Manuel M. Gómez de las Heras
@mmgomezheras.bsky.social
Postdoc researcher 🧬🥼 | Tissue immunity & Aging | María Mittelbrunn's lab
Pinned
CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.
www.science.org
Fresh from the oven 🧨💥
We show that CD4 T cells, especially Tregs, control host-microbiota symbiosis and intestinal barrier integrity to prevent inflammaging, tissue senescence and aging-related multimorbidity
🔥 👵🏻
www.science.org/doi/10.1126/...
We show that CD4 T cells, especially Tregs, control host-microbiota symbiosis and intestinal barrier integrity to prevent inflammaging, tissue senescence and aging-related multimorbidity
🔥 👵🏻
www.science.org/doi/10.1126/...
Reposted by Manuel M. Gómez de las Heras
Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV @cellcellpress.bsky.social @ragoninstitute.bsky.social @harvardmed.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV
PPARγ downregulation in colonic CD8+ T cells from people with HIV (PWH) on antiretroviral
therapy (ART) disrupts lipid metabolism and promotes contact-dependent epithelial
apoptosis, leading to intest...
www.cell.com
September 11, 2025 at 3:29 PM
Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV @cellcellpress.bsky.social @ragoninstitute.bsky.social @harvardmed.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Manuel M. Gómez de las Heras
Online now! Soto-Heredero et al. show that Tregs characterized by the expression of KLRG1 accumulate with age in both mice and humans, and exhibit features like mitochondrial decline and an inflammatory phenotype.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging
Nature Aging - T cells undergo age-related changes that impair their organismal functions. Here Soto-Heredero et al. show that regulatory T cells characterized by the expression of KLRG1 accumulate...
rdcu.be
May 5, 2025 at 12:56 PM
Online now! Soto-Heredero et al. show that Tregs characterized by the expression of KLRG1 accumulate with age in both mice and humans, and exhibit features like mitochondrial decline and an inflammatory phenotype.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Reposted by Manuel M. Gómez de las Heras
El grupo de María Mittelbrunn en el CBM descubre un mecanismo celular que altera la microbiota intestinal y aumenta la aparición de enfermedades. Con una terapia celular lograron restaurar la inmunidad intestinal y prevenir estos efectos.
www.cbm.uam.es/index.php/20...
www.cbm.uam.es/index.php/20...
Descubren un mecanismo celular que altera la microbiota intestinal y aumenta la aparición de enfermedades múltiples - Centro de Biología Molecular Severo Ochoa
La pérdida de función de los linfocitos T CD4 altera la microbiota intestinal y, en consecuencia, acelera el envejecimiento celular y aumenta el riesgo de enfermedades múltiples. Es lo que […]
www.cbm.uam.es
August 5, 2025 at 5:59 AM
El grupo de María Mittelbrunn en el CBM descubre un mecanismo celular que altera la microbiota intestinal y aumenta la aparición de enfermedades. Con una terapia celular lograron restaurar la inmunidad intestinal y prevenir estos efectos.
www.cbm.uam.es/index.php/20...
www.cbm.uam.es/index.php/20...
Reposted by Manuel M. Gómez de las Heras
🔬Un estudio del CSIC demuestra que el deterioro asociado a la edad de los linfocitos T CD4 debilita la barrera intestinal y favorece la inflamación crónica y el envejecimiento celular
💉 El trabajo también presenta una posible terapia
➡️ https://tinyurl.com/97ssrv74
💉 El trabajo también presenta una posible terapia
➡️ https://tinyurl.com/97ssrv74
August 4, 2025 at 8:02 AM
🔬Un estudio del CSIC demuestra que el deterioro asociado a la edad de los linfocitos T CD4 debilita la barrera intestinal y favorece la inflamación crónica y el envejecimiento celular
💉 El trabajo también presenta una posible terapia
➡️ https://tinyurl.com/97ssrv74
💉 El trabajo también presenta una posible terapia
➡️ https://tinyurl.com/97ssrv74
Reposted by Manuel M. Gómez de las Heras
#WeekendRead! #LiveForever & #MicrobiotaPower! Mittelbrun &co show @ Science Immunology that mitochondria alteration in T cells drives premature #inflammaging by decreasing Tfh & Treg cells which causes gut permeability & dysbiosis that can be corrected by T cell transfer! doi.org/10.1126/scii...
CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.
doi.org
August 2, 2025 at 4:04 PM
#WeekendRead! #LiveForever & #MicrobiotaPower! Mittelbrun &co show @ Science Immunology that mitochondria alteration in T cells drives premature #inflammaging by decreasing Tfh & Treg cells which causes gut permeability & dysbiosis that can be corrected by T cell transfer! doi.org/10.1126/scii...
Fresh from the oven 🧨💥
We show that CD4 T cells, especially Tregs, control host-microbiota symbiosis and intestinal barrier integrity to prevent inflammaging, tissue senescence and aging-related multimorbidity
🔥 👵🏻
www.science.org/doi/10.1126/...
We show that CD4 T cells, especially Tregs, control host-microbiota symbiosis and intestinal barrier integrity to prevent inflammaging, tissue senescence and aging-related multimorbidity
🔥 👵🏻
www.science.org/doi/10.1126/...
CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.
www.science.org
August 6, 2025 at 4:58 PM
Fresh from the oven 🧨💥
We show that CD4 T cells, especially Tregs, control host-microbiota symbiosis and intestinal barrier integrity to prevent inflammaging, tissue senescence and aging-related multimorbidity
🔥 👵🏻
www.science.org/doi/10.1126/...
We show that CD4 T cells, especially Tregs, control host-microbiota symbiosis and intestinal barrier integrity to prevent inflammaging, tissue senescence and aging-related multimorbidity
🔥 👵🏻
www.science.org/doi/10.1126/...
Reposted by Manuel M. Gómez de las Heras
This week's cover, illustrated by the amazing Ashley Mastin, highlights work by @mmgomezheras.bsky.social & al.!
CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.
www.science.org
August 1, 2025 at 8:29 PM
This week's cover, illustrated by the amazing Ashley Mastin, highlights work by @mmgomezheras.bsky.social & al.!
Reposted by Manuel M. Gómez de las Heras
The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice!
wwwscience.org/toc/sciimmun...
wwwscience.org/toc/sciimmun...
August 1, 2025 at 8:21 PM
The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice!
wwwscience.org/toc/sciimmun...
wwwscience.org/toc/sciimmun...
Reposted by Manuel M. Gómez de las Heras
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging @sciimmunology.bsky.social @mmgomezheras.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
August 1, 2025 at 8:24 PM
Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging @sciimmunology.bsky.social @mmgomezheras.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...