Lisandro Milocco
@milocco.bsky.social
Asst. Prof. and DDLS fellow
Dept. Zoology, Stockholm University and SciLifeLab
🇦🇷 -> 🇫🇮 -> 🇸🇪
Evo-devo and dynamical systems
https://lisandromilocco.github.io/
Dept. Zoology, Stockholm University and SciLifeLab
🇦🇷 -> 🇫🇮 -> 🇸🇪
Evo-devo and dynamical systems
https://lisandromilocco.github.io/
Pinned
Lisandro Milocco
@milocco.bsky.social
· Aug 25
🚨 We're hiring!
PhD position in Evolutionary Systems Biology at Stockholm University & SciLifeLab
🎓 Focus: evolution, development, computational & mathematical modeling, prediction
📍 Stockholm, Sweden
🕒 4 years, fully-funded
🔍 Details: su.varbi.com/en/what:job/...
Please share!
PhD position in Evolutionary Systems Biology at Stockholm University & SciLifeLab
🎓 Focus: evolution, development, computational & mathematical modeling, prediction
📍 Stockholm, Sweden
🕒 4 years, fully-funded
🔍 Details: su.varbi.com/en/what:job/...
Please share!
Reposted by Lisandro Milocco
Is it possible to estimate rates of phenotypic evolution that are independent of the time interval covered by the data? In theory, yes — even when the data are incomplete and biased. But in practice? Not so much. Amazing work by @vildebruhn.bsky.social
November 13, 2025 at 8:47 PM
Is it possible to estimate rates of phenotypic evolution that are independent of the time interval covered by the data? In theory, yes — even when the data are incomplete and biased. But in practice? Not so much. Amazing work by @vildebruhn.bsky.social
Reposted by Lisandro Milocco
How can we organize current theoretical approaches for developmental biology - from information to dynamical systems & GRNs - into a common framework?
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
November 10, 2025 at 6:46 AM
How can we organize current theoretical approaches for developmental biology - from information to dynamical systems & GRNs - into a common framework?
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
We propose to think along Marr's 3 levels: computational problem, algorithm, implementation
Check out our review:
arxiv.org/abs/2510.24536
Reposted by Lisandro Milocco
What is the origin of diversity in allometric laws scaling across species? Check our new paper led by Andrea Tabi where
we propose a new theory of metabolic scaling grounded in thermodynamics and stochastic fluctuations at the cellular level.
www.biorxiv.org/content/10.1...
we propose a new theory of metabolic scaling grounded in thermodynamics and stochastic fluctuations at the cellular level.
www.biorxiv.org/content/10.1...
November 9, 2025 at 2:39 AM
What is the origin of diversity in allometric laws scaling across species? Check our new paper led by Andrea Tabi where
we propose a new theory of metabolic scaling grounded in thermodynamics and stochastic fluctuations at the cellular level.
www.biorxiv.org/content/10.1...
we propose a new theory of metabolic scaling grounded in thermodynamics and stochastic fluctuations at the cellular level.
www.biorxiv.org/content/10.1...
Reposted by Lisandro Milocco
🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
November 3, 2025 at 2:46 PM
🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
Reposted by Lisandro Milocco
A personal favorite, long time in the making. Adelina and David (@dduneau.bsky.social) were instrumental in getting this done.
doi.org/10.1186/s129...
doi.org/10.1186/s129...
Wound-induced eyespots on butterfly wings at the intersection of immune response and pigmentation development - BMC Biology
Background Butterfly eyespots are striking examples of evolutionary novelty arising through the repurposing of ancestral genetic pathways, including pathways involved in wound healing. Given the activ...
doi.org
October 29, 2025 at 1:58 PM
A personal favorite, long time in the making. Adelina and David (@dduneau.bsky.social) were instrumental in getting this done.
doi.org/10.1186/s129...
doi.org/10.1186/s129...
Reposted by Lisandro Milocco
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
www.biorxiv.org
October 22, 2025 at 5:46 PM
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lisandro Milocco
Polygenic risk scores obtained for a single individual over a range of commercially available tests. FFS
October 23, 2025 at 1:41 PM
Polygenic risk scores obtained for a single individual over a range of commercially available tests. FFS
Reposted by Lisandro Milocco
I’m excited to announce the launch of my lab at EPFL in Jan 2026 🎉. We’ll combine evolution & synthetic biology to study and (re)engineer bacterial communication.
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
October 20, 2025 at 6:14 PM
I’m excited to announce the launch of my lab at EPFL in Jan 2026 🎉. We’ll combine evolution & synthetic biology to study and (re)engineer bacterial communication.
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
Reposted by Lisandro Milocco
New review out! With students in my lab, we explore how population size shapes speciation—from drift in small populations to selection in large ones. Do small or large populations speciate faster? The answer is more nuanced than you might think.
esj-journals.onlinelibrary.wiley.com/doi/full/10....
esj-journals.onlinelibrary.wiley.com/doi/full/10....
Speciation Through the Lens of Population Dynamics: A Theoretical Primer on How Small and Large Populations Diverge
Population size and dynamics fundamentally shape speciation by influencing genetic drift, founder events, and adaptive potential. Small populations may speciate rapidly due to stronger drift, whereas...
esj-journals.onlinelibrary.wiley.com
October 14, 2025 at 11:25 PM
New review out! With students in my lab, we explore how population size shapes speciation—from drift in small populations to selection in large ones. Do small or large populations speciate faster? The answer is more nuanced than you might think.
esj-journals.onlinelibrary.wiley.com/doi/full/10....
esj-journals.onlinelibrary.wiley.com/doi/full/10....
Reposted by Lisandro Milocco
Interpretable gene network inference with nonlinear causality https://www.biorxiv.org/content/10.1101/2025.09.28.678927v1
September 29, 2025 at 6:04 PM
Interpretable gene network inference with nonlinear causality https://www.biorxiv.org/content/10.1101/2025.09.28.678927v1
Reposted by Lisandro Milocco
I'm excited to share with you all a conference I'm planning Oct. 10-12: Dialectical Biology Today: Legacies of Richard Lewontin.
It will be hybrid in Toronto and on zoom, so please join us however you can! Register for zoom link here: ihpst.utoronto.ca/events/diale...
It will be hybrid in Toronto and on zoom, so please join us however you can! Register for zoom link here: ihpst.utoronto.ca/events/diale...
September 15, 2025 at 5:35 PM
I'm excited to share with you all a conference I'm planning Oct. 10-12: Dialectical Biology Today: Legacies of Richard Lewontin.
It will be hybrid in Toronto and on zoom, so please join us however you can! Register for zoom link here: ihpst.utoronto.ca/events/diale...
It will be hybrid in Toronto and on zoom, so please join us however you can! Register for zoom link here: ihpst.utoronto.ca/events/diale...
Reposted by Lisandro Milocco
Now out in @nature.com: Our study discovering a neural circuit in Drosophila that predictively inhibits proprioceptor axons during voluntary leg movements, such as walking and grooming. www.nature.com/articles/s41...
September 17, 2025 at 3:14 PM
Now out in @nature.com: Our study discovering a neural circuit in Drosophila that predictively inhibits proprioceptor axons during voluntary leg movements, such as walking and grooming. www.nature.com/articles/s41...
⏳ Only 2 weeks left to apply to our PhD in evolutionary prediction!
🚨 We're hiring!
PhD position in Evolutionary Systems Biology at Stockholm University & SciLifeLab
🎓 Focus: evolution, development, computational & mathematical modeling, prediction
📍 Stockholm, Sweden
🕒 4 years, fully-funded
🔍 Details: su.varbi.com/en/what:job/...
Please share!
PhD position in Evolutionary Systems Biology at Stockholm University & SciLifeLab
🎓 Focus: evolution, development, computational & mathematical modeling, prediction
📍 Stockholm, Sweden
🕒 4 years, fully-funded
🔍 Details: su.varbi.com/en/what:job/...
Please share!
September 17, 2025 at 11:31 AM
⏳ Only 2 weeks left to apply to our PhD in evolutionary prediction!
Reposted by Lisandro Milocco
(1/14) I’m happy and proud to introduce: SpinePy – a framework to detect the "spine" of gastruloids and measure biological and physical signals in a local dynamic 3D coordinate system. www.biorxiv.org/content/10.1...
September 12, 2025 at 12:44 PM
(1/14) I’m happy and proud to introduce: SpinePy – a framework to detect the "spine" of gastruloids and measure biological and physical signals in a local dynamic 3D coordinate system. www.biorxiv.org/content/10.1...
Reposted by Lisandro Milocco
Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution https://www.biorxiv.org/content/10.1101/2025.09.11.675703v1
September 12, 2025 at 3:32 PM
Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution https://www.biorxiv.org/content/10.1101/2025.09.11.675703v1
Reposted by Lisandro Milocco
A central finding is that, even if we could measure pairwise interactions up to a certain precision, strong indirect effects can make our efforts useless: at high collectivity, pairwise interactions no longer inform about community coexistence
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 12, 2025 at 10:28 AM
A central finding is that, even if we could measure pairwise interactions up to a certain precision, strong indirect effects can make our efforts useless: at high collectivity, pairwise interactions no longer inform about community coexistence
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Lisandro Milocco
Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria
in #PNAS from Raúl Fernández-López
with @pabnik.bsky.social @amazeld.bsky.social
www.pnas.org/doi/10.1073/...
in #PNAS from Raúl Fernández-López
with @pabnik.bsky.social @amazeld.bsky.social
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
September 4, 2025 at 10:59 AM
Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria
in #PNAS from Raúl Fernández-López
with @pabnik.bsky.social @amazeld.bsky.social
www.pnas.org/doi/10.1073/...
in #PNAS from Raúl Fernández-López
with @pabnik.bsky.social @amazeld.bsky.social
www.pnas.org/doi/10.1073/...
Reposted by Lisandro Milocco
DeepAtlas: a tool for effective manifold learning https://www.biorxiv.org/content/10.1101/2025.08.26.672474v1
August 31, 2025 at 4:04 PM
DeepAtlas: a tool for effective manifold learning https://www.biorxiv.org/content/10.1101/2025.08.26.672474v1
Reposted by Lisandro Milocco
Can a virus help uncover Turing patterns in nature? In this @commsbio.nature.com paper, researchers show how the tulip breaking virus triggers the expression of a pigment that can display a broad range of (observable) stripe patterns @philipcball.bsky.social
biorxiv.org/content/10.1...
biorxiv.org/content/10.1...
August 27, 2025 at 10:25 PM
Can a virus help uncover Turing patterns in nature? In this @commsbio.nature.com paper, researchers show how the tulip breaking virus triggers the expression of a pigment that can display a broad range of (observable) stripe patterns @philipcball.bsky.social
biorxiv.org/content/10.1...
biorxiv.org/content/10.1...
Reposted by Lisandro Milocco
🚨New PhD research published in PNAS!🚨
Combining fossils and lab experiments, we found that simple changes in tooth #development explain 6 million years of molar #evolution in #voles 🐭🦷
Shoutout to my coauthors @cnrs.fr @helsinki.fi @gtk-fi.bsky.social!
www.pnas.org/doi/10.1073/... #FossilFriday
Combining fossils and lab experiments, we found that simple changes in tooth #development explain 6 million years of molar #evolution in #voles 🐭🦷
Shoutout to my coauthors @cnrs.fr @helsinki.fi @gtk-fi.bsky.social!
www.pnas.org/doi/10.1073/... #FossilFriday
Six million years of vole dental evolution shaped by tooth development | PNAS
Morphological change occurs over macroevolutionary timescales under the action of
natural selection and genetic drift combined with developmental p...
www.pnas.org
August 1, 2025 at 5:00 PM
🚨New PhD research published in PNAS!🚨
Combining fossils and lab experiments, we found that simple changes in tooth #development explain 6 million years of molar #evolution in #voles 🐭🦷
Shoutout to my coauthors @cnrs.fr @helsinki.fi @gtk-fi.bsky.social!
www.pnas.org/doi/10.1073/... #FossilFriday
Combining fossils and lab experiments, we found that simple changes in tooth #development explain 6 million years of molar #evolution in #voles 🐭🦷
Shoutout to my coauthors @cnrs.fr @helsinki.fi @gtk-fi.bsky.social!
www.pnas.org/doi/10.1073/... #FossilFriday
🚨 We're hiring!
PhD position in Evolutionary Systems Biology at Stockholm University & SciLifeLab
🎓 Focus: evolution, development, computational & mathematical modeling, prediction
📍 Stockholm, Sweden
🕒 4 years, fully-funded
🔍 Details: su.varbi.com/en/what:job/...
Please share!
PhD position in Evolutionary Systems Biology at Stockholm University & SciLifeLab
🎓 Focus: evolution, development, computational & mathematical modeling, prediction
📍 Stockholm, Sweden
🕒 4 years, fully-funded
🔍 Details: su.varbi.com/en/what:job/...
Please share!
August 25, 2025 at 9:01 AM
🚨 We're hiring!
PhD position in Evolutionary Systems Biology at Stockholm University & SciLifeLab
🎓 Focus: evolution, development, computational & mathematical modeling, prediction
📍 Stockholm, Sweden
🕒 4 years, fully-funded
🔍 Details: su.varbi.com/en/what:job/...
Please share!
PhD position in Evolutionary Systems Biology at Stockholm University & SciLifeLab
🎓 Focus: evolution, development, computational & mathematical modeling, prediction
📍 Stockholm, Sweden
🕒 4 years, fully-funded
🔍 Details: su.varbi.com/en/what:job/...
Please share!
Reposted by Lisandro Milocco
!
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades
www.pnas.org/doi/10.1073/...
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades
www.pnas.org/doi/10.1073/...
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades | PNAS
Rates of phenotypic evolution vary across traits, and these evolutionary patterns
themselves evolve. Understanding how development contributes to s...
www.pnas.org
August 23, 2025 at 1:47 PM
!
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades
www.pnas.org/doi/10.1073/...
Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades
www.pnas.org/doi/10.1073/...
Reposted by Lisandro Milocco
Developmental bias explains the evolutionary trend towards simple leaf shapes https://www.biorxiv.org/content/10.1101/2025.08.17.670617v1
August 21, 2025 at 5:32 PM
Developmental bias explains the evolutionary trend towards simple leaf shapes https://www.biorxiv.org/content/10.1101/2025.08.17.670617v1
Reposted by Lisandro Milocco
How do regulatory genes control alternative life histories? We have an open PhD position to answer this question using functional genomics in Atlantic salmon.
Apply by October 15th through www.jobbnorge.no/en/available...
Please share widely! 🧬🦑🖥️
Apply by October 15th through www.jobbnorge.no/en/available...
Please share widely! 🧬🦑🖥️
August 21, 2025 at 6:48 AM
How do regulatory genes control alternative life histories? We have an open PhD position to answer this question using functional genomics in Atlantic salmon.
Apply by October 15th through www.jobbnorge.no/en/available...
Please share widely! 🧬🦑🖥️
Apply by October 15th through www.jobbnorge.no/en/available...
Please share widely! 🧬🦑🖥️
Reposted by Lisandro Milocco
What is emergence? This is one of the most central ingredients of complexity, and a challenging one to formalize. Here's a paper by @seanmcarroll.bsky.social & Achyth Parola that attempts to classify different forms of emergence. @manlius.bsky.social @sfiscience.bsky.social arxiv.org/pdf/2410.15468
August 17, 2025 at 3:50 PM
What is emergence? This is one of the most central ingredients of complexity, and a challenging one to formalize. Here's a paper by @seanmcarroll.bsky.social & Achyth Parola that attempts to classify different forms of emergence. @manlius.bsky.social @sfiscience.bsky.social arxiv.org/pdf/2410.15468