Nicolas Buchon
@nicobuchon.bsky.social
Associate Prof at Cornell interested in Host/microbe interactions, Gut Homeostasis, Stem Cell Biology, Innate Immunity, Vector Biology etc.
https://buchonlab.com/index.html
https://buchonlab.com/index.html
Our new study is out in Cell Reports!
We show that the DNA repair pathway ATM-γH2Av is repurposed in the gut during infection, even without DNA breaks. Pathogens, not microbiota, trigger it via NOX to clear damaged cells and drive stem cell regeneration. www.cell.com/cell-reports...
We show that the DNA repair pathway ATM-γH2Av is repurposed in the gut during infection, even without DNA breaks. Pathogens, not microbiota, trigger it via NOX to clear damaged cells and drive stem cell regeneration. www.cell.com/cell-reports...
Infectious bacteria, but not the microbiota, induce a NOX-ATM-cytokine pathway that controls epithelial turnover
Nagy et al. identify a NOX-ATM-cytokine signaling axis in the Drosophila gut that
is activated by infection independently of DNA damage. This pathway promotes enterocyte
loss, cytokine production, and...
www.cell.com
September 19, 2025 at 12:47 PM
Our new study is out in Cell Reports!
We show that the DNA repair pathway ATM-γH2Av is repurposed in the gut during infection, even without DNA breaks. Pathogens, not microbiota, trigger it via NOX to clear damaged cells and drive stem cell regeneration. www.cell.com/cell-reports...
We show that the DNA repair pathway ATM-γH2Av is repurposed in the gut during infection, even without DNA breaks. Pathogens, not microbiota, trigger it via NOX to clear damaged cells and drive stem cell regeneration. www.cell.com/cell-reports...
Reposted by Nicolas Buchon
It is difficult to interpret single #pathogen burden during #infection. It is hard to untangle default in resistance and tolerance to explain #susceptibility. We help making sense of with-host dynamics and give tools to study infection, especially in #Drosophila.
elifesciences.org/articles/104...
elifesciences.org/articles/104...
A within-host infection model to explore tolerance and resistance
A mathematical model of pathogen within-host dynamics and experimental validations elucidates the interplay between immune response, damage and pathogen proliferation, highlighting the limitations of ...
elifesciences.org
June 6, 2025 at 1:37 PM
It is difficult to interpret single #pathogen burden during #infection. It is hard to untangle default in resistance and tolerance to explain #susceptibility. We help making sense of with-host dynamics and give tools to study infection, especially in #Drosophila.
elifesciences.org/articles/104...
elifesciences.org/articles/104...
Reposted by Nicolas Buchon
In preprints: are microbes the architects of animal bodies?
Alessandro Bonfini, Peter Nagy and @nicobuchon.bsky.social @cornellentomology.bsky.social discuss a recent #preprint from Jinru He, Thomas Bosch and colleagues:
journals.biologists.com/dev/article/...
Alessandro Bonfini, Peter Nagy and @nicobuchon.bsky.social @cornellentomology.bsky.social discuss a recent #preprint from Jinru He, Thomas Bosch and colleagues:
journals.biologists.com/dev/article/...
May 19, 2025 at 8:51 AM
In preprints: are microbes the architects of animal bodies?
Alessandro Bonfini, Peter Nagy and @nicobuchon.bsky.social @cornellentomology.bsky.social discuss a recent #preprint from Jinru He, Thomas Bosch and colleagues:
journals.biologists.com/dev/article/...
Alessandro Bonfini, Peter Nagy and @nicobuchon.bsky.social @cornellentomology.bsky.social discuss a recent #preprint from Jinru He, Thomas Bosch and colleagues:
journals.biologists.com/dev/article/...