Mike Neugent PhD
@mikeneugent.bsky.social
Ruth L. Kirschstein NRSA Postdoctoral Fellow | NIDDK | host microbiome metabolic interfaces | biochemical ecology | Women’s health | The De Nisco Lab
Pinned
Mike Neugent PhD
@mikeneugent.bsky.social
· Mar 26
Urinary biochemical ecology reveals microbiome-metabolite interactions and metabolic markers of recurrent urinary tract infection
Recurrent urinary tract infections (rUTIs) are a major clinical challenge and their increasing prevalence underscores the need to define host-microbiome interactions underlying susceptibility. How the...
doi.org
🚨 Preprint update
Excited to share our updated preprint on the biochemical ecology of recurrent UTI.
🧬 #Metagenomics + #metabolomics
🧪 Lipid biomarkers for active UTI (AUC = 0.91)
⚠️ DCA as a predictor of recurrence
🔗 doi.org/10.1101/2024...
#UTI #Microbiome #Metabolomics #PrecisionMedicine
Excited to share our updated preprint on the biochemical ecology of recurrent UTI.
🧬 #Metagenomics + #metabolomics
🧪 Lipid biomarkers for active UTI (AUC = 0.91)
⚠️ DCA as a predictor of recurrence
🔗 doi.org/10.1101/2024...
#UTI #Microbiome #Metabolomics #PrecisionMedicine
Reposted by Mike Neugent PhD
My first author paper is out on JU Open Plus.Check it out!
Bladder Wall–Embedded Bacteria Associated With Increased... : JU Open Plus journals.lww.com/juop/fulltex...
Bladder Wall–Embedded Bacteria Associated With Increased... : JU Open Plus journals.lww.com/juop/fulltex...
Bladder Wall–Embedded Bacteria Associated With Increased... : JU Open Plus
eria within the bladder walls of women with rUTI. We hypothesized that increased bladder wall bacterial burden may be associated with incomplete rUTI resolution after EF.
Materials and Methods:
Aft...
journals.lww.com
July 18, 2025 at 6:29 PM
My first author paper is out on JU Open Plus.Check it out!
Bladder Wall–Embedded Bacteria Associated With Increased... : JU Open Plus journals.lww.com/juop/fulltex...
Bladder Wall–Embedded Bacteria Associated With Increased... : JU Open Plus journals.lww.com/juop/fulltex...
What are we not seeing in the microbiome? 🤔
Metagenomics tells us who’s there—but not what surrounds them.
That’s a huge blind spot in microbial ecology. Let me explain. 🧵
Metagenomics tells us who’s there—but not what surrounds them.
That’s a huge blind spot in microbial ecology. Let me explain. 🧵
March 28, 2025 at 4:05 PM
What are we not seeing in the microbiome? 🤔
Metagenomics tells us who’s there—but not what surrounds them.
That’s a huge blind spot in microbial ecology. Let me explain. 🧵
Metagenomics tells us who’s there—but not what surrounds them.
That’s a huge blind spot in microbial ecology. Let me explain. 🧵
🚨 Preprint update
Excited to share our updated preprint on the biochemical ecology of recurrent UTI.
🧬 #Metagenomics + #metabolomics
🧪 Lipid biomarkers for active UTI (AUC = 0.91)
⚠️ DCA as a predictor of recurrence
🔗 doi.org/10.1101/2024...
#UTI #Microbiome #Metabolomics #PrecisionMedicine
Excited to share our updated preprint on the biochemical ecology of recurrent UTI.
🧬 #Metagenomics + #metabolomics
🧪 Lipid biomarkers for active UTI (AUC = 0.91)
⚠️ DCA as a predictor of recurrence
🔗 doi.org/10.1101/2024...
#UTI #Microbiome #Metabolomics #PrecisionMedicine
Urinary biochemical ecology reveals microbiome-metabolite interactions and metabolic markers of recurrent urinary tract infection
Recurrent urinary tract infections (rUTIs) are a major clinical challenge and their increasing prevalence underscores the need to define host-microbiome interactions underlying susceptibility. How the...
doi.org
March 26, 2025 at 6:24 PM
🚨 Preprint update
Excited to share our updated preprint on the biochemical ecology of recurrent UTI.
🧬 #Metagenomics + #metabolomics
🧪 Lipid biomarkers for active UTI (AUC = 0.91)
⚠️ DCA as a predictor of recurrence
🔗 doi.org/10.1101/2024...
#UTI #Microbiome #Metabolomics #PrecisionMedicine
Excited to share our updated preprint on the biochemical ecology of recurrent UTI.
🧬 #Metagenomics + #metabolomics
🧪 Lipid biomarkers for active UTI (AUC = 0.91)
⚠️ DCA as a predictor of recurrence
🔗 doi.org/10.1101/2024...
#UTI #Microbiome #Metabolomics #PrecisionMedicine
Reposted by Mike Neugent PhD
TODAY
Are you interested in learning more about the urobiome?
Join the CAIRIBU U-RIG Research Hour to hear talks from Seth Reasoner, titled "Pathogen Evolution in Neurogenic Bladder" and Katy Patras, titled "The Vaginal Microbiota and Colonization by Uropathogens."
Are you interested in learning more about the urobiome?
Join the CAIRIBU U-RIG Research Hour to hear talks from Seth Reasoner, titled "Pathogen Evolution in Neurogenic Bladder" and Katy Patras, titled "The Vaginal Microbiota and Colonization by Uropathogens."
January 24, 2025 at 3:00 PM
TODAY
Are you interested in learning more about the urobiome?
Join the CAIRIBU U-RIG Research Hour to hear talks from Seth Reasoner, titled "Pathogen Evolution in Neurogenic Bladder" and Katy Patras, titled "The Vaginal Microbiota and Colonization by Uropathogens."
Are you interested in learning more about the urobiome?
Join the CAIRIBU U-RIG Research Hour to hear talks from Seth Reasoner, titled "Pathogen Evolution in Neurogenic Bladder" and Katy Patras, titled "The Vaginal Microbiota and Colonization by Uropathogens."
Reposted by Mike Neugent PhD
NEXT MONTH
Join Urobiome 2025 on February 24th, 2025 in San Diego, CA. Learn more about the state of urobiome research from expert investigators!
More information HERE: https://buff.ly/3PHUl0W
Join Urobiome 2025 on February 24th, 2025 in San Diego, CA. Learn more about the state of urobiome research from expert investigators!
More information HERE: https://buff.ly/3PHUl0W
January 24, 2025 at 4:00 PM
NEXT MONTH
Join Urobiome 2025 on February 24th, 2025 in San Diego, CA. Learn more about the state of urobiome research from expert investigators!
More information HERE: https://buff.ly/3PHUl0W
Join Urobiome 2025 on February 24th, 2025 in San Diego, CA. Learn more about the state of urobiome research from expert investigators!
More information HERE: https://buff.ly/3PHUl0W
Reposted by Mike Neugent PhD
THIS WEEK
Are you interested in learning about transitional care?
Join this CAIRIBU Catalyst Conversation to hear from Dr. Kristin Ebert. Her talk is titled "Navigating the Journey: Enhancing Transitional Care for Urology Patients."
More info: https://buff.ly/3Wtazij
Are you interested in learning about transitional care?
Join this CAIRIBU Catalyst Conversation to hear from Dr. Kristin Ebert. Her talk is titled "Navigating the Journey: Enhancing Transitional Care for Urology Patients."
More info: https://buff.ly/3Wtazij
January 27, 2025 at 3:00 PM
THIS WEEK
Are you interested in learning about transitional care?
Join this CAIRIBU Catalyst Conversation to hear from Dr. Kristin Ebert. Her talk is titled "Navigating the Journey: Enhancing Transitional Care for Urology Patients."
More info: https://buff.ly/3Wtazij
Are you interested in learning about transitional care?
Join this CAIRIBU Catalyst Conversation to hear from Dr. Kristin Ebert. Her talk is titled "Navigating the Journey: Enhancing Transitional Care for Urology Patients."
More info: https://buff.ly/3Wtazij
Reposted by Mike Neugent PhD
Don't forget to submit an abstract to the 10th Annual Duke University Multidisciplinary Benign Urology Research Symposium before the deadline on March 4th!
Submit here: https://buff.ly/4ggUSSc
Submit here: https://buff.ly/4ggUSSc
January 28, 2025 at 10:00 PM
Don't forget to submit an abstract to the 10th Annual Duke University Multidisciplinary Benign Urology Research Symposium before the deadline on March 4th!
Submit here: https://buff.ly/4ggUSSc
Submit here: https://buff.ly/4ggUSSc
Reposted by Mike Neugent PhD
I introduce to you Dr. Molina!!! Congratulations Jon!! You did a great job!!
January 15, 2025 at 1:09 AM
I introduce to you Dr. Molina!!! Congratulations Jon!! You did a great job!!
Reposted by Mike Neugent PhD
The GLP-1 family of drugs have anti-inflammatory effects independent of weight loss.
2 new studies shed light on the mechanisms
—brain-gut-GLP axis blocks inflammation induced by TLRs (toll-like receptor)
www.cell.com/cell-metabol...
2 new studies shed light on the mechanisms
—brain-gut-GLP axis blocks inflammation induced by TLRs (toll-like receptor)
www.cell.com/cell-metabol...
December 27, 2024 at 2:55 PM
The GLP-1 family of drugs have anti-inflammatory effects independent of weight loss.
2 new studies shed light on the mechanisms
—brain-gut-GLP axis blocks inflammation induced by TLRs (toll-like receptor)
www.cell.com/cell-metabol...
2 new studies shed light on the mechanisms
—brain-gut-GLP axis blocks inflammation induced by TLRs (toll-like receptor)
www.cell.com/cell-metabol...
Reposted by Mike Neugent PhD
Harvard scientists are leaving academia for the private sector to fast-track biomedical breakthroughs. Michael Mina (eMed), Douglas Melton (Vertex), Stuart Schreiber (Arena Bioworks) cite funding delays & admin hurdles as key reasons. #BiomedicalResearch www.harvardmagazine.com/2025/01/harv...
Harvard Professors Leaving for Private Sector Research | Harvard Magazine
Three distinguished scientists on leaving academia to advance biomedical research
www.harvardmagazine.com
December 24, 2024 at 7:46 PM
Harvard scientists are leaving academia for the private sector to fast-track biomedical breakthroughs. Michael Mina (eMed), Douglas Melton (Vertex), Stuart Schreiber (Arena Bioworks) cite funding delays & admin hurdles as key reasons. #BiomedicalResearch www.harvardmagazine.com/2025/01/harv...
I was today years old when i learned about the mixOmics R package… omg
December 20, 2024 at 9:52 PM
I was today years old when i learned about the mixOmics R package… omg
Reposted by Mike Neugent PhD
so proud of Adwaita Parab and Arnold Salazar Baylor College of Medicine presenting their work on #Bladder #organoids #ifrd1 #bladderProteostasis
December 6, 2024 at 5:40 PM
so proud of Adwaita Parab and Arnold Salazar Baylor College of Medicine presenting their work on #Bladder #organoids #ifrd1 #bladderProteostasis
Reposted by Mike Neugent PhD
must mention that our dinner at Zarletti Milwaukee was fantastic 😋
December 6, 2024 at 5:39 PM
must mention that our dinner at Zarletti Milwaukee was fantastic 😋
Reposted by Mike Neugent PhD
Outstanding annual #CAIRIBU meeting in #MilwaukeeWI.
excellent Basic, Translational, and Clinical Sciences research in #Urology #Urogynecology #bladder health #Aging #bladder #Immunology
excellent Basic, Translational, and Clinical Sciences research in #Urology #Urogynecology #bladder health #Aging #bladder #Immunology
December 6, 2024 at 5:38 PM
Outstanding annual #CAIRIBU meeting in #MilwaukeeWI.
excellent Basic, Translational, and Clinical Sciences research in #Urology #Urogynecology #bladder health #Aging #bladder #Immunology
excellent Basic, Translational, and Clinical Sciences research in #Urology #Urogynecology #bladder health #Aging #bladder #Immunology
Reposted by Mike Neugent PhD
Good morning, @mikeneugent.bsky.social!
(A year ago, Mike and I started spontaneously our coffee greeting thread on X, and, obviously now we are transferring it here)
(A year ago, Mike and I started spontaneously our coffee greeting thread on X, and, obviously now we are transferring it here)
November 26, 2024 at 12:13 PM
Good morning, @mikeneugent.bsky.social!
(A year ago, Mike and I started spontaneously our coffee greeting thread on X, and, obviously now we are transferring it here)
(A year ago, Mike and I started spontaneously our coffee greeting thread on X, and, obviously now we are transferring it here)
Where did November go?
November 23, 2024 at 7:19 AM
Where did November go?
November 22, 2024 at 3:50 AM
Reposted by Mike Neugent PhD
Amazing work from the lab of Sheng Xu in our UCSD Institute of Engineering in Medicine just published in Nature Biomedical Engineering.
This tiny wearable patch matched results from blood pressure cuffs and arterial lines — validated in more than 100 patients!
today.ucsd.edu/story/resear...
This tiny wearable patch matched results from blood pressure cuffs and arterial lines — validated in more than 100 patients!
today.ucsd.edu/story/resear...
Researchers Develop Clinically Validated, Wearable Ultrasound Patch for Continuous Blood Pressure Monitoring
A re-engineered wearable ultrasound patch for continuous and noninvasive blood pressure monitoring has undergone comprehensive clinical validation on over 100 patients, marking a major milestone in we...
today.ucsd.edu
November 21, 2024 at 3:14 PM
Amazing work from the lab of Sheng Xu in our UCSD Institute of Engineering in Medicine just published in Nature Biomedical Engineering.
This tiny wearable patch matched results from blood pressure cuffs and arterial lines — validated in more than 100 patients!
today.ucsd.edu/story/resear...
This tiny wearable patch matched results from blood pressure cuffs and arterial lines — validated in more than 100 patients!
today.ucsd.edu/story/resear...
Reposted by Mike Neugent PhD
Why is preterm birth risk doubled with maternal UTI? It depends on the immune response. We found distinct immune signatures in a UTI-associated preterm birth mouse model. In a human cohort from @AShea_Lab, urine cytokine levels could predict preterm birth. www.biorxiv.org/content/10.1...
Distinct maternofetal immune signatures delineate preterm birth onset following urinary tract infection
Preterm birth is the leading cause of infant mortality resulting in over one million neonatal deaths annually. Maternal urinary tract infection (UTI) during pregnancy increases risk for preterm birth;...
www.biorxiv.org
October 25, 2024 at 9:57 PM
Why is preterm birth risk doubled with maternal UTI? It depends on the immune response. We found distinct immune signatures in a UTI-associated preterm birth mouse model. In a human cohort from @AShea_Lab, urine cytokine levels could predict preterm birth. www.biorxiv.org/content/10.1...
Reposted by Mike Neugent PhD
This will me my fist blueet! Microbial N-Acyl lipids have been shown to regulate glucose, pain etc among other things. Therefore Helena, Vincent and Martijn asked the question - are there more and if so what types? And boy did they find some www.biorxiv.org/content/10.1...
The microbiome diversifies N-acyl lipid pools - including short-chain fatty acid-derived compounds
N -acyl lipids are important mediators of several biological processes including immune function and stress response. To enhance the detection of N -acyl lipids with untargeted mass spectrometry-based...
www.biorxiv.org
November 19, 2024 at 3:19 AM
This will me my fist blueet! Microbial N-Acyl lipids have been shown to regulate glucose, pain etc among other things. Therefore Helena, Vincent and Martijn asked the question - are there more and if so what types? And boy did they find some www.biorxiv.org/content/10.1...
Reposted by Mike Neugent PhD
Here is a second bleetorial about a paper we recently preprinted. Here @shipei-xing.bsky.social wanted to find a solution to be able to re-use data in the public domain with MS1 data only - LC-MS and imaging mass spectrometry data. www.biorxiv.org/content/10.1...
Annotating full-scan MS data using tandem MS libraries
Full-scan mass spectrometry (MS) data from both liquid chromatography (LC) and MS imaging capture multiple ion forms, including their in-source fragments. Here we leverage such fragments to structural...
www.biorxiv.org
November 19, 2024 at 4:47 PM
Here is a second bleetorial about a paper we recently preprinted. Here @shipei-xing.bsky.social wanted to find a solution to be able to re-use data in the public domain with MS1 data only - LC-MS and imaging mass spectrometry data. www.biorxiv.org/content/10.1...
Reposted by Mike Neugent PhD
Ok a third bleetorial or skeetorial of another preprint. www.biorxiv.org/content/10.1... in this case Nina, our exposome expert, Kine, our expert pharmacist, Corinna, the MS/MS guru, wanted to identify medication exposures from untargeted metabolomics data. Why? - aren’t there good medical records?
Empirically establishing drug exposure records directly from untargeted metabolomics data
Despite extensive efforts, extracting information on medication exposure from clinical records remains challenging. To complement this approach, we developed the tandem mass spectrometry (MS/MS) based...
www.biorxiv.org
November 20, 2024 at 3:18 AM
Ok a third bleetorial or skeetorial of another preprint. www.biorxiv.org/content/10.1... in this case Nina, our exposome expert, Kine, our expert pharmacist, Corinna, the MS/MS guru, wanted to identify medication exposures from untargeted metabolomics data. Why? - aren’t there good medical records?
Reposted by Mike Neugent PhD
This drug repurposing project for the clearance of intracellular pathogens - led by @ronni.bsky.social - is now published in ASC Infectious Diseases. 🤩 pubs.acs.org/doi/10.1021/...
November 19, 2024 at 1:10 AM
This drug repurposing project for the clearance of intracellular pathogens - led by @ronni.bsky.social - is now published in ASC Infectious Diseases. 🤩 pubs.acs.org/doi/10.1021/...
Is it odd for assistant professor job applications to ask for official transcripts from grad school… or even undergrad?
… asking for a friend.
… asking for a friend.
November 19, 2024 at 2:36 AM
Is it odd for assistant professor job applications to ask for official transcripts from grad school… or even undergrad?
… asking for a friend.
… asking for a friend.