its a long weekend here in Canada, which seems appropriate to mourn our recent @npp-journal.bsky.social paper, in which we find that FAAH inhibition does NOT improve symptoms in PTSD🙁
A heroic effort w/ @cannabrain.bsky.social @connorhaggarty.bsky.social @ryanntansey.bsky.social & many more 🧵⬇️
A heroic effort w/ @cannabrain.bsky.social @connorhaggarty.bsky.social @ryanntansey.bsky.social & many more 🧵⬇️
The efficacy of elevating anandamide via inhibition of fatty acid amide hydrolase (FAAH) combined with internet-delivered cognitive behavioral therapy in the treatment of post-traumatic stress disorde...
Neuropsychopharmacology - The efficacy of elevating anandamide via inhibition of fatty acid amide hydrolase (FAAH) combined with internet-delivered cognitive behavioral therapy in the treatment of...
www.nature.com
May 17, 2025 at 5:48 PM
Its a long weekend here in Canada, which seems appropriate to mourn our recent @npp-journal.bsky.social paper, in which we find that FAAH inhibition does NOT improve symptoms in PTSD🙁
A heroic effort w/ @cannabrain.bsky.social @connorhaggarty.bsky.social @ryanntansey.bsky.social & many more 🧵⬇️
A heroic effort w/ @cannabrain.bsky.social @connorhaggarty.bsky.social @ryanntansey.bsky.social & many more 🧵⬇️
Reposted by Olli Kärkkäinen
METABOLOMIC INSIGHTS: LC-MS PROFILING OF HUMAN PLACENTAL TISSUE FROM SSRI-TREATED PREGNANCIES https://www.medrxiv.org/content/10.1101/2025.05.12.25327429v1
May 13, 2025 at 9:15 PM
METABOLOMIC INSIGHTS: LC-MS PROFILING OF HUMAN PLACENTAL TISSUE FROM SSRI-TREATED PREGNANCIES https://www.medrxiv.org/content/10.1101/2025.05.12.25327429v1
First first author article for Eemeli Puhakka published!
We identified a profile of metabolites separating those with early stage progressive alcohol-related liver disease from non-progressive alcohol-related liver disease using metabolomics
doi.org/10.1111/liv....
#metabolomics #alcohol
We identified a profile of metabolites separating those with early stage progressive alcohol-related liver disease from non-progressive alcohol-related liver disease using metabolomics
doi.org/10.1111/liv....
#metabolomics #alcohol
Serum Metabolite Profile in Progressive Versus Nonprogressive Alcohol‐Related Liver Disease: A Cross‐Sectional Metabolomics Study
Background and Aims Alcohol-related liver disease (ALD) is a major cause of mortality and disability-adjusted life years. It is not fully understood why a small proportion of patients develop progre...
doi.org
May 14, 2025 at 7:10 PM
First first author article for Eemeli Puhakka published!
We identified a profile of metabolites separating those with early stage progressive alcohol-related liver disease from non-progressive alcohol-related liver disease using metabolomics
doi.org/10.1111/liv....
#metabolomics #alcohol
We identified a profile of metabolites separating those with early stage progressive alcohol-related liver disease from non-progressive alcohol-related liver disease using metabolomics
doi.org/10.1111/liv....
#metabolomics #alcohol
Reposted by Olli Kärkkäinen
🚨 📢 I’m #hiring!!! I am looking for an experienced #metabolomics scientist with a particular focus on LC-MS. Please follow the link below for more details and how to apply! 📢 🚨
Applications close at 23:59 on May 23rd!!!
www.crick.ac.uk/careers-stud...
Applications close at 23:59 on May 23rd!!!
www.crick.ac.uk/careers-stud...
Senior/Principal Laboratory Research Scientist: Metabolomics & Lipidomics Specialist
www.crick.ac.uk
May 7, 2025 at 1:40 PM
🚨 📢 I’m #hiring!!! I am looking for an experienced #metabolomics scientist with a particular focus on LC-MS. Please follow the link below for more details and how to apply! 📢 🚨
Applications close at 23:59 on May 23rd!!!
www.crick.ac.uk/careers-stud...
Applications close at 23:59 on May 23rd!!!
www.crick.ac.uk/careers-stud...
New publication from the Gut2Behave project!
Neyrinck, Ahmed et al. Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health.
doi.org/10.1038/s415...
#metabolomics
Neyrinck, Ahmed et al. Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health.
doi.org/10.1038/s415...
#metabolomics
Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health - Scientific Reports
Scientific Reports - Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health
doi.org
May 5, 2025 at 6:22 PM
New publication from the Gut2Behave project!
Neyrinck, Ahmed et al. Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health.
doi.org/10.1038/s415...
#metabolomics
Neyrinck, Ahmed et al. Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health.
doi.org/10.1038/s415...
#metabolomics
Reposted by Olli Kärkkäinen
Important update! Thinking of submitting a poster abstract? Do not delay. Due to the high (and exciting!) volume of abstracts we will likely close abstract submission BEFORE May 15. Submit your abstract ASAP!
April 22, 2025 at 8:05 PM
Important update! Thinking of submitting a poster abstract? Do not delay. Due to the high (and exciting!) volume of abstracts we will likely close abstract submission BEFORE May 15. Submit your abstract ASAP!
Reposted by Olli Kärkkäinen
Metabolomics analysis reveals that tobacco smoking during pregnancy is associated with altered levels of metabolites linked to endocrine disruption and oxidative stress, and these chanses are correlated with low birth weight and small head circumference at birth.
doi.org/10.1111/bcpt...
doi.org/10.1111/bcpt...
Alterations in the Plasma Metabolome Associated With Maternal Smoking During the First Trimester and Foetal Growth
Tobacco smoking during pregnancy has been associated with an increased risk of adverse outcomes like low birth weight. This study determined changes in the circulating metabolome linked to maternal s...
doi.org
April 14, 2025 at 12:00 PM
Metabolomics analysis reveals that tobacco smoking during pregnancy is associated with altered levels of metabolites linked to endocrine disruption and oxidative stress, and these chanses are correlated with low birth weight and small head circumference at birth.
doi.org/10.1111/bcpt...
doi.org/10.1111/bcpt...
Metabolomics analysis reveals that tobacco smoking during pregnancy is associated with altered levels of metabolites linked to endocrine disruption and oxidative stress, and these chanses are correlated with low birth weight and small head circumference at birth.
doi.org/10.1111/bcpt...
doi.org/10.1111/bcpt...
Alterations in the Plasma Metabolome Associated With Maternal Smoking During the First Trimester and Foetal Growth
Tobacco smoking during pregnancy has been associated with an increased risk of adverse outcomes like low birth weight. This study determined changes in the circulating metabolome linked to maternal s...
doi.org
April 14, 2025 at 12:00 PM
Metabolomics analysis reveals that tobacco smoking during pregnancy is associated with altered levels of metabolites linked to endocrine disruption and oxidative stress, and these chanses are correlated with low birth weight and small head circumference at birth.
doi.org/10.1111/bcpt...
doi.org/10.1111/bcpt...
We have a new preprint!
Here we looked at associations between levothyroxine treatment during pregnancy and metabolite and lipoprotein levels in the cord blood and in samples from the pregnant woman at different timepoints during pregnancy.
www.medrxiv.org/content/10.1...
Here we looked at associations between levothyroxine treatment during pregnancy and metabolite and lipoprotein levels in the cord blood and in samples from the pregnant woman at different timepoints during pregnancy.
www.medrxiv.org/content/10.1...
Levothyroxine treatment during pregnancy: a metabolomics study
Background: While levothyroxine is one of the most extensively prescribed drugs during pregnancy, the possible effects of levothyroxine on the metabolome are not well known. Our aim was to determine l...
www.medrxiv.org
April 8, 2025 at 7:07 PM
We have a new preprint!
Here we looked at associations between levothyroxine treatment during pregnancy and metabolite and lipoprotein levels in the cord blood and in samples from the pregnant woman at different timepoints during pregnancy.
www.medrxiv.org/content/10.1...
Here we looked at associations between levothyroxine treatment during pregnancy and metabolite and lipoprotein levels in the cord blood and in samples from the pregnant woman at different timepoints during pregnancy.
www.medrxiv.org/content/10.1...