Margaret Gadek
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margaretgadek.bsky.social
Margaret Gadek
@margaretgadek.bsky.social
66 followers 97 following 2 posts
UCSF MDPhD student studying the X chromosome
UChicago trained | Minnesota raised
Often found walking around the city or listening to the radio in the park
she/her
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Reposted by Margaret Gadek
denadubal.bsky.social
Congratulations @margaretgadek.bsky.social on a wildly successful PhD! On to the MD!
April 12, 2025 at 12:36 AM
Reposted by Margaret Gadek
science.org
A new #ScienceAdvances study examines how aging-driven reactivation of genes in the silent X chromosome affects cognitive decline in female mice. #WomensHealth scim.ag/3DxPjl7
Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
scim.ag
March 11, 2025 at 7:51 PM
Reposted by Margaret Gadek
science.org
A special issue on #WomensHealth in #ScienceAdvances highlights a growing wave of research focusing on women’s unique biological and psychological experiences.

Learn more: scim.ag/3R59fPe (THREAD 🧵)
Science Advances’ special issue on women’s health highlights a growing wave of research focusing on women’s unique biological and psychological experiences. Articles cover a range of studies from the interplay between menopause and Alzheimer’s risk to the menstrual cycle’s influence on the brain-heart connection. It also describes the opportunities pregnancy provides to research aspects of both physical and mental health. By prioritizing women’s unique physiological and psychological experiences, research can expand the frontiers of knowledge in ways that benefit everyone.
March 11, 2025 at 7:46 PM
margaretgadek.bsky.social
Thanks for sharing our work! The second X chromosome is a fascinating part of our genome.
nature.com Nature @nature.com · Mar 6
Women tend to live longer than men and are often more resilient to cognitive decline as they age.

Now researchers might have uncovered a source for this resilience: the second X chromosome in female cells that was previously considered ‘silent’

https://go.nature.com/3F40x10
Why women’s brains are more resilient: it could be their ‘silent’ X chromosome
Study in mice and human cadavers hints that a brain-protective gene in the chromosome becomes more active with age.
go.nature.com
March 6, 2025 at 3:40 PM
Reposted by Margaret Gadek
denadubal.bsky.social
"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @margaretgadek.bsky.social in Science Advances. www.science.org/doi/10.1126/...
Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
www.science.org
March 6, 2025 at 5:24 AM
margaretgadek.bsky.social
Our new Science Advances paper reveals activation of the silent X chromosome as a mechanism of female resilience in cognitive aging www.science.org/doi/10.1126/...

Many thanks to
@denadubal.bsky.social
for your mentorship on this project!!
Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
www.science.org
March 5, 2025 at 8:19 PM