Nathan Spencer
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nathantspencer.bsky.social
Nathan Spencer
@nathantspencer.bsky.social
CTO @ syGlass, building virtual reality solutions for the challenges faced by scientific researchers and educators.
Stereoscopic visualization can be achieved in a variety of ways, each with their own advantages. One of the many strengths of syGlass is its ability to seamlessly switch between them: immersive virtual reality, anaglyph (red/cyan) rendering, and now Sony's glasses-free 3D displays.
Exciting News! 😎 syGlass is proud to announce our new collaboration with Sony, featuring their revolutionary glasses-free 3D Spatial Reality Display. Experience the future of visualization at the 2025 Society for Neuroscience conference. Stop by our booth #813 to see it in action!

#sfn25 #sfn2025
November 14, 2025 at 7:58 PM
Reposted by Nathan Spencer
For #3DThursday we’re introducing Dynamic Depth color mapping! It encodes distance with smooth depth-aware gradients so layered structures pop without losing context.

🔬 #MicroCT of a P1 mouse
🥼 Hsu Lab, Baylor, @cwloganhsu.bsky.social
🎬 syGlass.io

#Microscopy #SciComm #3DVisualization #syGlass
November 13, 2025 at 1:31 PM
Reposted by Nathan Spencer
💧 A male water flea (#Daphnia magna) for #3DThursday! Yellow 🟨 is musculature, magenta/gray 🟪 shows autofluorescence of its outer cuticle.

🔬: Fluorescence Microscopy
🥼: Carsten Wolff
🏛️: Marine Bio Lab @mblscience.bsky.social
🎬: syGlass.io

#EnvironmentalScience #MBL #SciComm #Microscopy #syGlass
October 9, 2025 at 11:36 AM
Reposted by Nathan Spencer
🍺 It’s Oktoberfest, so let's look inside beer foam! Non-destructive imaging like this is key for food science and helps us understand how structure and stability affect things like aroma and taste.

🔬: TESCAN DynaTOM #microCT
🥼: Wesley De Boever
🎬: syGlass.io

#Oktoberfest #3DThursday #Microscopy
October 2, 2025 at 4:33 PM
Reposted by Nathan Spencer
👀 #3DThursday: Cross your eyes to see this super res pollen dataset in 3D! Good old fashioned stereo pairs in #syGlass bringing science to life. 🌿✨

🔬: Zeiss LSM 980 with Airyscan 2
🥼: Nat Prunet, @nat-prunet.bsky.social
🏛️: UNC Biological Microscopy Core: tarheels.live/biologymicro...
🎬: syGlass.io
September 25, 2025 at 2:55 PM
Reposted by Nathan Spencer
Non-destructive testing for #3DThursday!🥽 Apple Vision Pro vs MetaQuest in a microCT.

🔬: Lumafield @lumafield.bsky.social microCT
🎬: syGlass.io, loading two projects at once

3D imaging like this is used to validate design, catch flaws, and build smarter devices.

#MicroCT #syGlass #VR #SciComm
September 18, 2025 at 4:53 PM
Reposted by Nathan Spencer
Pollen diversity #3DThursday!🌼🌾 Thanks to Nat Prunet's careful microscopy, we see ridges, spikes & pores that reveal how plants spread & survive.
🔬: @zeiss-microscopy.bsky.social LSM 980, Airyscan 2
🥼: @nat-prunet.bsky.social
🏛️: UNC Biological Microscopy Core
🎬: syGlass.io v2.4.0 #syGlass
September 4, 2025 at 4:45 PM
Reposted by Nathan Spencer
Chicken balancing for #3DThursday!🐔 These utricle hair cells sense gravity & straight-line motion. We segmented them with #CellposeSAM in #syGlass.

🥼: Stefan Heller Group
🏛️: Stanford @stanfordmedicine.bsky.social
🎬: syGlass.io v2.4.0, out now!

#Neuroanatomy #Microscopy #3DVisualization #SciComm
August 28, 2025 at 3:54 PM
Reposted by Nathan Spencer
It's #MicroscopyMonday! Today we have a very special confocal dataset that HIGH SCHOOL students were able to label and image themselves at the MBL.

🐟: #Zebrafish
🔬: Nipam Patel, High School Science Discovery Programs
🏛️: @mblscience.bsky.social
🎬: syGlass.io

#NESM #Confocal #SciComm #ScienceEd
August 25, 2025 at 8:32 PM
Reposted by Nathan Spencer
4D bread baking inside a microCT for #3DThursday?!🍞

🔬: TESCAN DynaTOM
🏛️: TESCAN, thanks to Marijn Boone for the data!
🎬: syGlass.io

Total scan time: 22m8s
Time for 1 scan: 10 seconds
Total scans: 124 volumes

#4DImaging #MicroCT #DynamicImaging #FoodScience #syGlass #VRVisualization #ScientificVR
August 14, 2025 at 3:27 PM
Reposted by Nathan Spencer
Automated Segmentation by Cellpose-SAM using syGlass for #3DThursday! This took about 30 minutes to run on one of the gaming laptops. Crazy.

🔬: Synchrotron #MicroCT
🥼: Keith Cheng, MD, PhD, @pennstateuniv.bsky.social
📝: #CellposeSAM www.biorxiv.org/content/10.1...
🥽: syGlass.io v2.4.0 -- out soon!
July 31, 2025 at 2:52 PM
Reposted by Nathan Spencer
I love this for #3DThursday -- Zebrafish, but make it four and layer them!

🥼: Arnim Jenett
🏛️: TEFOR tefor.net/en/
🔬: #Lightsheet
🎬: syGlass in colorblind mode, #syGlass

Check it out for yourself with their resource "The Larval Standard Brain":
zebrafish.tefor.net#/home?_k=fz1...
July 17, 2025 at 4:20 PM
Reposted by Nathan Spencer
A #microscopy mystery for #3DThursday!🌾 What is this? 🔍 Things that I know: it is a #plant, it was imaged on a Lumafield #microCT, and the color is a LUT (look up table) that I applied in #syGlass and has nothing to do with the organism (microCT comes in as grayscale). Help! #SciComm
July 10, 2025 at 3:21 PM
Reposted by Nathan Spencer
Happy 4th for #3DThursday! 🎉 Do I occasionally forget and then remember ecstatically that we have a confetti cannon in the syGlass room? Yes, yes, I do ...

#syGlass #VRScience #Microscopy #SciComm
July 3, 2025 at 3:07 PM
Reposted by Nathan Spencer
Finally plants for #3DThursday!🌽 A maize root tip, imaged using #microCT, from the Topp Roots Lab.

🔬: @zeiss-microscopy.bsky.social Versa 520 XRM
🥼: Keith Duncan @cygnusplantxray.bsky.social
🏛️: Danforth Center @danforthcenter.bsky.social
📝: academic.oup.com/plphys/artic...
🎬: syGlass.io #syGlass
June 26, 2025 at 4:17 PM
Reposted by Nathan Spencer
Get your 3D glasses out for #3DThursday! And click the link below to see syGlass on the really big screen at the @mit.edu MIT Museum last week. (guys it's my first syGlass blog ...)

📝: www.syglass.io/blog/a-night...
🥼: Kory Evans @sternarchella.bsky.social , Rice University
🎥: syGlass.io #syGlass
June 19, 2025 at 3:42 PM
Reposted by Nathan Spencer
LIVE sea urchin larvae for #3DThursday! Catch me at the MIT Museum tonight at AfterDark and see it in person.

🔬: @brukercorporation.bsky.social TruLive3D
🥼: Amro Hamdoun @hamdounlab.bsky.social ‬, Tzer Han Tan's @tzerhan29.bsky.social group at UCSD
🌌: Painted Sea Urchin
🎥: syGlass.io #syGlass
June 12, 2025 at 2:07 PM
Reposted by Nathan Spencer
Up in Acadia at the @mdibiolab.bsky.social for #LSFM25! Here's a cleared whole mouse head on the SmartSPIM, 3.6X objective for #3DThursday.

🔎 @jtakatoh.bsky.social, now at @stonybrooku.bsky.social
🔬 LifeCanvas Technologies, lifecanvastech.com/products/sma...
🥽 syGlass.io

@lsfm-na.bsky.social
June 5, 2025 at 12:54 PM
Reposted by Nathan Spencer
✨ Heading to @mdibiolab.bsky.social next week for the LSFM course! Here’s some stunning lightsheet data from @erturklab.bsky.social
🔬: Blaze Ultramicroscope, LaVision Biotech
🥼: Hongcheng Mai, Jie Luo, Helmholtz Munich
📝: pmc.ncbi.nlm.nih.gov/articles/PMC...
🎬: syGlass.io
#3DThursday #LSFM2025
May 29, 2025 at 3:58 PM
Reposted by Nathan Spencer
For #3DThursday, whole mouse liver imaged with #mesoSPIM light sheet microscopy! Showing how structure meets function across the organ.
🥽: syGlass.io
🥼: Hei Ming Lai
📝: INSIHGT -> www.nature.com/articles/s41...
🏛️: Chinese University of Hong Kong

#LightSheet #SciComm #3DImaging #syGlass
May 15, 2025 at 4:31 PM
In the age of AI annotation tools, why use VR to segment or track objects in your image volumes?

My answer + more on new features from our spring release of syGlass:

www.syglass.io/blog/syglass...
syGlass Spring Release: v2.3.0 — syGlass
Our spring update is here in the form of syGlass v2.3.0, with new features that apply to a broad range of use cases, from image analysis and visualization to immersive content creation. Whether you’re...
www.syglass.io
May 13, 2025 at 3:12 PM
Every quarter, our fantastic development team at syGlass breaks new ground at the intersection of scientific research and virtual reality.

This spring release is the best iteration of syGlass yet, with many improvements under the hood in addition to the new features below.
🔬 For #3DThursday: syGlass v2.3.0 is here!🥽
Improved time series tracking, 📊 histogram view for thresholding, avatar preview before narration, 🕶️ real-time anaglyph rendering, and narration editing.

More upgrades + fixes inside.
📬 47483437.hs-sites.com/syglass-v2.2.3
#Microscopy #VR #SciComm
May 8, 2025 at 6:08 PM
Reposted by Nathan Spencer
For #3DThursday, a cleared axolotl on a line confocal!

🥽: syGlass.io
🔬: Dual-View Line Scanning Confocal: www.mbl.edu/research/res...
🥼: @ryliewalsh.bsky.social, @mblscience.bsky.social
🐉: @murawalalab.bsky.social, @mdibiolab.bsky.social
🏛️: MBL Center for Innovation in Imaging and Image Analysis
May 1, 2025 at 4:54 PM
Reposted by Nathan Spencer
Comparison may be the thief of joy, but in devbio it’s how researchers understand how life takes shape. Excited to be at SDB Northeast this weekend! www.sdbonline.org/nesdb2025

🔬: Zebrafish, synchrotron micro-CT
🥼: chenglab.io
🥽: syGlass.io

#DevBio #Zebrafish #syGlass #3DImaging #3DThursday
April 24, 2025 at 4:33 PM
Reposted by Nathan Spencer
Expansion Microscopy (ExM) for #3DThursday! Nanoscale details, regular microscope.🤯

🥼 Ksena Longrin
🥽 syGlass.io
🟦 vGlut1, Vesicular glutamate transporter 1
🟨​ Kv3.3 , a voltage-gated potassium ion channel subunit
🔬 @ZEISS Microscopy LSM980
📝 doi.org/10.7554/eLife.75219
April 3, 2025 at 2:24 PM