Kosuke Ogata
@ogatkk.bsky.social
Assistant Professor at Kyoto University, Japan. Proteomics; Mass spectrometry; Protein phosphorylation; Protein structure. Seeking the analytical method to evaluate the protein structure and phosphorylation.
Reposted by Kosuke Ogata
Excited to share some of my PhD work on ubiquitin www.biorxiv.org/content/10.1...!
Huge collaborative effort from many people
Check out the whole story here
Huge collaborative effort from many people
Check out the whole story here
October 9, 2025 at 7:15 AM
Excited to share some of my PhD work on ubiquitin www.biorxiv.org/content/10.1...!
Huge collaborative effort from many people
Check out the whole story here
Huge collaborative effort from many people
Check out the whole story here
We utilized protein kinases to probe substrate protein structures. The phosphate groups enabled selective extraction of labeled sites.
Detecting Protein Higher-Order Structural Changes Using Kinase as a Phospho-Labeler www.biorxiv.org/content/10.1...
Detecting Protein Higher-Order Structural Changes Using Kinase as a Phospho-Labeler www.biorxiv.org/content/10.1...
Detecting Protein Higher-Order Structural Changes Using Kinase as a Phospho-Labeler
We developed an approach to detect protein conformational changes on a proteome-wide scale by labeling proteins with phosphate groups through in vitro kinase reactions. This structural proteomics appr...
www.biorxiv.org
May 13, 2025 at 1:38 AM
We utilized protein kinases to probe substrate protein structures. The phosphate groups enabled selective extraction of labeled sites.
Detecting Protein Higher-Order Structural Changes Using Kinase as a Phospho-Labeler www.biorxiv.org/content/10.1...
Detecting Protein Higher-Order Structural Changes Using Kinase as a Phospho-Labeler www.biorxiv.org/content/10.1...
Reposted by Kosuke Ogata
In our latest @Nature review with Tiannan Guo & Judith Steen, we explore how technological breakthroughs are revolutionizing MS-based proteomics: From enhanced sensitivity enabling single-cell analysis to high-throughput plasma proteomics & AI-based data interpretation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mass-spectrometry-based proteomics: from single cells to clinical applications - Nature
This Review summarizes advances in mass-spectrometry-based proteomics and explores the potential applications of these technologies in the clinic.
www.nature.com
February 26, 2025 at 4:22 PM
In our latest @Nature review with Tiannan Guo & Judith Steen, we explore how technological breakthroughs are revolutionizing MS-based proteomics: From enhanced sensitivity enabling single-cell analysis to high-throughput plasma proteomics & AI-based data interpretation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kosuke Ogata
DIA-NN 2.0 is released! We consider it the biggest step forward in the history of DIA-NN. On modern LC-MS almost all identifications are now peptidoform-confident, with major improvements e.g. for phospho. Some other cool things too: github.com/vdemichev/Di...
Release DIA-NN 2.0 · vdemichev/DiaNN
We are excited to announce DIA-NN 2.0, the most significant milestone in the history of DIA-NN development.
Key Breakthroughs
Proteoform Confidence mode: DIA-NN 2.0 solves the long-standing chall...
github.com
January 29, 2025 at 9:04 AM
DIA-NN 2.0 is released! We consider it the biggest step forward in the history of DIA-NN. On modern LC-MS almost all identifications are now peptidoform-confident, with major improvements e.g. for phospho. Some other cool things too: github.com/vdemichev/Di...
Reposted by Kosuke Ogata
#teamMassSpec here is a starting pack in case you just moved over, or in case you've been absent for a while. This is #proteomics or #massspec related. The pack is not comprehensive but it's a start.
go.bsky.app/HH7kqEh
go.bsky.app/HH7kqEh
November 10, 2024 at 3:46 PM
#teamMassSpec here is a starting pack in case you just moved over, or in case you've been absent for a while. This is #proteomics or #massspec related. The pack is not comprehensive but it's a start.
go.bsky.app/HH7kqEh
go.bsky.app/HH7kqEh
Reposted by Kosuke Ogata
Here's a new list for early career researchers (=not had your own lab for ages) in proteomics.
Feel free to ask to be added or removed, I've tried to make a guess but could've got it wrong.
I think it's good to also have an ECR network.
#teamMassSpec
go.bsky.app/Dp8PHX1
Feel free to ask to be added or removed, I've tried to make a guess but could've got it wrong.
I think it's good to also have an ECR network.
#teamMassSpec
go.bsky.app/Dp8PHX1
November 16, 2024 at 6:55 PM
Here's a new list for early career researchers (=not had your own lab for ages) in proteomics.
Feel free to ask to be added or removed, I've tried to make a guess but could've got it wrong.
I think it's good to also have an ECR network.
#teamMassSpec
go.bsky.app/Dp8PHX1
Feel free to ask to be added or removed, I've tried to make a guess but could've got it wrong.
I think it's good to also have an ECR network.
#teamMassSpec
go.bsky.app/Dp8PHX1