The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.

Development of the vertebrate retina involves the interaction of multiple signaling pathways and cell types, and there is growing appreciation of the role of innate immune pathways in this process. Re...

Replacing brain macrophages holds substantial therapeutic promise but remains challenging. Bastos et al. uncover the requirements for monocytes to replace microglia and border-associated macrophages. They show that monocyte ontogeny shapes brain macrophage identity, with fetal monocytes acquiring a true microglial state. Using xenotransplantation and Alzheimer’s patient data, they identify human monocyte-derived microglia. These findings are important for microglia replacement therapies.

Cuts and layoffs to the National Institutes of Health threaten medical research around the U.S., agency insiders warn.

While university officials said they’ve still not received official word of such action, they acknowledged receiving about 100 stop-work orders from the federal government on roughly 100 fede…

Le et al. examined the sex-dependent effects of a drug that removes microglia, called PLX3397. They revealed that male microglia are more susceptible to being depleted by PLX3397 than female microglia...