Natalie Stanley
@natstann.bsky.social
∑ ∫: Assistant Professor of Computer Science and Computational Medicine at UNC-Chapel Hill. Studying immune control of aging 🧫💻
🔗https://compcylab.squarespace.com
🔗https://compcylab.squarespace.com
Reposted by Natalie Stanley
@natimmunol.nature.com News & Views
Quiet custodians of CD8+ T cell fate
www.nature.com/articles/s41...
on
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Quiet custodians of CD8+ T cell fate
www.nature.com/articles/s41...
on
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 14, 2025 at 7:44 PM
@natimmunol.nature.com News & Views
Quiet custodians of CD8+ T cell fate
www.nature.com/articles/s41...
on
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Quiet custodians of CD8+ T cell fate
www.nature.com/articles/s41...
on
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Natalie Stanley
Meeting report @natimmunol.nature.com
Neuroimmune interactions in health and disease
www.nature.com/articles/s41...
Neuroimmune interactions in health and disease
www.nature.com/articles/s41...
November 12, 2025 at 12:49 AM
Meeting report @natimmunol.nature.com
Neuroimmune interactions in health and disease
www.nature.com/articles/s41...
Neuroimmune interactions in health and disease
www.nature.com/articles/s41...
Reposted by Natalie Stanley
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
November 5, 2025 at 11:51 PM
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
trying to fit a project timeline and a power calculation into a proposal when it is stuffed to the brim 😂
Mickey Mouse Packing Struggles GIF
ALT: Mickey Mouse Packing Struggles GIF
media.tenor.com
November 1, 2025 at 8:08 PM
trying to fit a project timeline and a power calculation into a proposal when it is stuffed to the brim 😂
beautiful review article covering many key aspects for studying brain aging -- CD8T cell infiltration, DNA methylation, and killifish as a model system. Thanks to the @brunetlab.bsky.social !
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Brain aging and rejuvenation at single-cell resolution
This review by Sun, Nagvekar, Pogson, et al. focuses on single-cell “omics” studies
of brain aging to highlight changes in different cell types and cell-cell interactions
during aging and in response ...
www.cell.com
October 8, 2025 at 3:03 PM
beautiful review article covering many key aspects for studying brain aging -- CD8T cell infiltration, DNA methylation, and killifish as a model system. Thanks to the @brunetlab.bsky.social !
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Reposted by Natalie Stanley
Reminder starting in October NIH NOFOs won’t be posted in the Guide for grants and contracts.
Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...
Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...
New Tool to Explore NIH Grant Opportunities | Grants & Funding
grants.nih.gov
September 26, 2025 at 2:48 PM
Reminder starting in October NIH NOFOs won’t be posted in the Guide for grants and contracts.
Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...
Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...
Reposted by Natalie Stanley
Preprint: Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
September 26, 2025 at 6:44 PM
Preprint: Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
Reposted by Natalie Stanley
A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression - Nature Aging
Bodogai et al. identify a unique subset of CD8+ T cells expressing CD39 and CD73 that accumulate during aging and are recruited to and actively promote tumor progression by suppressing antitumor CD4+ T cells. Targeting their function or recruitment attenuates tumor growth in aged mice.
www.nature.com
September 26, 2025 at 3:00 AM
A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Natalie Stanley
Effector fates of ILC are epigenetically imprinted early in ontogeny through the selective loss of DNA methylation at signature genes encoding fate-determining regulators @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 19, 2025 at 7:01 PM
Effector fates of ILC are epigenetically imprinted early in ontogeny through the selective loss of DNA methylation at signature genes encoding fate-determining regulators @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Natalie Stanley
Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks @natgenet.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 19, 2025 at 7:03 PM
Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks @natgenet.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Natalie Stanley
Now out in @natmachintell.nature.com
TCRT5 is a rapid generator of target-conditioned CDR3b, leads SoTA, and yields the first AI-designed self-tolerant binder to an OOD non-viral epitope (w val)
📑: www.nature.com/articles/s42...
🤗: huggingface.co/dkarthikeyan1
👨💻: github.com/pirl-unc/tcr_translate
TCRT5 is a rapid generator of target-conditioned CDR3b, leads SoTA, and yields the first AI-designed self-tolerant binder to an OOD non-viral epitope (w val)
📑: www.nature.com/articles/s42...
🤗: huggingface.co/dkarthikeyan1
👨💻: github.com/pirl-unc/tcr_translate
September 9, 2025 at 9:25 AM
Now out in @natmachintell.nature.com
TCRT5 is a rapid generator of target-conditioned CDR3b, leads SoTA, and yields the first AI-designed self-tolerant binder to an OOD non-viral epitope (w val)
📑: www.nature.com/articles/s42...
🤗: huggingface.co/dkarthikeyan1
👨💻: github.com/pirl-unc/tcr_translate
TCRT5 is a rapid generator of target-conditioned CDR3b, leads SoTA, and yields the first AI-designed self-tolerant binder to an OOD non-viral epitope (w val)
📑: www.nature.com/articles/s42...
🤗: huggingface.co/dkarthikeyan1
👨💻: github.com/pirl-unc/tcr_translate
Reposted by Natalie Stanley
tl;dr T5 style translation model to generate T cell receptors from targets actually kinda works
Caveats: not full TCR (CDR3b), strong signal that public data biased towards “polyspecific” TCRs — lo and behold, generated TCR-T is polyspecific in vitro.
Open weights, go wild.
Caveats: not full TCR (CDR3b), strong signal that public data biased towards “polyspecific” TCRs — lo and behold, generated TCR-T is polyspecific in vitro.
Open weights, go wild.
This is a cool story that I've watched with great interest - making big steps in the field of de novo TCR generation! Great work @dkarthikey1.bsky.social / @benjamingvincent.bsky.social / @alexr.bsky.social et al
Conditional generation of real antigen-specific T cell receptor sequences @natmachintell.nature.com
www.nature.com/articles/s42...
www.nature.com/articles/s42...
September 9, 2025 at 12:33 AM
tl;dr T5 style translation model to generate T cell receptors from targets actually kinda works
Caveats: not full TCR (CDR3b), strong signal that public data biased towards “polyspecific” TCRs — lo and behold, generated TCR-T is polyspecific in vitro.
Open weights, go wild.
Caveats: not full TCR (CDR3b), strong signal that public data biased towards “polyspecific” TCRs — lo and behold, generated TCR-T is polyspecific in vitro.
Open weights, go wild.
Reposted by Natalie Stanley
Reorganization and progressive depletion of NK/ILC compartment in amyotrophic lateral sclerosis (ALS), with inverse correlation between NK and Th responses in fast progressors @biorxivpreprint.bsky.social @natstann.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
September 6, 2025 at 10:52 PM
Reorganization and progressive depletion of NK/ILC compartment in amyotrophic lateral sclerosis (ALS), with inverse correlation between NK and Th responses in fast progressors @biorxivpreprint.bsky.social @natstann.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Natalie Stanley
CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social
academic.oup.com/jimmunol/adv...
academic.oup.com/jimmunol/adv...
September 6, 2025 at 1:36 AM
CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social
academic.oup.com/jimmunol/adv...
academic.oup.com/jimmunol/adv...
Reposted by Natalie Stanley
@cp-trendspharma.bsky.social Multitargeting neuroimmune pathways: novel candidates for chronic pain relief
www.cell.com/trends/pharm...
www.cell.com/trends/pharm...
September 4, 2025 at 4:05 AM
@cp-trendspharma.bsky.social Multitargeting neuroimmune pathways: novel candidates for chronic pain relief
www.cell.com/trends/pharm...
www.cell.com/trends/pharm...
Reposted by Natalie Stanley
Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions @natmethods.nature.com @soumya-boston.bsky.social @dkotliar.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 4, 2025 at 5:16 AM
Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions @natmethods.nature.com @soumya-boston.bsky.social @dkotliar.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Natalie Stanley
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease
Microglia-mediated neuroinflammation drives Alzheimer's disease (AD) pathogenesis,
yet the underlying mechanism is poorly understood. Song et al. demonstrate that toxic
amyloid-β induces oxidation and...
www.cell.com
September 3, 2025 at 2:26 AM
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
Reposted by Natalie Stanley
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice
www.nature.com/articles/s41... @staceykigar.bsky.social @natcomms.nature.com
www.nature.com/articles/s41... @staceykigar.bsky.social @natcomms.nature.com
September 1, 2025 at 6:22 PM
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice
www.nature.com/articles/s41... @staceykigar.bsky.social @natcomms.nature.com
www.nature.com/articles/s41... @staceykigar.bsky.social @natcomms.nature.com
Reposted by Natalie Stanley
Follicular regulatory T cells promote B cell–mediated experimental neuroinflammation and are associated with multiple sclerosis activity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
August 28, 2025 at 2:09 AM
Follicular regulatory T cells promote B cell–mediated experimental neuroinflammation and are associated with multiple sclerosis activity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Natalie Stanley
Perspective @nataging.nature.com @miriammerad.bsky.social
Restoring resident tissue macrophages to combat aging and cancer
www.nature.com/articles/s43...
Restoring resident tissue macrophages to combat aging and cancer
www.nature.com/articles/s43...
Restoring resident tissue macrophages to combat aging and cancer - Nature Aging
Park and colleagues propose a conceptual framework in which dysregulation of resident tissue macrophages is both a central contributor to how an aging immune system causes diseases, including cancer, ...
www.nature.com
August 15, 2025 at 2:32 AM
Perspective @nataging.nature.com @miriammerad.bsky.social
Restoring resident tissue macrophages to combat aging and cancer
www.nature.com/articles/s43...
Restoring resident tissue macrophages to combat aging and cancer
www.nature.com/articles/s43...
Reposted by Natalie Stanley
This study, led by the talented grad student Boyang Li, identifies microglia undergoing cellular senescence in AD, and targeting cholesterol metabolism in senescent microglia is a therapeutic approach to slow AD progression. onlinelibrary.wiley.com/doi/10.1111/...
Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease
Senescent microglia in Alzheimer's disease exhibit dysregulated cholesterol metabolism and express Disease-Associated Microglia (DAM) signatures, including inflammatory and phagocytic markers. Single....
onlinelibrary.wiley.com
August 15, 2025 at 12:45 AM
This study, led by the talented grad student Boyang Li, identifies microglia undergoing cellular senescence in AD, and targeting cholesterol metabolism in senescent microglia is a therapeutic approach to slow AD progression. onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Natalie Stanley
Durable B-Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis
Objectives Ocrelizumab (OCR), a humanized anti-CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR-MS). We assessed early cellular B-cell profiles in patients...
onlinelibrary.wiley.com
August 13, 2025 at 3:02 PM
Durable B-Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Natalie Stanley
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age @natimmunol.nature.com @teichlab.bsky.social @donnafarber.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 13, 2025 at 6:38 PM
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age @natimmunol.nature.com @teichlab.bsky.social @donnafarber.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Natalie Stanley
When it comes to aging, the health of even the smallest vessels is critical to maintaining cognitive function.
New study in @nature.com finds that deterioration of the brain's drainage system contributes to reduced blood supply in deep white matter: www.nature.com/articles/s41...
New study in @nature.com finds that deterioration of the brain's drainage system contributes to reduced blood supply in deep white matter: www.nature.com/articles/s41...
The brain drain puts aging myelin in deep trouble - Nature Neuroscience
In this issue, Stamenkovic et al. describe deep in vivo imaging of the brain vasculature to document its evolution during aging, which identifies a unique vulnerability at the site of convergence of c...
www.nature.com
August 12, 2025 at 6:48 PM
When it comes to aging, the health of even the smallest vessels is critical to maintaining cognitive function.
New study in @nature.com finds that deterioration of the brain's drainage system contributes to reduced blood supply in deep white matter: www.nature.com/articles/s41...
New study in @nature.com finds that deterioration of the brain's drainage system contributes to reduced blood supply in deep white matter: www.nature.com/articles/s41...
Reposted by Natalie Stanley
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells @natimmunol.nature.com @idoyagalab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 12, 2025 at 6:39 PM
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells @natimmunol.nature.com @idoyagalab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...